1276 results about "Dispersible tablet" patented technology

The present invention relates to a novel dispersible tablet composition, which comprises of a pharmacologically active ingredient and at least one excipient, which reduces the sedimentation rate of active ingredient. This invention further relates to a process for the preparation of a dispersible tablet of a pharmacologically active ingredient.

The invention discloses a swertia mileensis dispersible tablet and a preparation method thereof. The preparation method is characterized by comprising the following steps: extracting swertia mileensis by adopting a carbon dioxide supercritical extraction method; drying at reduced pressure; crushing the swertia mileensis into nano-paste by using a high-energy nano-impact mill; adding a functional auxiliary material to prepare the swertia mileensis dispersible tablet. By adopting the preparation method, the contents of effective components are remarkably improved, the disintegration time is remarkably shortened, the curative effect is remarkably superior to the swertia mileensis tablet, and a positive effect is obtained.

The present invention relates to taste-masked oral formulations of influenza antivirals. The taste-masked pharmaceutical formulations for oral administration comprise one or more influenza antivirals, at least one taste-masking agent and at least one pharmaceutically acceptable excipient. Further, the taste-masked influenza antiviral formulations of the present invention are provided in the form of dispersible tablets, effervescent tablets, orally disintegrating tablets, chewable tablets, bite-dispersion tablets or the like, wherein the bitter taste of influenza antivirals is masked thereby providing palatable formulations.

The invention relates to a synbiotics of bacillus licheniformis and oligosaccharide class prebiotics and a composite and a formulation thereof, being characterized in that the synbiotics comprises bacillus licheniformis medical live bacterial powder and the oligosaccharide class prebiotics, wherein the bacillus licheniformis medical live bacterial powder contains live bacteria about 30 billion/gram; the weight ratio of the bacillus licheniformis medical live bacterial powder to the oligosaccharide class prebiotics is 1:1 to 76; the weight ratio of the medical live bacterial powder of the composite, the oligosaccharide class prebiotics and auxiliary materials is as follows: 1.25-5 percent of the bacillus licheniformis medical live bacterial powder, 5-95 percent of the oligosaccharide class prebiotics, 20-50 percent of preferable oligosaccharide class prebiotics, 30-65 percent of diluting agents, 1-20 percent of bonding agents, 1-15 percent of disintegrating agents, 0.1-3 percent of lubricating agents, 1-10 percent of coating agents, 0.01-0.1 percent of flavoring agents, 0.0001-0.001 percent of coloring agents, and 0.1-15 percent of suspending agents. The synbiotics composite is prepared into oral common tablets, oral cavity disintegration tablets, dispersing tablets, enteric-coated tablets, granular formulation, enteric-coated granular formulation, capsules, enteric-coated capsules, dry supensoid agents and external tablets according to a conventional process; and an in vitro test shows that each formulation can promote the growth and the reproduction of the synbiotics of bacillus licheniformis, restrain the growth of harmful bacteria, enhance the immunizing power of parasitifers, reduce diarrhea and enhance the health care.

The invention discloses a gefitinib dispersible tablet, a preparation method and an application thereof. The gefitinib dispersible tablet of the invention comprises the following components by weight: 10-65% of gefitinib, 1-30% of fillers, 10-50% of disintegrants, 1-60% of acidifiers, 0.1-20% of adhesives, and 0.1-30% of lubricants and glidants. According to the invention, gefitinib is wrapped bythe acidifier or gefitinib and the acidifier are wrapped with each other so as to reach the embedding effect. Compared with commercially available common tablets, the gefitinib dispersible tablet of the invention does not contain surfactants, has good dissolvability, dispersibility and disintegrability, and can be disintegrated completely within one minute. The gefitinib dispersible tablet prepared by the method of the invention has a high dissolution rate, good bioavailability, rapid distribution in vivo, and stable quality, and the preparation method is simple and practical, and is applicable to industrial production.

The invention relates to a novel dispersible tablet which is prepared from a certain amount of antipsychotic medicines or pharmaceutically acceptable salt or ester thereof or mixture thereof, a certain amount of selective serotonin reuptake inhibitors (SSRIs) and at least one of pharmaceutically acceptable carriers, wherein the antipsychotic medicines are aripiprazole, fluvoxamine, escitalopram, olanzapine, mirtazapine, clozapine, ziprasidone, mianserin, agomelatine, lurasidone, iloperidone, blonanserin, moclobemide, timiperone, palipeddone, trimipramine, carpipramine, lofepramine or mosapramine. The novel dispersible tablet is used for preventing, delaying or treating depression or schizophrenia of patients. Compared with common tablets or capsules, the novel dispersible tablet has the characteristics of quick and uniform dispersion, short disintegration time, quick medicine absorption, high bioavailability and good stability, and is convenient to take.

