The invention belongs to the technical field of
medicine, and discloses an
olaparib dihydrate and a preparation method thereof. Characteristic
diffraction peaks are displayed at 6.75 DEG, 7.04 DEG, 9.16 DEG, 10.53 DEG, 15.20 DEG, 17.46 DEG, 20.68 DEG, 22.21 DEG, 27.43 DEG, 28.62 DEG, 29.30 DEG, 35.23 DEG and 37.14 DEG of X-
ray powder diffraction spectra of the crystalline compound expressed at
diffraction angles of 2Theta+ / -0.2 DEG, and the X-
ray powder diffraction spectra measured by the aid of Cu-
K alpha rays are shown as a graph 1 and are totally different from X-
ray powder diffraction spectra in the prior art. The experiment proves that the dissolvability of the
olaparib dihydrate is obviously increased. The invention also discloses the preparation method of the
olaparib dehydrate, the preparation method is simple and easy to carry out, the yield and purity are high, the reaction condition is mild, and the method is suitable for large scale production. A
dissolution rate and the stability of the
capsule prepared by the olaparib dihydrate are obviously increased, and the
capsule is very suitable for clinical application.