1046 results about "Softgel" patented technology

The present invention relates to a soft capsule which is easily disintegrated in the stomach, wherein the contents thereof are not easily leaked at the time of mastication, which is obtained by providing a soft capsule comprising (2R)-2-propyloctanoic acid or a salt thereof with at least one property, preferably all properties, selected from (A) wherein it has a strength of 150 to 400 N by a cracking test; (B) wherein it has a disintegration time of 3 to 10 minutes by the disintegration test stipulated in Japanese Pharmacopoeia; (C) wherein the capsule shell has a shell thickness of 0.05 to 0.50 mm; (D) wherein the capsule shell has a first seam thickness of 0.10 to 0.55 mm; (E) wherein the capsule shell has a second seam thickness of 0.05 to 0.50 mm; (F) wherein the capsule shell has a water content of 5.0 to 9.0%.

This invention provides a nutritional supplement containing docosahexaenoic acid (DHA), antioxidants and anthocyanosides. The supplement is useful for improving night vision acuity, field of vision and adaptation to light.

A soft capsule containing a solution or suspension of a PDE5 inhibitor, and use of the capsule in treating sexual dysfunction.

A curcumin medicine for preventing and treating cancer and cardiovascular and cerebrovascular disease includes a pre-concentrated curcumin liquid in the form of softgel and prepared from the precursor of curcumin and emulsifier and a fatty curcumin emulsion prepared from the precursor of curcumin, emulsifier, antioxidant, isotonic regulator, stabilizer, pH regulator, and the water for injection. It can also provide energy to the patient.

A non-gelatin encapsulation system for liquid filled soft capsules, by nature of the carrier, the cationic-ionic balance of the carrier and the active ingredients, or the concentration of the active ingredients and excipients, are difficult or impossible to commercially encapsulate in gelatin capsules. In particular, the system is adapted for the encapsulation of highly basic, or alkaline, fills. The system provides for a predominantly starch and gelling carrageenan based shell, which displays high resistance to both concentrated fills and to alkaline fills, in particular, to those fills which contain the salt or salts of weak acids and strong bases.

The invention discloses a lutein ester health care product for protecting eyesight. The lutein ester health care product is prepared by taking lutein ester as a main material, and adding any one or more materials including taurine, selenium, zinc, alpha-lipoic acid, docosahexaenoic acid (DHA), vitamin A, vitamin E, vitamin B1, vitamin B2 and bilberry extract, and pharmaceutically acceptable formulation accessories. The outstanding innovation of the invention is the implementation of the method for preparing a functional eye health care product with the lutein ester instead of lutein, so that the bioavailability, the stability and the health care effect of the product are improved, and production cost can be greatly reduced. The health care product can be prepared into common dosage forms, such as tablets, capsula, granules and soft capsules. The lutein ester health care product is mainly used for the treatment on diseases, such as myopia, amblyopia, hyperopia, presbyopia, cataract, vitreous opacity, retinal pigment degeneration, macular degeneration, asthenopia, and retinopathy caused by diabetes, and the like. The lutein ester health care product adopts a unique formulation of multiple constituents, measures and mechanisms, and has significant treatment effects and excellent social and economic benefits.

The invention relates to the technical field of vegetable-oil soft capsules, in particular to a peony-seed-oil soft capsule and a preparation method thereof. The peony-seed-oil soft capsule is prepared by mixing and gelling of raw materials, capsule pressing and forming, hardening, sizing, scrubbing and drying. The peony-seed-oil soft capsule comprises the following raw materials in parts by weight: 80-95 parts of peony seed oil, 1-3 parts of fucosterol, 1-3 parts of squalene, 1-3 parts of propyl gallate, 0.05-0.25 part of tocopherol, 0.05-0.25 part of soya bean lecithin, 0.15-0.25 part of vitamin C, 5-10 parts of gelatin, 5-10 parts of water, 1.3-2.5 parts of sorbierite, and 2.5-5 parts of glycerol. The peony-seed-oil soft capsule is nutritious and safe, has the obvious effects of reducing blood fat, blood pressure and cholesterol, and can enhance the self immunity, prevent the diabetes, prevent and treat cancers, reduce weight, prevent cerebral stroke and myocardial infarction, clear harmful substances in blood, prevent and treat heart diseases and relieve the climacteric syndrome.

