1168 results about "Pharmacopoeia" patented technology

The invention combines two different subunits with different release profiles in novel sustained-release oral dosage forms. In particular, the oral dosage forms include a subunit that comprises an opioid analgesic and a sustained-release material, wherein the dissolution rate in-vitro of the subunit, when measured by the standard USP Drug Release test of U.S. Pharmacopeia XXVI (2003) <724>, is less than about 10% within about 6 hours and at least about 60% within about 24 hours; less than about 10% within about 8 hours and at least about 60% within about 24 hours; less than about 10% within about 10 hours and at least about 60% within about 24 hours; or less than about 10% within about 12 hours and at least about 60% within about 24 hours; the dosage form providing a duration of therapeutic effect of about 24 hours.

The present invention relates to a soft capsule which is easily disintegrated in the stomach, wherein the contents thereof are not easily leaked at the time of mastication, which is obtained by providing a soft capsule comprising (2R)-2-propyloctanoic acid or a salt thereof with at least one property, preferably all properties, selected from (A) wherein it has a strength of 150 to 400 N by a cracking test; (B) wherein it has a disintegration time of 3 to 10 minutes by the disintegration test stipulated in Japanese Pharmacopoeia; (C) wherein the capsule shell has a shell thickness of 0.05 to 0.50 mm; (D) wherein the capsule shell has a first seam thickness of 0.10 to 0.55 mm; (E) wherein the capsule shell has a second seam thickness of 0.05 to 0.50 mm; (F) wherein the capsule shell has a water content of 5.0 to 9.0%.

A pharmaceutical composition for oral administration comprising PTH, wherein the in vitro release of PTH-when tested in a dissolution test of pharmacopoeia standard-is delayed with at least 2 hours and once the release starts, at least 90% w / w such as, e.g., at least 95% or at least 99% of all PTH contained in the composition is released within at the most 2 hours. The composition may also comprises a calcium containing compound and / or a vitamin, D. In particular, PTH is administered in combination with a calcium-containing compound for the treatment or prevention of bone-related diseases, so that I) an effective amount of a calcium-containing compound is administered to lower the plasma level of endogenous PTH, and II) an effective amount of PTH is administered to obtain a peak concentration of Pm once the endogeneous PTH level is lowered. This present a potential therapeutic or prophylactic regimen for bone-related disorders including osteoporosis.

The invention combines two different subunits with different release profiles in novel sustained-release oral dosage forms. In particular, the oral dosage forms include a subunit that comprises an opioid analgesic and a sustained-release material, wherein the dissolution rate in-vitro of the subunit, when measured by the standard USP Drug Release test of U.S. Pharmacopeia XXVI (2003) <724>, is less than about 10% within about 6 hours and at least about 60% within about 24 hours; less than about 10% within about 8 hours and at least about 60% within about 24 hours; or less than about 10% within about 12 hours and at least about 60% within about 24 hours; the dosage form providing a duration of therapeutic effect of about 24 hours.

The invention discloses a novel traditional Chinese medicine composition for treating cough and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the following raw medicines: stemona root, almond, hogfennel root, common coltsfoot flower, dried snakegourd fruit, perilla, fineleaf schizonepeta herb, divaricate saposhnikovia root, baical skullcap root, platycodon root, inula flower, fritillary, concretio silicea bambusae, pumice, bamboo juice, aster, lepidium seed, Radix cynanchi, ginkgo seed, white mulberry root-bark, loquat leaf, honeysuckle flower, forsythia fruit, white peony root and the like. The traditional Chinese medicine composition can be prepared into any one normally used oral preparation according to the conventional method of traditional Chinese medicine preparations. The invention can obviously improve the symptoms of cough, expectoration, shortness of breath, asthma, recurrent cough, chronic cough and the like, and has obvious clinical curative effect, significant curative effect and rapid effect. Since the traditional Chinese medicine composition adopts medicinal and edible medicines stipulated in the Chinese Pharmacopoeia to compound, the composition has the advantages of low cost, basically no toxicity and side effects and the like.

