59 results about "Gastrointestinal Injury" patented technology

The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention also encompasses methods of treating patients by administering this coordinated release, gastroprotective, antiarthritic / analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages.

Nitric oxide releasing oxindole prodrugs are described which are useful in methods of treating or preventing pain, inflammation, fever, or gastrointestinal lesions in a patient in need of such treatment, or of modifying an inflammatory disease or condition by favorably affecting the outcome thereof in said patient, wherein there is administered to said patient a therapeutically effective amount of a compound of Formula (I): and pharmaceutically acceptable salts thereof. In preferred embodiments, X is a covalent bond; RA and RB are both hydrogen; n is the integer 4; Y is -O-; Z is -NO2; RC is a member selected from the group consisting essentially of 5-Cl and 5-F; RD is a member selected from the group consisting essentially of 6-Cl and 6-F; and RE is a member selected from the group consisting essentially of benzyl, 2-furyl, 2-thienyl, 5-chloro-2-thienyl and 5-trifluoromethyl-2-thienyl.

The present invention relates to medicine preparation, and is especially one kind of fast releasing solid omerprazole preparation and its preparation process. The present invention combines omerprazole with certain amount of sodium hydroxide, and the medicine preparation can neutralize gastric acid and the medicine may be absorbed effectively. Certain amount of sodium hydroxide can neutralize gastric acid without causing gastrointestinal damage.

The invention discloses a medicine composition for assisting chemotherapeutics and an application of the medicine composition. An effective dose of antrodia camphorata sporocarp extract is obtained by hot water soaking, low polar solvent extraction and other steps and collocated with a pharmaceutically acceptable supporting agent to prepare the medicine composition; the medicine composition can be used for improving a treatment effect of the chemotherapeutics cisplatin and gemcitabine on a cancer; and at the same time, the medicine composition can improve side effects such as hair slipping, muscle degradation and atrophy, gastrointestinal injury and kidney inflammation injury in a process of treating the cancer.

The invention discloses the application of glycyrrhetinic acid derivatives in the preparation process of anti-inflammatory drugs, in particular to the glycyrrhetinic acid derivatives as well as pharmaceutically acceptable salt thereof, drug compositions containing the derivatives and anti-inflammatory action of the drug compositions, wherein, the glycyrrhetinic acid derivatives can release gaseous signal molecule hydrogen sulfide. The invention discloses and provides the glycyrrhetinic acid derivatives that can release gaseous signal molecule H2S, wherein, glycyrrhetinic acid and gaseous signal molecule hydrogen sulfide release groups are coupled through ester bonds or amido bonds so as to obtain the glycyrrhetinic acid derivatives. Pharmacology experimental results show that the glycyrrhetinic acid derivatives achieve remarkable anti-inflammatory action and have no significant gastrointestinal tract injury, and show that the glycyrrhetinic acid derivatives can be used for preparing the drugs for treating various inflammations and related diseases thereof.

The invention discloses a compound with a novel structure and a preparation method and applications thereof. The compound comprises a part related to hydrogen sulfide and is generally covalently bonded with compounds or forms a salt. The structural formula is shown. The results of pharmacological experiments show that the compound has significant anti-inflammatory and anti-tumor effects without obvious gastrointestinal tract damage. The compound can be used for preparing medicines for treating various diseases, in particular diseases related to inflammation, heart and blood vessels and tumor. In addition, the invention also provides a method for preparing the compound.

The invention discloses a novel gas signal molecule donator and a preparation method and medical use thereof, in particular to a compound with new structure and the preparation method and medical use of the compound. The compound is a compound with a general formula YLXYII or the salt of the compound, comprises the portion related with hydrogen sulfide and is often combined with compounds in covalence mode or forms the salt. Pharmacological results show that the compound has remarkable anti-inflammatory effect and tumor resistance without remarkable damage to gastrointestinal tract, so that the compound can be used for preparing and treating various diseases such as inflammation, cardiovascular diseases, and diseases related with tumor. In addition, the preparation method for preparing the compound is further provided.

The invention relates to the use of elsiglutide to prevent or reduce the occurrence of gastrointestinal damage caused by chemotherapeutic agents, including gastrointestinal mucositis and chemotherapy-induced diarrhea (CID).