A formulation of Coenzyme Q10, beta-carotenes, Vitamin E, and medium chain triglycerides in rice bran oil and an optional thickener, such as bee's wax, is provided in a soft gel capsule so that a maximum of the Coenzyme Q10 is absorbed by the human body. Generally, about 60 mg of Coenzyme Q10 is the normal amount provided daily to a healthy sedentary adult.

The invention relates to a peony essential oil soft capsule which is prepared by using peony seed oil, peony essential oil and vitamin E as raw materials according to a proportion of 1:0.0005-0.005:0.001-0.01 through the steps of essential oil extraction, seed oil extraction, content preparation, soft capsule preparation, and the like. The invention not only provides an extraction method of paeonia rockii essential oil, but also develops a product being suitable to be developed by using the peony essential oil, thereby solving the problems of inconvenient taking of fresh flower essential oil and difficult quantification and filling the blank of the development of a paeonia rockii essential oil product. The peony essential oil soft capsule product has abundant nutrition, and the peony essential oil contains abundant natural scent substances such as citronellol, geraniol, linalool, and the like and also contains abundant terpenes and hydrocarbons which can relax human bodies, calm down emotions and diminish inflammation and has good effect on adjusting female incretion. Meanwhile, the peony seed oil and the vitamin E in the raw materials have the effects of enhancing intelligence, enhancing immunity, reducing blood fat, preventing inflammation, delaying senescence, and the like.

The wild camellia seed oil soft capsule includes capsule content liquid and capsule shell, and the capsule content liquid consists of wild camellia seed oil and supplementary material not more than 25 wt%. The wild camellia seed oil soft capsule as one new preparation form of wild camellia seed oil has correct dosage, high bioavailability, high curative effect, long preservation period, short production period and low production cost.

The invention discloses a method for manufacturing salvianolic acid A of danshen root, which is characterized in that total salvianolic acid in the danshen root is transformed into salvianolic acid A by adopting a certain method. The method increases greatly the extraction yield of salvianolic acid A. The salvianolic acid A is prepared into tablets, capsule, granula, soft capsule, micro pill, dripping pill and oral liquid, which have good pharmacological action indicated by pharmacological experiments.

Pharmaceutical compositions in unit dose form comprising a hard or soft capsule containing a fill consisting of one or more inert ingredients, and one or more coatings on the capsule, wherein at least one coating comprises at least one active pharmaceutical ingredient.

A Chinese medicine in the form of fluid extract for losing weight and decreasing fat is prepared from 12 Chinese-medicinal materials including rhubarb, cassia seed, haw, lotus leaf, etc and additives. Its product can be made into tooth-paste, massage cream, and capsule or softgel. Its preparing process is also disclosed.

The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate release solid dosage forms, extended release solid dosage forms and zero order release solid dosage forms, said apparatus comprising: (a) two spreader boxes; (b) two casting drums; (c) a pair of rotary dies having means for suction; (d) a liquid fill system; (e) a wedge for heating gelatine ribbons and feeding said fill; and (f) two lateral dispensing devices said lateral dispensing devices including hoppers having said solid dosage forms, channelguides for transporting said solid dosage forms and a grasping claw for dispensing said solid dosage form into the softgel pocket formed in the rotary dies.

The invention relates to a Niuhuangshangqing soft capsule and a preparation method thereof, as well as a quality control method of capsule contents. The Niuhuangshangqing soft capsule comprises contents and capsule shell. The contents include an extent of Chinese medicinal materials in Niuhuangshangqing prescription and a dispersion medium with a weight ratio of 1:(1-2), wherein, the dispersion medium is vegetable oil. The soft capsule is prepared by extracting effective components from Chinese medicinal materials in Niuhuangshangqing prescription in accordance with the properties of the effective components by using different modern extraction techniques and making into soft capsule. The soft capsule has embedding and masking effects, and can prevent volatilization loss of oil components and oxygenation or photodecomposition of effective components. The soft capsule also has the advantages of rapid disintegration, uniform dispersion, high bioavailability, good stability of effective components, low liability of moisture absorption, good air tightness, direct intestinal absorption after disintegration, masking of unpleasant odors of effective components, convenience for administration and carrying, and so on.

