147 results about "Ear swelling" patented technology

The invention provides an oleanolic acid triterpenoid, whose A ring and C ring contain multiple oxygen substituents, represented as formula (1). The inventive compound can inhibit the growth activity of tumor cell, thereby being applied in the preparation of anti-tumor drug and can inhibit mice ear swelling caused by dimethylbenzene, thereby being applied in the preparation of anti-inflammatory agent. The formula (1) is represented as above.

The invention relates to an oral medicinal combination and the preparing method, using Epimedium Herb, Coix Seed, Tangerine Peel, Perilla Leaf, Common Floweringqince Fruit and other Chinese drugs as raw materials, first decocting these raw materials to extract fragrant liquid, then decocting twice and filtering, combining the filtrate, fragrant liquid and auxiliaries and making the mixture into different preparations. It can remove damp and dredge meridian, and eliminating rheumatism and stop pain, and is used to relieve joint gall of toes and metatarsi caused by gout caused by damp and corruption. In addition, the curative effect test verifies that it can prohibit joint gall of sole of the foot of a rat caused by sodium urate (MSU), remarkably reduce white cells in joint liquid of a rabit with acute arthritis induced by MSU, remarkably prohibit the foot swelling of a rat caused by carageen glue and the ear swelling of a mouse caused by dimethylbenzene, and obviously prohibit the forming of granulation swelling of a rat.

The invention discloses a preparation method of eupolyphaga seu steleophagadry dry powder extract. The method adopted by the invention includes water extraction method or enzymolysis method. The eupolyphaga seu steleophagadry dry powder is firstly processed with water extraction or enzymolysis; the water extraction liquid or enzymolysis liquid is chromatographically separated through Sephadex G25column to obtain the polypeptide component series, and then the polypeptide component is frozen and dried to prepare frozen dry powder. The model evaluation of mouse ear swelling indicates that the polypeptide component series of eupolyphaga seu steleophagadry dry powder extract has obvious inhibition effect on pain. The experiment of feeding mice for a month indicates that the polypeptide component has no toxicity and no dependence. The invention provides the application of polypeptide component series of eupolyphaga seu steleophagadry dry powder extract in the preparation of analgesic medicines.

The invention relates to bifidobacterium longum capable of relieving atopic dermatitis and application thereof, and belongs to the technical field of microorganisms and the technical field of medicine. Bifidobacterium longum has the effect of relieving atopic dermatitis, and has the advantages that the ear swelling degree of a mouse with atopic dermatitis is remarkably decreased; dermal pathologysymptoms of the mouse with atopic dermatitis are relieved remarkably, and inflammatory cell infiltration is relieved; the serum IgE of the mouse with atopic dermatitis is reduced remarkably; the levelof IL-4 and IL-13 in skin tissue of the mouse with atopic dermatitis is decreased remarkably; the level of histamine in the skin tissue of the mouse with atopic dermatitis is decreased remarkably. Inthis way, bifidobacterium longum has broad application prospects in preparation of products for preventing and / or treating atopic dermatitis.

The invention discloses a phenolic extract of stevia rebaudiana and application of the phenolic extract in anti-inflammatory products, and belongs to the technical field of plant extracts. Main components of the phenolic extract of stevia rebaudiana disclosed by the invention are chlorogenic acid and flavonoid compounds. The phenolic extract of stevia rebaudiana can significantly inhibit xylene-induced ear swelling and carrageenin-induced paw swelling, inhibit LPS-induced macrophage NO release, can decrease the content of inflammatory factor NO in serum, and has good anti-inflammatory activity; the phenolic extract of stevia rebaudiana provided by the invention has advantages of rich source of raw materials, easy industrialization, no toxic or side effect and the like, and has broad development and application prospects as anti-inflammatory products.

The invention discloses a medicinal composition with effects of relieving pain, resisting inflammation, activating blood and dissolving stasis and a preparation method and application thereof. The medicinal composition is prepared from the following raw materials in part by weight: 20 to 100 parts of rhubarb and 20 to 100 parts of gardenia. In order to better perfect the compatibility of medicaments, the medicinal composition also can comprise the following raw materials in part by mass: 20 to 100 parts of rhubarb, 20 to 100 parts of gardenia, 10 to 30 parts of common monkshood mother root, 10 to 30 parts of kusnezoff monkshood root, 20 to 80 parts of divaricate saposhnikovia root, 20 to 80 parts of incised notopterygium rhizome, 30 to 70 parts of Chinese angelica and 30 to 70 parts of szechuan lovage rhizome. Animal experiments prove that the medicinal composition can obviously reduce various hemorheological indexes of a qi-stagnation blood-stasis model rat, has the effects of promoting qi and blood circulation, can increase pain threshold of the rat and reduce the writhing response times of the rat, has obvious analgesic effect, can inhibit ear swelling of the rat caused by dimethyl benzene and has obvious anti-inflammatory and anti-swelling effects.