The invention relates to the use of a composition comprising extract of Buddleja globosa Hope and pharmacologically accepted excipients for the preparation of a phyto-pharmaceutical agent, a drug or a nutraceutical for the prevention of gastrointestinal disorders, particularly those associated with treatment with nitrofurantoin or gastric disorders produced by ulcers, gastric diseases or damage to the gastrointestinal tract. The aforementioned disorders can correspond to abdominal pain, dyspepsia, nausea, vomiting, diarrhea, constipation, inflammation and cephalalgia resulting from treatment with nitrofurantoin and other antimicrobials. In addition, the extract and the compositions thereof can be used to enhance the antibacterial action of nitrofurantoin, particularly against Escherichia coli.

A nutritional supplement containing fish oil and selenium has been identified that potentiates radiotherapy of tumors in a synergistic fashion. Cotherapy with such a supplement and radiotherapy results in substantially improved reductions in tumor volume of animal models relative to radiotherapy alone, and reduces common side effects such as weight loss, inflammation, and damage to the gastrointestinal tract. Such cotherapy was also found to reduce the incidence of metastasis from the primary implantation site, and to modulate expression of genes associated with apoptosis in tumor cells. A formulation for such a supplement that is both well tolerated and palatable is also provided.

The invention relates to a cell growth factor gene drug for preventing and / or treating acute stress-related gastrointestinal injury, and use of HIF-1 alpha and KGF genes in preparing drugs for preventing and / or treating acute stress-related gastrointestinal injury diseases. The invention also relates to a pharmaceutical composition comprising HIF-1 alpha and KGF. The growth factor gene drug provided by the invention can beneficially prevent and / or treat acute stress-related gastrointestinal injury diseases.

A liquid pharmaceutical composition of a GABA analog comprising at least one polyhydric alcohol containing 2 to 6 carbon atoms having a pH of about 5.5 to about 7.0 and additionally a two-component liquid pharmaceutical composition comprising a first component comprising a powder mixture comprising a GABA analog and a solid polyhydric alcohol, and a second component comprising a liquid base are described, as well as methods to prepare the compositions and a method for treating cerebral diseases, including epilepsy, faintness attacks, hypokinesia and cranial traumas, neurodegenerative disorders, depression, mania and bipolar disorders, anxiety, panic, inflammation, renal colic, insomnia, gastrointestinal damage, incontinence, pain, including neuropathic pain, muscular pain, skeletal pain, and migraine using a therapeutically effective amount of the pharmaceutical compositions.

The present invention provides compositions and methods for treating or preventing gastrointestinal damage associated with acute or chronic non-steroidal anti-inflammatory drug (NSAID) therapy, including, for example, NSAID-induced gastropathy or enteropathy. In various embodiments, the invention relates to administering a regimen of larazotide (or a derivative) to a patient to repair or prevent injury to mucosal tissue of the gastrointestinal epithelium. In accordance with the invention, larazotide functions to repair injured mucosal tissue or prevent injury to mucosal tissue in a patient undergoing acute or chronic NSAID therapy.

The invention discloses a traditional Chinese medicine composition for preventing acute gastrointestinal injury of sepsis which includes coptis, scutellaria, phellodendron, gardenia, peony bark, radix rehmanniae, radix paeoniae rubra, and fructus aurantii. The traditional Chinese medicine composition of this invention can significantly reduce the incidence of acute gastrointestinal injury in sepsis patients, significantly shorten mechanical ventilation and retention time of iCU and lower the 28 day mortality and gastrointestinal attributable mortality. These differences are statistically significant. This medicine can significantly reduce the severity of disease in patients with severe sepsis, relieve illness effectively, improve prognosis and have the advantages of safety without side effects.

The invention relates to the field of medicine, and discloses a pharmaceutical composition and a preparation method and an application thereof. The pharmaceutical composition disclosed by the invention includes an effective treatment dosage of clopidogrel hydrogen sulfate and aspirin, as well as a non-water vector containing phospholipid. In the invention, the aspirin and the clopidogrel hydrogen sulfate, as well as the phospholipid, are prepared into the brand new pharmaceutical composition, the pharmaceutical composition is used for greatly reducing the risk of gastrointestinal injury generated by drug combination of clopidogrel hydrogen sulfate and aspirin without changing the pharmacokinetic level of the two active ingredients, and can be used for preparing drugs of various forms for preventing and treating cardiovascular and cerebrovascular diseases..