The present invention provides a pharmaceutical formulation suitable for filling softgel capsules comprising: (a) from about 1% to about 90% by weight of a bisphosphonic acid or a pharmaceutically acceptable salt; and (b) from about 40% to about 80% by weight of a liquid carrier comprising 50% to 80% by weight polyethylene glycol; 5% to 15% by weight of glycerin; and 5% to 20% by weight water. The invention also describes a method for preparing alendronate or its pharmaceutical acceptable salts in encapsulated therapeutic dosage form, comprising the steps of reducing the size of alendronate particles to an average size no larger than about 80 microns, then mixing the micronized particles of alendronate with a solvent essentially consisting predominantly of polyethylene glycol of a molecular weight no greater than about 1000, and heating the mixture at a temperature of from about 40° C. to about 50° C. until the alendronate is dissolved in the solvent, and then encapsulating therapeutic doses of the dissolved alendronate in gelatin capsules soluble in water but insoluble in said solvent.

The invention relates to the field of chemical preparation and dosage form modification, in particular to a silybin-phospholipid complex and a preparation process thereof and a silybin-phospholipid complex soft capsule prepared from the complex. According to the silybin-phospholipid complex and the preparation process, a phospholipid complex is prepared from silybin, so that the water solubility of the silybin is greatly improved, the lipid solubility and water solubility of the obtained complex are balanced, and the bioavailability is greatly improved; moreover, the silybin-phospholipid complex soft capsules prepared from the complex also have high bioavailability, and are convenient to take; the utilization of the silybin is greatly promoted.

The invention relates to a kind of DHA microcapsule food additive and DHA microcapsule functional food, both of which are made up of core material and capsule wall material. What's unique about the products is that the core material contains the docosahexaenoic acid and / or the compound which docosahexaenoic acid is its component fatty acid. Besides, the ratio of docosahexaenoic acid and icosapentaenoic acid is 7 or higher. The products are low in EPA, pollutants, and offensive smell of fish. So they are quite safe to serve as the additive or functional food for infants and children.

The invention discloses a method for preparing starch-based softgel capsules, which, specifically, includes the following 2 steps: 1, Extrude the starch-based premixed material into starch-based extrusion film, 2, Apply the gel solution coating to the extrusion film to form composite starch film, 3) Process two composite starch films into starch-based softgel capsules by rotary die process.

The invention relates to the technical field of biological engineering and the fields of food and medicaments, particularly provides a method for extracting refined yeast grease from yeast, particularly waste saccharomyces cerevisiae and oil production yeast, and further provides soft capsules prepared by compounding the yeast grease, vegetable grease rich in necessary fatty acid for a human bodyand anti-oxidation grease and a preparation method thereof. The obtained yeast grease composite soft capsules have the effects of reducing serum cholesterol and reducing blood fat; the method for producing the yeast grease by using the waste yeast has powerful results of improving the additional value of the waste yeast and generating higher economic benefit; and meanwhile, by comprehensive utilization of the waste yeast, the problem that wastes pollutes environment is solved, and the requirement of circular economy development is met.

The invention relates to a soft capsule with good chewability, quick dissolution and good taste, and a preparation thereof. A gelatin material is composed of 30%-60% of gelatin, 20%-45% of a kneading agent, 1-5% of a humidizer, 0.5%-8% of a food additive and 8%-14% of water which are matched with an inclusion with bioactive oil phase liquid or a bioactive emulsion, and the mixture is pressed to obtain the chewable soft capsule which belongs to the health food field. The soft capsule has the advantages of reasonable proportioning, convenient carrying and administration, high bioavailability, no side effect, easily controllable preparation process and stable product quality, and the soft capsule is a healthcare nutriment with food safety and wide application.

The invention discloses an extrusion method for preparing starch-based softgel capsules, which, specifically, includes the following 2 steps: 1, co-extruding the starch premix and gel solution to form composite starch film. 2, processing two composite starch films into starch-based softgel capsules by rotary die process.

The invention relates to a capsule shell and a preparation method thereof, in particular to a konjak polysaccharide compound soft capsule shell and a preparation method thereof. The capsule shell comprises the following components in parts by weight: 0.5-8 parts of konjak polysaccharide, 2-10 parts of wheat starch, 3-15 parts of k-carrageenan, 0.2-4 parts of xanthan gum, 7-45 parts of swelling agent, 6-30 parts of plasticizer and 0.5-3 parts of other additives, wherein the other additives refer to a coloring agent, a preservative, a seasoning agent, a flavoring agent, an opacifying agent, an opalizer and the like. The capsule shell has the advantages of low cost, high moisture retention, long storage time, contribution to digestive absorption of medicaments, reduction in the stimulation of medicaments on the stomach, wide medicament selecting range, stable performance, good appearance, high airtightness and high toughness.

