247 results about "Phthalide" patented technology

The invention relates to an ester obtained by the reaction of 3-(3'-hydroxyl)-butylphthalide and acids, wherein, the acids can be acceptable inorganic acids or organic acids in pharmacy. Proved by testing, the efficacy of the ester is increased significantly. Part of the ester can go on reacting with the acids or alkalis to form salts in order to increase water solubility and prepare injection preparations; being proved by testing, the injection preparations have no muscle and vascular stimulation.

A therapeutic agent and prophylactic agent for a disease accompanying an abnormality in an amount of insulin or insulin response, an agent for an insulin-mimetic action, a food, beverage and feed, an agent for enhancing glucose uptake into a cell, and an agent for inducing differentiation into an adipocyte, characterized in that each comprises as an effective ingredient at least one compound selected from the group consisting of a chalcone compound, an acetophenone compound, a coumarin compound, a phthalide compound, derivatives thereof, and pharmacologically acceptable salts thereof.

The invention relates to the pharmaceutical chemistry filed, and particularly relates to novel nitric oxide donor butyl phthalide derivatives (I), the preparation method thereof, a drug preparation containing the derivatives (I) and the application as a drug for resisting thrombosis and cerebral ischemia. Wherein, the definitions of R and A are shown in the instruction.

The invention discloses a preparation method of Olaparib and an analogue of the Olaparib. 2-fluoro-5-formyl benzoic acid is taken as a raw material and reacts with 1-substitutent piperazine to produce 3-(4-substitutent)piperazine-1-carbonyl)-4-fluorobenzalde which reacts with (3-oxo-1,3-dihydro-isobenzofuran-1-yl)dialkyl phosphate to produce 1-(substitutent)-4-[5-(3-oxo-3H-isobenzofuran-1-yl-methylene)-2-fluorobenzoyl]piperazine, then the 1-(substitutent)-4-[5-(3-oxo-3H-isobenzofuran-1-yl-methylene)-2-fluorobenzoyl]piperazine reacts with hydrazine hydrate to produce the Olaparib (Ia,R=cyclopropyl formyl) and the analogue (Ib,R=BOC) of the Olaparib; or 3-(4-substitutent)paperazine-1-carbonyl)-4-fluorobenzalde reacts with phthalide to produce 1-(substituent)-4-[5-(2,3-dihydro-1,3-dioxo-1H-indene-2-yl)-2-fluorobenzoyl]piperazine which reacts with the hydrazine hydrate to produce the Olaparib (Ia,R=cyclopropyl formyl) and the analogue (Ib,R=BOC) of the Olaparib.

The invention is concerned with the injection thick solution and the preparation method that is made of butyl phthalide.

The invention relates to new use of 3-n-butylphthalide (abbreviated as butyl phthalide) and derivatives thereof, in particular to the use of the compounds in the preparation of the medicine for treating Parkinson disease. A mat model of hemiparkinsonian disease is built by using three-dimensional targeted injection of rotenone to perform a test, and the result of the test shows that the butyl phthalide and derivatives thereof can effectively improve symptoms aroused by Parkinson and have a nerve-protecting effect.

The invention discloses a phthalide type ingredient effective part as well as a preparation method and an application of the phthalide type ingredient effective part and belongs to the technical field of traditional Chinese medicine and natural product extraction and application. The preparation method of the phthalide type ingredient effective part comprises the following steps that hemlock parsley medicinal materials are extracted by an ultrasonic extraction method, a solvent extraction method, a microwave extraction method, a solvent backflow extraction method or a supercritical fluid extraction method, extracts are added with water to be dispersed and are then respectively extracted by two different-polarity solvents, extraction liquid is purified by positive-phase silica gel, the content of the phthalide type ingredient effective part accounts for more than 50 percent of the total weight of the extracts, and in addition, different solid phase extraction operation modes can be adopted according to different ingredient requirements. The phthalide type ingredient effective part, the preparation method and the application have the advantages that the preparation speed is fast, the phthalide type ingredient content in the product is high, the ingredient is definite, the quality is controllable, and good economic benefits and social benefits are realized.

