73058 results about "Curative effect" patented technology

A neurological control system for modulating activity of any component or structure comprising the entirety or portion of the nervous system, or any structure interfaced thereto, generally referred to herein as a “nervous system component.” The neurological control system generates neural modulation signals delivered to a nervous system component through one or more neuromodulators to control neurological state and prevent neurological signs and symptoms. Such treatment parameters may be derived from a neural response to previously delivered neural modulation signals sensed by one or more sensors, each configured to sense a particular characteristic indicative of a neurological or psychiatric condition.

Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, for example a baroreceptor in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements / consumption.

A nano-class biologic product of Chinese-medicinal material for higher biological utilization rate and target nature, lower toxic by-effect and improved curative effect is prepared through preparing the nanoparticles of Chinese-medicinal materials, and preparing nano-class (50-80 nm) biologic product.

A method and apparatus for direct interstitial treatment of tissue, while preventing backflow and decreasing drainage of a flowable composition from an injected area, by using a catheter and / or a needle with single or multiple inflatable member(s) that stretches, dilates and compresses target tissue and allows for an improved interstitial deposition, distribution and retention of the flowable composition, drug(s), agent(s), or particle(s), into a body organ, fluid, tissue, or tumor, thereby increasing procedural safety and efficacy of direct interstitial therapies.

The invention provides a method for predicting the efficacy of a compound for treating psoriasis based on a pharmacokinetic / pharmacodynamic model.

Nonlinear generalized dynamic regression analysis system and method of the present invention preferably uses all available data at all time points and their measured time relationship to each other to predict responses of a single output variable or multiple output variables simultaneously. The present invention, in one aspect, is a system and method for predicting whether an intervention administered to a patient changes the physiological, pharmacological, pathophysiological, or pathopsychological state of the patient with respect to a specific medical condition. The present invention uses the theory of martingales to derive the probabilistic properties for statistical evaluations. The approach uniquely models information in the following domains: (1) analysis of clinical trials and medical records including efficacy, safety, and diagnostic patterns in humans and animals, (2) analysis and prediction of medical treatment cost-effectiveness, (3) the analysis of financial data, (4) the prediction of protein structure, (5) analysis of time dependent physiological, psychological, and pharmacological data, and any other field where ensembles of sampled stochastic processes or their generalizations are accessible. A quantitative medical condition evaluation or medical score provides a statistical determination of the existence or onset of a medical condition.

A Chinese medicine for treating cervical spondylopathy, periomethritis, lumbar intervertebral disc protrusion and hyperosteogeny is prepared from 79 Chinese-medicinal materials including centipede, ground beetle, Chuan-xiong rhizome, myrrh, etc. Its preparing process is also disclosed.

The invention relates to new use of levo-oxiracetam in pharmaceutical field, and in particular relates to application of levo-oxiracetam in preparation of a medicine for treating memory and intelligence disturbance. The experiment result shows that the levo-oxiracetam is a main active ingredient for playing efficacy in oxiracetam, the clinical dosage can be greatly reduced by singly using the levo-oxiracetam, and the potential toxic and side effect is reduced. According to the invention, the levo-oxiracetam is a single active ingredient, the raw material purity is greater than 99.5% so as to effectively avoid the toxicity risk caused by other impurities in the medicine, the pharmacy is safer, the medicine quality is more controllable, and the curative effect is more precise.

This invention concerns the method of extracting salvianolic acid A from Chinese crude drug: danshen root, and the quality control methods and drug combinations, and the application of this drug. It can be used in the preparation of the prevention drugs for cardiovascular disease, liver damage, liver fibrosis, pulmonary fibrosis and other.

Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention, such as alpha-tocopherol quinone. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.

The invention discloses a human-body absorbable trauma dressing containing Yunnan white drug powder or Yunnan white drug powder extractive, which is a novel medicine-carried dressing or a novel formulation of Yunnan white drug powder. The invention has the following remarkable characteristics: (1) the dressing can be absorbed by human bodies to lessen the pain added by dressing change and reduce the treatment cost; (2) the dressing can be made into a film solid dressing or an aquagel dressing so as to expand the use modes, the scope of applications and the drug effect of the Yunnan white drug powder; and (3) the curative effect of the dressing is enhanced by selecting a carrier material, auxiliary medicaments and functional accessories and adjusting the microstructure structure. The novel absorbable Yunnan white drug powder dressing overcomes the defects of the traditional Yunnan white drug powder in use and has economic and social values.

