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117 results about "Male mice" patented technology
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ADAM6 mice
ActiveUS8642835B2Reduces and eliminates ADAM activityImprove fertilityHydrolasesImmunoglobulins against growth factorsMatingNucleotide sequencing
Owner:REGENERON PHARM INC
Adam6 Mice
ActiveUS20120322108A1Reduce eliminateImprove fertilityHydrolasesImmunoglobulins against growth factorsMatingNucleotide sequencing
Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.
Owner:REGENERON PHARM INC
Adam6 mice
ActiveUS20130254911A1Reduces and eliminates ADAM activityImprove fertilityHydrolasesImmunoglobulins against growth factorsNucleotide sequencingMale mice
Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.
Owner:REGENERON PHARM INC
Non-human animal model of systemic lupus erythematosus
InactiveUS7265261B2Microbiological testing/measurementImmunoglobulins against animals/humansScreening methodAnti-dsDNA antibodies
The present invention is to provide a non-human animal model of systemic lupus erythematosus wherein generation of anti-double stranded DNA antibody and anti-single stranded antibody is induced, and that is made to spontaneously develop glomerulonephritis and arthritis, and a screening method for a therapeutic agent for systemic lupus erythematosus wherein the non-human animal model is used. FcγRIIB deficient mouse that is not made to spontaneously develop autoimmune pathology although its autoantibody response is enhanced is backcrossed into C57BL / 6J (B6) mouse for 12 generations to generate FcγRIIB deficient B6 mouse, the FcγRIIB deficient B6 male mouse is intercrossed with lpr / B6 female mouse, and thus obtained FcγRIIB+ / − / lpr+ / − mice were further crossed to generate a mouse model of systemic lupus erythematosus.
Owner:JAPAN SCI & TECH CORP
Method for establishing SD mouse fat and diabetes research model through diet and STZ induction
InactiveCN109221011AExplain stabilityEasy to get materialsOrganic active ingredientsAnimal husbandryAnimal scienceHuman type
The invention provides a method for establishing an SD mouse fat and diabetes research model through diet and STZ induction. Through high-fat feed and STZ induction, the attacking characteristics of fat and diabetes of humans are induced, and an animal model for establishing pathogenesis of fat and type-2-diabetes caused by insulin resistance and partial defects of pancreatic beta cells is provided. Mice are divided into a normal control group, a fat group and a diabetes group, and each group has six SD male mice. The high-fat feed is adopted for feeding mice for eight weeks, a pure-fat insulin resistance model is induced, after the mice are fed with the high-fat feed for eight weeks, injection of STZ small doze in batch is conducted, and establishment of the diabetes animal model is induced. The method can better simulate the attacking characteristics of human type-2-diabetes caused by improper diet and enjoinment factors currently, and compared with other modeling, the method has better scientific significance of clinical and fundamental research combination.
Owner:任慧雯
Imaging model in small animal living bodies with echinococcus granulosus and construction method thereof
InactiveCN105641716AHigh incidenceIncreased mortalityCompounds screening/testingLuminescence/biological staining preparationIntraperitoneal routePositive control
The invention discloses an imaging model in small animal living bodies with echinococcus granulosus and a construction method thereof. The construction method comprises the steps of: feeding CF-1 male mice; carrying out in vitro culture and drug treatment on protoscolex; carrying out in vitro fluorescence imaging and fluorescence gradient analysis; pretreating mice with depilatory paste for experimental animals, injecting the abdominal cavity of each mouse with chloral hydrate anesthetic, implanting three groups of stained scoleces under Glisson capsules by injection, dividing the mice into three groups according to different groups of injected protoscolex; in a control group, injecting the livers of mice with protoscolex on which drug treatment is not carried out, collecting images every 12 hours after injection, carrying out fluorescence intensity analysis on the ROIs region, putting into a polyethylene cage after imaging, and carrying out in vitro fluorescence gradient detection in the positive control group. The construction method constructs a mouse model with echinococcus granulosus which can express luciferase, provides a platform for drug sensitive tests in living bodies with echinococcosis, and can monitor the growth and transfer of hydatid in the living model dynamically in a long term.
