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305 results about "Honokiol" patented technology

Honokiol is a lignan isolated from the bark, seed cones, and leaves of trees belonging to the genus Magnolia. It has been identified as one of the chemical compounds in some traditional eastern herbal medicines along with magnolol, 4-O-methylhonokiol, and obovatol.

Magnolia extract containing compositions

Disclosed is a composition comprising at least two of the following ingredients: Magnolia extract, honokiol, humulus lupulus extract, hesperidin methyl chalcone, gotu kola, dipeptide valyl-tryptophane, palmitoyl tetrapeptide-3, corylus avellana bud extract, centella asiatica extract, cucumis sativa extract, morus alba extract, hibiscus sabdariffa flower extract, vitis vinifera extract, ascorbyl glucoside, citrus medica limonum extract, avena sativa kernel extract, hydrolyzed soy protein, aniseed myrtle extract, tasmania lanceolata leaf extract, artemisia abrotanum extract, or citrus grandis fruit extract or any combination thereof. Also disclosed are methods of treating skin conditions by topically applying the composition to skin.
Owner:MARY KAY INC

Antibacterial and anti-inflammatory oral care composition

ActiveUS20060134024A1Inhibiting plaque formationMaintain Oral HealthBiocideCosmetic preparationsMagnololToothpaste
An efficacious antibacterial and anti-inflammatory oral composition is provided having an active ingredient combination comprising one or more active compounds from an extract of magnolia and an extract of hops. Preferably, the active compounds from magnolia extract comprise honokiol and magnolol, and the active compounds from hops extract comprise hexahydrogenated beta acids. The oral composition can be in the form of a mouth rinse or dentifrice, including toothpaste, gels, powders, confectionaries, lozenges, animal products, and the like. Methods of making and using the oral composition are also provided.
Owner:COLGATE PALMOLIVE CO

Compositions and methods of use for extracts of magnoliaceae plants

InactiveUS6582735B2Reduce and preventWithout reduction and loss of motor functionBiocideNervous disorderHonokiolMagnolol
The invention relates to compositions and methods for preventing, treating, or managing sleeplessness, restlessness, weight gain including weight gain due to stress or lack of sleep, or all three comprising the administration of a prophylactically and therapeutically effective amount of Magnoliaceae plant or extracts thereof to a mammal in need of such therapy. Preferably the mammal is human and the compositions have comprise at least two compounds selected from magnolol, honokiol, and magnoflorine. Alternatively, the compositions may also comprise about 2% honokiol by weight of the composition.
Owner:INTERHEALTH NUTRACEUTICALS

Methods of treating mild cognitive impairment (MCI) and related disorders

ActiveUS20120071468A1Progression from an asymptomatic state to a symptomatic state is prevented or delayedBiocideNervous disorderHonokiolMedicine
The invention provides compositions and methods for the treatment of mild cognitive impairment (MCI), and for inhibiting, reducing, delaying and / or preventing the progression of MCI to Alzheimer's disease. The methods entail administering an effective amount of one or more compounds selected from the group consisting of tropisetron, disulfuram, honokiol and nimetazepam. The methods also are useful for prophylactic and therapeutic treatment of amyloidogenic diseases, including Alzheimer's disease.
Owner:THE BUCK INST FOR RES ON AGING

Active compounds of Bao-Ji-Wan for anti-diarrhea and relieving gastrointestinal symptoms

InactiveUS6923992B2Decreased chloride ionDecreased water secretionBiocideHydroxy compound active ingredientsDiseaseMagnolol
The invention provides methods for treating medical conditions caused by abnormal chloride ion flux with compositions containing active ingredients isolated from the traditional Chinese medicine Bao-Ji-Wan (BJW). The compositions comprise any one, two, or three of the following: magnolol, honokiol, imperatorin, isoimperatorin or only magnolol, honokiol, imperatorin, isoimperatorin and a physiologically acceptable carrier. In preferred embodiments, the medical conditions include disorders of the gastrointestinal tract, such as diarrhea and constipation.
Owner:THE CHINESE UNIVERSITY OF HONG KONG