The invention relates to the field of a pharmaceutical preparation, and in particular discloses an olaparib solid dispersion preparation and a preparation method thereof. The olaparib solid dispersion preparation consists of olaparib, povidone, a special lubricating agent, a special disintegrating agent and a thinner. According to the olaparib solid dispersion preparation disclosed by the invention, povidone, replacing the existing copovidone, is used as a matrix polymer, and appropriate auxiliary materials are added, so that the povidone, as the matrix polymer of the olaparib solid dispersion preparation, is wide in source, low in cost and clear in quality standard in accordance with Chinese Pharmacopoeia; meanwhile, the dissolution effect, bioavailability and stability of the preparation are guaranteed; and the industrial production of the olaparib solid dispersion preparation is facilitated.

A new method is described to produce large volumes of low cost sterile, Water-for-Injection (WFI) grade water on-line, on-demand from potable water in order to meet the needs of dialysis therapies and other biological applications for sterile, injectable grade water. The source water is processed by a combination of membrane and column chromatographic methods including reverse osmosis, chemical sterilization, reduction of iodine sterilant to iodide, deionization, endotoxin-specific adsorption and polishing filtration in order to reduce contaminant levels below those specified by the US Pharmacopoeia.

The invention discloses a method for separating chondroitin polysulfate from heparin sodium by an extraction method, breaking through the conclusion drawn by domestic and international experts, i.e., the chondroitin polysulfate in the heparin sodium is inseparable. The technical scheme is as follows: an acetone extraction method is adopted to remove the chondroitin polysulfate in the heparin sodium and thoroughly separate the chondroitin polysulfate from the heparin sodium by the refinement steps of crude product dissolution, enzymolysis, rapid heating, impurity centrifugation, a plurality of precipitation and oxidation so that the refined product rate of the heparin sodium reaches over 83 percent, the activity valence is over 180 usp / mg and over 200 iu / mg by being converted into the WHO international standard, and the quality standard accords with various indexes specified by Chinese pharmacopoeias, America pharmacopoeias, English pharmacopoeias and Western European pharmacopoeias.

The invention discloses a Chinese medicine composition for treating gastric ulcer and a preparation method thereof. The Chinese medicine composition is mainly formed by the following raw medicine materials: Poria cocos, coix seed, prepared frankincense, prepared myrrh, dalbergia wood, storax, rheum officinale, coptis, sangusis draconis, Rhizoma atractylodis, Mangnolia officinalis, fructus amomi, netmeg, Rhizoma atractylodis Macrocephalae, Chinese yam, Herba lycopi, charred catnip, charred Chinese arborvitae twig, dandelion, Mongolian snakegourd root, lightyellow sophora root, honeysuckle, lightyellow sophora root, white paeony root, Taraxacum officinale root, rhizoma cyperi and the like. The Chinese medicine composition of the invention can be prepared into any kind of common oral preparation according to the conventional Chinese medicine preparation method. The invention has the advantages that symptoms such as epigastralgia, ructus, acid regurgitation, heartburn, nausea, vomiting and the like are obviously improved, the clinical curative effect is exact, the curative effect is obvious and the rapid effect is obtained. Moreover, since the Chinese medicine composition is basically combined by homologous plant food medicines regulated in state pharmacopoeia, the cost is low, basically no toxic side effect exists and the like.

The invention relates to a preparation method for directly producing enoxaparin sodium from crude product heparin sodium. The preparation method comprises the following steps of: taking the crude product heparin sodium as a raw material, performing fractionated precipitation through an organic solvent to remove most of impurities in the crude product heparin sodium, and then removing part of residual impurity proteins, pigments and other impurities by oxidation through hydrogen peroxide so as to get the high-purity heparin sodium which is in line with the production requirements of the enoxaparin sodium; and taking the high-purity heparin sodium as an intermediate product, preparing a heparin quaternary ammonium salt, preparing heparin benzyl ester, performing alkaline depolymerization on the heparin benzyl ester, neutralizing with an acid, performing alcohol precipitation, refining, decoloring, dehydrating and drying to get an enoxaparin sodium finished product. By adopting the method disclosed by the invention, the use of the organic solvent is greatly reduced, the production efficiency is improved, the influences on the environment are reduced, the enoxaparin sodium finished product which achieves or is better than European Pharmacopoeia 7.0 version is obtained, and the method is simple to operate and can realize industrialized production.