The invention relates to blueberry weight losing glue and a preparation method thereof, and belongs to the technical field of paint. The blueberry weight losing glue consists of the following components in parts by weight: 250-500 parts of blueberry powder, 500-750 parts of konjac flour and 3.75-6.25 parts of table salt. The finished product disclosed by the invention is safe and free of any side effect, and a product can be use for solving the problem of a pineapple weight losing product which causes relatively serious gastrointestinal injury and also can avoid injury in human bodies caused by the use of Chinese herbal medicines or hormone products; the product can be used by users selves without the real-time guidance of doctors, and instead of controlling diet, the users can take up nutrients required by human bodies normally; the preparation method disclosed by the invention is simple and reliable, and the prepared product is excellent in performance; and when the product is taken up for 15 days, the weight can be reduced by 7-8kg, so that public demands are met.

The invention discloses a food retention removing preparation as well as a preparation method and application thereof. The food retention removing preparation is prepared from the following raw materials in parts by weight: 1-10 parts of malt, 1-30 parts of hawthorn fruits, 1-15 parts of radish seeds, 1-10 parts of pericarpium citri reticulatae, 1-15 parts of fructus cannabis, 1-15 parts of lotusleaves and 1-15 parts of semen cassiae. The raw materials of the food retention removing preparation are medicinal and edible materials, so that the food retention removing preparation is safe and free of toxic and side effects, causes small gastrointestinal injury, can tonify the spleen, invigorate the stomach and help digestion, has a function of relaxing bowels, can fundamentally solve the problem of food retention and has a better food retention removing effect. The preparation method of the food retention removing preparation is simple and convenient to operate and easy for industrial mass production, and an adopted microwave vacuum low-temperature drying technology has higher drying speed and higher working efficiency.

Methods of preventing, ameliorating and / or treating radiation induced gastrointestinal tract injury comprising the administration of a therapeutically effective amount of Mesna to a patient are provided. Methods for preventing, treating and / or ameliorating gastrointestinal tract injury induced by radiation therapy, alone or in combination with other therapies for diseases or conditions such as gastrointestinal malignancies, urogenital malignancies, gynecologic malignancies, and osteogenic and other sarcomatous malignancies in which pelvic structures are involved.

The invention relates to the technical field of alcohol making, in particular to liver protection beer and a preparation method thereof. According to the liver protection beer, bitter orange, herba sedi sarmentosi and common leafflower herb are jointly fermented with malt and hops, the effects of the bitter orange for regulating qi, invigorating the spleen, removing stagnation and relieving distention and the effects of the herba sedi sarmentosi for clearing heat and promoting diuresis are exerted fully; the common leafflower herb has the effects of calming the liver, clearing heat, promotingurination, removing toxicity, inhibiting hepatitis B virus, inhibiting and reversing liver fibrosis, protecting liver cells and preventing liver cancer; damage of alcohol to the liver is reduced, nutrients in the beer is increased, and finally, the bear with few side effects and less damage to the liver and the gastrointestinal tract is obtained.

Disclosed are nutritional compositions including human milk oligosaccharides that can be administered to individuals including preterm infants, infants, toddlers, children, and adults for preventing injury and / or improving the healing of the gastrointestinal tract. Additional suitable methods of using the nutritional compositions including the human milk oligosaccharides are also disclosed.

The invention discloses a novel gas signal molecule donator and a preparation method and medical use thereof, in particular to a compound with new structure and the preparation method and medical use of the compound. The compound is a compound with a general formula YLXYII or the salt of the compound, comprises the portion related with hydrogen sulfide and is often combined with compounds in covalence mode or forms the salt. Pharmacological results show that the compound has remarkable anti-inflammatory effect and tumor resistance without remarkable damage to gastrointestinal tract, so that the compound can be used for preparing and treating various diseases such as inflammation, cardiovascular diseases, and diseases related with tumor. In addition, the preparation method for preparing the compound is further provided.

The invention discloses application of porphyra haitanensis polysaccharide in invigorating stomach and preventing or repairing gastrointestinal injury. The porphyra haitanensis polysaccharide disclosed by the invention can play a role in proliferation and repair of injured IEC-6 cells, can effectively enhance the adhesion of IEC-6 cells, and up-regulate the expression of 8 proteins such as Cdc-42,Rac-1, Par-3, aPKC, PKC beta II, paxillin, FAK and GAPDH in IEC-6 cells. When being used as a raw material of food such as rice porridge, the porphyra haitanensis polysaccharide not only can improvethe nutritional value of the rice porridge and enrich the taste and flavor of the rice porridge, but also has the effects of invigorating stomach and preventing and repairing gastrointestinal injury.

