2177results about How to "Shorten the duration" patented technology

The present invention relates to biphenyl-pyrazole compounds and in particular biphenyl-pyrazolecarboxamides. The invention further provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by antagonism or inverse agonism of the CB1 receptor, such as obesity, smoking cessation, and normalization of blood lipid composition.

A computer-implemented method for managing operating-room resources in a hospital includes the steps of receiving at least one surgery request, identifying the resources required for surgery associated with the surgery request, capturing initial data on availability of the resources, capturing initial patient data, and establishing a pre-scheduled operating-room plan based on an initial optimization, and the further steps of capturing current data on availability of the resources, capturing current patient data and establishing a current operating-room plan based on a current optimization. A computer-based system for managing operating-room resources in a hospital and a modular computer-based system for managing operating-room related processes in a hospital are also disclosed.

A method and apparatus for direct interstitial treatment of tissue, while preventing backflow and decreasing drainage of a flowable composition from an injected area, by using a catheter and / or a needle with single or multiple inflatable member(s) that stretches, dilates and compresses target tissue and allows for an improved interstitial deposition, distribution and retention of the flowable composition, drug(s), agent(s), or particle(s), into a body organ, fluid, tissue, or tumor, thereby increasing procedural safety and efficacy of direct interstitial therapies.

System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.

A plurality of pins attach to bone, such as a vertebra (not shown). Spacers interpose between pins. A cable extends through pins and spacers between a cap and an expansion sleeve. The expansion sleeve increases cable tension to restrict movement among pins and spacers.

A pulsed laser comprises an oscillator and amplifier. An attenuator and / or pre-compressor may be disposed between the oscillator and amplifier to improve performance and possibly the quality of pulses output from the laser. Such pre-compression may be implemented with spectral filters and / or dispersive elements between the oscillator and amplifier. The pulsed laser may have a modular design comprising modular devices that may have Telcordia-graded quality and reliability. Fiber pigtails extending from the device modules can be spliced together to form laser system. In one embodiment, a laser system operating at approximately 1050 nm comprises an oscillator having a spectral bandwidth of approximately 19 nm. This oscillator signal can be manipulated to generate a pulse having a width below approximately 90 fs.

The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.

The present invention provides methods for inhibiting interleukin-3 receptor-expressing cells, and, in particular, inhibiting the growth of such cells by using a diphtheria toxin-human interleukin-3 conjugate (DT-IL3) that is toxic to cells expressing the interleukin-3 receptor. In preferred embodiments, the DT-IL3 conjugate is a fusion protein comprising amino acids 1-388 of diphtheria toxin fused via a peptide linker to full-length, human interleukin-3. In certain embodiments, the methods of the present invention relate to the administration of a DT-IL3 conjugate to inhibit the growth of cancer cells and / or cancer stem cells in humans, which cells express one or more subunits of the interleukin-3 receptor. Exemplary cells include myeloid leukemia cancer stem cells. In other embodiments, the methods of the present invention relate to ex vivo purging of bone marrow or peripheral blood to remove cells that express one or more subunits of the interleukin-3 receptor such that the purged bone marrow or peripheral blood is suitable, e.g., for autologous stem cell transplantation to restore hematopoietic function.

There is provided a water level sensing apparatus including: a body disposed to be exposed within a liquid tank and having an accommodating space therein; and a capacitance detecting unit accommodated in the accommodating space of the body, wherein the capacitance detecting unit compares an upper side capacitance value and a lower side capacitance value and turns on or off an output signal. Because a changeable reference that the capacitance values of a reference surface and a detected surface of the body are simultaneously changed is used, even if the body comes in contact with moisture or debris, the reference surface and the detected surface are equally affected by the moisture or debris, thus reducing the occurrence of malfunction.

The present invention relates to a system and methods for noninvasively providing therapy for movement disorder symptoms. The present invention provides such a therapy system which provides trans-cranial direct current stimulation (tDCS) in order to treat those symptoms and the disorders. The present invention further provides such tDCS therapy while the subject sleeps in order to minimize the time required and impact of the therapy on the subject's waking life. The system, methods, and devices of the present invention are intended to provide a low-dose electrical current, trans-cranially, to a specific area of the subject's brain while he or she sleeps in order to decrease the occurrence, severity, and duration of the symptoms of movement disorders. The present invention aims to reduce the amount of medication necessary, counteract the effects of medication wearing off during sleep, and to overall improve the quality of life of subjects suffering from movement disorders.