625 results about "Drug content" patented technology

A system and method for tracking longitudinal data for the maintenance and management of health of an individual. The method entails marking numerous groceries, drugs, beverages, etc., with labels that may be read by a scanner or reader embedded in a PDA or cell phone or similar small electronic device, and providing users with a suitable scanner or reader. Users scan the labels of the products they consume during the course of a day, and the system keeps track of calories, fat content, carbohydrate content, etc. of the food consumed, drug content of the drugs consumed, etc. The system can also be operated to track exercise levels and energy expenditure during the day. The system is operable to provide a comparative display of various databased information, such as calorie intake versus calorie expenditure during exercise.

The invention relates to a dual-emission ratio-type quantum dot fluorescence probe for visual detection of aspirin, a preparation method and an application thereof and belongs to the technical field of preparation of material and detection of content of medicines. The preparation method of the probe includes following steps: preparing a precursor NaHTe solution from sodium borohydride, tellurium powder and water under an ultrasonic environment; adding the precursor to an aqueous solution of CdCl2.2.5H2O in the presence of thioglycollic acid; carrying out a reflux reaction with a nitrogen protecting condition to obtain required green fluorescence quantum dot and red fluorescence quantum dot; by means of a sol-gel method, wrapping the red fluorescence quantum dot with silicon spheres with amino group being connected; dispersing a green fluorescence quantum dot solution and the red fluorescence quantum dot wrapped with the silicon spheres in an MES buffer solution with addition of an EDC/NHS solution; and carrying out a reaction at room temperature in a dark place to obtain the dual-emission ratio-type quantum dot fluorescence probe. The dual-emission ratio-type quantum dot fluorescence probe is used in detection of the content of the aspirin through fluorescence quantitation and visualized analysis. The quantum dot fluorescence probe is quite good in optical performance and stability and has a capability of visualizedly detecting the aspirin.

Controlled release of active agents from sustained release push delivery devices having high drug loading are described wherein residual drug content in the device is minimized by the utilization of a flow-promoting layer between a semi-permeable wall and drug layer comprising the device.

The invention discloses a traditional Chinese medicine health product preparation for preventing and treating alcohol liver disease and a preparation method. According to the parts by weight, the traditional Chinese medicine health product preparation is prepared by adopting the following raw materials: 250 to 328 parts of pueraria flower, 250 to 328 parts of semen hoveniae, 250 to 328 parts ofradix puerariae, 125 to 164 parts of fructus amomi, 250 to 328 parts of dark plum fruit, 250 to 328 parts of date and 125 to 164 parts of liquoric root. The traditional Chinese medicine health product preparation can effectively prevent the alcohol from causing GSH exhaustion and MDA rising of the liver, reduce fatty degeneration of liver cells and has the function of preventing alcoholic liver damage; the health product preparation has condense medicinal odour, stable and controllable preparation technique and product quality, obvious curative effect and fast effect; the provided formulation has convenient in use, reduces the oral dosage; and in the formulation, all the drug contents are obtained from natural resources, has lower cost and is conveniently to promote and broad masses of the people are willing to adopt the traditional Chinese medicine health product preparation.

The invention relates to a dirithromycin (DRM) enteric preparation with hydroxypropyl methylcellulose phthalate (HPMCP) being the framework material of drug-containing core and the coating material of an enteric coating layer. The enteric preparation has the advantages that the drug content is higher, the drug dissolution rate is less affected by the coating material, the preparation cost is low and the preparation process is simple.