A nutritional supplement containing fish oil and selenium has been identified that potentiates radiotherapy of tumors in a synergistic fashion. Cotherapy with such a supplement and radiotherapy results in substantially improved reductions in tumor volume of animal models relative to radiotherapy alone, and reduces common side effects such as weight loss, inflammation, and damage to the gastrointestinal tract. Such cotherapy was also found to reduce the incidence of metastasis from the primary implantation site, and to modulate expression of genes associated with apoptosis in tumor cells. A formulation for such a supplement that is both well tolerated and palatable is also provided.

The invention relates to the use of a composition comprising extract of Buddleja globosa Hope and pharmacologically accepted excipients for the preparation of a phyto-pharmaceutical agent, a drug or a nutraceutical for the prevention of gastrointestinal disorders, particularly those associated with treatment with nitrofurantoin or gastric disorders produced by ulcers, gastric diseases or damage to the gastrointestinal tract. The aforementioned disorders can correspond to abdominal pain, dyspepsia, nausea, vomiting, diarrhea, constipation, inflammation and cephalalgia resulting from treatment with nitrofurantoin and other antimicrobials. In addition, the extract and the compositions thereof can be used to enhance the antibacterial action of nitrofurantoin, particularly against Escherichia coli.

Disclosed is a method for treating tumor in a mammalian subject, which comprises administering a combination of (a) an anti-tumor agent and (b) a fatty acid derivative represented by the formula (I):to the subject in need thereof. The application also discloses a method for treating damages, especially gastrointestinal damages including mucositis such as stomatitis induced by an anti-tumor agent, wherein the method comprises administering a fatty acid derivative of formula (I) to the subject who is receiving the anti-tumor agent.

The invention provides a new medical application of a chiral spiro indole-pyran pyrimidine base compound, particularly application of the compound in preparation of anti-inflammatory drugs. An in vitro cyclooxygenase (COX) activity inhibiting experiment, an experiment of inhibiting generation of an inflammatory molecule (nitric oxide) in primary mice macrophage and inhibition test on an ear swelling and paw edema model in mice, show that the chiral compound has an obvious anti-inflammatory effect and has extremely low gastrointestinal injury effect; therefore, the chiral compound, as an active ingredient, can be prepared into anti-inflammatory drugs in various dosage forms through pharmaceutically acceptable technologies and auxiliary materials, so that the chiral compound has an excellent medical application prospect.

The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from, by weight, 10-40 parts of sargentg loryvine stems, 10-40 parts of astragali radix and 10-40 parts of glossy privet fruit. The invention further provides a preparing method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is low in price, efficient, convenient, safe and capable of effectively reducing damage to the gastrointestinal tract and / or reduction of peripheral blood lymphocytes caused by chemotherapy drugs.

The invention discloses the application of Codonopsis oligosaccharides in the preparation of drugs for preventing or treating gastrointestinal injury caused by hypoxia, the hypoxia being plateau hypoxia and / or tissue ischemic hypoxia; Methods for the preparation of polysaccharides. The beneficial effects of the present invention are: the application of Codonopsis oligosaccharides provided by the present invention in the preparation of drugs for preventing or treating gastrointestinal damage caused by hypoxia, the prepared drugs have good effects, and the drugs themselves Safe and effective, without toxic and side effects; it has been verified by experiments that drugs containing Codonopsis oligosaccharides can improve spleen atrophy and lung enlargement caused by high-altitude hypoxia in rats, enhance their antioxidant levels, improve inflammation, and relieve intestinal mucosal damage. Reducing EPO expression, and protein expression detection further indicated that Codonopsis oligosaccharides can reduce the expression of HIF-1α in the duodenum of high-altitude hypoxic rats.

The invention discloses an evaluation device for acute gastrointestinal injury in sepsis, which at least includes an evaluation value calculation unit, and the evaluation value calculation unit calculates the evaluation value based on a TCM syndrome scoring scale for acute gastrointestinal injury in sepsis. The apparatus further includes an evaluation value reference evaluation unit that evaluates the degree of sepsis acute gastrointestinal injury of the subject based on the evaluation value calculated in the evaluation value calculation unit. The evaluation device for acute gastrointestinal injury in sepsis provided by the present invention is relatively reasonable in assigning scores, intervals of scores and assigning trends, has strong reliability, can reflect the severity of diseases, and is suitable for quantifying and scoring diseases.