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546 results about "Chalcone" patented technology

Chalcone is an aromatic ketone and an enone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones or chalconoids. Alternative names for chalcone include benzylideneacetophenone, phenyl styryl ketone, benzalacetophenone, β-phenylacrylophenone, γ-oxo-α,γ-diphenyl-α-propylene, and α-phenyl-β-benzoylethylene.

Magnolia extract containing compositions

Disclosed is a composition comprising at least two of the following ingredients: Magnolia extract, honokiol, humulus lupulus extract, hesperidin methyl chalcone, gotu kola, dipeptide valyl-tryptophane, palmitoyl tetrapeptide-3, corylus avellana bud extract, centella asiatica extract, cucumis sativa extract, morus alba extract, hibiscus sabdariffa flower extract, vitis vinifera extract, ascorbyl glucoside, citrus medica limonum extract, avena sativa kernel extract, hydrolyzed soy protein, aniseed myrtle extract, tasmania lanceolata leaf extract, artemisia abrotanum extract, or citrus grandis fruit extract or any combination thereof. Also disclosed are methods of treating skin conditions by topically applying the composition to skin.
Owner:MARY KAY INC

Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders

InactiveCN101257897AHydroxy compound active ingredientsMetabolism disorderSirtuin-activating compoundTannin
Provided herein are methods and compositions for treating or preventing metabolic disorders, such as obesity and diabetes. Methods may comprise modulating the activity or level of a sirtuin, such as SIRTl or Sir2. Exemplary methods comprise contacting a cell with a sirtuin activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin, or an inhibitory compound, such as nicotinamide.
Owner:SIRTRIS PHARMA INC

Sulfide, sulfoxide and sulfone chalcone analogues, derivatives thereof and therapeutic uses thereof

Compounds useful as antiproliferative agents according to formula (I): wherein Ar1, Ar2, Ar3, m and n are as defined herein, salts, antibody conjugates, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.
Owner:TEMPLE UNIVERSITY

Magnolia extract containing compositions

Disclosed is a composition comprising at least two of the following ingredients: Magnolia extract, honokiol, humulus lupulus extract, hesperidin methyl chalcone, gotu kola, dipeptide valyl-tryptophane, palmitoyl tetrapeptide-3, corylus avellana bud extract, centella asiatica extract, cucumis sativa extract, morus alba extract, hibiscus sabdariffa flower extract, vitis vinifera extract, ascorbyl glucoside, citrus medica limonum extract, avena sativa kernel extract, hydrolyzed soy protein, aniseed myrtle extract, tasmania lanceolata leaf extract, artemisia abrotanum extract, or citrus grandis fruit extract or any combination thereof. Also disclosed are methods of treating skin conditions by topically applying the composition to skin.
Owner:MARY KAY INC

2-hydroxyl chalcone compound as well as preparation method and purpose thereof

The invention discloses a novel 2-hydroxyl chalcone compound (I), as well as pharmacy acceptable salt, preparation method, medical composition, and purpose thereof in preparing medicines for treating and / or preventing neurodegenerative diseases including but not limited to vascular dementia, Alzheimer's diseases, Parkinson's diseases, Huntington's diseases, dementia relevant to HIV, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, glaucoma and the like (As shown in the description.).
Owner:SICHUAN UNIV

Sofalcone preparation method

Disclosed is a Sofalcone preparation method which mainly comprises, (1) subjecting p-hydroxybenzaldehyde and 2,4-ihydroxyacetophenone to condensation reaction under alkaline condition, obtaining 2,4,4-Trihydro-xychalcone, (2) subjecting 2,4,4-trihydro-xychalcone and 1-bromo-3-methyl-2-butene to condensation reaction, obtaining 2-hydroxyl-4,4-bis (3-methyl-2-butenyloxy) chalcone, (3) subjecting the 2-hydroxyl-4,4-bis (3-methyl-2-butenyloxy) chalcone and ethyl bromoacetate to condensation under the action of potasium carbonate, thus obtaining sofalcone. The mol ratio of p-hydroxybenzaldehyde, 2.4-dihydroxyacetophenone, 1-bromo-3-methyl-2-butene, and ethyl bromoacetate can be 1 : (0.90-1.50) : (1.60-2.55) : (0.60-1.25).
Owner:阮华君