The invention relates to a medicine composition for treating skin diseases, in particular to a composition which is prepared with Chinese medicinal materials including radix sophorae flavescentis, rhizoma smilacis glabrae, oriental wormwood, golden cypress, rough gentian, cortex dictamni, purslane, broom cypress fruit, stemona, raw liquorice and optional menthol and borneol. The composition remarkably increases an itch irritating field, can effectively suppress mouse ear swelling, and has high expected safety. In addition, the composition can effectively suppress mouse ear swelling caused by dimethylbenzene, and can effectively suppress rat egg white induced paw swelling.

The invention provides application of nitidine chloride to the preparation of a medicament for resisting autoimmunity disease and graft versus host disease. An experiment shows that the nitidine chloride can inhibit the proliferation of human dendritic cells in vitro, inhibit the human dendritic cells from promoting the proliferation reaction of allogeneic T cells and strengthen the capacity of secreting interleukin 10 of the human dendritic cells. Meanwhile, in an experimental autoimmunity disease cerebrospinal meningitis model, when used in vivo, the nitidine chloride can reduce the average clinical score of a mouse and inhibit the spinal marrow infiltration degree of monocytes and can obviously improve the secretion level of the interleukin 10 in the blood serum of the mouse. In a heart transplantation experiment, when used in vivo, the nitidine chloride can prolong the survival time of the transplanted heart. In a delayed type hypersensitivity reaction model, when used in vivo, the nitidine chloride can reduce the ear swelling degree of the mouse. Both in-vivo and in-vitro results show that the nitidine chloride has a certain effect of resisting the autoimmunity disease and the graft versus host disease. The medicament is a preparation which consists of the nitidine chloride serving as an active ingredient and a pharmaceutical carrier. The medicament can be prepared into an oral preparation, an injection, a suppository or an external preparation and the like.

The invention discloses a new medical use of myricetin, belonging to the technology field of medicines. Through acetic acid writhing test, formaldehyde-induced pain test, glacial acetic acid-induced capillary permeability test, dimethybenzene-induced mouse ear swelling test, egg white and carrageenin-induced paw edema test, test of leukocytoplania of pleurisy caused by carboxymethyl cellulose, granuloma (chronic) inflammation test, and screening of adjuvant arthritis animal models with primary and secondary inflammations, the myricetin is found to have high antiphlogistic and analgesic activity and can prevent and treat adjuvant arthritis, the antiphlogistic activity of myricetin is equivalent to that of aspirin but no gastrointestinal toxicity, and the anti-rheumatoid arthritis activity of myricetin is equivalent to that of Tripterygium wilfordii, and the myricetin has liver protecting effect and is an ideal drug for preventing and treating acute and chronic inflammations and rheumatoid arthritis. The myricetin can be prepared into various preparations with pharmaceutically-acceptable carrier for relieving inflammations, reliving pain and treating rheumatoid arthritis.

The invention belongs to the field of cosmetics and particularly relates to a skin-whitening, anti-aging and anti-allergic hesperidin composition, an application and a preparation. According to the composition containing hesperidin and pectolinarin, provided by the invention, the number of melanin particle-containing positive cells and the content of tyrosinase can be remarkably reduced, the SOD activity can be remarkably improved, the MDA content can be reduced, and the ear swelling and the licking frequency of an experimental animal can be remarkably reduced; and the hesperidin and the pectolinarin are compounded to achieve the effects of remarkably whitening skin, resisting aging and resisting allergy.

The invention relates to the technical field of health-care products, in particular to a traditional Chinese medicine composition with the clear-heat-from-throat function and a deep-processing preparing method and product thereof. The traditional Chinese medicine composition is prepared from lonicera japonica extract, fructus momordicae extract, figwort root extract, platycodon extract, medicine terminalia fruit extract and licorice root extract. According to the traditional Chinese medicine composition with the clear-heat-from-throat function and the deep-processing preparing method and product thereof, a functional test is carried out, the result shows that by means of the traditional Chinese medicine composition, the mouse ear swelling rate can be effectively reduced, the weight of cotton ball granuloma can be obviously reduced, the effect of the traditional Chinese medicine composition is better than the effect that all single dosages are separately used, the traditional Chinese medicine composition has the remarkable anti-inflammatory effect and the clear-heat-from-throat function, and synergistic interaction is achieved.