Abstract of the Disclosure The present invention is directed to a homogeneous, thermoreversible gel comprising carrageenan wherein the carrageenan has a viscosity of less than 10 cP at 75 °C when measured in a 0.10 molar aqueous sodium chloride solution containing 1.5% by weight of the carrageenan based on the weight of all components in the solution, and optionally at least one of a plasticizer, a second film former, a bulking agent, and a pH controlling agent, wherein the gel has a solids content of at least 40%. The present invention is also directed to processes for the preparation thereof, as well as to variety of products containing the gel including edible products, soft capsules, hard capsules and solid forms encapsulating powders, tablets, caplets, etc.

The invention relates to a medicinal composition containing ibuprofen sodium salt, which is prepared by taking ibuprofen sodium salt and other one or a plurality of medicinal components as active ingredients, and combing the active ingredients with pharmaceutically appropriate auxiliary materials. The medicinal composition can be made into oral preparations, including conventional tablets, dispersible tablets, sustained release tablets, capsules, sustained release capsules, soft capsules, particles, dry suspension, suspension and the like, and used for symptomatic treatment of being antipyretic, antiphlogistic, analgesic and anti-allergic, and improving sleeping.

The invention discloses a soft capsule of lycopene, comprising a filler and a capsule material. The even and stable filler is formed by using lycopene, vitamins, edible vegetable oil and beeswax as raw materials and comprising the steps of heating the edible oil, adding and evenly stirring the beeswax, the lycopene and the vitamins and homogenating the mixture, wherein the capsule material is prepared from gelatin, glycerin and water. The lycopene in the filler of the invention is lycopene crystal or lycopene oleoresin which is extracted and finely prepared by removing odor and residual solvent and has the advantages of high contents, no pollution or odor, high biological activity, and the like. The capsule material of the invention contains no pigment or preservative and has good safety.Proved by tests, the soft capsule of the invention has good stability, hardly loses the protected effective contents, is not demixed after preserved for a long time and is convenient to take.

The present invention relates to a tea-polyphenol soft capsule including capsule core and capsule shell, its capsule core contains (wt%) 5-60% of tea-polyphenol, 0-20% of soya bean lecithin, 0-2% of vitamin E, 0-15% of stabilizing agent and the rest is diluting agent. Its capsule shell composition contains (wt%) 35-45% of gelatin, 0-3% of polyglycol 400, 18-22% of plasticizer, 0.08-0.11% of preservative, 0-1% of covering agent, 0-0.35% of coloring matter, 0-0.1% of corrective and the rest is water. Its preparation process includes preparation of capsule core, preparation of capsule shell and pressing capsule. The capsule has the several actions of reducing blood fat, resisting cancer, resisting free radical oxidation, resisting atheroscleorsis, promoting absorption of VitC and preventing and curing scorbutus.

The invention provides a preparation method of Mythic Fungus spore oil. The preparation method comprises the following steps: carrying out wall breaking on Mythic Fungus spores and sporophores as a raw material, screening, granulating, carrying out supercritical extraction, and collecting to obtain the Mythic Fungus spore oil; and mixing the Mythic Fungus spore oil with ingredients, and carrying out a series of technologies to prepare a Mythic Fungus spore oil softgel. The Mythic Fungus spore oil extraction method provided by the invention has the advantages of wide range of suitable raw materials, simple technology, convenient operation and easy implementation; and the Mythic Fungus spore oil softgel prepared by using the Mythic Fungus spore oil extracted through the method is convenient to carry and administrate, and can promote absorption.

The invention discloses a dutasteride soft capsule preparation, comprising a soft capsule and contents. A prescription for the contents comprises 0.5 g of a dutasteride raw material, 200 to 250 g of labrasol, 30 to 60 g of polyglycerol oleate, 50 to 100 g of medium-chain triglyceride and 0.02 to 0.05 g of 2,6-di-t-butyl p-cresol. The dutasteride soft capsule prepared in the invention is substantially improved in accumulated dissolution in 5 minutes of dissolving-out and enhanced in the dissolving-out efficiency of a main drug in a preceding time period and has good stability and good appearance quality.