The present invention discloses an accurate radiation treatment planning system, which mainly comprises a three-dimensional medical image reconstruction module for reconstruction of human organs and the tumor target area, a three-dimensional dose calculation module of high accuracy photon beam, a three-dimensional dose calculation module of high accuracy electron beam, a conventional radiation plan designing module of the photon beam and the electron beam, a conformal radiation designing module of the photon beam and the electron beam, a reverse plan scheme designing module focused on the photon beam treatment. The present invention independently resolves the main and key technology of the radiation treatment planning system. The present invention develops a highly accurate algorithm and a fast precise optimal method of the three-dimensional dose distribution in photon beam and the electron beam, which distributes in non-uniform human medium. The present invention greatly improves accuracy of the embarking dose in tumor target area in patient body. Because the dose calculation speed has been improved dramatically, the advanced conformal radiation treatment planning system and the treatment planning system focused on radiation are feasible for clinical application. The present invention brings important benefits for improving the radiation treatment effect and improving life quality of the patient.

The invention relates to a Chinese medicinal preparation for treating bone fracture, which is prepared from 84 raw medicinal materials such as radix astragali, Chinese angelica, rehmanniae vaporata, rehmanniae praeparatum, suberect spatholobus stem, human placenta and the like. The medicament can be made into an oral preparation and external application preparation. A preparation method comprises the following steps: preparing an aqueous extract of the raw medicinal materials, and preparing an oral solution and a spraying agent from the aqueous extract; and preparing extracting pulvis from the aqueous extract, and preparing granules, pills, medicinal granules, tablets or capsules from the extracting pulvis. Raw medicinal powder also can be ground into raw powder pulvis which can be prepared into the granules, the pills, the medicinal granules, the tablets or the capsules, or the raw powder pulvis is prepared into external application ointment. In addition, the raw medicinal materials also can be infused to form medicinal liquor. The Chinese medicinal preparation has good curative effect on bone fracture diseases of different types, is mainly used for treating different types of fracture, muscles and bones breakage, traumatic injury, new and old incised wound and gunshot wound, bleeding and blood stasis which are caused by traumatism and other symptoms, and has the obvious curative effect on rheumatoid arthritis. The Chinese medicinal preparation is prepared from pure Chinese medicaments, and has convenient use, safety, reliability, no toxic or side effect and long-term use.

Milling and drilling tools and soft tissue management techniques are provided for arthroplasty that facilitate intraoperative and postoperative efficacy and ease of use. In one embodiment, resiliently biased soft tissue protective sleeves surround a side cutting tool and are interposed along the longitudinal axis of the cutting tool, preferably adjacent each side of the bone. The soft tissue protective sleeves are biased to track along the contour of the side of the bone and prevent the cutting tool from being exposed to soft tissue during the resection. In another embodiment, a pilot drill is initially utilized to create an initial bore in the bone to be resected. The pilot drill preferably has an end cutting arrangement and a non-cutting removal channel that minimizes the tendency of the pilot drill bit to drift off-axis as the initial bore in the bone is created. Once the initial bore is created, the pilot drill bit is withdrawn and a second side cutting tool, such as a milling bit, is then inserted into the bore to perform the desired surface resection.

The present invention generally relates to a combination of the fields of tissue engineering, drug discovery and drug development. It more specifically provides new methods and materials for testing the efficacy and safety of experimental drugs, defining the metabolic pathways of experimental drugs and characterizing the properties (e.g., side effects, new uses) of existing drugs. Preferably, evaluation is carried out in three-dimensional tissue-engineered systems, wherein drug toxicity, metabolism, interaction and / or efficacy can be determined.