Owner:王思博
The Construction method and application of type ii animal model of mucopolysaccharide storage disease
ActiveCN106282231AShort cycleGenetic stabilityNucleic acid vectorVector-based foreign material introductionDiseaseAgricultural science
This invention provides a method for constructing type ii animal model of mucopolysaccharide storage disease, which comprises synthesizing the oligonucleotide strand and annealing annealing the pUC57 T7 SgRNA with it, then connect to gain a sgRNA expression vector according to the mouse iDS gene design target; to obtain a mouse fertilized egg; mix the transferred Cas9mRNA and sgRNA to obtain an RNA mixture, microinject the RNA mixture to the cytoplasm of that fertilized egg, then implant the it into the female mice to get a F0 generation mice; extract the genomic DNA of them and use them as a template to carry out PCR reaction. The product was digested and the mutant ones were selected to determine Founder Mice; Founder Mice and those wild male mice were mated to obtain F1 mice. The invention also provides an animal model constructed by this method and the usage of the model in the study of mucopolysaccharide sequestration type ii.
Owner:SHAANXI HUIKANG BIO TECH CO LTD
New method for improving transgenic efficiency of animals
InactiveCN102181462AImprove transgenic efficiencyVector-based foreign material introductionAnimal husbandryMammalEmbryo
The invention discloses a new method for improving transgenic efficiency of animals. In the transgenic method, the sperm cells and the oocytes are used as vectors, through improvement of the method, the exogenous genes are respectively led to the sperm cells and the oocytes and the exogenous genes carried by the sperm cells and the oocytes are further integrated in the embryos through fertilization process, thus improving the efficiency of leading the exogenous genes to the nuclei and then realizing high efficiency expression. The method is characterized by respectively transfecting female and male reproductive cell systems by adopting a point injection method before the female and male mice mate with each other and then selecting the male mice 1-5 days and 35-40 days after surgery and the female mice 1-7 days after surgery to mate with each other to obtain the transgenic mouse offspring. By adopting the method, transgenosis of sheep is explored, the transgenic efficiency of big mammals can be improved and a new approach is provided for breeding in the animal husbandry. In the method, a transgenic system adopting female and male reproductive cells for joint mediation is explored.
Owner:INST OF ANIMAL SCI OF CHINESE ACAD OF AGRI SCI
Research method for protective mechanism of learning and memorizing function
InactiveCN109430166AMicrobiological testing/measurementBiological material analysisPhases of clinical researchMale mice
The invention discloses a research method for a protective mechanism of learning and memorizing functions. The research method comprises the steps that ICR male mice are divided into groups randomly to detect the effects of learning and memorizing of the mice in different stages and different time in the classic space recognition memory experiment, and the autophagy expression of synaptosome of the mice in the cerebral cortex is detected; then gamma-aminobutyric acidreceptor antagonist dicentrine and autophagy inhibitor 6-amino-3-methyl purine are used for separating cultured ICR mouse original generation nerve and intracerebroventricular injection of the ICR mice respectively, the learning and memorizing situation of the mice is detected by using Morris water maze and conditioned fear experiment, the expression of autophagy protein and PSD protein of the cerebral cortex of the mice and the change of synaptosome morphology are detected through immunohistochemistry, and then a regulatory mechanism between NMDA receptor subtypes and the autophagy process is observed.