Magnolia extract containing compositions

Disclosed is a composition comprising at least two of the following ingredients: Magnolia extract, honokiol, humulus lupulus extract, hesperidin methyl chalcone, gotu kola, dipeptide valyl-tryptophane, palmitoyl tetrapeptide-3, corylus avellana bud extract, centella asiatica extract, cucumis sativa extract, morus alba extract, hibiscus sabdariffa flower extract, vitis vinifera extract, ascorbyl glucoside, citrus medica limonum extract, avena sativa kernel extract, hydrolyzed soy protein, aniseed myrtle extract, tasmania lanceolata leaf extract, artemisia abrotanum extract, or citrus grandis fruit extract or any combination thereof. Also disclosed are methods of treating skin conditions by topically applying the composition to skin.
Owner:MARY KAY INC

Magnolol derivative, honokiol derivative and preparation method and application thereof

The invention discloses a magnolol derivative, a honokiol derivative and a preparation method and an application thereof, and belongs to the field of magnolol or honokiol derivatives. Aiming at the defects that the magnolol and the honokiol are poor in water solubility, the invention structurally modifies or transforms the magnolol and the honokiol, introduces corresponding functional molecules and obtains the magnolol or honokiol derivative shown in formula I. Water solubility tests show that the magnolol or honokiol derivative shown in formula I has good water solubility. Pharmacodynamic tests show that the magnolol or honokiol derivative shown in formula I has an excellent antithrombosis activity and has a protection capability to cerebral ischemia-reperfusion injury.
Owner:BEIJING HONGHUI MEDITECH CO LTD

Application of magnolia bark preparation in preparing medicine for treating diabetes and obesity

The application of Magnolia officinalis preparation for the production of medicaments for treating diabetes and obesity belongs to the field of medicinal application. The Magnolia officinalis preparation is extracted from Magnolia officinalis by soaking in ethanol with magnolol and honokiol as main ingredients. The preparation has effects of in-vitro inhibiting the activity of protein-tyrosine phosphatase 1B (PTP1B) and reducing blood sugar level in rat model of type 2 diabetes. The preparation can be made into powder, pill, capsule, tablet, oral liquid and injection. It can be used for treating diabetes, obesity, and diseases related to PTP1B.
Owner:JILIN UNIV

Honokiol series derivates, preparation and use thereof

The invention relates to magnolola derivatives, the preparation method thereof, medical compounds with the magnolola derivatives as active components, as well as the application of the medical compounds in cancer treatment, pertaining to the technical field of pharmaceutical chemistry. The magnolola derivatives of the invention mainly include 3-substituted derivatives of magnolola; wherein the magnolola derivative with the formula I a is an intermediate product; the structural formula of the magnolola derivatives is II, wherein R1 is one of the following: H, halogen, hydroxyl, cyano, nitryl, amidocyanogen, alkyl, halogenated alkyl, cyanogens alkyl, hydroxide alkyl, allyl, amide, alkyloxyacyl, alkoxy, thiol group, alkyl, phenyl or heterocyclic radical. Cell poison tests and anti-tumor cell tests show that the magnolola derivatives have good anti-tumor effects.
Owner:CHENGDU JINRUI FOUND BIOTECH CO LTD

Highly effective extraction method for magnolol and honokiol crude extract

The invention discloses a method for extracting magnolol and honokiol crude extract with high efficiency, the method is that: the magnolol is dried up and crushed and sieved into 30 mesh, the magnolol is added to edible alcohol twice at the weight proportion of one grams of magnolol powder to 12 to 20ml edible alcohol, the extract temperature is 80 to 90 DEGC, the extract time is 2.0 to 3.0 hours each time, the concentration of edible alcohol is 50 to 70 percent, the two extraction crude filter liquors are combined and sieved into 200-mesh nylon fabric, a high speed centrifuge is used for centrifuging and clarifying and a clear liquid is taken out; the clear liquid at the temperature of 40 to 45 DEG C is carried out vacuum concentration by a rotary evaporator, the edible alcohol solvent is recovered and is frozen and dried in vacuum so as to obtain the crude extract, the extract rate of magnolol and honokiol is obviously higher than that of the prior art, the amounted manufacturing cost is relatively low. The method is harmless to the human body as well as to the environment by adopting edible alcohol for extraction; therefore, the method is particularly safe.
Owner:HUNAN AGRICULTURAL UNIV

