773 results about "Biological availability" patented technology

The invention relates to the field of environmental protection and restoration and in particular relates to an environmental-friendly heavy metal stabilizer used for soil restoration of an industrial pollution site and an application method thereof. The environmental-friendly heavy metal stabilizer is prepared from the following material components in parts by weight: 40-50 parts of clay mineral, 17-24 parts of adsorbing material, 10-18 parts of heavy metal chelating agent, 4-8 parts of heavy metal precipitating agent and 10-15 parts of alkaline modifier. Main ingredients of the adopted stabilizer are natural materials, heavy metal pollutant in soil can be rapidly and effectively stabilized through composite action such as chelating, precipitation and adsorption; the heavy metal pollutant is stabilized for a long time, toxicity and biological availability of the heavy metal pollutant can be reduced, risk of the heavy metal polluted soil to the environment and human health is reduced, and the heavy metal polluted soil is restored; besides, a soil texture improving ingredient is contained, so that soil is restored while tillability of the soil is improved.

A composite forage for piglet is prepared from 21 raw materials including corn, cracker dreg, fermented soybean, fish powder, Chinese-medicinal materials, glucose, etc.

The invention relates to a capsule preparation containing tegafur, Jimeisita and Potassium Oxonate and a preparation method thereof, which is characterized in that the capsule preparation contains tegafu micropill, Jimeisita micropill and Potassium Oxonate micropill, wherein, the micropill is prepared from active drug ingredient, thinner, bond and surface active agent. The micropill is prepared with the extruding-rolling method, the centrifugal-fluidifying method, the pan coating pill floating method and the like, and then, other minor ingredients are added; finally, the capsule is filled. The capsule prepared with the preparation method can be steadily and quickly released in bodies, thus the drug stability is improved. The capsule has high dissolution rate and biological availability, and reduces adverse reaction of medicine.

The invention relates to an enzymolytic lactoprotein ferrous complex, a microcapsule iron supplement and a preparation method thereof. In the preparation method, ferrous salt is complexed with an enzymolysis product of lactoprotein, which can improve solubility of iron salt under an alkalescent intestinal condition, improves absorptivity and availability of iron and ensures a safe and pollution-free preparation process; a proper coating material is adopted for microencapsulating the enzymolytic lactoprotein ferrous complex to prepare the microcapsule iron supplement agent of the enzymolytic lactoprotein ferrous complex; the iron supplement agent can mask self-odor of the ferrous salt, prevent the ferrous iron from oxidation, gradually release Fe under the alkalescent intestinal condition to ensure high biological absorptivity and biological availability of the Fe, and has no toxic and side effect; and the enzymolytic lactoprotein can prevent and treat iron-deficiency anemia, and has physiological functions of resisting oxidation, adjusting immunity, lowering blood pressure and the like.

A preparation method of vitamin A and vitamin E nano-sphere / microsphere double-embedding system belongs to the technical field of biological active substance control release microencapsulation. In the present invention, food grade vitamin A is nano-sphere core material and monoglyceride or beeswax is nano-sphere wall material to be made into nano-sphere suspension which is used as microsphere core material together with the vitamin E; ocentyl succinate esterified starch containing tween-80 is used as microsphere wall material; the nano-sphere / microsphere double-embedding system is manufactured by a thermal homogenization-spray drying method. The encapsulation rate towards the vitamin A of vitamin A nano-sphere manufactured by the present invention can reach to 82 percent to 94 percent, and the particle size of the nano-sphere is 200nm to 370nm. The encapsulation rate towards the vitamin A of the double-embedding system is 86 percent to 91 percent and the encapsulation rate towards the vitamin E is 89 percent to 93 percent. The double-embedding system can embed the vitamin A and the vitamin E synchronously and has the effect of releasing step be step, so as to avoid the mutual interference of active components, improve the biological utilization rate and can be added into various foods as vitamin intensifier and extender.

The invention provides a pharmacy acceptable salt type of imidazole-5-carboxyl acid derivative, a relative preparation method and a drug compound. The inventive salt has good solubility in general solvent as water and methanol, good biological availability in animal body and the application for developing general agent to treat high blood pressure.