The invention provides a curcumin oral emulsion and injection, wherein the emulsion comprises curcumin, oil, emulsifying agent and water, the injection also contains isotonic agent. The invention also discloses the process for preparing the emulsion and its use in preparing medicaments for treating or preventing tumor, resisting tumor transfer, enhancing curative effects of chemotherapy drugs, reducing side effects of chemotherapy and improving immunity functions for tumor patients.

The invention discloses a pharmaceutical composition for treating rheumatism and rheumatoid disease, wherein the constituents include black-tail snake, gastrodia tuber, Clematis chinensis, pubescent angelica root, notopterygium root, ledebouriella root, speranskia herb, Loranthus mulberry mistletoe, cortex acanthopanacis, root of herbaceous peony, earthworm, achyranthes and cyathula root, dipsacus root, drynaria, east Asian tree fern rhizome, broomrape, psoralea fruit, eucommia bark, deer horn gum, homalomena rhizoma, hairy birthwort, batryticated silkworm, dragon's blood resin, Moghania philippinensis, futokadsura stem, rhizoma dioscoreae hypoglaueae, herba siehesbeckiae, root of red rooted saliva, buck grass, orienavine, anisetree bark, Japanese yam, pawpaw, large-leaf gentian root, and Tripterygium wilfordii 120-150, prepared Sichuan aconite root, prepared wild aconite root, processed semen strychni each 280-320g, Chinese angelica root, red ginseng, astragalus root each 140-180, pipe-fish, wood louse, buthus martensi karsch, Chinese ephedra, licorice root each 70-80, safflower, Ligusticum wallichii, notoginseng, cassia twig, hornet nest 100-120, centipede 50-60, asaryl, aniseed 80-100 and Aconitum pendulum Busch 15-20.

The invention discloses a traditional Chinese medicine for treating acne through oral administration and is prepared by more than fifty traditional Chinese medicinal materials of gamene, broom cypress fruit, cortex dictamni, and so on; moreover, the invention is added with proper amount of pangolin so as to strengthen the effect of pus evacuation. According to the traditional Chinese theory of clearing away heat and toxic material, clearing lung heat, invigorating the spleen, relieving dyspepsia, promoting qi, removing dampness, dispelling wind, arresting itching, strengthening interior, relieving superficies, activating blood circulation, cooling the blood, removing stagnation, dredging the collaterals, resisting bacterium and diminishing inflammation, the invention makes use of the synergetic effect of the components to treat acne. The medicine for oral administration has short treatment course, stable curative effect and no recurrence; mild acne can be cured in about 30 days, moderate acne about 45 days and severe acne about 60 days; through the clinical observation of 100 cases of patients with acne, the effective rate of the invention can be 100 percent and the cure rate thereof can reach 62 percent; therefore the invention solves the problems of long treatment course, insignificant curative effect, easy recurrence and certain side effect on the human body in the existing medicines used for treating acne. .

The invention relates to a Chinese herbal medicine paste for relieving pain, comprising a plurality of medicine materials of angelica, cassia twig, rhizoma chuanxiong, olibanum, myrrh, sylvestris, pubescent angelica, milettia reticulate, pheretima, siegesbeckiae, balsamine, japan yam rhizome, futokadsura stem, orientavine, a millet liquor flavored with the root bark, nuxvomica, Chinese polyphaga, homalomena rhizome, Chinese clematis radix clematidis with fixed weight proportions. The preparation method comprises the following steps: immerse the Chinese herbal medicine materials with fixed weight proportions into sesame oil; 1 kilogram medicine consumes 0.5kg sesame oil; after sever days of immersion, heat mixture for boiling and deslag the mixture; place the residual material on cloth to form a plaster. When in use, slightly heat the plaster and adhere the plaster to the affected part; and each plaster can be used for four days. The Chinese herbal medicine paste has the advantages of effective pain relief and elimination, simple application, rapid and persistent therapeutic effect and low side effect.

