Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

363results about How to "Deleterious effect" patented technology

Stimulus regimens for cardiovascular reflex control

InactiveUS6985774B2Reduces excessive blood pressure ,Minimize their deleterious effectSpinal electrodesStentsNervous systemHormone
Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, for example a baroreceptor in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements / consumption.
Owner:CVRX

Mapping methods for cardiovascular reflex control devices

Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably in the carotid sinus. A mapping method permits the baroreceptor activation device to be precisely located to maximize therapeutic efficacy.
Owner:CVRX

Analyte sensor, and associated system and method employing a catalytic agent

An analyte sensor for use in connection with a biofluid is described. The analyte sensor may comprise any suitable interface between the biofluid and a derivative of the biofluid and any suitable transducer of information concerning an analyte. At least one catalytic agent is provided in a locale or vicinity of the interface. The catalytic agent, such as a proteinaceous agent or a non-proteinaceous, organic-metal agent, is sufficient to catalyze the degradation of reactive oxygen and / or nitrogen species that may be present in the vicinity of the interface. An analyte-sensing kit and a method of sensing an analyte are also described.
Owner:ABBOTT DIABETES CARE INC

Analyte Sensor, and Associated System and Method Employing a Catalytic Agent

An analyte sensor for use in connection with a biofluid is described. The analyte sensor may comprise any suitable interface between the biofluid and a derivative of the biofluid and any suitable transducer of information concerning an analyte. At least one catalytic agent is provided in a locale or vicinity of the interface. The catalytic agent, such as a proteinaceous agent or a non-proteinaceous, organic-metal agent, is sufficient to catalyze the degradation of reactive oxygen and / or nitrogen species that may be present in the vicinity of the interface. An analyte-sensing kit and a method of sensing an analyte are also described.
Owner:ABBOTT DIABETES CARE INC

Electrode designs and methods of use for cardiovascular reflex control devices

Devices, systems and methods by which the blood pressure, nervous system activity, and neurohornonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably in the carotid sinus. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
Owner:CVRX

Modular, high energy, widely-tunable ultrafast fiber source

A modular, compact and widely tunable laser system for the efficient generation of high peak and high average power ultrashort pulses. Modularity is ensured by the implementation of interchangeable amplifier components. System compactness is ensured by employing efficient fiber amplifiers, directly or indirectly pumped by diode lasers. Peak power handling capability of the fiber amplifiers is expanded by using optimized pulse shapes, as well as dispersively broadened pulses. After amplification, the dispersively stretched pulses can be re-compressed to nearly their bandwidth limit by the implementation of another set of dispersive delay lines. To ensure a wide tunability of the whole system, Raman-shifting of the compact sources of the ultrashort pulses in conjunction with frequency-conversion in nonlinear optical crystals can be implemented, or an Anti-Stokes fiber in conjunction with fiber amplifiers and Raman-shifters are used.
Owner:IMRA AMERICA

Pharmaceutical compositions for the coordinated delivery of NSAIDs

The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention also encompasses methods of treating patients by administering this coordinated release, gastroprotective, antiarthritic / analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages.
Owner:NUVO PHARMA IRELAND DESIGNATED ACTIVITY CO

Fiber optic plug and receptacle assembly

A relatively small fiber optic plug is provided to facilitate pulling of the fiber optic plug and an associated fiber optic cable through small passageways. The fiber optic plug may include a shroud that protects the fiber optic connector and that may further define at least one opening, and preferably a pair of openings. The openings are sized to receive portions of an adapter sleeve once the fiber optic plug is mated with a fiber optic receptacle. The fiber optic plug may also include a cap mounted upon and adapted to swivel relative to the remainder of the fiber optic plug to serve as a pulling grip during installation of the fiber optic cable. Further, the fiber optic plug may include a crimp band that is mechanically coupled to both the fiber optic cable and the plug body in order to isolate the fiber optic connector from torque otherwise created by forces to which the fiber optic cable is subjected.
Owner:CORNING OPTICAL COMM LLC

Baroreflex Modulation Based On Monitored Cardiovascular Parameter

The present invention is a system for providing baroreceptor stimulation comprising, a sensor to sense a physiologic parameter and provide a signal indicative of the physiologic parameter, a baroreceptor activation device, which includes, a pulse generator to intermittently generate a stimulation signal to provide baroreceptor stimulation for a baroreflex therapy, and a control system to adjust the stimulation signal based on the signal indicative of the physiologic parameter such that the stimulation signal provides a desired baroreceptor stimulation corresponding to a desired physiologic parameter.
Owner:CVRX