The invention provides a quantum dot fluorescent aspirin imprinted sensor and its preparation method and use and belongs to the technical field of material preparation and drug content detection. The preparation method comprises the following steps of preparing a precursor NaHTe solution from sodium borohydride, tellurium powder and water in an ultrasonic environment, injecting the precursor NaHTe solution into a CdCl2.2.5H2O solution fed with nitrogen for oxygen removal, having a pH value of 10.5-11.5 and containing thioglycollic acid (TGA), carrying out backflow reaction processes in a nitrogen protective atmosphere at a temperature of 100-110 DEG C to obtain quantum dots having different sizes according to different backflow time periods, and synthesizing a fluorescent molecule imprinted polymer from the CdTe quantum dots as fluorescent carriers, aspirin as a template molecule, (3-aminopropyl)triethoxysilane (APTES) as a functional monomer and tetraethyl orthosilicate (TEOS) as a cross-linking agent by a sol-gel method, wherein the fluorescent molecule imprinted polymer can be used for optical detection of aspirin. The fluorescent molecule imprinted polymer has good optical and pH stability and has an aspirin selective-identification function.

The invention discloses an astragalus planting method. The steps comprise: preparing field; treating seeds; sowing; performing field management, and controlling pests. In each step, a scientific treatment method is used. A soil conditioner in the step 1 can improve soil physical and chemical properties, reduce pest and disease damage in growth, and improve stress resistance. In step, on the premise of ensuring yield and quality of the astragalus, hard seed property of astragalus seeds is overcome through treatment before sowing, so as to improve rooting and developing efficiency of the astragalus seeds. In step 3 and step 4, fertilizer makes survival seedling rate of the astragalus high, and large amount of organic fertilizer generated in a yield increasing fertilizer can satisfy rapid growth requirements of the astragalus, so growth speed of the astragalus is fast, flowers are flourishing and fruits are rich, seeds are full, and leaf surface drug content is high. The method increases yield and solves a problem of repeated fertilization, and effectively controls incidence of astragalus root rot disease, improves yield and quality, and generates effective economical value.

The present invention generally relates to a pharmaceutical dosage form and controlled release of biologically active agents, diagnostic agents, reagents, cosmetic agents, and agricultural/insecticide agents. In one embodiment, the dosage form has a substrate that forms a compartment, wherein the substrate includes at least a first piece and a second piece, wherein the first piece operably links to the second piece. The dosage form contains a drug content that is loaded into the compartment. The dosage form also has a releaser operably linked to the substrate which upon contact with water or body fluid is capable of separating the first and second piece to open the compartment and release the drug content.

The invention discloses a hypocrellin liposome preparation and a preparation method thereof. The hypocrellin liposome preparation comprises the following components according to parts by weight: 1-5 parts of hypocrellin, 40-200 parts of phospholipids, 2.4-12 parts of cholesterol and 50-100 parts of protective agent for freeze drying. The hypocrellin liposome preparation prepared by the high pressure homogenization is characterized in that: the preparation contains no surfactant of Tween; the drug content of the preparation can be increased to more than 1.2 percent from 0.6 percent; the drug concentration of redissolution reaches 1mg/ml, an increase of 100 percent. The invention substitutes the high pressure homogenization for the ultrasonic method so that the quality of the hypocrellin liposome preparation can be assured and the yield greatly increased which meets dual requirements of the industrial production and clinical application of drugs of hypocrellin liposome; meanwhile, the invention substitutes rapid pre-freezing for steady pre-freezing, which can ensure that solid powder of hypocrellin liposome with good monodispersity and more stable morphology after the redissolution is obtained.

The invention belongs to the medicine technical field, relates to epirubicin hydrochloride liposome and a preparation method. The liposome comprises epirubicin hydrochloride and neutral phospholipid and cholesterol and/or negative charge phospholipids and/or long-circulating phospholipids and buffer solution, and actively carries drug with a PH gradient method or an ammonium sulphate gradient method; the entrapment rate of the achieved liposome is more than 90%, to make smaller volume contain more main drug component of epirubicin. Compared with the exiting techniques, the epirubicin hydrochloride liposome and the preparation method has the advantages of high drug content, high bioavailability, long internal circulation time, low toxic and side effect and other advantages; besides, the production cost can be reduced obviously, the epirubicin hydrochloride liposome is more suitable for industrial production after being made into lyophilized preparation. The liposome is clinically suitable for the tumor therapy, in particular to the tumor therapy for children.

Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition containing such polymeric micelle. Disclosed are a production process for a polymeric micelle, comprising the steps of dissolving a drug and a specific copolymer in a water non-miscible organic solvent to prepare a solution, mixing the resulting solution with water to form an O/W type emulsion and then slowly volatilizing the organic solvent from the solution, and a polymeric micelle composition charged therein with a water-scarcely soluble drug, which can be obtained by the above production process.

The invention relates to preparation of solid dispersions and oral preparations of paclitaxel and homologous compounds thereof, wherein solid dispersions and solid dispersion microspheres are prepared to increase rapid release and oversaturation maintenance of paclitaxel and homologous compounds thereof so as to increase bioavailability. According to the present invention, a carrier is hydroxypropylmethylcellulose acetate succinate or hydroxypropylmethylcellulose tetrabutyl titanate, or/and a mixture of hydroxypropylmethylcellulose acetate succinate and micro-powder silica gel or a mixture of hydroxypropylmethylcellulose tetrabutyl titanate and micro-powder silica gel; the drug and macromolecule are dissolved into a mixing solvent of a good solvent and a liquid bridging agent, and the obtained drug-containing solution is slowly added to a poor solvent under a stirring effect; under a shearing force effect of stirring, the drug-containing solution is emulsified and dispersed in the poor agent to form temporary translucent emulsion droplets, the emulsion droplets continuously diffuse to the poor solvent along with the good solvent and the bridging agent, and the drug and the macromolecule in the emulsion droplet are oversaturated so as to gradually solidify to form the solid dispersion microspheres; and the prepared solid dispersion microspheres have characteristics of a size particle of 100-600 mum, a yield of more than 80%, and a drug content of 5-35%.

The invention discloses a preparation method for a doxycycline modified release pellet and preparation. The method includes the steps of: preparing a doxycycline hydrochloride drug loaded pellet, then mixing the pellet with an appropriate amount of a coating material, applying a fluidized bed to perform coating by bottom spraying, and carrying out drying to obtain the doxycycline hydrochloride modified release pellet; mixing auxiliary materials evenly, and mixing an adhesive with the auxiliary materials uniformly according to a weight ratio of 0.01-1:1; and under a molten state of the adhesive, sticking the auxiliary materials to the surface of the coated pellet prepared form doxycycline by the adhesive so as to obtain a pellet particle; and subjecting the pellet particle to direct tabletting, or mixing the pellet particle with a buffer particle prepared by a conventional method according to a weight ratio of 1:9-9:1 and then conducting tabletting, thus obtaining a pellet tablet. The preparation method provided by the invention is free of layering phenomenon in the tabletting process, and the prepared pellet tablet has uniform quality and drug content. Thus, the method is suitable for industrial production.

The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.

The invention relates to a medicinal oral preparation, i.e., a saussurea involucrata drop pill for treating rheumatic arthritis, chronic infectious arthritis and dysmenorrheal, which has the advantages of high biological availability, quick-speed medicine release, quick-speed effect, less toxic and side effects, higher medicinal content, smaller amount of administration, accurate administration dosage, easy administration, low price, and facilitated carrying. The medicine is prepared through the conventional drop pill preparing process.

The invention relates to an Asenapine maleate oral instant membrane used for treating adult schizophrenia, chronic severe brain dysfunction and type I bipolar disorder, and a making method thereof. The above dosage form has the advantages of convenient administration, administration without water, rapid dissolving in the oral cavity, restriction or complete prevention of the removal of a medicine by a schizophrenia patient, and improvement of the compliance f the patient. The main drug content of the dosage form made through the making method can reach the unit dosage of Asenapine maleate, and the dosage form has the characteristics of drug loading uniformity, good appearance and good stability. In the production process, the technology is simple, the cost is low, and almost no dust is generated.