The present invention provides an injection preparation containing ibuprofen and its preparation method. Said invention provides the concrete steps of its preparation method. Said ibuprofen injection preparation has high solubility and bioavailability, and its product quality is stable.

The invention belongs to the technical field of pharmaceutical preparation, and in particular relates to a cefixime dispersible tablet and a method for preparing the same. The method comprises the following steps: firstly, weighing cefixime, starch, microcrystalline cellulose, partially cross-linked polyvinylpyrrolidone, partially cross-linked sodium carboxymethyl cellulose, and partially low substituted-hydroxypropyl cellulose, and mixing the components evenly; secondly, dripping 5 percent polyvinylpyrrolidone K30 ethanol solution into the mixture prepare a soft material, and performing granulating through a sieve of between 18 and 24 meshes; thirdly, drying wet particles at a temperature of between 50 and 80 DEG C, palletizing the particles through the sieve of between 18 and 24 meshes, adding the remaining cross-linked polyvinylpyrrolidone, the remaining cross-linked sodium carboxymethyl cellulose, and the remaining low substituted-hydroxypropyl cellulose, magnesium stearate and superfine silica gel powder into the mixture to be mixed evenly, and tabletting the mixture to obtain the required cefixime dispersible tablet. The cefixime dispersible tablet has the characteristics of rapid disintegration with water, even dispersion, high dissolution, and convenient taking and carrying around.

The invention discloses a dispersible tablet of colloid pectin, which comprises (by weight ratio, in mg) colloid pectine bismuth 25-100 (by bismuth), filling agent 60-400, crumbling agent 42-280, flow aid 1-6, lubricant 0.25-5, the filling agent can be selected from lactose, white dextrine, pregelatine starch or/and starch. The crumbling agent can be selected from cross bonding polyvinylpyrrolidone, crystalline cellulose, cross-linked sodium carboxymethylstarch, low substituted methylcellulose propylene glycol ether, sodium carboxymethylstarch, the glidant can be selected from miropowdered silica gel, the lubricant can be selected from magnesium stearate or/and talcum powder.

The invention discloses to dispersible tablets containing valsartan and amlodipine besylate and a preparation method thereof, and relates to medicament dispersible tablets and the preparation method thereof, solving the problem of poor stability, slow disintegration and dissolution, low oral bioavailability and high cost existing in the traditional medicine containing valsartan and amlodipine besylate. The dispersible tablets are prepared from valsartan, amlodipine besylate, disintegrant, diluent, adhesive, lubricant, fluidizer, surfactant and flavoring agent. The method comprises the following steps of: weighting and screening materials; mixing the valsartan, disintegrant and diluent to obtain mixed powder A; mixing amlodipine besylate and the mixed powder A to obtain mixed powder B; mixing the adhesive, surfactant and the mixed powder B to prepare soft material; screening, granulating and drying the soft material; mixing and screening and the dried granules with the fluidizer, lubricant, disintegrant and flavoring agent; and finally carrying out size stabilization and tabletting. The medicine prepared by the method has good stability, fast disintegration and dissolution, high oral bioavailability and low cost.

The invention relates to a rapidly-dispersible tablet and a preparation method thereof, in particular to a rapidly-dispersible tablet composition containing no disintegrating agent and a preparation process thereof, which belong to the field of drugs and healthcare products. The invention discloses a rapidly-dispersible tablet. The rapidly-dispersible tablet is prepared from 0.5 to 900 parts by weight of active components, 200 to 900 parts by weight of excipient and 5 to 30 parts by weight of lubricating agents, wherein the active component is a water-insoluble active component. The rapidly-dispersible tablet has the advantages that the rapidly-dispersible tablet composition containing insoluble active component is prepared into the tablet rather than a liquid dosage form, so that a complex process for preparing the insoluble active component into the liquid preparation is not needed, the layering phenomenon of the product liquid during a long-term storage period can also be avoided, and the rapidly-dispersible tablet has accurate dose and stable quality, is convenient to store and carry, can be swallowed and can also be administered after being dissolved.