The invention discloses a Chinese medicine composition for treating headache and a preparation method thereof. The Chinese medicine composition is mainly formed by the following raw medicine materials: angelica root, Ligusticum wallichii, storax, snowbell, Rhizoma acori Graminei, holy basil, rheum officinale, Chinese angelica, white paeony root, red paeony root, immature bitter orange, rhizoma cyperi, notopterygium root, agilawood, dalbergia wood, Salvia miltiorrhiza Bunge, peach kernel, safflower, motherwort herb, pangolin scale and the like. The Chinese medicine composition of the invention can be prepared into any kind of common oral preparation according to the conventional Chinese medicine preparation method. The invention has the advantages that symptoms such as headache, parietal headache, medial headache and migraine, facial neuralgia, dysphoria, emotional instability, anxiety, insomnia, amnesia and the like are obviously improved, the clinical curative effect is exact, the curative effect is obvious and the rapid effect is obtained. Moreover, the Chinese medicine composition is basically combined by homologous plant food medicines regulated in National Formulary, thereby having the advantages of low cost, basically no toxic side effect and the like.

The present invention is directed to pharmaceutical compositions, and methods of making such compositions, wherein the compositions comprise a plurality of TPR and RR particles, wherein: the TPR particles each comprise a core coated with a TPR layer; the core comprises a weakly basic, poorly soluble drug and a pharmaceutically acceptable organic acid separated from each other by an SR layer; the RR particles each comprise the weakly basic, poorly soluble drug, and release at least about 80 wt.% of the weakly basic, poorly soluble drug in about 5 minutes when dissolution tested using United States Pharmacopoeia (USP) dissolution methodology (Apparatus 2—paddles@ 50 RPM and a two-stage dissolution medium at 37° C., (first 2 hours in 0.1N HCl followed by testing in a buffer at pH 6.8).

The invention discloses a traditional Chinese medicine composition for treating acute enteritis and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the following raw medicines: medicated leaven, malt, Alisma orientale, Poria, Rhizoma atractylodiss, Magnolia officinalis, Atractylodes macrocephaia, Chinese yam, coix seed, Amomum villosum, honeysuckle, dandelion, Chinese violet, plantain seed, gordon euryale seed, Limonitum, blighted wheat, Amomum cardamomum, cinnamon, nutgall, angelica, Ligustrum lucidum, cherokee rose and the like. The traditional Chinese medicine composition can be prepared into any one commonly used oral preparation according to the conventional method of traditional Chinese medicine preparations. The invention can obviously improve the symptoms of excessive diarrhea, loose stool, watery stool, abdominal pain, nausea, vomiting, dyspepsia, fever, body pain, limb weakness and the like, and has obvious clinical curative effect, significant curative effect and rapid effect. Since the traditional Chinese medicine composition adopts medicinal and edible medicines stipulated in the Chinese Pharmacopoeia to compound, the composition has the advantages of low cost, basically no toxicity and side effects and the like.

A system and method for comparing pharmaceutical prices and mediation utilization that provides separate databases containing (i) client pharmaceutical wholesaler and non-wholesaler purchase data, (ii) pharmaceutical compendia information, (iii) client pharmaceutical contract information, (iv) client organizational profile information, and (v) client patient volume and acuity data; and a processor in communication with the databases that (i) uploads the data and information from the databases into an input module that standardizes, validates and merges the data and information, (ii) processes the data and information from the input module by performing pricing and utilization analyses on the information and generating savings opportunities information, and (iii) formats the savings opportunities information and generates and pricing and utilization reports. A database interface for customized reporting and research analytics is also provided.

The invention discloses a stem cell freezing and storing medium and a preparation method and freezing and storing method thereof. The stem cell freezing and storing medium comprises, by weight, 3-10 parts of dimethyl sulfoxide, 2-7 parts of human serum albumin, 0.5-3 parts of mycose, 0.2-2 parts of dextran 40 and 2-6 parts of hetastarch. Cells can be frozen for a long time by the stem cell freezing and storing medium, freezing damage of the cells can be remarkably reduced, the resuscitated cells have a high degree of survival rate and adherent property, and freezing and storing effect of the cells is improved; meanwhile, the compositions of the stem cell freezing and storing medium are clear and are medical compendial injection-grade excipients without containing serum, the risk of contamination and allergen introduced by the use of heterogeneous serum is effectively prevented, the content of DMSO (dimethylsulfoxide) is low, the negative effect of the DMSO on the cells is lowered, highsecurity and good stability are achieved, requirements of CFDA (China food and drug administration) and FDA (food and drug administration) are met, and the stem cell freezing and storing medium can be directly used in human infusion and is suitable for clinical research and treatment.