The invention discloses a conjugate of curcumin and an oligopeptide Arg-Gly-Asp-Ser, a preparation method of the conjugate and the tumor cell proliferation resisting activity, the A549 cell migration and invasion inhibiting effects, the S180 tumor-bearing mouse tumor weight increasing inhibiting activity, the Lewis lung cancer metastasis inhibiting activity, the xylene-induced mouse ear swelling inhibiting activity and the rat thrombus generation inhibiting activity of the conjugate. The conjugate has the following formula (please see the formula in the description).

The invention discloses a Leu-Asp-Val modified curcumin and oligopeptide conjugate of the following formula, a preparation method thereof, its activity of inhibiting tumor cell proliferation, its effect of inhibiting migration and invasion of A549 cells, its activity of inhibiting S180 tumor-bearing mice tumor weight increase, its activity of inhibiting Lewis lung cancer metastasis, its activity of inhibiting xylene induced mice ear swelling, and further discloses its activity of inhibiting rat thrombosis.

The invention discloses a hydrolysable tannin compound, which is formed by connecting glucose and gallic acid by ester bond or glycosidic bond. According to the number of composing sugar, the compound falls into monomer, dimer and trimer hydrolysable tannin derivatives, the hydrolysable tannin compound is characterized in that the end group of soup is free hydroxyl group. Animal experiments prove that the hydrolysable tannin compound can inhibit croton oil induced mouse ear swelling and carrageenin induced mouse foot swelling, has obvious inhibitory activity on type II collagen induced DBA-1 type mouse arthritis, and can be used for prevention and / or treatment of rheumatism and rheumatoid arthritis.

The invention provides a plant extract, and a preparation method and application thereof. The plant extract is obtained by extracting paniculate microcos leaves and guava leaves. The plant extract contains more than 60 percent by weight of flavone active substances. The plant extract can eliminate DPPH free radicals in vitro, can remarkably reduce the blood fat of mice fed with high-fat feed, can effectively improve mouse ear swelling inflammation caused by xylene and can protect rat acute myocardial damage caused by isoproterenol. The plant extract derives from pharmacological plants or medicinal and edible plants, is safe and reliable, does not have toxic or side effects, and can serve as novel anti-oxidation, anti-inflammation and fat-reducing medicines or health-care food.

The invention relates to a traditional Chinese medicine composition preventing and curing cardiovascular and cerebrovascular diseases. With milkvetch roots being principal herbs, the composition of salvia roots, ginkgo leaves and pseudo-ginseng in a specific proportion has the obvious effect of preventing and curing the cardiovascular and cerebrovascular diseases, can obviously reduce blood lipid of rats with hyperlipemia, has the obvious effect of restraining artery, vein and vein bypass thrombus and can improve hemorheology, restrain ear swelling caused by xylene and inflammatory reaction caused by cotton ball granuloma and obviously prolong survival time of the rats which are suffered from normal-pressure hypoxia tolerance, sodium nitrite poisoning and acute cerebral ischemic anoxia. In this way, the hypoxia tolerance capacity of organisms is improved, and the traditional Chinese medicine composition has a certain effect of protecting myocardial ischaemia injuries and cerebral injuries, and is free of acute toxicity, genetic toxicity and chronic toxicity and suitable for preventing and curing the cardiovascular and cerebrovascular diseases.

Belonging to the field of drugs or health care products, the invention in particular relates to a gynura formosana kitam. total flavone extract, a preparation method and anti-inflammatory and analgesic use thereof. The extract contains, by weight percentage, 80-85% of rutin. The experimental result of mouse ear swelling experiments and carrageenan induced rat foot swelling experiments shows that the extract has certain anti-inflammatory effect; the experimental result of mouse hot plate experiments and acetic acid writhing experiments show that a high and middle dose of the extract can reach good analgesic effect, therefore, the gynura formosana kitam. total flavone extract provided by the invention can be used as a potential anti-inflammatory and analgesic drug. According to the preparation method of the gynura formosana kitam. total flavone extract, after an extraction step, a compound enzyme composed of specific enzymes in specific proportion is selected for enzymolysis, and furtherthrough macroporous resin extraction concentration and macroporous resin separation and purification steps, the HPLC purity of rutin in the prepared gynura formosana kitam. total flavone extract canreach 80-85%.