The invention discloses an organic selenium-supplementing feed additive and preparation and a using method thereof. The feed additive is prepared by the following steps of: adding chitosan with deacetylation degree of 70 to 100 percent into 0.5 to 2 volume percent of diluted acid with stirring at the temperature of between10 and 60 DEG C to obtain 0.5 to 10 percent acid solution of chitosan; adding solution of inorganic selenium into acid solution of chitosan, wherein the mass of inorganic selenium is 1 / 6 to 1 / 2 time that of the chitosan; and reacting for 1 to 12h and separating, washing the obtained solid matter by using distilled water for many times until selenium ions cannot be detected, and drying and crushing to obtain chitosan selenium chelate. The chitosan selenium serving as the feed additive is applied to feeds for livestock, poultry and aquatic animals and is effectively absorbed and utilized in the animals by using proper stability and dissolution performance thereof, so that disease resistance, production performance and meat quality of the animals are obviously improved. The chitosan selenium has the advantages of little toxicity, high biological availability, small addition amount, and capability of saving resources and protecting the environment, so that the feed additive is a safe and effective environment-friendly feed additive.

A process for preparing 1,3-propanediol biologically features that in the culture medium for fermenting or in the anaerobic fermenting procedure, appropriate reducer is added to increase the accumulation of reduction equivalent weight in thallus for promoting metabolism of glycerine along the reductino approach, and increasing the concentration and transform rate of 1,3-propanediol. Its advantageis high biologic utilization rate.

The invention discloses a normal-temperature preparation method for ultrafine lung-regulating and cough-relieving powder. The method comprises the following steps of: selecting bulk pharmaceutical decoction pieces of lily, dwarf lilyturf root, rhizoma pinelliae preparata, aster, liquoric root, thinleaf milkwort root-bark, common anemarrhena, coastal glehnia root, dried orange peel, indian buead and floatstone; smashing bulk pharmaceuticals into coarse powder at the normal temperature; uniformly mixing the obtained coarse powder according to a certain proportion, putting into a rod mill for smashing, conveying into a special bilateral airflow sieving machine through wind for sieving with a 500-mesh sieve, sieving to obtain powder of which the particle diameter is less than or equal to 25 micrometers, conveying the powder which is obtained by sieving to a cyclone aggregator through airflow generated by a draught fan for collecting to obtain finished ultrafine lung-regulating and cough-relieving powder; and collecting powder which is not sieved with the 500-mesh sieve, and conveying to the rod mill through a pipeline for smashing circularly once again. The method has the advantages that: the entire preparation process is performed at the normal temperature; the particle diameter of a prepared finished medicament is less than or equal to 25 micrometers, and the cell-wall breaking rate and the biological availability are greatly increased; and due to the adoption of the bilateral airflow sieving machine, the preparation process of the ultrafine lung-regulating and cough-relieving powder is simplified.

A process for preparing the polypeptide-protein feed from the low-value fish and shrimp and the leftover of aquatic products includes removing impurities, steaming for defatting, oil-water separating, pulverizing, sterilizing, enzymolyzing, deactivating enzyme, concentrating and drying. The obtained feed features high contents of polypeptide and protein, and high reward rate.

The invention discloses a normal-temperature preparation method for ultrafine powder hawthorn. The method comprises the following steps of: cleaning hawthorn, and drying till the water content is less than or equal to 10 percent; smashing the hawthorn at the normal temperature to obtain coarse powder of which the granularity is 60-80 meshes; putting the coarse powder into a rod mill for smashing,conveying into the special bilateral airflow sieving machine through wind for sieving with a 500-mesh sieve, sieving to obtain powder of which the particle diameter is less than or equal to 25 micrometers, and conveying to a cyclone aggregator through airflow generated by a draught fan for collecting to obtain finished ultrafine powder coccidia powder; and collecting powder which is not sieved with the 500-mesh sieve with a funnel, and conveying to the rod mill through a pipeline for smashing circularly once again. The method has the advantages that: the entire preparation process is performed at the normal temperature without low temperature or special additional conditions; the particle diameter of prepared finished hawthorn micro powder is less than or equal to 25 micrometers, the cell-wall breaking rate and biological availability are greatly increased, and the pharmacological action of a medicament is enhanced; and due to the adoption of the bilateral airflow sieving machine, thepreparation process of ultrafine powder hawthorn is simplified, and the aim of controlling the quality standard of Chinese medicinal powder is fulfilled.