Skincare formulations and regimens

ActiveUS20160120781A1Reduce visible signReducing visible signBiocideHeavy metal active ingredientsHonokiolRegimen
Provided are compositions, comprising a neolignan, ectoin, and a molecule of Formula I:wherein R1, R2 and R3 are independently H, methyl, ethyl, propyl, or isopropyl; wherein X is S or O. In some cases, the molecule of Formula I is ergothioneine (EGT). In some cases, the at least one neolignan is honokiol or a derivative thereof. Honokiol may be provided in the form of magnolia bark extract. Methods of making and using these compositions are also provided.
Owner:STELLA & DOT

Honokiol Derivates For the Treatment of Proliferative Disorders

The present invention provides novel honokiol derivatives, as well as pharmaceutical compositions containing the honokiol derivatives. These compounds and pharmaceutical compositions can be used in the prevention and / or treatment of cancer. In particular, honokiol derivatives, pharmaceutical compositions comprising the derivatives, and methods for their use in the treatment of myeloma are provided.
Owner:EMORY UNIVERSITY

Method for preparing high-purity magnolol and magnolol

The invention discloses a method for preparing high-purity magnolol and magnolol. The method comprises the following steps: preparing a Magnolia officinalis bark extract by use of a weakly polar solvent under heating condition, concentrating the extract, and adopting an ethanol water precipitation method to remove partial impurities; filtering, concentrating the filtrate under reduced pressure to obtain magnolol and magnolol extractum; standing the extractum to separate out the precipitate, dissolving with a small amount of petroleum ether, filtering, washing with petroleum ether, and precipitating to obtain a solid material which is crude magnolol; and then performing selective extraction with a solvent to separately obtain magnolol and crude magnolol, and recrystallizing the crude magnolol to obtain high-purity magnolol and magnolol respectively. The technology of the method has the advantages of fewer production steps, simple equipment and operation method, short production cycle and high product yield and purity; and the method is suitable for industrial production.
Owner:GUANGXI UNIV

Officinal magnolia phenol lipid frozen dried powder preparation and its use in preparing drug for cancers

ActiveCN1895237AImprove the efficiency of tumor suppressionBoost and/or modulate immunityPowder deliveryHydroxy compound active ingredientsOfficinalCholesterol
A freeze-dried powder of honokiol liposome for preparing the medicines to treat lung cancer and mammary cancer is proportionally prepared from honokiol, polyethanediol-phosphatidylethanolamine, lecithin and cholesterol. It has high synergistic and sensitizing action when it is applied in conjunction with chemicotherapeutic medicine.
Owner:CHENGDU JINRUI FOUND BIOTECH CO LTD

Compound for delaying senescence of human mesenchymal stem cells and application of same

The invention discloses the applications of compounds, selected from quercetin, chrysophanic acid, digicitrine, formononetin, honokiol, berberine, kaempferol, bergenin, deoxyepinephrine and licochalcone A, as well as derivatives thereof, in preparation of medicines applied to methods that are used for promoting stem cell proliferation, delaying senescence of stem cells, promoting differentiation of the stem cells into osteoblasts, chondrocytes and adipocytes, enhancing the vascularization capability of the stem cells and / or improving exercise tolerance of mice. The invention also discloses that the compounds can be combined with vitamin C for application.
Owner:INST OF ZOOLOGY CHINESE ACAD OF SCI