The invention relates to the field of traditional Chinese medicine pharmacy, in particular to an application of steroidal compounds in the preparation of anti-inflammatory drugs. The invention adoptsmodern pharmacological screening technology and adopts an activity-oriented separation method to separate two steroidal compounds (compound 1 and compound 2) from the ethyl acetate and n-butanol fractions of the ethanol extracts of reineckia carnea (andr.) kunth. In vitro anti-inflammatory activity tests have showed that both compound 1 and compound 2 have relatively strong anti-inflammatory activity, and the inhibition rates of compound 1 and compound 2 on NO are 35.6% and 19.4% respectively under the condition that the concentration is 0.1 umo / L. At the same time, in vivo anti-inflammatory experiments on inflammatory mice have showed that compound 1 and compound 2 have significant anti-inflammatory effects on ear swelling inflammation induced by xylene in mice, so the two compounds can be used to prepare anti-inflammatory drugs with high efficiency and low side effects.

The invention discloses a phenolic extract of stevia rebaudiana and application of the phenolic extract in anti-inflammatory products, and belongs to the technical field of plant extracts. Main components of the phenolic extract of stevia rebaudiana disclosed by the invention are chlorogenic acid and flavonoid compounds. The phenolic extract of stevia rebaudiana can significantly inhibit xylene-induced ear swelling and carrageenin-induced paw swelling, inhibit LPS-induced macrophage NO release, can decrease the content of inflammatory factor NO in serum, and has good anti-inflammatory activity; the phenolic extract of stevia rebaudiana provided by the invention has advantages of rich source of raw materials, easy industrialization, no toxic or side effect and the like, and has broad development and application prospects as anti-inflammatory products.

The invention relates to the technical field of medicines, in particular to an application of an xanthiazone compound in preparing a drug for preventing or treating rheumatoid arthritis. A formula ofthe xanthiazone compound is shown as follows as shown in the specification. The compound significantly inhibits NO generation for RAW264.7 inflammatory cells and fibroblast-like synoviocytes stimulated by LPS (lipopolysaccharide), and has an obvious inhibiting effect on mouse ear swelling caused by dimethylbenzene and the rheumatoid arthritis induced by collagen, and an obvious swelling diminishing and anti-inflammatory effect on rat toe swelling due to inflammation caused by a Freund adjuvant; and therefore, the compound can be used for preventing and treating the rheumatoid arthritis.

The invention provides a compound shown as formula (I) and a preparation method and application thereof. The compound provided herein is an artesunate derivative; through the comparison of influence on DTH (delayed type hypersensitivity) mouse ear swelling degree and spleen index to that of a matrix control group, the compound shown as the formula (I) and transdermally delivered can significantly inhibit DTH mouse ear swelling and reduce spleen index, the differences are of great significance, and it is indicated that the compound shown as the formula (I) under experimental conditions shows certain immunosuppression effect, is effective for down-regulating body cellular immune response and is more effective than artesunate.

A purified Arabinogalactan-Protein (AGP) composition isolated through a selective method from the leaves and / or stems of Argemone mexicana plant is described. Also described is a purified Arabinogalactan-Protein (AGP) composition isolated from the leaves and / or stems of Argemone mexicana plant, which has one or more of the following effects: immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFN-γ inhibition, or IL-10 induction; keratinocyte proliferation inhibition, keratolytic activity and inhibitory activity in Mouse Ear Swelling test (MEST).

The invention discloses an application of zanthoxylum schinifolium volatile oil in preparation of anti-inflammatory analgesic drugs. According to the application, researches find that a zanthoxylum schinifolium volatile oil part can relieve xylene-induced ear swelling and carrageenan-induced foot swelling, and improve abnormal expression of inflammatory factors such as TNF-alpha, IL-6 and IL-1betainduced by carrageenan; meanwhile, the zanthoxylum nitidum maxim volatile oil part has an inhibiting effect on a body twisting reaction caused by acetic acid and a licking reaction caused by formalin, and release of pain-causing factors such as 5-hydroxytryptamine, bradykinin, a P substance and prostaglandin E2 induced by formalin is reduced, so that the zanthoxylum nitidum maxim volatile oil part has anti-inflammatory and analgesic effects; and the analgesic effect is possibly related to the anti-inflammatory effect and inhibition of release of inflammatory substances, and the research results provide a new choice for application of anti-inflammatory analgesic drugs.