The invention discloses a new Chinese medicine composite for treating duodenal ulcer and a preparation method thereof. The Chinese medicine composite mainly comprises the following active pharmaceutical ingredients of stir-fried frankincense, stir-fried myrrh, semen coicis, lignum dalbergiae odoriferae, pericarpium citri reticulatae, fructus hordei germinatus, medicated leaven, radix trichosanthis, tuckahoe, rhizoma coptidis, baikal skullcap root, radix sophorae flavescentis, densefruit pittany root-bark, Chinese wolfberry root-bark, white flower patrinia herb, fructus amomi, lignum aquilariae resinatum, aspongopus, rhizoma corydalis, raw radix astragali, rhizoma dioscoreae, radix codonopsis and white peony root, and the like. The Chinese medicine composite can be prepared to be any common oral preparation according to the conventional Chinese medicine preparation method. The Chinese medicine composite can obviously improve epigastric pain, vague pain and complaint, hemorrhea, gastric perforation, obstruction and the like, which has definite clinical effect, obvious curative effect and fast desired effect. Due to the combination of the medicines both as food and medicine according to state-promulgated pharmacopoeia, the Chinese medicine composite of the invention has the advantages of low cost, basically no toxic side effect and the like.

2-Pyrrolidone derivatives are provided as preservatives for topical formulations, particularly for ophthalmic, otic, and nasal formulations. N-octyl-2-pyrrolidone, without any other preservative or preservative aid in an isotonic pH 7.5 formulation, provided sufficient preservation to comply with the European Pharmacopoeia 5.0 standards in addition to the United States Pharmacopoeia 24 standards for parenteral and ophthalmic preparations. On the other hand, N-dodecyl-2-pyrrolidone requires a second anti-microbial agent to achieve such preservation standards.

The invention belongs to the technical field of medicine, and specifically relates to an industrial tegafur synthesizing method comprising the steps that: under inert gas pressure control and the effects of a Lewis acid catalyst, 5-fluorouracil and 2,3-dihydrofuran are subjected to a substitution reaction in an aprotic polar solvent; and acidification and refining are carried out, such that tegafur is obtained. The method has the advantages of simple reaction process, high yield, less side reactions, mild reaction conditions, and the like. Pharmacopoeia standards can be satisfied with simple refining, and purity is higher than 99.7%.

The invention belongs to the field of traditional Chinese medicinal preparation detection, and in particular relates to a fingerprint map detection method for ganmaoling granules. According to the method disclosed by the invention, traditional Chinese medicinal components, including linarin, in the ganmaoling granules are detected by utilizing a high-performance liquid chromatography; quality information of the ganmaoling granules can be reflected comprehensively; the intrinsic quality of the ganmaoling granules can be effectively controlled; moreover, the established method is relatively high in stability, precision and reproducibility; a traditional Chinese medicine chromatographic fingerprint map similarity evaluation system specified by the Pharmacopoeia Committee of China is adopted, so that the operation is quick, and results are objective and accurate.

The invention discloses a similar Chinese herbal medicine search method based on a probability topic model. The method includes the following steps: transforming Chinese herbal medicine information in 'China Great Pharmacopoeia' and 'Chinese Materia Medica' into digital text through an optical character recognition tool; extracting information such as efficacy, property and flavor and channel tropism of Chinese herbal medicines by using a regular expression, and building a Chinese herbal medicine information base; generating corresponding vector spaces according to efficacy, property and flavor and channel tropism attributes of the Chinese herbal medicines respectively, and regulating the vector spaces of the efficacy according to the probability topic model; and at last, calculating similarity of the efficacy, property and flavor and channel tropism attributes between the Chinese herbal medicines according to cosine coefficients, and generating a Chinese herbal medicine similarity database. A user inputs the name of a Chinese herbal medicine, and a system displays the Chinese herbal medicine and similar Chinese herbal medicines visually in the form of a relational graph through searching in the corresponding Chinese herbal medicine pair similarity information database. By means of the similar Chinese herbal medicine search method based on the probability topic model, relevant Chinese herbal medicines can be searched according to attribute similarity, and the method is of great significance for Chinese herbal medicine study and Chinese herbal medicine informatization.