The invention provides a butylphthalide medicine active composition, which comprises the following ingredients: first ingredients: the butylphthalide content is higher than or equal to 98.0 percent; second ingredients: the second ingredients are one kind of materials or several kinds of materials selected from methylene phthalide, ethylene phthalide, propylene phthalide, butane phthalide, amylene phthalide, phthalide, methyl phthalide, ethyl phthalide, propyl phthalide and amyl phthalide, in addition, the content of the second ingredients is higher than 0 but is lower than or equal to 2.0 percent, when the second ingredients comprise any one kind of materials from methylene phthalide, ethylene phthalide, propylene phthalide, butane phthalide and amylene phthalide, the content of any one kind of included ingredients does not exceed 0.5 percent, and when the second ingredients comprise any one kind of materials from phthalide, methyl phthalide, ethyl phthalide, propyl phthalide and amyl phthalide, the content of any one kind of included ingredients does not exceed 1.0 percent. The quality of the medicine active composition is stable, and the clinic curative effect and the medication safety of the butylphthalide preparation can be ensured.

The invention discloses an organic reversible thermochromic microcapsule with long service life and large color difference and a preparation method thereof. A wall material of the organic reversible thermochromic microcapsule is prepared from the following raw materials in percentage by weight through polymerization: 30-95% of acrylate and/or methacrylate, 5-70% of a divinyl and/or polyvinyl monomer mixture, and 0-10% of an acrylic acid and/or methacrylic acid mixture, and a core material is composed of a colour former 3,3-di(4-dimethylaminophenyl)-6-dimethylamino phthalide, a color developing agent 4,4'-dihydroxydiphenylsulfone, and a solvent selected from 1-dodecanol, 1-tetradecanol, 1-hexadecanol and 1-octadecanol; and the preparation method is implemented through carrying out prepolymerization on monomers and carrying out suspension polymerization on the obtained product. The obtained organic reversible thermochromic microcapsule has the advantages of long service life and large color difference; the microcapsule does not release formaldehyde, and does not contain bisphenol A, so that the microcapsule is safer to use.

A gas chromatographic method for determining a residual solvent in a phthalide compound takes cyanopropyl phenyl-dimethyl polysilicone as a stationary liquid capillary chromatographic column, hydrogenas a flame ionization detector and nitrogen as a carrier gas and calculates content of the residual solvent in peak area according to an external standard process. The method can determine normal heptane and other residual solvents in the phthalide compound and has the advantages of high sensitivity, strong specificity and high accuracy.

The invention discloses a penicillium vulpinum fungi strain and a method for preparing levo 7-hydroxyl butylphthalide ((S)-(-)-butyl-7-hydroxyl phthalide) employing the fungi strain. The fungi strain disclosed by the invention is a penicillium vulpinum fungi strain NCC3421 (penicillium vulpinum) and is preserved at the China General Microbiological Culture Collection Center (CGMCC for short); and the preservation number is CGMCC No.9094. Under the culture condition provided by the method, the fermentation unit of the levo 7-hydroxyl butylphthalide reaches over 1600mg/L; the fermented product is relatively single in components, and easy to separate and purify, and can be applied to industrialized production of the levo 7-hydroxyl butylphthalide.

The present invention provides a Chuanxiong rhizome volatile oil soft capsule and its preparation method and use. The Chuanxiong rhizome volatile oil described in the invention is prepared by a carbon dioxide supercritical extraction method, the contend of the effective component Chuanxiong rhizome phthalide in the Chuanxiong rhizome volatile oil reaches the medicinal standard, and the quality is stable and can be controlled. The invention also provides the use of the Chuanxiong rhizome volatile oil soft capsule for preparing the medicine for curing cerebral apoplexy during recovery period.

The invention provides 3-substituent phthalide compounds first. The constitutional formula of the compounds is shown in the right. The compounds are sifted through a drosophila study ability model to find that most of the compounds play the role of restoring study ability on defected individuals; and specific compounds thereof express better activities, allow the defected individuals to restore over 85 percent of study ability and play the role of stable treatment in multiple rounds of experiments. Based on the experiments, the novel 3-substituent phthalide compounds are bioactive molecules for treating Alzheimer's disease.