The invention discloses a dendrobium candidum ganoderma lucidum capsule, and relates to a traditional Chinese medicine capsule, in particular to a dendrobium candidum ganoderma lucidum capsule free from influence of air humidity and having high absorption and high bioavailability and a preparation method thereof. The dendrobium candidum ganoderma lucidum capsule disclosed by the invention is characterized by being prepared by the four steps of processing of dendrobium candidum, ultrafine grinding of dendrobium candidum, ultrafine grinding of ganoderma lucidum and mixing and capsule filling. In the dendrobium candidum ganoderma lucidum capsule disclosed by the invention, the ultrafine powder of dendrobium candidum and the ultrafine powder of ganoderma lucidum are mixed and packed in a capsule form, the influence of air humidity can be avoided, and the human body absorption and the bioavailability are high; and moreover, the dendrobium candidum ganoderma lucidum capsule has the functions of dendrobium candidum and ganoderma lucidum, and has a better taking effect.

The invention provides a bean pulp rainbow trout parr compound feed and a preparation method thereof. Every 100kg of bean pulp rainbow trout parr compound feed is manufactured by 6 to 12kg of steam fish meal, 50 to 60kg of expanded bean pulp, 10 to 15kg of corn protein powder, 3 to 5kg of beer yeast, 0.5 to 1.0kg of Squid paste, 0.5 to 1.0kg of betaine, 2 to 6kg fo flour, 1.5 to 2.5kg of soybean lecithin, 5 to 6kg of fish oil, 5 to 63kg of soybean oil, 0.3 to 0.5kg of methionine, 0.1 to 0.3kg of lysine, 0.3 to 0.5kg of Choline Chloride, 0.5 to 1.0kg of composite vitamin, 0.5 to 1.0kg of composite mineral salt and water. The invention aims at the digesting physiological characteristic during the parr period of the rainbow trout and solves the balancing problem of amino acid by optimizing and adjusting the prescription of the feed, and solves the problems of anti-nutritional factors and palatability by comprehensively using enzyme preparation and feeding promoting agent. The invention selects the feed materials with high biological availability, and has the advantages of remarkably promoting the quick growth of the rainbow trout parr, improving the surviving rate of culturing, improving the digesting and absorbing rates of the rainbow trout parr on the feed, reducing the drainage of P and N, reducing the culturing cost, and the like. The materials used by the compound feed of the invention have the advantages of reliable source, stable quality and low cost.

The invention relates to a dispersible tablet containing oryzanol for treating neurological system diseases and its preparing process, wherein the tablet comprises (by weight parts): oryzanol 5-200, filling agent 20-200, crumbling agent 15-40, bonding agent 1-70, flowing adjuvant or lubricating agent 0-5.

The invention discloses a tilmicosin solid dispersible granule as well as a preparation method and an application thereof. The tilmicosin solid dispersible granule consists of tilmicosin and a carrier accessory. The carrier accessory is one of glycerin monostearate, stearyl alcohol, saturated triglyceride, glycerinum simple lipid, paraffin wax, animal wax, vegetable wax or fatty powder or mixture thereof. The preparation method of the tilicosin solid dispersible granule comprises the following steps: weighing respective carrier accessories according to the formula proportion, heating, melting and mixing uniformly; adding the tilmicosin, stirring uniformly, cooling, pelleting through spraying of a fluidized bed, balling, cooling, sieving and collecting to obtain the tilmicosin solid dispersible granule. The tilmicosin solid dispersible granule solves the problem of medicine palatability, by feed mixing administration, the fluidity and dispersibility are good and medication is convenient; after animals take the granule, the medicine releases slowly, so that the safety is high; besides, the biological availability of tilmicosin medicine is enhanced, and the clinical using effect is remarkable.