Aryl-substituted chalcones compound, its preparation method and its application

The invention discloses an aryl-substituted chalcones compound, a preparation method and an application. The aryl-substituted chalcones compound has a structure shown as a formula(I) or a formula(II), wherein, R1, R2, R3, R4, R5 are aromatic groups or aromatic groups with a substituent, the aromatic groups are phenyl, furan, thienyl, pyridyl, pyrimidyl, thiazolyl or pyrrolyl, the substituent is one or more selected from hydroxyl, methoxyl, ethoxyl, methyl, ethyl, trifluoromethyl, halogen, amino, methylamino or dimethylamino; R3 is selected from hydrogen, amino or-NHCOCH3. The aryl-substituted chalcones compound introduces the aromatic groups based on a phenyl skeleton to form a structure with steric hindrance, the molecule presents a V-shaped spatial conformation, compared with the current chalcone compounds, and the aryl-substituted chalcones compound has higher inhibitory activity to cancer cells and can be used for preparing the antitumor drugs.
Owner:NEOPANORA BIO TECH ZHUHAI LTD

Formulation for insulin and glucose control

The formulation includes a combination of a chalcone, specifically, methylhydroxychalcone polymer, in the amount of 6 mg to 24 mg, and chromium, in the amount of 500 mcg to 2000 mcg. The formulation also includes a plurality of vitamins and nutrients, vitamins B6, C, E and K including green tea polyphenols and other nutrients.
Owner:WRIGHT JONATHAN V +1

Triazine ring based polymers for photoinduced liquid crystal alignment, liquid crystal alignment layer containing the same, liquid crystal element using the alignment layer and method of manufacturing the same

Triazine ring based polymers for photoinduced liquid crystal alignment introduces photoactive groups for inducing, reinforcing, improving and preserving liquid crystal alignment, for example photoreactor such as cinnamate, coumarin, chalcone and maleimide, as a chain to have at least one photoactive group. One of the photoactive groups can experience Fries rearrangement which induces liquid crystal alignment, and other groups can experience photodimerization, photoisomerization, photocrosslinking or photodegradation to reinforce, change or preserve the generated alignment.
Owner:LS MTRON LTD

Method for extracting and refining hydroxysafflor yellow A from safflower

ActiveCN102675379AThe purification process is stable and controllableHigh puritySaccharide with carbocyclic radicalsSugar derivativesFreeze-dryingCarthamus yellow
The invention discloses a method for extracting and refining hydroxysafflor yellow A from safflower. The hydroxysafflor yellow A is a compound with a chalcone monoside structure, and is abundant in traditional Chinese medicinal material safflower (CARTHAMI FLOS). The hydroxysafflor yellow A with content of over 80 percent is obtained through the following five steps of: extracting form the traditional Chinese medicine safflower; purifying through ion exchange resin; purifying through neutral polarity macro-porous adsorption resin; purifying through non-polar macro-porous adsorption resin; and freeze-drying, wherein the transfer rate is over 20 percent.
Owner:HEBEI YILING MEDICINE INST

Novel chalcone compound and preparation method and application thereof

The invention discloses novel a chalcone compound extracted and purified from Oxytropis falcate, a preparation method and an application thereof. Identified through a spectral method, the novel chalcone compound has the structural formula C15H1203 and is named 2', 4'-dihydroxy chalcone, and the preparation method combines column chromatography and preparative liquid purification method. Result from experiments in vitro shows that the novel chalcone compound can remarkably restrain the growth and proliferation of tumor cells and has good efficacy of restraining acute inflammation of mice and chronic inflammation of rats. Therefore, the novel chalcone compound is expected to be developed to be a new generation of antitumor drugs or anti-inflammatory drugs.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

Application of chalcone compounds in preparations of inflammation resisting medicines

The invention belongs to the field of pharmaceutical chemistry, and specifically relates to an application of specific chalcone compounds in the preparations of inflammation resisting medicines and medicines used for treating inflammation-related diseases. With the chalcone compounds, expression and release of various inflammatory factors such as TNF-alpha, IL-6, COX-2, IL-1beta and IL-12 can be inhibited; nuclear translocation of an inflammation-regulation-related nuclear factor -kappaB can be substantially inhibited; and phosphorylation of inflammation signal pathways ERK and p38 can be inhibited. As a result of in-vivo experiments, with the compounds, the survival rate of LPS-introduced mice mortality can be substantially improved.
Owner:WENZHOU MEDICAL UNIV