Owner:XUZHOU MEDICAL UNIV
Establishment method of primary liver cancer mouse model
The invention provides an establishment method of a primary liver cancer mouse model and relates to an establishment method of a liver cancer mouse model. The invention solves the problems of an existing establishment method of the primary liver cancer mouse model that the establishment time is long, the feeding cost is high, and the death easily occurs in feeding. The establishment method comprises the following steps of: 1, selecting a 4-week-old ICR (Institute for Cancer Research) male mouse, and observing and feeding the mouse for 2 weeks; 2, after the male mouse is fed for 2 weeks, determining the body weight of each mouse and the daily water intake; 3, disinfecting the abdomen of the mouse by using alcohol cotton with a volume concentration of 75 percent, injecting DEN (Diethylnitrosamine) aqueous solution into an abdominal cavity, enabling the mouse to drink water containing DEN with a volume concentration of 0.15 percent after 12 hours and feeding for 4 weeks; 4, after 4 weeks, injecting the DEN aqueous solution into the abdominal cavity again, then feeding and drinking the water containing the DEN freely during the feeding period; 5, feeding to 10 weeks as of the day of injecting the DEN aqueous solution for the first time to obtain the primary liver cancer mouse model. The establishment method is also used for establishing an in-situ liver cancer animal model.
Owner:HEILONGJIANG HEIKE TECH CO LTD
Modeling method of depression animal model of pubescent mouse
PendingCN108782435AFill in the blanksSuccessful modelingAnimal husbandryIndividual animalModelling methods
The invention discloses a modeling method of a depression animal model of a pubescent mouse. According to the current situation of stay-at-home children in today's society and the pathogenesis mechanism of depression, it is verified through a large number of experiments that a weanling male mouse of a C57BL / 6J strain is raised through a single cage, and the depression animal model of the pubescentmouse is established on the periphery. It is shown through experimental results that the mouse of a model group produces depression-like phenotypes, including animal behaviors, corticosterone and sleeping situation, so that the modeling of the depression animal model of the pubescent mouse succeeds. The model is simple in operation, the current situations of the stay-at-home children can be verywell simulated, and the blank of depression animal models at the key pubescent development stage is also filled. Through the model, the modeling method can be very well used for screening anti-pubescent depression drugs and has the important application value in pathogenesis mechanism of pubescent depression in future.
Owner:SOUTHERN MEDICAL UNIVERSITY
Method for building mouse model with multiple-generation obesity and fatty liver pathologic change
The invention discloses a method for building a mouse model with multiple-generation obesity and fatty liver pathologic change. The method comprises the steps of: respectively feeding mice with normal food (NC) and high-fat food (HF) to obtain F0-generation mice, namely an NCF0 group and an HFF0 group; feeding female mice with different foods until sexual maturity, breeding with male mice fed with normal food to obtain F1-generation mice, namely an NCF1 group and an HFF1 group; after ablactation, respectively and continuously feeding the two groups of mice with normal food and high-fat food, respectively feeding female mice with normal food and high-fat food until sexual maturity, breeding with male mice fed with normal food to obtain F2-generation mice, namely an NCF2 group and an HFF2 group; and after ablactation, respectively and continuously feeding the NCF2 group and HFF2 group of mice with normal food and high-fat food. The specific modeling route is shown in Figure 1. The result shows that the obesity degree, insulin resistance degree and fatty liver pathologic change degree of the mice fed with high-fat food are progressively increased generation by generation.
Owner:WUHAN UNIV
Method for preparing transgenic mouse with central nervous system specific expression Cre recombinase
A process for preparing the transgenic mouse able to specifically express Cre recombinant enzyme in cental nerve system includes such steps as using the terminals' regulatory sequence of 1.8 kb GFAP gene to configure the transgenic carrier pGFAP-Cre-hGH containing two beta-glubolin insulators, GFAP5' terminal regulatory region, Cre recombinant enzyme gene and human growth hormone gene, injecting the 7.6 kbtransgenic fragment beta globin insulator-pGFAP-Cre-hGH into mouse's fertilizer eggs, transplating them in the deference duct of male mouse, and developing to obtain the target mouses.
