Application of patchouli alcohol in preparation of medicine for treating rheumatoid arthritis

A rheumatoid, patchouli alcohol technology is applied in the new application field of patchouli alcohol, which can solve the problems such as the therapeutic effect and action mechanism of patchouli alcohol that have not been reported in literature, and achieve an increase in foot pain threshold, alleviation of pathological changes, The effect of reducing pathological damage

Pending Publication Date: 2022-06-03
SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no literature report that patchouli alcohol has a therapeutic effect on RA and its mechanism of action

Method used

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  • Application of patchouli alcohol in preparation of medicine for treating rheumatoid arthritis
  • Application of patchouli alcohol in preparation of medicine for treating rheumatoid arthritis
  • Application of patchouli alcohol in preparation of medicine for treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Anti-inflammatory and analgesic effects of patchouli alcohol on adjuvant arthritis mice

[0046] 1.1 Modeling and group administration

[0047] 60 Kunming male mice were randomly numbered, 10 were randomly selected into the blank control group, and the remaining 50 were injected with complete Freund's adjuvant (CFA) for adjuvant arthritis (AA) mouse modeling experiment. The specific method was as follows: after the mice were immobilized, CFA was subcutaneously injected into the left hind foot pad, 50ul per mouse to induce inflammation, and the blank control group was injected with an equal volume of normal saline at the same site. The mice with successful modeling were randomly divided into 5 groups with 10 mice in each group, which were model control group, tripterygium glycosides group (10 mg / kg), patchouli alcohol high-dose group (80 mg / kg), and middle-dose group ( 40mg / kg), low dose group (20mg / kg). The corresponding drugs were administered by gavage on the 11t...

Embodiment 2

[0075] Anti-RA activity of patchouliol on TNF-α transgenic mice and its mechanism

[0076] 2.1 Experimental grouping and administration

[0077] Of the 32 transgenic mice, 26 were positive and 6 were negative (wild type). Positive mice were randomly divided into model control group, high-dose patchouliol group (40 mg / kg), low-dose patchouliol group (20 mg / kg), and 6 wild-type mice were used as blank group. The mice in the blank group were given 0.5% Tween solution at the same dose, 6 days a week, for 6 consecutive weeks.

[0078] 2.2 Arthritis index score and ankle circumference changes in transgenic mice

[0079] Before the experiment, one mark was made on the left and right ankle joints of the mice, and the arthritis index was scored before the experiment and in the first week, the second week, the third week, the fourth week, the fifth week and the sixth week of the experiment. The scoring standard is shown in Table 5. The total score of four feet is taken for each mou...

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Abstract

The invention relates to a novel application of patchouli alcohol, in particular to an application of patchouli alcohol in preparation of drugs for treating rheumatoid arthritis and a pharmaceutical composition. Research finds that the patchouli alcohol can treat rheumatoid arthritis through a multi-target and multi-path action mode, the characteristic of a natural product of the patchouli alcohol can also exert the remarkable advantages of high efficiency and low toxicity in the treatment process, the patchouli alcohol can be used for preparing the medicine for treating rheumatoid arthritis, and a brand new choice is provided for treatment of rheumatoid arthritis.

Description

technical field [0001] The invention relates to the technical field of new uses of patchouli alcohol, in particular to the use of patchouli alcohol in preparing medicines for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease characterized by inflammation of the joint synovium. The main clinical manifestations are symmetrical, multiple and recurrent arthritis, which is mainly characterized by abnormal joint synovial structure and function. It has a high disability rate and seriously endangers people's health. The main pathological changes are synovial tissue hyperplasia, interstitial infiltration of a large number of inflammatory cells, pannus formation, cartilage and bone tissue destruction. At present, the commonly used drugs for the treatment of RA are: non-steroidal anti-inflammatory drugs, glucocorticoid drugs, disease-modifying anti-rheumatic drugs (DMARDs), biological products, etc., most ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A61P19/02A61P29/00A61P37/02
CPCA61K31/045A61P19/02A61P29/00A61P37/02
Inventor 李晋奇张珍珍童荣生佘姝娅周亚茹
Owner SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL
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