Carbamate chalcone compound, preparation method therefor and use of carbamate chalcone compound

The invention discloses a novel carbamate chalcone compound represented by a formula I shown in the description and pharmaceutically acceptable salts thereof, a preparation method for the novel carbamate chalcone compound and the pharmaceutically acceptable salts thereof, a pharmaceutical composition and use of the pharmaceutical composition in the preparation of drugs for treating and / or preventing neurodegenerative related diseases, including, but not limited to neurodegenerative diseases such as vascular dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV related cretinism, multiple sclerosis, progressive lateral spinal sclerosis, neuropathic pain and glaucoma.
Owner:SICHUAN UNIV

Antibacterial small molecules and methods for their synthesis

The present invention relates generally to compounds providing antibacterial therapeutic agents and preparations, and related methods of using and making antibacterial compounds. Antibacterial compounds of the present invention include chalcone, alkylpyrimidine, aminopyrimidine and cyanopyridine compounds and derivatives thereof exhibiting minimum inhibitory concentrations (MIC) similar to or less than conventional antibacterial compounds in wide use.
Owner:WISCONSIN ALUMNI RES FOUND

Calcium-containing tissue strengthening agents and use thereof

The present invention has an object to provide an agent for strengthening calcium-containing tissues, which can be safely applied; and its use: The present invention solves the object by providing an agent for strengthening calcium-containing tissues, which comprises one or more flavones, flavonols, flavanones, flavanonols, anthocyanidins, flavanols, chalcones, and aurones.
Owner:HAYASHIBARA BIOCHEMICAL LAB INC

1-adamantyl chalcones for the treatment of proliferative disorders

The present invention relates to the compounds of the general formula (I), a composition for and a method of treating breast cancer or other proliferative disorders in a subject using a compound of general formula [I], wherein the substituents are as defined in the specification.
Owner:ANDERSON GLORIA L +1

Process for synthesizing chalcone and derivates thereof by using ion liquid

The invention relates a method of the synthesis of chalcone and derivatives thereof by using ionic liquid. Benzaldehyde and acetophenone are used as reactants and the molar ratio of the benzaldehyde and the acetophenone is 1:1 to 5:1; the ionic liquid is used as a catalyst and solvent and the mass of the ionic liquid added takes up 1:20 to 10:1 of the total mass of the reactants; the reaction pressure is normal pressure, the reaction temperature is 80 to 200 DEG C and the reaction time is 0.5 to 1.2 hours; the ionic liquid is composed of an alkyl imidazole cation or a pyridine cation functionalized by sulfonic group and inorganic or organic anions. The ionic liquid used by the invention is stable in the air and the water, is provided with an ignorable vapor pressure and is non volatile, which is an environment friendly catalyst and reaction solvent. The chalcone (or the derivatives of the invention ) of the reaction products of the ionic liquid can automatically be layered with the ionic liquid, which leads separation process to be easier and the ionic liquid can be used repeatedly by being dried in vacuum with the temperature of 110 DEG C for 1 to 6 hours after the reactions.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI

Ashitaba drink and preparation method thereof

The invention discloses an ashitaba drink. The ashitaba drink comprises the following raw materials in parts by weight: 10-30 parts of ashitaba, 0-30 parts of chrysanthemum, 0-30 parts of liquorice root, 0-15 parts of bitter gourd, 0.5-3 parts of xylitol, 0.1-0.2 part of sodium carboxymethyl cellulose, 0.01-0.03 part of xanthan, 0.01-0.03 part of sodium copper chlorophyllin and an appropriate amount of water. The invention further discloses a preparation method of the ashitaba drink. The ashitaba drink disclosed by the invention retains most of biological active substances in ashitaba to a greater extent and comprises various trace elements, vitamins and chalcone; and furthermore, ashitaba green juice is favorable for keeping unique color, luster and flavor of the ashitaba, and the health-care drink formed by compounding the ashitaba with other natural plant water extracts has certain compatibility in chemical ingredients and has better synergy in the aspects of nutritional ingredients and health-care functions.
Owner:上海鑫钰生物科技有限公司