Honokiol nanoparticles and preparation method thereof

InactiveCN103705469AImprove tissue distribution in the bodyImproved drug distributionAntibacterial agentsPowder deliveryFreeze-dryingIntravenous drug
The invention belongs to the technical field of medicines, and relates to honokiol nanoparticles and a preparation method thereof. The honokiol nanoparticles are prepared by adopting an ultrasonic-precipitation method in combination with a freeze-drying technology, and the composition of prescription is as follows: the combination ratio of honokiol to a stabilizer is 1:(0.05-50). According to the honokiol nanoparticles and the preparation method thereof, through prescription optimization, povidone (PVP) and bovine serum albumin (BSA) are screened as the best stabilizer combination. The prepared honokiol nanoparticles are high in drug loading, stable in nature, simple in prescription composition, easy, convenient and feasible in preparation process, and the particle size range is 100nm-300nm; and through the preparation of the nanoparticles, the dissolution of honokiol can be obviously promoted, the oral bioavailability is improved, and tissue distribution in the body is improved. In addition, the honokiol nanoparticles can be freeze-dried, and a suitable excipient is added into the obtained freeze-dried powder for further preparing different dosage forms such as oral liquid, tablets, granules and capsules, and also can be prepared into injection for subcutaneous, muscle or intravenous drug delivery so as to be convenient for clinical application.
Owner:INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI

Product for treating skin diseases caused by Malassezia

The invention provides a product for treating skin diseases caused by Malassezia, and medicines and daily chemical products of honokiol, wherein the product treats honokiol or its derivative as an active component; and the medicines and the daily chemical products are prepared through dispersing the honokiol or its derivative in medicine carriers. Above medicaments provided by the invention can effectively inhibit the breeding of the Malassezia, have the advantages of low toxicity and high medicine effect efficiency, and have wide application prospects.
Owner:晟薇药业(上海)有限公司

Method for extracting honokiol and magnolol from mangnolia officinalis crude extract

The invention discloses a method for extracting honokiol and magnolol from a mangnolia officinalis crude extract. In existing methods of separating the honokiol from the magnolol in the mangnolia officinalis crude extract, in some methods, the cost is too high, the production volume is low, and mass production is not easy to achieve. In the method disclosed by the invention, by means of the characteristic that the magnolol and the honokiol contained in the mangnolia officinalis crude extract can be completely separated in a weak polar solution under an alkaline condition with certain concentration, the magnolol is extracted from a mixed solution by using a weak alkaline solvent, the honokiol is left in the solution, the honokiol is extracted by a strong alkaline solution, some oily impurities are left in an organic solvent layer, then acid regulation and precipitate out are carried out respectively, at this time, the contents of the honokiol and the magnolol in the obtained coarse-grain are greatly improved. The method disclosed by the invention is simple and feasible in separation and purification process and is suitable for large-scale industrial production, and the prepared magnolol and honokiol can be used for developing new medicines with single components.
Owner:浙江得恩德制药股份有限公司

Method for preparing stomach pill of aucklandia and amomum fruit

The invention provides a preparation method of stomachic pill with cyperus and amomum, including following steps: banksian rose, amomum fruit, astraolylis lancea formalyrata, dried old orange peel, tuckahoe, pinellia(processed), autgrass galingale rhizome(processed with vinegar), fruit of immature citron(sauted), round cardamom(decladded), bark of official magnolia( baked with ginger),patchouli and liquorice are respectively pulverized and mixed at first, then through the steps such as adding adhesive, granulating, drying, finishing granule, pelleting and lagging cover orderly, the product can be obtained; the adhesive is decoction solution of ginger and jujube. The preparation method has the advantages of simple technology and convenient operation, moreover, the finished product has steady quality, and compared with the former stomachic pill with cyperus and amomum, the stomachic pill with cyperus and amomum can shorten dissolving time by over 70 to 90 percent, thereby the medicine can be absorbed faster, and the contents of magnolol and honokiol are higher, thus solving the problem of nonuniform size of the pellet prepared by the water-pill method, and the dosage of the medicine can be more exact; at the same time, the invention also increases rate of finished products at one time.
Owner:上海复星临西药业有限公司 +1