The invention relates to a nutritious noodles of a submicron powder fungus and a preparation method thereof, comprising by weight: from 1% to 10% of a fungus submicron powder, from 0 to 0.6% of a sodium alga acid, from 0 to 4% of a table salt, allowance flour. The preparation method comprises preparing the fungus submicron powder, slurring, maturing, tabletting, strip cutting, and drying. The fungus is crushed into the submicron powder below 60 um and filled into the noodles, no feeling of any granularity in the mouth, enabling the noodles to have rich nutrition and health care ingredients of the fungus, and endowing the noodles with a natural light coffee color. The dry product of the invention is represented with the light coffee color and even lustre, the noodles becomes a dark color with faint scent of the fungus, strong connecting strength, no sticking, transparent, and less breakage after well done. The nutritious noodles of the submicron powder fungus and the preparation method have the advantages of applying the modern superfine pulverizing technology, significantly increasing the cell wall breakage rate, greatly improving the absorptivity of the fungus, reserving the biological active component, and heightening the biological utilization ratio.

The invention relates to a drug preparation and a preparation method thereof, in particular to a compound Alpha-ketonic acid chewable tablet used for curing chronic renal failure, and a preparation method thereof. The compound Alpha-ketonic acid chewable tablet comprises the following components: Alpha-ketophenylalanine calcium, Alpha-hydroxymethionine calcium, Alpha-ketoleucine calcium, Alpha-ketoisoleucine calcium, Alpha-ketovaline calcium, tryptophan, histidine, tyrosine, threonine, lysine, acetate, a filling agent, a bonding agent, a taste-masking agent, a lubricant and a coating agent. The compound Alpha-ketonic acid chewable tablet not only widens the dosage form range of the compound Alpha-ketonic acid chewable tablets, but also has the advantages of having good dispersing state, short disintegration time, fast drug dissolution, rapid absorption, high biological availability and convenient taking, being capable of being swallowed, chewed and sucked and being especially suitable for old people, stroke patients, patients with special diseases and patients having swallowing difficulty.

The invention provides primary walnut pulp and a production method thereof. The primary walnut pulp is prepared from raw materials of walnut kernels and pure water through pulping, enzymolysis, oil taking and standardization; and through detection, the product has the protein content of more than or equal to 2.5 percent, the fat content of more than or equal to 2.6 percent and the polypeptide content of more than or equal to 18mg / ml. The production method comprises the following steps of: preparing walnut pulp, performing enzymolysis, centrifuging to take oil, and performing secondary enzymolysis; adding pure water for standardization; and homogenizing feed liquid, separating impurities by using a self-discharging disc centrifuge, performing ultra high temperature short-time sterilizationtreatment, cooling to the temperature below 35DEG C, and performing sterile filling to obtain the final product. The obtained product is white in color and thick in walnut flavor, contains nutrient components such as walnut protein, linoleic acid, linolenic acid and walnut phosphatide, and is rich in walnut polypeptide with high bioactivity, does not contain cholesterol or lactose; the bioavailability of walnut protein is greatly improved; and the product has high stability and meets the consumption requirements of people on nature, health and nutrition.

The invention relates to a preparation method of nanoparticles for improving the bioavailability of curcumin, and belongs to the technical field of functional food production process. The problems oflow solubility, poor stability of processing and storage and low bioavailability of curcumin are solved, curcumin and zein are dissolved in ethanol to form an organic phase, then an aqueous solution of casein is subjected to ultrasonic treatment, casein is crosslinked by transglutaminase, chitooligosaccharide is grafted onto casein, the nano gel aqueous phase of cross-linked casein and the casein-chitosan oligosaccharide graft material is formed, finally, the organic phase is mixed with the casein-chitosan oligosaccharide nano gel aqueous phase by a high-pressure homogenization method or a solvent evaporation method, ethanol is removed by a rotary evaporation method, high speed centrifugation is carried out and freeze-drying is carried out, and finally, nanoparticles loaded with curcumin is obtained. The average particle size of the nanoparticles ranges from 140 to 390 nm, and the encapsulation rate of curcumin is about 70%-82%. The nanoparticles have good physical and chemical stability during storage.

The invention provides an oligosaccharide chelated composite trace element mineral matter supplement. The supplement is prepared through alkalizing and chelating reactions of oligosaccharides and a trace element mixture according to a molar ratio of 2.1-2.5:1; the oligosaccharide is sucrose, lactose, trehalose or raffinose; and the trace element mixture is a ferrous sulfate, copper sulfate, zinc sulfate, manganese sulfate and cobalt sulfate mixture with the molar ratio of 3-4:2-3:2-3:1:0.5-1. The oligosaccharide chelated composite trace element mineral matter supplement has the advantages of high bioavailability and small dosage as a domestic animal mineral matter supplement.