The invention discloses a pesticide water effervescent dispersible tablet and a preparation method thereof. According to the pesticide water effervescent dispersible tablet and the preparation method thereof, ammonium hydrogen carbonate is used as a gas source, and an acid source or alkali source is selected according to the physical property of different raw materials, i.e. the acid source and the ammonium hydrogen carbonate are added into the acid-resistant raw materials, and tablets are put into water to produce carbon oxide during use; and the alkali source and the ammonium hydrogen carbonate are added into the alkali-resistant raw materials, and tablets are put into water to produce ammonia gas. The pesticide water effervescent dispersible tablet can rapidly boil and disintegrate in water and therefore avoid the reduction of application effect caused by degradation of effective components of the pesticide effervescent dispersible tablet, so that the pesticide water effervescent dispersible tablet with stable chemical properties is obtained.

The invention relates to a preparation having the functions of promoting blood circulation, enlivening spleen and tonifying kidney, the process for preparation and quality control method, wherein the preparation is produced mainly from astragalus root, Chinese ephedra, Chinese angelica root, herba ecliptae, atractylodes rhizome, safflower, radix paeoniae rubrathe, peach kernels, achyranthes and cyathula root, Ligusticum wallichii, bitter orange and root of balloonflower. The preparation can be made into injections and various oral administration preparations including dripping pills, mini-pills and dispersible tablets. The invention also provides the method for determining and identifying contents of the preparation.

The invention discloses Yueju Baohe dispersible tablets and a preparing method thereof. The Yueju Baohe dispersible tablets are prepared from, by weight, 10-50% of traditional Chinese medicine extract, 10-80% of filler, 5-50% of internally added disintegrant, 5-15% of externally added disintegrant, 0.1-10% of corrigent, 0.1-20% of wetting agent and 0.05-20% of lubricant. The traditional Chinese medicine extract comprises, by weight, 60-120 parts of ginger-processed fructus gardeniae, 60-120 parts of medicated leaven stir-fried with bran, 60-120 parts of vinegar-processed rhizoma cyperi, 60-120 parts of rhizoma chuanxiong, 60-120 parts of rhizoma atractylodis, 60-120 parts of radix aucklandiae and 60-120 parts of semen arecae. The preparing method comprises the steps of material preparation, extraction, tablet preparation and packaging. The Yueju Baohe dispersible tablets can soothe liver and dispel melancholy, whet the appetite and promote digestion, and are used for treating symptoms like dyspepsia, qi depression and stasis, poor appetite and thoracico-abdominal swelling pain.

The invention discloses a cefetamet pivoxil hydrochloride tablet and a preparation method thereof. On the premise of specific active ingredients of the cefetamet pivoxil hydrochloride, the invention takes into account the varieties and dosages of disintegrating agents and joint usage thereof, suitable components and ratios of bonding agents and other filling agents, and the micronization treatment of the raw and auxiliary materials and selection of corresponding optimized process conditions. Experiment results indicate that compared with the prior art, the product of the invention has quick disintegration and dissolution and stable quality.

The present invention relates to a new preparation of a Chinese medicine. The present invention particularly relates to a novel preparation of a drug with the effervescent tablet property and the dispersing agent property. In the effervescent dispersing tablet of the present invention, the weight ratio of each components are as following, which comprises 5 percentage to 60 percentage of effervescent agent, 3 percentage to 30 percentage of effervescing agent, 3 percentage to 30 percentage of disintegrant, 3 percentage to 30 percentage of excipient of the hydrophilic medicine, 1 percentage to 5 percentage of correctant. The effervescent dispersing tablet of the present invention is a novel preparation of the Chinese medicine, which has the effervescent tablet property and the dispersing agent property. The present medicine is a tablet, which can produce the gas in the water, which can disaggregate quickly and disperse evenly. The present invention is a novel preparation of the medicine, which can generate the gas; as a result the medicine can disaggregate more quickly. The drug loading dosage of the agent is large, which is beneficial for improving the dispersion uniformity, the dissolution and the bioavailability of the medicine. The present invention has the characteristics of convenience for oral administration and small dose. The present invention can sufficiently display the drug efficacy in order to meet the drug requirement of the patients.

The invention provides a pachyman preparation, wherein the dosage forms include oral liquid, capsule, pill, tablet, pelletized granule, dispersible tablet, effervescent tablet, and injection, the main composition is pachyman (C6H1206)n no less than 90% calculated by glucose. The preparing process for the pachyman is also disclosed.