The invention provides an oleanane derivative whose C ring is provided with carbonyl and oxygen substituent, represented as formula (1). The inventive compound can inhibit the growth activity of tumor cell, thereby bing applied in the preparation of anti-tumor drug and can inhibit mice ear swelling caused by dimethylbenzene, thereby being applied in the preparation of anti-inflammatory agent. The formula (1) is represented as above.

The invention discloses an application of globeflower flavonoids in preparation of a medicine for treating itch dermatoses. The application range of globeflower flavonoids is expanded; a novel medicine is provided for treatment of itch dermatoses; from a pharmacology experiment, the globeflower flavonoids have good prevention and treatment effects on a mice chronic eczema model, have an obvious inhibiting effect on mice delayed-type allergic reaction caused by 2,4-dinitrofluorobenzene, have obvious anti-inflammatory effect in ear swelling in mice caused by xylene, and have a significant inhibiting effect on capillary permeability increase in mice caused by glacial acetic acid; and the globeflower flavonoids can have relatively good counteraction on guinea pig pruritus caused by histamine phosphate, are low in toxicity and safe to use, and have a relatively good application prospect.

The invention discloses application of thais clavigera to the preparation of an antipyretic and anti-inflammatory medicine. The pharmacological activity of the thais clavigera is screened through a lot of experiments; and experimental results show that a soft body extract of the thais clavigera or shell powder of the thais clavigera has a strong effect of inhibiting acute inflammation models of mouse ear swelling caused by dimethylbenzene and mouse pedal swelling caused by carrageenan, shows good antipyretic and anti-inflammatory activities, also has the antioxidant capacity, and can strengthen the activity of superoxide dismutase (SOD), eliminate oxygen free radicals, and reduce the release of malondialdehyde. The thais clavigera has an important significance for fully utilizing vast ocean resources and developing novel safe and effective marine medicines.

The invention provides a diene oleanolic acid pentacyclic triterpenoid derivative, relative medicine salt or solvate, represented as formula (1). The inventive compound can inhibit the growth activity of tumor cell to be applied in anti-tumor drug and can inhibit mice ear swelling caused by dimethylbenzene to be applied in anti-inflammatory agent. The formula (1) is represented as above.

The invention discloses application of lophatherum gracile total flavonoids in preparation of medicine and functional food for preventing and treating myocardial ischemia disease. Shown by the experiment results, the lophatherum gracile total flavonoids are safe without toxic or side effect, and have obvious inhibiting effect on ear swelling model caused by p-dimethylbenzene, can inhibit platelet aggregation and prolong the thrombosis time, and have better protection effect on rat myocardial ischemia and myocardial ischemia reperfusion injury caused by pituitrin. Furthermore, shown by screening results of a great amount of experiments, after being combined with antiplatelet aggregation medication, beta-receptor blocking pharmacon, calcium ion antagonist, statins, RAS system blocking agent, nitrite medication and thrombolysis medication or angiotensin-converting enzyme inhibitor, the the lophatherum gracile total flavonoids show better antiplatelet aggregation, is capable of prolonging the thrombosis time, have better protection effect on rat myocardial ischemia and myocardial ischemia reperfusion injury caused by pituitrin, and play a better synergistic effect.

The invention provides preparation methods of a formulated composition and an externally used preparation thereof with the effects on alleviating pain, diminishing inflammation, destroying parasites and relieving itching for treating trichomonal vaginitis and colpomycosis. The formulated composition and externally used preparation thereof comprise the following components in contents: 20-95% of angelica sinensis extract, 1-10% of gromwell extract and 3-30% of sophora alopecuroide extract. Shown by a mouse hot plate method, a torsion pain experiment, a mouse ear swelling method caused by xylene, a rat toe swelling experiment and an anti-mildew experiment, both the composition and the externally used preparation have notable analgesic, antiphlogistic and antibacterial actions. The formulated composition and the externally used preparation provided by the invention adopt traditional Chinese medicinal materials as raw materials, have no toxic and side effects and can be used for a long term; especially, the preparation methods of externally used suppository, lotion and effervescing agent provided by the invention have simple processes and are favorable for industrialized production; the externally used preparation not only plays a local therapeutic action, but also can play a systemic therapeutic action; and shown by clinical tests, the formulated composition and the externally used preparation provided by the invention have the efficacies of alleviating pain, diminishing inflammation, destroying parasites and relieving itching, and can be used for effectively treating vaginitis.