The invention discloses pure purple yam powder as well as a preparation method and an application thereof. The pure purple yam powder uses fresh pollution-free purple yam as a raw material, and is prepared by the steps of pre-processing, slicing and granulating, drying, crashing, and sterilizing and split-charging; and the fineness of the pure purple yam powder is more than 100 meshes. The preparation method of the pure purple yam powder comprises the following steps of pre-processing, slicing and granulating, dewatering and drying, crashing, and sterilizing and split-charging, and specifically comprises the following steps of: selecting non-decayed and non-mildewed fresh purple yam without macroscopic exogenous impurities; washing with running water, and shelling and sterilizing; cutting in slices or dices; crashing to the granularity of 3-5 mm and drying until the moisture content is 1-9%; crashing and meshing through a 100-mesh sieve, so as to obtain a target; sterilizing and split-charging; and carrying out sampling inspection and providing an inspection report. The pure purple yam powder provided by the invention serves as a medicine and a health-care food. The pure purple yam powder provided by the invention is pure and natural and has good quality; and effective constituents can be comprehensively kept, and can sufficiently release within a short time period, so that the biological availability is effectively improved.

The invention provides a baricitinib polymorph A. The baricitinib polymorph A is characterized in that diffraction peaks are arranged on an XRPD (X Ray Powder Diffraction) map when values of 2 theta are equal to 12.46, 13.921, 14.94, 15.359, 16.26, 16.639, 17.36, 19.08, 20.321, 21.961, 22.381, 24.118, 25.42, 27.441, 28.381, 29.321, 29.799, 32.675, 33.14, 33.563, 33.923 and 41.6, wherein an error range of the values of the 2 theta is + / - 0.2. The baricitinib polymorph A provided by the invention has good high-temperature stability, good high-humidity stability and good illumination stability, can be applied to medicine for treating or preventing diseases related to JAK (Janus Kinase) and has better biological availability; meanwhile, provided qualitative and quantitative information has important significance in further studying the therapeutic effect of such solid medicine.

The invention belongs to the field of health care foods and specifically relates to compound dendrobium candidum and American ginseng buccal tablets and a preparation method thereof. The method comprises the following steps of: performing ultrafine grinding on dendrobium candidum and American ginseng, taking ultrafine powder of the dendrobium candidum and the American ginseng as raw material, adding resistant starch, a sweetening agent and a bonding agent, preparing wet particles, drying, sizing, finally mixing with a lubricating agent, and then tabletting to get finished products. According to the compound dendrobium candidum and American ginseng buccal tablets prepared by the method disclosed by the invention, the raw material is subject to the ultrafine grinding, various biological active substances in the raw material can be retained to the greatest extent, the biological availability is high, and the dendrobium candidum and the American ginseng are compatible for use, so that the effects of resisting fatigue, nourishing Yin, producing body fluid and the like can be enhanced. The resistant starch is added in the buccal tablets so as to enhance the effects of preventing and treating intestinal diseases, reducing blood sugar and the like; and the compound dendrobium candidum and American ginseng buccal tablets are suitable for more people and more suitable for patients with diabetes for taking, have the characteristics of convenience in carrying, convenience in taking, easiness in control of dosage and the like, and are further in line with simple, convenient and fast consumer demands of modern people.

The invention relates to a technology for pre-treating residual sludge, in particular to a microwave-hydrogen peroxide synergism-based method and device for treating residual sludge. In the method, a hydrogen peroxide solution is fed according to the mass ratio of pure hydrogen peroxide to the dry weight of the sludge being 0.2-2; under the normal-pressure opening condition, the high-efficiency decomposition of the residual sludge is realized by adopting a microwave-hydrogen peroxide technology and the subsequent biological availability of the residual sludge is improved. Before reaction, the treatment effect of the residual sludge is enhanced by controlling the condition of pH value. The device disclosed by the invention mainly comprises a heat exchanger and a microwave reactor. The method disclosed by the invention has the advantages of simple process, short flow and high efficiency. In addition, the treated residual activated sludge can be recycled. The device disclosed by the invention has less investment and is suitable for various medium-small systems for treating the residual sludge.