Stimulus regimens for cardiovascular reflex control

ActiveUS20050251212A1Reduces excessive blood pressureDeleterious effectElectrotherapyAngle modulation detailsNervous systemRegimen
Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, for example a baroreceptor in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements / consumption.
Owner:CVRX

Exchange method for emboli containment

The present invention provides a method for exchanging catheters while containing emboli within a blood vessel such as a saphenous vein graft, coronary artery, carotid artery, or other similar vessels. A guidewire is inserted through the vasculature of a patient until it reaches a desired treatment site. A therapy catheter is then inserted over the guidewire until the distal end of the therapy catheter reaches the treatment site. The guidewire has a distally mounted balloon which is inflated to occlude the blood vessel. Then, the therapy catheter provides means for treating the vessel at the treatment site. After treatment, the therapy catheter is removed from the guidewire and exchanged with an aspiration catheter which rides over the guidewire until the distal end of the aspiration catheter reaches the treatment site. The aspiration catheter applies negative pressure to remove any emboli formed by the treatment procedure.
Owner:KARDIAMETRICS

Stimulus regimens for cardiovascular reflex control

Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, for example a baroreceptor in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements / consumption.
Owner:CVRX

Method and Apparatus for Incrementally Stretching a Web

A method and apparatus is provided which uses activation members for incrementally stretching a web at a low strain rate. The activation members include an activation belt and a single activation member wherein the activation belt and single activation member comprise a plurality of teeth and grooves that complement and engage one another at a depth of engagement in a deformation zone. The depth of engagement can be controlled to increase linearly over at least a portion of the deformation zone such that a web interposed between the activation belt and the single activation member in the deformation zone is incrementally stretched at a low rate of strain.
Owner:THE PROCTER & GAMBLE COMPANY

Delivery of therapeutic compounds to the brain and other tissues

ActiveUS20050048047A1Reduces and eliminates glycogen storage granuleReduce eliminateNervous disorderPeptide/protein ingredientsMeningesIntrathecal use
The present invention relates to the intrathecal (IT) administration of recombinant enzyme to treat lysosomal storage disorders. In an exemplary embodiment, intrathecal administration of human α-L-iduronidase (rhIDU) injections in MPS I affected animals resulted in significant enzyme uptake, significant rh-iduronidase activity in brain and meninges and a decrease of glycosaminoglycan (GAG) storage in cells of MPS I subjects to that of normal subjects. Intrathecal administration proved more effective than intravenous treatment at alleviating MPS I symptoms, indicating it is a useful method of treating lysosomal storage disorders.
Owner:BIOMARIN PHARMA INC

Baroreflex Therapy for Disordered Breathing

A method is provided for treating respiration conditions of a patient. The method comprises monitoring or measuring a respiration parameter indicative of a need to modify activity of a baroreflex system of the patient, and controlling a baroreceptor activation device to cause or modify activation of a baroreflex response of the patient in response to the monitoring or measuring of the respiration parameter.
Owner:CVRX

Adaptive Active Suspension System With Road Preview

A method for controlling an active suspension includes steps of determining a dimension of a road abnormality ahead of the vehicle and comparing the dimension with a vehicle dimension. Responsive to the comparison, the abnormality is classified as one type of a plurality of predetermined types. Responsive to a height dimension of the abnormality, the abnormality is further classified as having one of a small, medium, or large severity. The suspension is controlled responsive to the type and severity.
Owner:FORD GLOBAL TECH LLC

Systems and methods for controlling renovascular perfusion

Devices, systems and methods by which the real or apparent renovascular perfusion and intrarenal pressure may be selectively and controllably increased. By selectively and controllably increasing renovascular perfusion and interstitial hydrostatic pressure when the heart is unable to pump sufficient blood or when renal perfusion is suboptimal, the present invention reduces or reverses neurohormonal activation and fluid retention, and thereby minimizes their deleterious effects on the heart, vasculature, kidneys and other body systems.
Owner:CVRX