Owner:INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE
Anti-breeding rodenticide
InactiveCN103125530AReduce in quantityImprove palatabilityBiocideChemosterilantsInterstitial cellBiology
The invention discloses an anti-breeding rodenticide. Melia azedarach oil is served as an anti-breeding agent, and the weight percent of the melia azedarach oil in the anti-breeding rodenticide accouts for 0.08%-0.1%. Through researching the intrinsic rules and hormone regulation mechanism of mouse breeding as well as studying the toxicological and function mechanism of a vegetable anti-breeding agent, ideal anti-breeding agent-melia azedarach oil is screened. The anti-breeding rodenticide is low in effective dosage, makes mice infertile, and has the advantages of low toxicity index, high safety, no harm to human being and animals and no secondary poisoning. After the anti-breeding rodenticide is eaten 10 days later, main reproductive organs-testicles of male mice generate the following variation: the organ coefficient gets small, the sperm amount is reduced, the seminiferous tubule diameter is thinned, lumens are reduced, germinal epithelium thickness is thinned, and interstitial cells are decreased; and ovarial organ coefficient of female mice is obviously reduced, and the corpus luteum in an ovarial structure is contracted. Dead fetus are increased after male and female mice coition, and the breeding number is greatly decreased.
Owner:XIAN UNVERSITY OF ARTS & SCI
Preparation method, application and evaluation method of collagen-induced arthritis animal model
The invention provides a preparation method of a collagen-induced arthritis animal model. The method includes the steps that 6-8 week old male DBA / 1 mice are selected; the mice selected in step (1) are placed and raised in a clean animal room where the temperature is 20-24 DEG C, the humidity is 50%-60%, and light and dark are alternating every 12 hours, the mice are free to take food and drink water, and after three days of acclimatization the mice are used for preparing the model; a chicken type-II collagen is used for immunizing the DBA / 1 mice to induce the CIA model, and the mice are immunized by intradermal injection into the tail bases of the mice; three immunizations are conducted. The method is of great significance for the pathological mechanism study and drug development of arthritis. Meanwhile, an evaluation method of the collagen-induced arthritis animal mode, through arthritis clinical index grading, ankle joint pathology examination, and determination of serum anti-CII-IgG antibody level and other indicators, is used for verifying whether the model is successful and comprehensively evaluating the collagen-induced arthritis animal model.
Owner:NANTONG UNIVERSITY
Poison bait for inhibiting mouse breeding and preparation method of poison bait
ActiveCN106472533ABehavioral impact is smallLow toxicityBiocidePest attractantsDrospirenoneDrug content
The invention belongs to the technical field of poison bait for deratization and particularly relates to poison bait for inhibiting mouse breeding and a preparation method of the poison bait. The poison bait for inhibiting mouse breeding comprises a poison layer and a food layer, wherein the food layer wraps the poison layer; the poison layer is prepared from drospirenone, quinestrol and an auxiliary material; the content of drospirenone is 0.005%-0.01% of the total weight of the poison bait, the content of quinestrol is 0.001%-0.01% of the total weight of the poison bait, the content of the auxiliary material is 5%-30% of the total weight of the poison bait, and the balance is the food layer. The poison bait for inhibiting mouse breeding has little influence on mouse behaviors, can inhibit breeding of female and male mice, has more lasting efficacy and contains fewer poisons.
Owner:SHAANXI INST OF ZOOLOGY NORTHWEST INSTOF ENDANGERED ZOOLOGICAL SPECIES
Humanized universal light chain mice
Mice, tissues, cells, and genetic material are provided that comprise a humanized heavy chain immunoglobulin locus, a humanized light chain locus that expresses a universal light chain, and a gene encoding an ADAM6 or ortholog or homolog or functional fragment thereof. Mice are provided that express humanized heavy chains comprising human variable domains, and that express humanized light chains comprising human variable domains wherein the light chains are derived from no more than one, or no more than two, light chain V and J or rearranged V / J sequences. Fertile male mice that express antibodies with universal light chains and humanized heavy chains are provided. Methods and compositions for making bispecific binding proteins are provided.