Compositions and methods for managing weight

ActiveUS20140004215A1Promoting and managing weight lossMaintain weightBiocideNervous disorderPsychotropic AgentStimulant
The present disclosure provides Diels-Alder adducts of chalcone and prenylphenyl moieties capable of modulating the activity of cannabinoid receptors, and to oligomers of flavan-3-ol capable of modulating fat absorption and storage. Such Diels-Alder adducts of chalcone and prenylphenyl moieties or oligomers of flavan-3-ol can optionally be used in combination with other weight management agents, such as anorectic agents, a lipase inhibitors, other cannabinoid receptor modulators, psychotropic agents, insulin sensitizers, stimulants, or satiety agents, as well as to methods of use thereof such as treating or preventing weight gain or obesity, promoting weight loss, appetite suppression, modifying satiety, or the like.
Owner:UNIGEN

Fragrant microcapsule for composite cigarettes and preparation method and application thereof

The invention discloses a fragrant microcapsule for composite cigarettes.A nucleus of the microcapsule is prepared from novel methyl hesperidin dihydro chalcone, rhodinol and rhodinol-beta-D-glucopyranoside.A shell of the microcapsule is prepared from chitosan.The invention further discloses a preparation method of the fragrant microcapsule for composite cigarettes and application for increasing fragrance of cigarettes.The fragrant microcapsule for composite cigarettes can keep cigarette fragrance stability, durability and uniformity consistency of fragrance release along with time.
Owner:CHINA TOBACCO YUNNAN IND

Seedlessness roxburgh rose and angelica keiskei compound drink and preparation method thereof

The invention provides a seedlessness roxburgh rose and angelica keiskei compound fruit and vegetable juice drink which is prepared from the following components in parts by weight: 20-80 parts of seedlessness roxburgh rose, 10-80 parts of angelica keiskei, 0-10 parts of stevia rebaudiana, 1-5 parts of citric acid, 0.5-3 parts of newtol, 0.1-0.2 parts of sodium carboxymethylcellulose, 0.01-0.03 parts of xanthan gum, 0.01-0.03 parts of sodium copper chlorophyllin and defined quantity of water. The invention further comprises a preparation method of the seedlessness roxburgh rose and angelica keiskei compound drink, and the preparation method comprises processes of clear juice preparation, mixing, homogenizing, degassing, sterilizing and the like. Prepared seedlessness roxburgh rose and angelica keiskei compound fruit is rich in bioactive constituents such as chalcone, superoxide dismutase (SOD), natural organic germanium, choline, a plurality of families of vitamins, in particualr B12, pantothenic acid, vitamin C and the like and has abundant nutrition and health care effects. Simultaneously, products are good in taste and tasty in sour and sweet degree.
Owner:SHANGHAI JIAO TONG UNIV

Antibacterial agents and related screening methods using small molecule macroarrays

The present invention relates generally to compounds providing antibacterial therapeutic agents and preparations, and related methods of using and making antibacterial compounds. Antibacterial compounds of the present invention include chalcone, alkylpyrimidine, aminopyrimidine and cyanopyridine compounds and derivatives thereof exhibiting minimum inhibitory concentrations (MIC) similar to or less than conventional antibacterial compounds in wide use. For example, the present invention provides chalcone and cyanopyridine compounds, and derivatives thereof, exhibiting high antibacterial activities having multiple electron withdrawing group substituents, such as halogens and fluorinated alky groups, and optionally having hydroxyl and / or alkoxyl groups substituents.
Owner:WISCONSIN ALUMNI RES FOUND

Process method for baking angilica keiskei koidzumi

ActiveCN103719305AGuaranteed nutrition and health careReduce lossesPre-extraction tea treatmentVitamin CTwo step
The invention relates to the field of tea preparation and particularly relates to a process method for baking angilica keiskei koidzumi. According to the process method, an angilica keiskei koidzumi baking technical method, comprising the steps of baking at low temperature, adding jasmine flowers and producing fragrance at high temperature, is established, the steps of a preparation process are simple, the loss of chalcone and vitamin C in angilica keiskei koidzumi during preparation is reduced, and the content of chalcone and vitamin C is obviously higher than that of tea products which are prepared by only frying leaves under conventional process conditions, so that the nutritional healthcare effects of angilica keiskei koidzumi are guaranteed; according to the prepared angilica keiskei koidzumi product, baking and frying processes are replaced with low-temperature baking, so that the tea is uniform in heated degree and good in sensory character, and the problem of charring due to excessive baking and frying is effectively solved; due to the two steps of adding jasmine flowers and producing fragrance at high temperature, the fragrance of angilica keiskei koidzumi is guaranteed.
Owner:青岛海隆达生物科技有限公司

