81 results about "Imperatorin" patented technology

The invention provides methods for treating medical conditions caused by abnormal chloride ion flux with compositions containing active ingredients isolated from the traditional Chinese medicine Bao-Ji-Wan (BJW). The compositions comprise any one, two, or three of the following: magnolol, honokiol, imperatorin, isoimperatorin or only magnolol, honokiol, imperatorin, isoimperatorin and a physiologically acceptable carrier. In preferred embodiments, the medical conditions include disorders of the gastrointestinal tract, such as diarrhea and constipation.

The invention provides a compound fertilizer for radix angelicae and radix bupleuri. The compound fertilizer is prepared by comprising the following steps of: selecting multiple organic fertilizers of plant ash, pig manure, saw dust, straw, corn flour, soybean cakes and the like; fermenting so as to kill pathogenic bacteria and promote partial organisms to decompose to improve the fertilizer effects; combining and utilizing various substances of sea algae extracts and formulas so as to lower the premature seeding rate of radix angelicae and improve the content of imperatorin in radix angelicae and saponin a, d in radix bupleuri; regulating the carbon nitrogen ratio by a certain amount of nitrogenous fertilizers, phosphatic fertilizers and potash fertilizers, thereby obtaining a special nutritious compound fertilizer for culturing radix angelicae and radix bupleuri three-dimensionally. The compound fertilizer designed by the invention can meet the differences of different nutrition requirements and different growth seasons of radix angelicae and radix bupleuri purposefully, improves the medicinal material quality, and has obvious economical benefit. The compound fertilizer for radix angelicae and radix bupleuri provided by the invention is the special nutritious compound fertilizer for culturing radix angelicae and radix bupleuri three-dimensionally, and can be used for lowering the premature seeding rate of radix angelicae, improving the content of imperatorin in radix angelicae and saponin a, d in radix bupleuri, and improving the medicinal material quality of radix angelicae and radix bupleuri.

The invention provides a method for detecting coumarin series compounds, which comprises the following steps that: ultra high-efficiency liquid chromatography and tandem mass spectrometry detection are carried out to a sample, so as to determine the types and the content of coumarin series compounds contained in the sample. The coumarin series compounds comprise one or more types in vinegar Glass coumarin, dicoumarol, 6-methoxy-7-hydroxy coumarin, 7-hydroxycoumarin, 8-hydroxy-psoralen, 4-methyl-7-hydroxy coumarin, 6,7-dimethoxy coumarin, coumarin, 7-methoxy coumarin, dihydro coumarin, psoralen, psoralen, 8-methoxypsoralen, 7-methyl, 5-methoxypsoralen, 4-methyl-7-ethoxyl coumarin, 4-methyl-7-diethylamino coumarin, 2', 4,8-trimethyl psoralen, imperatorin, isoimperatorin, columbianadin and cyclocoumarol. The method of the invention can complete the analysis and the detection of 22 coumarin series compounds within 4 min.

The invention provides an angelica dahurica coumarin extract, wherein the total content of coumarin is not lower than 44.672mg / g, and the content of imperatorin is not lower than 68.623mg / g. The invention further provides an extraction method and a quality control method of the extract. The angelica dahurica coumarin extract has high extraction purity, high content of coumatin, stable quality andfunction of 5-hydroxytryptamine regulation, is capable of treating diseases caused by 5-hydroxytryptamine besides migraine, has distinguished efficacy and strong pertinency of indications, and provides a new choice for clinical treatment.

The invention relates to the technical field of medicament, providing a novel application of coumarin compound imperatorin in preparing a medicament for preventing and treating virus hepatitis and resisting immunological liver injury or chemical liver injury. Pharmacological tests prove that the imperatorin has stronger activity of inhibiting hepatitis B surface antigen (HbsAg) and hepatitis B virus e antigen (HbeAg) and resisting the immunological liver injury or the chemical liver injury, so the imperatorin can be used for preparing the medicament for preventing and treating the virus hepatitis and resisting the immunological liver injury or the chemical liver injury. The imperatorin has the advantages of convenient preparation, wide sources, low price and high safety. The invention provides the novel application of the imperatorin, and provides a new medicinal source for preventing and treating the virus hepatitis and resisting the immunological liver injury or the chemical liver injury.

The invention relates to a content determination method for an orifice-freeing rhinitis tablet, in particular to a content determination method for effective components such as cimicifugoside, 5-O-methylvisamminol, calycosin-7-glucoside, magnolin, imperatorin and isoimperatorin in the orifice-freeing rhinitis tablet. The method comprises preparation of a test solution, preparation of a control solution and determination with an UPLC (Ultra Performance Liquid Chromatography) method. By adopting the content determination method provided by the invention, a stable detection baseline, a high separation degree, high detection accuracy and high stability are achieved during determination; the content determination time is shortened greatly, the detection efficiency is increased stably, the dosage of a toxic chemical reagent is reduced greatly, and the method is more economical and environmentally friendly; meanwhile, multi-index component detection is performed, and a rapid, effective and feasible detection method is provided for the establishment of a liquid-phase fingerprinting database of the orifice-freeing rhinitis tablet; moreover, and a more comprehensive method for quantitativelycomparing and inspecting the stability of the effective components can be provided for the stability inspection of the orifice-freeing rhinitis tablet.