One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., insomnia and / or depression. The first component of the pharmaceutical composition is a GABA receptor modulating compound. The second component of the pharmaceutical composition is a serotonin reuptake inhibitor, a norepinephrine reuptake inhibitor, a 5-HT2A modulator, or dopamine reuptake inhibitor. In certain embodiments, the pharmaceutical composition comprises eszopiclone. In a preferred embodiment, the pharmaceutical composition comprises eszopiclone and fluoxetine. The present invention also relates to a method of treating a sleep abnormality, treating insomnia, treating depression, augmenting antidepressant therapy, eliciting a dose-sparing effect, reducing depression relapse, improving the efficacy of antidepressant therapy or improving the tolerability of antidepressant therapy, comprising co-administering to a patient in need thereof a GABA-receptor-modulating compound; and a SRI, NRI, 5-HT2A modulator or DRI.

An anion generator includes a base and a shell assembled on the base, needle stripes of homopolar spray points vertically lined with equal spacing fixed between a partition plate and a window grating, and a control circuit. The technical proposal is that the shell consists of a rear shell and a front shell; the window grating is moveably connected with the rear shell; the homopolar tungsten alloy spray points vertically lined with equal spacing are fixed between the needle stripes and press plates through the one-off sealing and packaging technique; the carbide fibre fixed on the needle stripes is communicated with the small high voltage blocks; a closed carbide fibre ring is arranged in a circular slot on the circumference of the needle stripes; the high voltage block assembly components fixed in the shell are sealed and packaged in a shield screen; the base and the shell are hinged together by a rotary positioning device. The invention has the advantages of reasonable structure design, convenience in adjustment and positioning, good transmission direction of the anion, high concentration and small grain size of the generated anion, large output quantity within unit time and obvious improvement of the air quality, thus obviously improving the curative effect of diseases and the air purification efficiency, and obviously extending the service life.

The invention relates to a Chinese medicinal preparation for treating cancer, and the Chinese medicinal preparation is prepared from 110 raw material drugs, such as yew, barbed skullcap herb, hairyvein agrimony and laggera pterodonta. The preparation can be oral solution, granules, powder, capsules, electuary and tablets. 110 Chinese medicaments are adopted, and monarch, minister, assistant and guide drugs are reasonably compatible and are comprehensively taken to play the effect of treating both principal and secondary aspect of cancers. The raw material drugs adopted in the Chinese medicinal preparation are common Chinese medicaments, and are low in manufacture cost and small in side effect. The medicament has the advantages of capabilities of effectively strengthening the body immunity and attacking pathogen without hurting a body along with quick response, high curative rate, high heal rate, low relapse rate, treatment of both principal and secondary aspect of cancers, safety and reliability, and can be used for treating various types of cancers, especially lung cancer, gastric cancer, liver cancer, esophagus cancer, pancreatic cancer, cervical cancer and breast cancer.

The present invention provides methods and devices for modulating the efficacy and / or increasing the efficiency of treatment of disease and / or cosmetic conditions through photobiostimulation combined with heating and / or cooling of the treatment region. In one aspect, methods and devices of the present invention are directed to modulating the efficacy of photobiostimulation in a target region by controlling the temperature in the region and / or its surrounding volume. According to some aspects of the present invention, tissue is heated such that biostimulation is applied to tissue that is hyperthermic. Alternatively, portions of the target region can be cooled to selectively target biostimulation to a specific region at a desired depth below the skin surface. A feedback mechanism is also provided so that the temperature of the target region can be selectively and accurately controlled.

Lumenectomy material is tested to determine the efficacy of a test drug in a patient population having a cardiovascular condition. The material is removed from at least a first and a second patient and tested for one or more markers of a cardiovascular condition. The first patient is administered the test drug, and the second patient is administered a placebo. At a later date, more lumenectomy material is removed and tested for the same marker or markers. The presence, absence or amount of the markers is compared in the first patient receiving the drug and the second patient receiving the placebo to determine whether the drug is effective in the patient population. The patient population can comprise as little as two individuals or as many as dozens, hundreds or thousands of patients. The drugs tested include drugs believed to be effective in treating a cardiovascular condition. The markers used can include any marker that can indicate the effectiveness of the drug being tested, including amino acid and nucleic acid markers and markers that indicate a cardiovascular condition.

Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A / 2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing MK-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an MPTP primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent. These data support the hypothesis that 5HT2A / 2C receptor inverse agonism may confer antipsychotic and anti-dyskinetic efficacy in humans, and indicate a use of the compound of formula (I) and related agents as novel therapeutics for Parkinson's Disease, related human neurodegenerative diseases, and psychosis.