Method for synthesizing fluorofluorenone compound

The invention discloses a method for synthesizing a fluorofluorenone compound. the method is characterized in that a o-t-butyl ethynyl chalcone compound as shown in the formula 1 is used as a raw material to react in an organic solvent under the action of a copper catalyst and a fluorine oxidizer at the temperature of 25-60 DEG C for 0.5-6 h; and a reaction liquid undergoes separation and purification to prepare the fluorofluorenone compound as shown in the formula 2. The method has advantages of simple reaction steps, good substrate universality, mild reaction condition, safety and environmental protection, etc. According to the method, various fluoride-free nonaromatic chalcones are directly used as raw materials and cheap copper is used as a catalyst. The method is a new route for synthesizing various fluorofluorenone compounds containing a substituent group.
Owner:ZHEJIANG UNIV OF TECH

Michael addition product of ferrocene-based chalcone and ethyl acetoacetate and preparation method thereof

The invention provides a Michael addition product of ferrocene-based chalcone and ethyl acetoacetate and a preparation method thereof. The preparation method comprises the steps: adding A mol of ferrocene-based chalcone and B mol of ethyl acetoacetate into a dry reaction container, adding an alkaline substance as a catalyst, and grinding until the raw materials are subjected to complete reaction, wherein the ratio of A to B is 1:1; washing the product obtained from the reaction with water, carrying out suction filtration, recrystallizing the filter cake, and thus obtaining the Michael addition product of ferrocene-based chalcone and ethyl acetoacetate. The preparation method has the advantages of simple operation, short reaction time, mild reaction conditions, and low equipment requirements, the reaction is carried out only with grinding, at the same time, the catalyst is cheap and easy to get, the yield of the obtained product is up to 91.3% or more, the purity is high, and the preparation method is a green, simple and fast method for preparation of the Michael addition product of ferrocene-based chalcone and ethyl acetoacetate.
Owner:SHAANXI UNIV OF SCI & TECH

Extraction separation method of a flavone component based on graphene

The present invention refers to the technical field of flavone component extraction, and provides an extraction separation method of a flavone component based on amination graphene. The flavone components comprise flavones, flavanols, isoflavones, flavanones, flavanonols, flavanones, anthocyanidins, chalcones, and chromones etc. The extraction separation method is adsorption extraction, and amination graphene is taken as a medium of adsorption extraction. The extraction separation method of the flavone components based on amination graphene is superior in separation speed and product purity, low cost and convenient operation.
Owner:SHENZHEN XIHAN MEDICAL & HEALTH ENVIRONMENTAL PROTECTION CO LTD

Preparation technology of ashitaba tea

ActiveCN103564113AGuaranteed nutrition and health careHigh ChalconesTea substituesCooking & bakingVitamin C
The invention relates to the field of tea preparation, in particular to a preparation technology of ashitaba tea. The established preparation method of the ashitaba tea comprises the steps of separate leaf-stem treatment, gradient low temperature baking, intermittent kneading and forming, and short-time high-temperature perfuming. All stem and leaf tissues of whole ashitaba are taken as raw materials, and treated separately, so that phenomena such as excessive loss of chalcone, a nonuniform drying degree, and burning of leaves due to excessive baking are avoided; the prepared product is uniform in baking degree and good in sense organ character; a chalcone content and a vitamin C content are higher than tea products stir-fried only by the leaves under conventional technological conditions on the basis that the perfume of the ashitaba tea is ensured due to the gradient low temperature baking, the intermittent kneading and forming, and the short-time high-temperature perfuming; the nutritive and health-care effects of the ashitaba tea are ensured.
Owner:青岛海隆达生物科技有限公司

Acrylate compound, preparing process thereof and its use

An acrylate compound containing photosensitive chalcone groups in its side chain, its preparing process, and its use in preparing acrylate polymer are disclosed. A liquid crystal orientating materialcontaining said polymer is also disclosed.
Owner:ETERNAL MATERIALS CO LTD
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