20754results about How to "Shorten the construction period" patented technology

The present invention provides methods of re-engineering or re-shaping an antibody from a first species, wherein the re-engineered or re-shaped antibody does not elicit undesired immune response in a second species, and the re-engineered or re-shaped antibody retains substantially the same antigen binding-ability of the antibody from the first species. In accordance with the present invention, a combinatorial library comprising the CDRs of the antibody from the first species fused in frame with framework regions derived from a second species can be constructed and screened for the desired modified antibody. In particular, the present invention provides methods utilizing low homology acceptor antibody frameworks for efficiently humanizing an antibody or a fragment thereof. The present invention also provides antibodies produced by the methods of the invention.

A method and system for providing flexible subscriber VCR control of an interactive media system that limits the consumption of bandwidth capacity, the method comprising establishing a viewing time window during which a subscriber can watch an ordered program, enabling the subscriber to freely pause, rewind, and fast-forward the program so long as the end of the program does not exceed the end of the window, automatically tracking the remaining program running time against the time remaining in the window, deactivating the pause and rewind features if the remaining program running time equals the time remaining in the window, and reactivating the pause and rewind features if the program is fast-forwarded such that the time remaining in the window exceeds the remaining program running time. The system of the present invention is any interactive media system that delivers video streams such as an interactive television system that supports services such as pay-per-view and video-on-demand, or an internet-based interactive media system that downloads video streams through the internet to be played on a subscriber's personal computer or other viewing device.

A software platform in communication with networked distributed energy resource energy storage apparatus, configured to deliver various specific applications related to offset demand monitoring, methods of virtual power plant and orchestration, load shaping services, methods of reducing demand at aggregated level, prioritizing computer programs related to virtual energy pool, energy cloud controllers methods, charge discharge orchestration plans of electric vehicles, distributed energy resources, machine learning predictive algorithms, value optimizing algorithms, autonomous sensing event awareness, mode selection methods, capacity reservation monitoring, virtual power plant methods, advanced DER-ES apparatus features, energy management system for governing resources and methods, aggregated energy cloud methods, load shaping methods, marginal cost cycle-life degradation, load shaping API, forward event schedule, on demand request, and load service state request methods. Various rules, constraints of predictive algorithms for signal inputs to determine incremental storage cycles, cycle life degradation marginal cost, iterative and forward event schedule development, and load control.

The present invention relates to a stent including a variable porosity, tubular structure having pores defined by structural surfaces. The tubular structure has a low porosity region in proximity to or at either end of the tubular structure, where the low porosity region is less porous than other regions located on the tubular structure and fully or partially obstructs passage of fluid. Any arcuate path that starts at one point within the low porosity region and goes around the perimeter of the tubular structure to stop at the same point within the low porosity region must have at least a portion that is outside of the low porosity region. Also disclosed is a method of modifying blood flow within and near an opening of an aneurysm in a blood vessel by deploying one or more stents of the present invention near an opening of the aneurysm in a blood vessel.

Methods and systems are provided for routing callers to agents in a call-center routing environment. An exemplary method includes identifying caller data for a caller in a queue of callers, and jumping or moving the caller to a different position within the queue based on the caller data. The caller data may include one or both of demographic data and psychographic data. The caller can be jumped forward or backward in the queue relative to at least one other caller. Jumping the caller may further be based on comparing the caller data with agent data via a pattern matching algorithm and/or computer model for predicting a caller-agent pair outcome. Additionally, if a caller is held beyond a hold threshold (e.g., a time, “cost” function, or the like) the caller may be routed to the next available agent.

Methods and systems are provided for routing callers to agents in a call-center routing environment. An exemplary method includes routing a caller from a pool of callers based on at least one caller data associated with the caller, where a pool of callers includes, e.g., a set of callers that are not chronologically ordered and routed based on a chronological order or hold time of the callers. The caller may be routed from the pool of callers to an agent, placed in another pool of callers, or placed in a queue of callers. The caller data may include demographic or psychographic data. The caller may be routed from the pool of callers based on comparing the caller data with agent data associated with an agent via a pattern matching algorithm and/or computer model for predicting a caller-agent pair outcome. Additionally, if a caller is held beyond a hold threshold (e.g., a time, “cost” function, or the like) the caller may be routed to the next available agent.

Systems and methods are disclosed for routing callers to agents in a contact center, along with an intelligent routing system. An exemplary method includes combining multiple output variables of a pattern matching algorithm (for matching callers and agents) into a single metric for use in the routing system. The pattern matching algorithm may include a neural network architecture, where the exemplary method combines output variables from multiple neural networks. The method may include determining a Z-score of the variable outputs and determining a linear combination of the determined Z-scores for a desired output. Callers may be routed to agents via the pattern matching algorithm to maximize the output value or score of the linear combination. The output variables may include revenue generation, cost, customer satisfaction performance, first call resolution, cancellation, or other variable outputs from the pattern matching algorithm of the system.

A preformed, seamless, three-dimensional, anatomically contoured prosthetic device for reinforcing breast tissue and supporting a breast implant includes a flat back wall, a concave front wall and a curved transitional region between the flat back wall and the front wall defining a smoothly curved bottom periphery. A concave receiving space is defined by the back wall and the front wall for at least partially receiving and supporting the breast implant therein. The three-dimensional prosthetic device is free of wrinkles, creases, folds or seams, which may have otherwise caused potential tissue irritation, bacteria hosting, infection and palpability problems.

The present invention includes methods and materials for implantable devices (markers) which are disclosed for permanently marking the location of a biopsy or surgery for the purpose of identification. The devices are remotely delivered, preferably percutaneously. Visualization of the markers is readily accomplished using various state of the art imaging systems. Preferred visualization is through MRI, X-ray and ultrasound. The markers function to provide evidence of the location of the lesion after the procedure is complete for reference during future examinations or procedures.

Systems, methods, and computer-readable storage media for inter-node data replication while reducing network traffic for remote backup. A system receives a command to duplicate a dataset, located on a source network node, to a remote network node, accesses, on the source network node, signatures of a previous snapshot of the dataset and signatures of a current snapshot of the dataset, performs, at the source network node, a local signature comparison between the previous snapshot and the current snapshot to identify one or more signatures that do not match, sends the signatures that do not match to the remote network node, searches, on the remote network node, for the signatures that do not match, and sends data associated with the signatures that do not match to the remote network node for incorporation within a current remote snapshot if they do not exist on a current remote network node.

The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.