Owner:REGENERON PHARM INC
Application of Jilin ginseng oligopeptide to preparation of food or health food capable of improving and strengthening sexual functions
The invention discloses application of Jilin ginseng oligopeptide to preparation of food or health food capable of improving and strengthening sexual functions. Jilin ginseng oligopeptide is a mixture of micromolecular biologically-active peptides extracted from Jilin ginseng by using biological enzymolysis technology. The Jilin ginseng oligopeptide is low in viscosity, high in bioavailability and fast in absorption, and the Jilin ginseng oligopeptide can be directly absorbed by the human body without digestion. Male mice are administered with an aqueous solution of the Jilin ginseng oligopeptide by intragastric injection for 30 days, and results show that the Jilin ginseng oligopeptide can increase the indexes of the accessory sexual organs of the male mice, raise the concentrations of NO and testosterone in the serum of the male mice, shorten the period of mating latency of the mice and increase mating frequency. According to the invention, the Jilin ginseng oligopeptide has obvious effect on improving and strengthening sexual functions, can be used for preparation of food or health food capable of improving and strengthening sexual functions and provides a novel approach to improvement and strengthening of sexual functions through dieting.
Owner:JILIN PEPTIDE VALLEY BIOENG CO LTD
Unilateral ureteral ligation recanalisation animal model and building method thereof
InactiveCN101990859AImprove performanceGood repeatabilityAnimal husbandryUreter implantationElastic plastic
The invention discloses a unilateral ureteral ligation recanalisation animal model and a building method thereof. The method comprises the following steps of: 1) preparing an elastic plastic tube; and 2) after implanting an elastic plastic fat pad into the left ureter of an SD male mouse to pressurize to perform ligation obstruction, performing a surgery 7 days later for the second time, in the surgery, taking out the elastic plastic tube, dredging the left ureter to release the left kidney obstruction and separate the envelope of the left kidney at the same time, and ligaturing the right ureter with a NO. 4 thread. In addition, the invention also discloses the animal model built by the method. The animal model can reduce renal functions and cause renal tubule mesenchyme fibrosis change. The model building period is short; the response is quick; the cost is low; the model is convenient to use; the performance of the model is stable; the repeatability is good; pathomorphological changes of kidney after obstruction can be observed; the functional level of the kidney can be studied; and the relation between the pathomorphological changes and the functional level can be embodied; and the animal model provides a new study target for clinical research and development of medicaments for preventing and treating renal fibrosis.
Owner:SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
Ddx5 gene deleted spermatogenesis disorder mouse model and construction method thereof
ActiveCN111466338AFertility suppressionFertility suppression is completeHydrolasesStable introduction of DNAPhysiologyPlant Germ Cells
The invention provides a Ddx5 gene deleted spermatogenesis disorder mouse model and a construction method thereof, and the inventor finds that a relationship exists between the Ddx5 gene and spermatogenic disorder or fertility dysfunction in research, the testicle volume of a male mouse with Ddx5 gene deletion is obviously reduced compared with that of a wild mouse. Moreover, the testicle of the mouse is free of germ cells, the epididymis is free of sperms, and any offspring cannot be obtained after the mouse is mated with a female mouse. Therefore, the Ddx5 gene deleted male mouse has the advantages of stability and thorough spermatogenic function inhibition, and is a good research model for male fertility disorders.
Owner:GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
Application of donkey-hide gelatin to preparing drugs or health-care products for treating premature ovarian failure
The invention discloses application of donkey-hide gelatin to preparing drugs or health-care products for treating premature ovarian failure and belongs to the field of new drug application of donkey-hide gelatin. On the basis that a premature ovarian failure animal model is established through cyclophosphamide, influences of donkey-hide gelatin on the weight, the weight increase, the food intake amount, the estrous cycle, the ovary organ coefficient, the sex hormone level, histopathology and follicle counting and the like of premature ovarian failure animals are observed, according to the experiment result, it is found that donkey-hide gelatin has a certain effect on weight restoration of female mice after modeling of cyclophosphamide and has the tendency to increase the ovary and uterus weight and the organ coefficient of male mice, donkey-hide gelatin has a certain forward regulating effect on follicular development, it is shown that donkey-hide gelatin has the effects of increasing the ovary coefficient and enhancing the functions of the ovary, premature ovarian failure can be inhibited, and therefore donkey-hide gelatin can be applied to preparing drugs or health-care products for treating premature ovarian failure.
