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Salt of leonurine and its preparation

A technology of leonurine and preparation, which is applied in the field of alkaloids and preparations thereof, can solve the problem of not seeing leonurine to be made into soluble salt, etc., and achieve the effects of ensuring stability and less vascular irritation.

Inactive Publication Date: 2003-05-07
李晓祥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Leonurine extracted from plant species and artificially synthesized is insoluble in water, and it can be prepared into soluble salts, which can be conveniently made into clinically available preparations. At present, there is no report of making soluble salts of motherurine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0023] The above experimental results show that leonurine acetate is easily decomposed into leonurine and acetate in water, and the stability of leonurine and acetic acid will not be affected after the salt formation. (two), preparation embodiment 1. tablet

[0024] The specifications are (calculated based on the content of motherurine): 1.25, 2.5, 5, 10, 20, 50, 100, 200mg / tablet. The preparation process of motherurine sulfate is described below with the specification of 10mg / tablet as an example. Ratio of raw and auxiliary materials: Take 10mg / tablet as an example

[0025] Leonurine Sulfate (calculated as Leonurine) 10g

[0026] Compressible starch 50g

[0027] Sodium carboxymethyl starch 40g

[0028] Magnesium Stearate 5g

[0029] 70% ethanol solution appropriate amount

[0030] Made into 1000 pieces

[0031] Weigh motherurine sulfate, compressible starch, sodium carboxymethyl starch according to the pres...

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PUM

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Abstract

A leonurin salt is soluble salt which is prepared by reaction of leonurin on the acidic salt of inorganic, organic, or polybasic acid. It can be used to prepare tablet, capsule, softgel, particle, oral liquid, injection, syrup, etc.

Description

1. Technical field [0001] The present invention relates to a kind of alkaloid and preparation thereof, specifically a kind of inorganic salt of motherwortine and organic salt and preparation thereof. 2. Background technology [0002] Motherwort is the dry aerial part of Leonurns heterophyllus Sweet, a plant of the Lamiaceae family. It is a traditional Chinese medicine species recorded in the Chinese Pharmacopoeia. It is a commonly used traditional Chinese medicine in clinical gynecology. Its active ingredients are alkaloids, and the main alkaloids are beneficial motherwort (C 14 h 21 o 5 N 3 ) and stachydrine. Studies have shown that motherwort has an excitatory effect on the uterus and is the main component of motherwort to exert its curative effect. Leonurine extracted from plant species and artificially synthesized is insoluble in water, and it can be prepared into soluble salts, which can be conveniently made into clinically available preparations. So far, there is n...

Claims

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Application Information

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IPC IPC(8): A61K31/155A61P15/00C07C279/10
Inventor 李晓祥李德刚
Owner 李晓祥
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