Modular, high energy, widely-tunable ultrafast fiber source

A modular, compact and widely tunable laser system for the efficient generation of high peak and high average power ultrashort pulses. Modularity is ensured by the implementation of interchangeable amplifier components. System compactness is ensured by employing efficient fiber amplifiers, directly or indirectly pumped by diode lasers. Peak power handling capability of the fiber amplifiers is expanded by using optimized pulse shapes, as well as dispersively broadened pulses. Dispersive broadening is introduced by dispersive pulse stretching in the presence of self-phase modulation and gain, resulting in the formation of high-power parabolic pulses. In addition, dispersive broadening is also introduced by simple fiber delay lines or chirped fiber gratings, resulting in a further increase of the energy handling ability of the fiber amplifiers. The phase of the pulses in the dispersive delay line is controlled to quartic order by the use of fibers with varying amounts of waveguide dispersion or by controlling the chirp of the fiber gratings. After amplification, the dispersively stretched pulses can be re-compressed to nearly their bandwidth limit by the implementation of another set of dispersive delay lines. To ensure a wide tunability of the whole system, Raman-shifting of the compact sources of ultrashort pulses in conjunction with frequency-conversion in nonlinear optical crystals can be implemented, or an Anti-Stokes fiber in conjunction with fiber amplifiers and Raman-shifters are used. A particularly compact implementation of the whole system uses fiber oscillators in conjunction with fiber amplifiers. Additionally, long, distributed, positive dispersion optical amplifiers are used to improve transmission characteristics of an optical communication system. Finally, an optical communication system utilizes a Raman amplifier fiber pumped by a train of Raman-shifted, wavelength-tunable pump pulses, to thereby amplify an optical signal which counterpropogates within the Raman amplifier fiber with respect to the pump pulses.
Owner:IMRA AMERICA

Delivery of therapeutic compounds to the brain and other tissues

ActiveUS7442372B2Reduces and eliminates glycogen storage granuleReduce eliminateNervous disorderPeptide/protein ingredientsMeningesIntrathecal use
The present invention relates to the intrathecal (IT) administration of recombinant enzyme to treat lysosomal storage disorders. In an exemplary embodiment, intrathecal administration of human α-L-iduronidase (rhIDU) injections in MPS I affected animals resulted in significant enzyme uptake, significant rh-iduronidase activity in brain and meninges and a decrease of glycosaminoglycan (GAG) storage in cells of MPS I subjects to that of normal subjects. Intrathecal administration proved more effective than intravenous treatment at alleviating MPS I symptoms, indicating it is a useful method of treating lysosomal storage disorders.
Owner:BIOMARIN PHARMA INC

Method of forming high-k gate electrode structures after transistor fabrication

A sophisticated high-k metal gate electrode structure may be formed after the deposition of a first part of an interlayer dielectric material, thereby providing a high degree of process compatibility with conventional CMOS techniques. Thus, sophisticated strain-inducing mechanisms may be readily implemented in the overall process flow, while nevertheless avoiding any high temperature processes during the formation of the sophisticated high-k dielectric gate stack.
Owner:ADVANCED MICRO DEVICES INC

Modular, high energy, widely-tunable ultrafast fiber source

A modular, compact and widely tunable laser system for the efficient generation of high peak and high average power ultrashort pulses. Modularity is ensured by the implementation of interchangeable amplifier components. System compactness is ensured by employing efficient fiber amplifiers, directly or indirectly pumped by diode lasers. Peak power handling capability of the fiber amplifiers is expanded by using optimized pulse shapes, as well as dispersively broadened pulses. Dispersive broadening is introduced by dispersive pulse stretching in the presence of self-phase modulation and gain, resulting in the formation of high-power parabolic pulses. In addition, dispersive broadening is also introduced by simple fiber delay lines or chirped fiber gratings, resulting in a further increase of the energy handling ability of the fiber amplifiers. The phase of the pulses in the dispersive delay line is controlled to quartic order by the use of fibers with varying amounts of waveguide dispersion or by controlling the chirp of the fiber gratings. After amplification, the dispersively stretched pulses can be re-compressed to nearly their bandwidth limit by the implementation of another set of dispersive delay lines. To ensure a wide tunability of the whole system, Raman-shifting of the compact sources of ultrashort pulses in conjunction with frequency-conversion in nonlinear optical crystals can be implemented, or an Anti-Stokes fiber in conjunction with fiber amplifiers and Raman-shifters are used. A particularly compact implementation of the whole system uses fiber oscillators in conjunction with fiber amplifiers. Additionally, long, distributed, positive dispersion optical amplifiers are used to improve transmission characteristics of an optical communication system. Finally, an optical communication system utilizes a Raman amplifier fiber pumped by a train of Raman-shifted, wavelength-tunable pump pulses, to thereby amplify an optical signal which counterpropogates within the Raman amplifier fiber with respect to the pump pulses.
Owner:IMRA AMERICA