The invention discloses a novel traditional Chinese medicine composition for treating toothache and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the following raw medicines: pricklyash peel, clove, storax, venenum bufonis, borneol, camphor, grassleaf sweetflag rhizome, cornu saigae tatariace powder, tall gastrodia tuber, the larva of silkworm with botrytis, nidus vespae, catechu, dragon blood, unbracteolated spurge root, Chinese eaglewood wood, rosewood, rhubarb, officinal magnolia bark, villous amomum fruit, atractylodes rhizome, fineleaf schizonepeta herb, divaricate saposhnikovia root, frankincense and myrrh. The traditional Chinese medicine composition can be prepared into any one commonly used oral preparation according to the conventional method of traditional Chinese medicine preparations. The invention can obviously improve the symptoms of toothache, gingival swelling, pain in case of hot and cold stimulation, cheek swelling and the like, and has obvious clinical curative effect, significant curative effect and rapid effect. Since the traditional Chinese medicine composition adopts medicinal and edible medicines stipulated in the Chinese Pharmacopoeia to compound, the composition has the advantages of low cost, basically non-toxic side effects and the like.

The invention discloses a quality control method of a pulse-invigorating and heart-nourishing pill. The method comprises the following steps: the contents prepared tuber fleece flower and Chinese magnolia vine fruit are identified, and the contents are tested according to the method described in the pharmacopoeia, and liquoric root in the contents is assayed. The quality of the related drugs can be guaranteed more accurately by the assay of the active component liquoric root in the pulse-invigorating and heart-nourishing pill to effectively ensure safety, uniformity, stability, effectiveness and controllability of the pulse-invigorating and heart-nourishing pill. The new quality control method is simple and convenient, gives accurate result and better reproducibility, and can achieve the purpose of quality control.

Resin particles are produced by adding a liquid material having a boiling point of 100° C. or higher to an aqueous dispersion of resin particles to yield a mixture, recovering a wet cake from the mixture by filtration, and drying the wet cake. A water-soluble material is preferably used as the liquid material. The liquid material may also be at least one compound selected from compounds listed in The Japanese Standards of Cosmetic Ingredients, The Japanese Cosmetic Ingredients Codex, The Pharmacopoeia of Japan, and The Japan's Specifications and Standards for Food Additives. According to this method, there are provided resin particles which are resistant to coagulation upon drying and are satisfactorily dispersible in other materials.

A pyridoxal-5′-phosphate pharmaceutical formulation suitable for oral administration is provided comprising a dissolution profile, when measured in a standard dissolution apparatus, according to the United States Pharmacopoeia dissolution test, at 37° C. in a 0.05M phosphate buffered solution having a pH of 6.8 at 75 rpm, as follows: (a) greater than about 30% at 15 minutes, (b) greater than about 85% at 30 minutes, (c), greater than about 90% at 45 minutes, or (d) greater than about 95% at 60 minutes. Additionally, in vivo oral intake of between 15 and 60 mg / kg of a pyridoxal-5′-phosphate pharmaceutical formulation can produce a maximum plasma level (Cmax) of between about 1 mg / L and 8 mg / L. A pharmaceutical formulation provided comprises (a) a core, wherein said core comprises pyridoxal-5′-phosphate or a pharmaceutically acceptable salt thereof; (b) a sub-coat surrounding the core; and (c) an enteric coat surrounding the sub-coat.

A preparation method of sulfadoxine belongs to the field of sulfanilamide antimicrobial drug preparation. Cyclization reaction comprises the following steps of: firstly pouring a sodium methoxide solution into a reactive pan, then successively adding methanamide and methyl ethyl methoxymalonate, keeping warm, recovering methanol, cooling for crystallization, drying by centrifugation, discharging,and drying to obtain 5-methoxy-4,6-disodium dihydroxypyrimidine; Chlorination reaction comprises the following steps of: firstly putting phosphorus oxychloride into a reaction vessel for heating, adding 5-methoxy-4,6-disodium dihydroxypyrimidine into the reaction vessel to react, decompressing and recovering phosphorus oxychloride until the material is dry, cooling, adding trichloro ethylene withuniformly stirring, putting into a hydrolysis pan for hydrolyzation, collecting a trichloro ethylene layer after standing and delaminating, followed by a neutralization reaction, controlling pH value, washing, removing a water layer, recovering trichloro ethylene, and releasing crystals to obtain 5-methoxy-4,6-dichloropyrimidine. The preparation method provided by the invention can be used to guarantee the product purity, prolong the service life of equipment, avoid the damage to the environment and human body, reduce emission, and save energy, and accords with foreign pharmacopoeia standard requirements.