Microprojection members (10) having a reservoir containing an antigenic agent and methods of using such members to vaccinate mammals (e.g., humans) are disclosed. The microprojection members are used to transdermally deliver an antigenic agent (e.g., a vaccine antigen) with substantially reduced skin reactions. This is achieved by delivering an induction amount and thereafter delivering one or more subsequent booster amounts. The induction amount is relatively larger than the booster amount. This technology has broad applicability for a wide variety of therapeutic vaccines to improve efficacy and convenience of use.

The invention relates to chimeric antigen receptors (CAR), particularly relates to dual-signal independent chimeric antigen receptors (dsCAR), and also relates to immune response cells of the dual-signal independent chimeric antigen receptors (dsCAR) and uses of the immune response cells in preparation of drugs for treatment of malignant tumor and virus infected diseases. In detail, the dual-signal independent chimeric antigen receptors (dsCAR) can respectively identify two different family antigens of tumor cells and can respectively transmit two T-cell-activation related signals. One of the CAR can transmit a first T-cell-activation related signal by combing a ligand of a tumor specific antigen or a tumor-associated antigen to decide T-cell killing specificity, and the other CAR can transmit a second T-cell-activation related signal by combing a ligand of a membrane receptor (such as EGFR (epidermal growth factor receptor) family protein) widely expressed by the tumor cells to promote T cell activation, proliferation and survival. The dual-signal independent chimeric antigen receptors (dsCAR) can avoid the potential safety problems on the basis of maintaining curative effects of second generation and third generation CAR.

The invention discloses an anti-microbial healing-promoting hydrogel dressing and a preparation method therefor. The main ingredients of the dressing are water-soluble high-molecular polymers, functional polymers with pseudoplastic, anti-microbial agents and water. The above ingredients are dissolved into a whole after a series of technologies. The solution is poured into a mold, and the hydrogel dressing is obtained after curing and irradiation disinfection. The results of wound healing experiments and in vitro anti-microbial experiments show that the hydrogel dressing can promote wound healing effectively, and has good bacteriostatic activity to multiple bacteria (the sterilizing rate is above 70%). The anti-microbial healing-promoting hydrogel dressing is better than existing hydrogel dressings obviously, and has advantages of substantial anti-microbial curative effects, transparency, high water content, simple preparation method, pure product, nontoxicity, innocuousness, no stimulation, good biocompatibility and the like. The hydrogel dressing is suitable for large-area promotion and application.

The invention relates to a Chinese medicinal preparation for treating a prostate disease, which is a medicament prepared from 70 raw material medicaments such as ginseng, deerhorn glue, medicinal indianmulberry root, common curculigo rhizome and the like. The medicament can be prepared into oral liquid, granules, powder, capsules, electuary, tablets or pills. A preparation method of the medicament comprises the following steps of: (1) preparing water extracting solution by the raw material medicaments; (2) preparing oral liquid by the water extracting solution; (3) drying, crushing and sieving the water extracting solution, and taking screening as medicinal extracting powder; and (4) preparing tablets, granules, pills or capsules from the medicinal extracting powder. The preparation method also can comprise the following steps of: (1) crushing and sieving the raw material medicaments, and taking the screening as medicinal powder; (2) disinfecting and sterilizing the medicinal powder to obtain raw powder; and (3) preparing tablets, granules, pills, electuary or capsules from raw powder. The adopted raw material medicaments are common Chinese medicaments, so the Chinese medicinal preparation has the advantages of low manufacturing cost, and nearly no toxic or side effects. The medicament has good curative effects on prostatitis, prostatic hypertrophy and prostatomegaly, and has obvious effect on prostate cancers.

Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A / 2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing MK-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an MPTP primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent. These data support the hypothesis that 5HT2A / 2C receptor inverse agonism may confer antipsychotic and anti-dyskinetic efficacy in humans, and indicate a use of the compound of formula (I) and related agents as novel therapeutics for Parkinson's Disease, related human neurodegenerative diseases, and psychosis.