Exchange method for emboli containment

InactiveUS20050245866A1Rapid and easy exchangeSafely be deflatedStentsBalloon catheterCoronary arteriesAfter treatment
The present invention provides a method for exchanging catheters while containing emboli within a blood vessel such as a saphenous vein graft, coronary artery, carotid artery, or other similar vessels. A guidewire is inserted through the vasculature of a patient until it reaches a desired treatment site. A therapy catheter is then inserted over the guidewire until the distal end of the therapy catheter reaches the treatment site. The guidewire has a distally mounted balloon which is inflated to occlude the blood vessel. Then, the therapy catheter provides means for treating the vessel at the treatment site. After treatment, the therapy catheter is removed from the guidewire and exchanged with an aspiration catheter which rides over the guidewire until the distal end of the aspiration catheter reaches the treatment site. The aspiration catheter applies negative pressure to remove any emboli formed by the treatment procedure.
Owner:MEDTRONIC VASCULAR INC

Securing an augment to a prosthetic implant component

A selected augment, shown as a tibial augment, is secured at an augmentation location on a prosthetic implant component, shown as a tibial implant component, by a securing element assembled with the body of the augment for displacement relative to the augment body to selectively engage an abutment located on a depending structure of the implant component, adjacent the augmentation location, so as to establish a securing force between the securing element and the depending structure for urging the augment against the implant component, and thereby secure the augment to the implant component at the augmentation location. In the tibial augment, a distal surface includes surface portions extending in anterior-posterior directions and oriented essentially normal to medial-lateral directions.
Owner:HOWMEDICA OSTEONICS CORP

Apparatus and method for controlled cleaving

An apparatus and method for controlled cleaving is presented. Embodiments of the present invention include an apparatus for cleaving a substrate comprising a bottom shell coupled to a hinge mechanism, a top shell coupled to the hinge mechanism, a plurality of o-rings or suction cups coupled to the top and bottom shells for providing a suction force sufficient to exert a tensile force to the top and bottom of a substrate, a compliant member for sealing a portion of a grove edge of a substrate and for maintaining a pressure inside a volume formed between the groove edge and the groove edge of the substrate, a gas port for supplying gas to the volume, and a height adjustment mechanism coupled to the top shell and the bottom shell for separating the top shell from the bottom shell. One embodiment of the invention eliminates the use of gas system and is replaced by a blade edge to initiate propagation and applied tensile force of suction cups to apply tensile forces prior to initiation, control cleave process and maintain layer separation during and after cleaving.
Owner:SILICON GENERAL CORPORATION

Method and apparatus for testing and evaluating wireless communication devices

A testing chamber is configured to evaluate the accuracy of a wireless communication device under test in a production environment. The configuration of the testing chamber may resemble an enclosed structure having a wall that includes multiple layers. An array of antennas, which serves as a layer of the wall, is strategically positioned within the testing chamber to receive and transmit signals emitted to / from the wireless communication device. Located within the testing chamber is either a stationary or moveable holder to support the wireless communication device. Furthermore, during testing, the forward link and the reverse communication links are monitored by selectively or alternatively adjusting and shifting the phase / amplitude of the antenna of the wireless communication device to mitigate the effects of multi-path fading.
Owner:QUALCOMM INC

Pharmaceutical compositions for the coordinated delivery of NSAIDs

The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention also encompasses methods of treating patients by administering this coordinated release, gastroprotective, antiarthritic / analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages.
Owner:NUVO PHARMA IRELAND DESIGNATED ACTIVITY CO +1

Method of manufacture of ceramic composite wiring structures for semiconductor devices

Method of manufacture of a composite wiring structure for use with at least one semiconductor device, the structure having a first conductive member upon which the semiconductor device can be mounted for electrical connection thereto. A dielectric member, made of ceramic or organo-ceramic composite material, is bonded to the first conductive member and contains embedded therein a conductive network and a thermal distribution network. A second conductive member may be incorporated with the composite wiring structure, with a capacitor electrically connected between the conductive network and the second conductive member. Bonding between the dielectric member and the conductive members may be in the form of a direct covalent bond formed at a temperature insufficient to adversely effect the structural integrity of the conductive network and the thermal distribution network.
Owner:L PIERRE DEROCHEMONT C2 TECH

Technique for forming recessed strained drain/source regions in NMOS and PMOS transistors

By forming a strained semiconductor layer in a PMOS transistor, a corresponding compressively strained channel region may be achieved, while, on the other hand, a corresponding strain in the NMOS transistor may be relaxed. Due to the reduced junction resistance caused by the reduced band gap of silicon / germanium in the NMOS transistor, an overall performance gain is accomplished, wherein, particularly in partially depleted SOI devices, the deleterious floating body effect is also reduced, due to the increased leakage currents generated by the silicon / germanium layer in the PMOS and NMOS transistor.
Owner:ADVANCED MICRO DEVICES INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products