Owner:SHAN DONG DONG E E JIAO
Application of compound preparation containing angelica keiskei to a medicine for preventing or treating sexual dysfunction
PendingCN109528933AEasy to acceptSimple extraction methodSexual disorderPlant ingredientsSide effectMale mice
The invention belongs to the technical field of medicine, and specifically discloses a preparation method of a compound preparation made of angelica keiskei, dendrobium officinale and Chinese wolfberry fruits, and an application of the preparation to a medicine for preventing or treating sexual dysfunction. The compound preparation is prepared by mixing angelica keiskei extractum, dendrobium officinale extractum and Chinese wolfberry fruit extractum. Experiments show that the preparation can increase the number of bestriding in sexual behavior of castrated male mice, increase the number of sperm in sexual dysfunction, and improve the contents of serum testosterone, lutropin, follicle-stimulating hormone and serotonin in individuals with sexual dysfunction. In addition, after using the compound preparation of the present invention, the tissue structure of mouse testesis is relatively complete and distinct in gradation, and more sperm cells exist. The preparation for improving sexual dysfunction of the invention has clear effective components, determined curative effect, no toxic and side effect, easy-to-implement extraction method and broad application prospect.
Owner:深圳市本源生物科技有限公司
A kind of establishment method of type 2 diabetes animal model
InactiveCN107929311BHigh molding rateEasy to operateOrganic active ingredientsAnimal husbandryEscherichia coliIntraperitoneal route
Owner:UNIV OF ELECTRONICS SCI & TECH OF CHINA
Non-obese diabetic animal model and construction method and application thereof
The invention provides a method of producing a non-obese diabetic (insulin-dependent diabetes mellitus) animal model. The method comprises overexpressing NIK (NF-kappa-B-inducing kinase) gene in pancreatic beta cells of an animal. Compared with existing non-obese diabetic (NOD) mouse models, beta-NIK-OE male mice herein have the advantages of good stability, short period, low expense and the like,and are applicable to the research on diabetic pathogenesis, the research on diabetic complications and the screening of diabetes drugs.
Owner:HARBIN INST OF TECH
Novel use of aromatase inhibitors
InactiveCN102641502AEffective treatmentSignificant relief of symptomsOrganic active ingredientsUrinary disorderAromatase inhibitorEffective treatment
The invention relates to a novel use of aromatase inhibitors, in particular to application of the aromatase inhibitors in terms of preparation of medicines for treating male bladder outlet obstruction and lower urethral syndromes caused by the same. The medicines can rapidly and effectively treat bladder outlet obstruction of male mice. The novel use can be clinically applied better, provides a fundamental basis for clinical treatment, and is a novel method for treating the bladder outlet obstruction.
Owner:CHINA AGRI UNIV
Nonhuman Model animal of syntemic lupus erythematosus
InactiveUS20050066378A1Microbiological testing/measurementImmunoglobulins against animals/humansScreening methodSingle strand
The present invention is to provide a non-human animal model of systemic lupus erythematosus wherein generation of anti-double stranded DNA antibody and anti-single stranded antibody is induced, and that is made to spontaneously develop glomerulonephritis and arthritis, and a screening method for a therapeutic agent for systemic lupus erythematosus wherein the non-human animal model is used. FcγRIIB deficient mouse that is not made to spontaneously develop autoimmune pathology although its autoantibody response is enhanced is backcrossed into C57BL / 6J (B6) mouse for 12 generations to generate FcγRIIB deficient B6 mouse, the FcγRIIB deficient B6 male mouse is intercrossed with lpr / B6 female mouse, and thus obtained FcγRIIB+ / − / lpr+ / − mice were further crossed to generate a mouse model of systemic lupus erythematosus.
