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Application of zanthoxylum schinifolium volatile oil in preparation of anti-inflammatory or analgesic drugs

A technology of green prickly ash and volatile oil, applied in the field of biomedicine, can solve problems such as the pharmacological activity of the volatile oil of prickly ash, and achieve the effect of reducing ear swelling

Active Publication Date: 2020-12-04
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, at present, the research on Zanthoxylum bungeanum is mainly focused on the cultivation technology, and there is no report on the pharmacological activity of the volatile oil of Zanthoxylum bungeanum in anti-inflammatory and analgesic aspects.

Method used

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  • Application of zanthoxylum schinifolium volatile oil in preparation of anti-inflammatory or analgesic drugs
  • Application of zanthoxylum schinifolium volatile oil in preparation of anti-inflammatory or analgesic drugs
  • Application of zanthoxylum schinifolium volatile oil in preparation of anti-inflammatory or analgesic drugs

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Experimental program
Comparison scheme
Effect test

Embodiment 1、 9

[0029] Embodiment 1, the preparation method of the volatile oil part of Nine-leaf Green Zanthoxylum bungeanum

[0030]Nine-leaf green Zanthoxylum bungeanum is crushed into a coarse powder, and deionized water equivalent to 6 times the weight of the medicinal material is added, and under the condition of an oil bath at 130°C, the extract is heated and refluxed with a water distillation device for 6 hours to obtain the extract of the volatile oil. GCMS analysis was performed on this part, and the spectrogram results were as follows figure 1 As shown in Table 1, a total of 19 compounds were isolated, which can reflect the main chemical components of the volatile oil of Zanthoxylum bungeanum. The main compounds are alkanes, linalool and D-limonene.

[0031] Table 1. The main chemical components of the volatile oil of Zanthoxylum bungeanum

[0032]

Embodiment 2、 9

[0033] Example 2. Pharmacodynamic study on anti-inflammatory and analgesic effects of the volatile oil of Zanthoxylum bungeanum

[0034] 1. Xylene-induced ear swelling test (anti-inflammatory test)

[0035] (1) Select 48 SPF grade Kunming male mice weighing (18-22g) and carry out adaptive feeding for a period of one week. During the feeding period, the temperature is 25±1°C, and the light is cycled for 12 hours and the darkness is 12 hours. After one week of adaptive feeding, one group was randomly selected as the normal control group (Control), and the other groups were the model group (Model), the positive drug indomethacin group (Indometacin), the Oil-L group (the extract of volatile oil was low dosage group), Oil-M group (medium dose group of extracts from volatile oil parts), and Oil-H group (high dose group of extracts from volatile oil parts) were set to 100mg / kg, 200mg / kg and 300mg / kg respectively, and the positive drug ind The dose of domethacin is 5mg / kg.

[0036] ...

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Abstract

The invention discloses an application of zanthoxylum schinifolium volatile oil in preparation of anti-inflammatory analgesic drugs. According to the application, researches find that a zanthoxylum schinifolium volatile oil part can relieve xylene-induced ear swelling and carrageenan-induced foot swelling, and improve abnormal expression of inflammatory factors such as TNF-alpha, IL-6 and IL-1betainduced by carrageenan; meanwhile, the zanthoxylum nitidum maxim volatile oil part has an inhibiting effect on a body twisting reaction caused by acetic acid and a licking reaction caused by formalin, and release of pain-causing factors such as 5-hydroxytryptamine, bradykinin, a P substance and prostaglandin E2 induced by formalin is reduced, so that the zanthoxylum nitidum maxim volatile oil part has anti-inflammatory and analgesic effects; and the analgesic effect is possibly related to the anti-inflammatory effect and inhibition of release of inflammatory substances, and the research results provide a new choice for application of anti-inflammatory analgesic drugs.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of the volatile oil fraction of Zanthoxylum bungeanum in the preparation of anti-inflammatory or analgesic drugs. Background technique [0002] Pain is an unpleasant feeling or emotional experience associated with actual or potential tissue damage, and is a subjective experience of the human body. Inflammatory pain refers to the pain caused by tissue damage caused by trauma, infection or arthritis, which is mainly manifested as allodynia, spontaneous pain, diffuse pain, hyperalgesia and accompanied by a certain degree of tissue pain. Edema. Statistics show that there are more than 100 million chronic pain patients in my country, and the number is on the rise. As a complex and intractable chronic pain, inflammatory pain has complex etiology and unclear mechanism. It will not only cause physical discomfort and physical impairment of patients, but also cause anxiety and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/758A61P29/00A61K131/00
CPCA61K36/758A61P29/00
Inventor 陈敏宗伟廖志华曾庆鸿韦琳孟凡成
Owner SOUTHWEST UNIV
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