Antibacterial oral care product for refreshing breath

The invention provides an antibacterial oral care product for refreshing breath. The oral care product comprises mangnoliaofficinalis bark extract and fruit and vegetable plant fermentation products. The mangnoliaofficinalis bark extract comprises magnolol and honokiol, and the fruit and vegetable plant fermentation products comprise superoxide dismutase, protease, lipase, cellulase, polypeptide and amino acid, and polypeptide and amino acid are generated through fermentation. The two natural components of the mangnoliaofficinalis bark extract and the fruit and vegetable plant fermentation products are combined for use, a remarkable synergistic interaction is achieved, adhering and breeding of bacteria in the teeth and the oral cavity are inhibited, deposition of protein, starch and fat is inhibited, and the oral problem of smelly breath is fundamentally solved. The oral care product can be prepared into multiple oral preparations by adding accessories, good stability and a good use effect are achieved, and the use form of the oral care product is greatly enriched.
Owner:SHANGHAI ZHONGYI DAILY CHEM CO LTD

Method for extracting total magnolol according to alcoholic-alkaline method

The invention provides a method for extracting total magnolol according to an alcoholic-alkaline method. The method comprises the following steps: firstly drying magnolia bark, smashing the magnolia bark and screening the magnolia bark through a 100 mesh screen, then preparing alcoholic-alkaline solution with 0.01 to 0.025N alkalinity through 50 to 70 percent alcoholic solution, mixing the magnolia bark powder and the alcoholic-alkaline solution according to the ratio of sample to solution (g / ml) being 1:10 to 1:20, performing ultrasonic extraction for 20 to 40 min, performing centrifugal separation, obtaining magnolia bark residue and alcoholic-alkaline solution I containing total magnolol, performing ultrasonic extraction again, concentrating the alcoholic-alkaline solution, adjusting the pH value of the concentrated solution to 2 to 3 through hydrochloric acid, refrigerating the concentrated solution for 6 to 8h at 2 to 6 DEG C, obtaining sediment, washing the sediment through water to be neutral, and the like. The method extracts the total magnolol according to the alcoholic-alkaline method by combining magnolol and physical and chemical properties of the magnolol, and has the advantages that the extraction efficiency is high, the energy consumption is low, the production is reduced, and the method is simple and efficient.
Owner:YAAN TAISHI BIOLOGICAL SCI & TECH CO LTD +1

Preparation of pure magnolol

A process for preparing high-purity magnolol from magnolia bark includes such steps as pulverizing, thermal extracting in ethyl acetate, vacuum concentrating while recovering ethyl acetate, extracting by petroleum ether 4-5 times, collecting liquid extract, concentrating is rotary evaporator, adding the aqueous solution of NaOH, back extracting 4-5 times, and drying deposit in air.
Owner:HEBEI AGRICULTURAL UNIV.

Method for extracting magnolol from officinal magnolia barks

The invention discloses a method for extracting magnolol from officinal magnolia barks. The method comprises the following steps of raw material processing, high-pressure microjet superfine smashing processing, supersonic extraction, extraction, crystallization and drying to obtain the magnolol, and has the advantages of being high in content, high in extraction rate, simple in process, suitable for production, low in production cost and the like.
Owner:GUILIN SANBAO PHARMA

Honokiol or magnolol or honokiol-magnolol mixed solid lipid nanosphere preparation and preparation method thereof

The invention relates to a honokiol or magnolol or honokiol-magnolol mixed solid lipid nanosphere preparation and a preparation method thereof. According to the invention, the production problem of the honokiol or magnolol or honokiol-magnolol mixed solid lipid nanosphere preparation can be effectively solved. The raw materials of the honokiol or magnolol or honokiol-magnolol mixed solid lipid nanosphere preparation comprise 0.001-40 wt% of honokiol or magnolol or the honokiol-magnolol mixture, 0.05-99.9 wt% of the solid lipid material, 0.001-85 wt% of a surfactant, and the balance being disperse medium, wherein the sum of the weight of honokiol or magnolol or the honokiol-magnolol mixture, the solid lipid material and the surfactant accounts for 0.01-60% of the total weight of the lipid nanosphere preparation. The preparation method provided by the invention comprises the following steps of: preparing a dispersed phase, preparing a continuous phase, mixing the dispersed phase and the continuous phase, dispersing the mixture to a nanometer preparation, filtering and sterilizing. The honokiol or magnolol or honokiol-magnolol mixed solid lipid nanosphere preparation has advantages of scientific composition, simple preparation and good stability, can be prepared in the forms of an injection and an ophthalmic preparation, or processed in the forms of a solid preparation, a semisolid preparation and a gas preparation.
Owner:ZHENGZHOU UNIV