The invention discloses a new traditional Chinese medicine composition for treating min-term malignant liver tumor symptoms and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from the following medicine components: pangolin, red-rooted salvia root, tuckahoe, angelica, white peony root, red-rooted salvia root, peach seed, safflower, rhizoma sparganii, Rhizoma Zedoariae, giant knotweed, Chinese rrichosanthes root, coptis, flavescent sophora root, red paeonia, gromwell, orientvine, magnolia bark, Evodia rutaecarpa, Fructus Aurantii Immaturus, costus root, rhizoma cyperi, notoginseng, mastic, myrrh, draconis sanguis, Bupleurum, kudzu root, dandelion, madder, hyacinth bletilla, sanguisorba, ganoderma lucidum, ground beetle, agilawood, leech, vallicepobufagin, raw Astragalus root, ginseng and white atractylodes rhizome. The traditional Chinese medicine composition can be prepared into any commonly-used oral preparation by using the conventional traditional Chinese medicine preparation method. The invention can obviously improve the liver tumors and the symptoms of the abnormity of the liver function, the liver cell trauma, the hepatalgia, the hepatocirrhosis, the liver ascites and the like, obviously shrink the liver tumours, recover the liver function, activate the activity of the stem cells, regulate qi, remove the stasis, decrease the swelling, relieve the pain, enhance the body resistance to diseases, and obviously improve the life quality. The traditional Chinese medicine composition has exact and obvious clinical curative effect, high efficiency and quick action. By basically combining edible and pharmaceutical products specified in the national pharmacopoeia, the traditional Chinese medicine composition has the advantages of low cost, no toxic or side effects and the like.

Absorbable monofilament fibers and self-retaining sutures with high tensile strengths have been developed. The straight pull tensile strengths of the absorbable self-retaining sutures closely approximate, equal or exceed the average minimum knot-pull tensile standards set by the United States Pharmacopeia (USP). These higher strength absorbable self-retaining sutures can therefore be used either without needing to oversize the suture for a given procedure, or by oversizing the self-retaining suture by no more than 0.1 mm in diameter. In one embodiment, the absorbable self-retaining sutures are made from poly-4-hydroxybutyrate or copolymers thereof.Methods for producing absorbable self-retaining sutures that have high tensile strengths and pronounced sheath-core structures wherein the sheath is harder than the core are also provided. The self-retaining sutures may be made by spinning and orienting a monofilament fiber of poly-4-hydroxybutyrate or copolymer thereof and inserting retainers in monofilament fibers.

The invention discloses a new Chinese medicine composite for treatment of acute gastroenteritis and a preparation method thereof. The Chinese medicine composite of the invention mainly comprises the following materials of tuckahoe, magnolia officinalis, rhizoma atractylodis macrocephalae, plantain seed, dried ginger, rhizoma pinelliae, styrax, medicated leaven, fructus hordei germinatus, semen arecae prepareta, endothelium corneum gigeriae galli, rhizoma corydalis, medicinal evodia fruit, cassia, fructus quisqualis, pericarpium citri reticulatae, rhizoma coptidis, oriental water plantain rhizome, cortex periplocae radicis, taraxacum, bunge corydalis herb , pollen typhae carbonisatus, honeysuckle flower, jobstears seed, and the like. The Chinese medicine composite of the invention can be prepared into any common oral preparation according to the conventional Chinese medicine preparation method. The composite can obviously improve nausea, emesis, abdominal pain, diarrhea, fever, and the like. The serious patient may have symptoms of dehydration, electrolyte disturbance, shock bowel, septicemia and the like. The composite has reliable and apparent clinical effect and fast desired effect. Due to the combination of the medicines both as food and medicine according to state-promulgated pharmacopoeia, the Chinese medicine composite of the invention has the advantages of low cost and no toxic and side effect basically.