Owner:JAPAN SCI & TECH CORP
Application of pulse and blood improving preparation and leech in preparing medicament for treating sexual dysfunction
InactiveCN102973607AHas a facilitative functionIncrease indexSexual disorderLeech/worm material medical ingredientsSexual functionSexual dysfunction
The invention provides application of a pulse and blood improving preparation and leech in preparing a medicament for treating sexual dysfunction. Particularly, according to the pulse and blood improving preparation and leech, the incubation period of a male mouse in capturing a female mouse is shortened, the number of capture times is increased, the weight of prostate and semen sac of the mouse can be increased, and the index of accessory sex organ of the mouse is increased. The pulse and blood improving preparation and leech have the effect of promoting sexual function, and have certain curative effect in treating sexual dysfunction.
Owner:GUIZHOU XINBANG PHARMACEUTICAL CO LTD
Construction method and application of PHF6 <delta> and JAK3<M511I> double-mutation acute T lymphocytic leukemia mouse model
ActiveCN113549655AShort passage timeStable proliferationCompounds screening/testingTransferasesLymphocytic cellDouble mutation
The invention discloses a construction method and an application of a PHF6 <delta> and JAK3<M511I> double-mutation acute T lymphocytic leukemia mouse model. The preparation method comprises the following steps: utilizing a Vav1-Cre mouse to mate with a Phf6<fl / fl> mouse to obtain Vav1-Cre; a Phf6<fl / Y> (Phf6<- / Y>) male mouse; mating the Mx1-Cre mouse and the Phf6<fl / fl> to obtain Mx1-Cre; Phf6<fl / Y>male mouse; respectively enriching Lin-cells in bone marrow of two male mice, infecting retroviruses overexpressing GFP-JAK3M511I, and transplanting GFP + cells into receptor mice irradiated by a lethal dose through caudal vein injection, so as to construct two T-ALL leukemia mouse models. The model provided by the invention can be rapidly passed in mice, simulates the leukemia process of a T-ALL patient with PHF6 gene and JAK3 gene double mutation, and is used for targeted therapy drug screening and curative effect evaluation.
Owner:INST OF HEMATOLOGY & BLOOD DISEASES HOSPITAL CHINESE ACADEMY OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
Uses of mito-ob transgenic mice
The Mito-Ob obese mouse model overexpresses the mitochondrial protein prohibitin (PHB). Mito-Ob male mice develop insulin resistance in addition to obesity and they do not develop overt diabetes. It has been discovered that these mice also spontaneously develop nonalcoholic steatohepatitis (NASH) and hepatocarcinogenesis over time. Also described is a mutant Mito-Ob mouse that develops lymphadenopathy and histiocytosis.
Owner:UNIVERSITY OF MANITOBA
Application of seal oil in preparing medicaments for treating sexual disorder
InactiveCN101239074ASymptoms of increased contraction-related diseasesProlong erectionAerosol deliveryOintment deliveryDiseaseArteriolar Vasoconstriction
The invention relates to an application of fur seal oil which mainly contains EPA, DHA and DPA during the preparing of the medicine for curing sexual disorder, belonging to the field of medicine preparation. The fur seal oil is a fine product obtained through the esterification of the rough fur seal oil and the molecular distillation, wherein, the weight percentages of three omega-3 polyene unsaturated fatty acid are respectively 6.5 to 9.0 percent EPA, 10.5 to 12.5 percent DHA and 4.0 to 8.0 percent EPA. The active ingredient (fur seal oil) of the invention can increase the weight of the gonad of a large male mouse which is weak in sexual ability, increase the plasma stosterone content, prolong the time of the erection of penis, and increase the mating times of the male mouse with the female mouse. Thereby, the invention can improve the erection of penis and better the symptoms of the diseases related to vasoconstriction.
Owner:山东泰洋树生物工程有限公司
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