Method for refining honokiol

The invention discloses a method for refining honokiol, which relates to the technical field of biomedicine. The honokiol is prepared by the following steps of material preparation, water extraction, ethanol extraction, concentration, precipitation, dissolution, absorption separation, elution, concentration, precipitation, silica gel column chromatography, gradient elution, concentration, drying,crude product obtaining, n-hexane extraction, concentration, cooling and devitrification. The method has the characteristics of short production cycle and low cost, capability of extracting and purifying the honokiol in cortex magnoliae officinalis at one time and the like, can replace the conventional two-step extraction method, and is used for extracting the honokiol from the cortex magnoliae officinalis.
Owner:李文东

Method for separating and purifying magnolol and honokiol by HP-20 macroporous resin

The invention provides a method for separating and purifying magnolol and honokiol by HP-20 macroporous resin. The method comprises a step of extracting coarse extracts of magnolia bark by 50 to 70 volume percent edible ethanol at the temperature of between 80 and 90 DEG C; and the method also comprises a step of separating and purifying the coarse extracts of magnolia bark by the HP-20 macroporous adsorptive resin, in which the coarse extracts of magnolia bark is dissolved in the edible ethanol, the HP-20 macroporous adsorptive resin is used for adsorption until saturated, the coarse extracts of magnolia bark are eluted by water, low-concentration edible ethanol and high-concentration edible ethanol respectively, the eluent is collected in order, the collected eluent is condensed by decompression to recover the ethanol, and then freeze-dried under a vacuum condition to obtain the purified magnolol and honokiol. By adopting the method, the magnolol and honokiol can be safely and effectively separated and purified by industrialized production.
Owner:HUNAN AGRICULTURAL UNIV

A synergist with synergistic antifungal effect with fluconazole

The invention discloses a novel application of honokiol and fluconazole in antifungal cooperation. According to the invention, the fungi are candida albicans. According to the invention, a standard macrodilution drug sensitivity experiment recommended by CLSI is adopted, in vitro sensitivity of honokiol towards clinically separated drug resistant candida albicans is evaluated with systematic methods such as a checkerboard macrodilution method and a time-kill curve method. Also, an in vitro synergistic effect of honokiol and fluconazole in clinic drug resistant fungi resistance is evaluated. Further, with a mice infection and treatment experiment, an in vivo synergistic effect of honokiol and fluconazole in clinic drug resistant fungi resistance is evaluated.
Owner:JILIN UNIV

Preparation method for magnolol molecularly imprinted polymer film

The invention discloses a preparation method for a magnolol molecularly imprinted polymer film. The preparation method includes the following concrete steps: both imprinted molecule magnolol and solid-phase reagent are put into a ball mill and ball-milled, so that imprinted molecule inclusion compound is obtained, and the inclusion compound, functional monomer, cross-linking agent and initiator are put into porogen, ultrasonically degasified, then added with bond and ultrasonically stirred, so that mixture is obtained; filter paper is immersed in the mixture, taken out, clamped between two glass sheets, put into an oven and heated to be polymerized, so that polymer is obtained; imprinted molecules are removed from the obtained polymer, and after washing and drying, the magnolol molecularly imprinted polymer film is obtained. The preparation method adopts the mechanochemical technology to include the imprinted molecules, so that the ability of the imprinted molecules in specific binding with the functional monomer is enhanced, as a result, the recognition selectivity of the finally prepared molecularly imprinted polymer film is greatly enhanced, and the magnolol separation effect is good.
Owner:ZHEJIANG UNIV OF TECH
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