The invention discloses a magnetic resonance-based water treatment device. The magnetic resonance-based water treatment device realizes water treatment through electromagnetic waves produced by magnetic resonance. The magnetic resonance-based water treatment device is characterized in that a power signal is subjected to transformation rectification by a transformation rectification circuit and then is input into a high-frequency inverter and a low-frequency inverter; radio frequency pulses having different frequency values are invertedly output by the high-frequency inverter and the low-frequency inverter; and the radio frequency pulses having different frequency values are transmitted to corresponding electromagnetic vibration wave transducers in a water treatment tank so that two different electromagnetic wave energy zones are formed. Through the magnetic resonance-based water treatment device, a water molecule is stimulated by resonance-supported radio frequency pulse energy waves and then splits and thus a hydrogen bond active force, an organization structure and an energy load capacity of water are changed. Water treated by the magnetic resonance-based water treatment device has the advantages that the bioavailability and the biological activity are improved; metabolism quality is improved; a free radical inhibition and removal capability is obtained; and a gene control capability is improved. The magnetic resonance-based water treatment device can produce health water, adopts a physical production technology and simple production processes, and has high production efficiency and a low cost.

The invention discloses an ambroxol hydrochloride granule, whose ingredients (by weight ratio) include ambroxol hydrochloride 10-17 parts, lactose 170-670 parts, sucrose 170-670 parts, stevioside 3-27 parts, Firmenich and fragrant citrus essence 3-138 parts, and right amount of binding agent. The invention relates to an ambroxol hydrochloride pelletized granule has the advantages of convenience in carrying, accurate quantitative determination, good taste, high biological availability, thus is especially suitable for children.

The invention relates to a method used for raising the output of marsh gas by using anaerobic fermentation of organic effluent water, which pertains to the technical field of biological treatment of effluent water. The invention adopts simulated organic effluent water or practical wastewater from chemical industry as treatment objects, by adding trace metal element Co and metal ion chelating agent to an anaerobic reactor to improve the biological availability of trace metal elements which are essential for methanogen and promote the growth and activity of methanogen, thereby, methane output and transformation efficiency of contaminating material of the system is improved. The method needs only extreme micro-amount of trace metal element Co and metal ion chelating agent, therefore, the invention is not only convenient to be manipulated with high efficiency and but also low in cost which leads the invention to be extensively applicable in engineering practice.

The invention discloses a palbociclib pharmaceutical composition, comprising palbociclib or its medicinal salt and a pharmaceutically acceptable auxiliary material, wherein the palbociclib or its medicinal salt is 50-150 Mum, and the medicinal salt includes isethionates, hydrochlorides, sulfates or benzene sulfonates.Direct mixing and capsuling process of raw and auxiliary materials is used for the pharmaceutical composition provided herein, the biological availability is high, product quality stability is good, the technical process is easy to control, inter-batch reproducibility is good, and the composition is easy to industrialize.

The invention discloses a composite calcium preparation, and belongs to the technical field of health-care food. Calcium citrate, collagen peptide, glucosamine and chondroitin sulfate are used as main materials; lactose, starch, dextrin and magnesium stearate are used as auxiliary materials; and the main materials and the auxiliary materials are prepared into tablets or capsules. The composite calcium preparation comprises the following components based on total weight: 40 to 60 percent of calcium citrate, 10 to 30 percent of collagen peptide, 10 to 25 percent of glucosamine, 5 to 15 percent of chondroitin sulfate, 2 to 8 percent of lactose, 2 to 6 percent of dextrin, 5 to 10 percent of starch and 0.2 to 2 percent of magnesium stearate. The composite calcium preparation has the advantages that: by adopting an organic calcium source, the biological utilization rate of the body on calcium can be effectively increased; and meanwhile, by using the complexing effect of the collagen peptide and calcium ions, absorption of the calcium is enhanced. Compared with the prior art, the composite calcium preparation can enhance the immunity of the body at the same time of supplementing the calcium, further promotes the absorption of the calcium, is a good calcium supplementing preparation, is safe and reliable, and has no toxic or side effect.