The invention discloses a Duliang compound soft capsule and a preparation method thereof. The soft capsule comprises the following components (per 1,000 capsules) angelica dahurica 1,128 g, ligusticum chuanxiong 282 g, and soybean oil 324-432 g. The preparation method comprises the following steps of extracting angelica dahurica and ligusticum chuanxiong with supercritical carbon dioxide to obtain volatile oil and residue; decocting the residue in water, precipitating with ethanol, vacuum drying at low temperature, and making into soft capsule. The soft capsule uses soft capsule shell material to wrap medicinal content, so as to mask the bitter taste and unpleasant taste of the medicinal content. The inventive soft capsule also has the advantages of easy administration, rapid release of medicinal content after disintegration of the soft capsule shell material, quick action, remarkably increased content of active ingredients such as imperatorin by using supercritical carbon dioxide extraction technique, high bioavailability of medicinal content, reduced impurities of extract powder, more accurately dosage, remarkably reduced particle size of medicinal powder, quick absorption during clinical treatment, good therapeutic effect, and no toxic or side effects.

The invention discloses a biphenyl furocoumarin compound and a preparation method and an application thereof; the provided biphenyl furocoumarin compound is a new compound with vasodilating activity, which is obtained by modifying and optimizing the structure based on a natural product imperatorin, reserving the pharmacological activity, improving the physicochemical property and enhancing the druggability. The preparation method of the biphenyl furocoumarin compound provided by the invention has the advantages of easily-obtained material source, mild reaction conditions, simple operation in reaction process, and cheap and easily-obtained reagents. The prepared biphenyl furocoumarin compound is a ramification of the imperatorin and has the effect similar to the imperatorin; an in vitro vascular ring tension research shows that the biphenyl furocoumarin compound has a relaxant effect on the mesenteric microvessels of rats, so that the biphenyl furocoumarin compound can be applied to preparing antihypertensive drugs.

The invention relates to the field of Chinese medicines and discloses Chinese medicinal capsules for treating prostatitis and prostatic hyperplasia and a preparation method for the Chinese medicinal capsules. By the preparation method, the transfer rates of eight medicinal active ingredients, namely phellodendrine, tanshinone IIA, salvianolic acid B, paeoniflorin, amarogentin, linderane, vaccarin and imperatorin in phellodendron, red paeony root, root of red-rooted salvia, peach kernel, root of combined spicebush, cowherb seed and angelica dahurica are all improved to over 95 percent, and are remarkably higher than the transfer rate obtained by the conventional method in China, so that the medicinal effect is improved and the cost is reduced.

The invention provides an essence suitable for low-temperature non-combustion smoke products, a preparation method and an application thereof, and relates to the technical field of low-temperature non-combustion smoke products. The essence comprises components with antitussive and expectorant effect and the components with antitussive and expectorant effect is prepared from at least one of foliumArtemisiae Argyi oil, daurian rhododendron oil, oleum viticis negundo, alpha-asarone, Germacrone, P-Cymene, guaiacol sulfonic acid potassium, acetylcysteine, isofraxidine, esculetin, ligustilide, stachydrine, ligustrazine, imperatorin, isoimperatorin, Praeruptorin A, Praeruptorin B, Praeruptorin C, hygrine, and Cuscohygrine. The antitussive and expectorant active ingredient is natural active ingredient, which can volatilize and transfer to the total particulate matter of the smoke at atomization temperature, enrich the smoke and enhance the mouthfeel, and at the same time is partly absorbed bythe human body, so that the low-temperature non-combustible smoking product has the function of regulating the respiratory system function to a certain extent.

The invention discloses a medicinal composition containing tetrahydropalmatine and imperatorin and application. The medicinal composition is prepared into various pharmaceutically acceptable solid oral formulations, such as granules, powder, tablets, pills and capsules, from the tetrahydropalmatine and the imperatorin in a weight ratio of (1-8):(1-5). Pharmacological tests show that the composition has the effects of suppressing pain and discomforts, including headache, migraine, stomachache, neuralgia, lumbago and menstrual pain; and the composition can be used for treating the pains.

The invention discloses a furocoumarin compound with a hypertension activity reducing function and preparation method thereof; the furocoumarin compound has similar nature to imperatorin, shows the activity of dilating blood vessels in isolated vascular ring tension research, and can be applied to the preparation of antihypertensive drugs. The preparation method of the furocoumarin compound has the advantages of easily available raw material sources, mild reaction conditions, simple reaction process operation, and inexpensive and easily available reagent.

The invention discloses a method for determining the content of imperatorin in perfume material angelica officinalis tincture for cigarettes, which is characterized by taking the mixed liquor of methanol and water as a mobile phase, and using a high performance liquid chromatography to detect, wherein the detector used by the high performance liquid chromatography is a diode array detector. In the method for detecting the content of imperatorin in perfume material angelica officinalis tincture for cigarettes, methanol and water are simultaneously taken as mobile phases and diluent of a sample, thus the pretreatment of the sample is relatively simple; and the high performance liquid chromatography separates matrix interferential peakbase of a target compound and the sample, thus ensuring more accurate detection result and more reliability.

The invention discloses a quality control method of radix rubiae-angelica Chinese material medical preparation for treating female metrorrhagia. The quality control method includes identification method and content measurement method of the Qianzhi Chinese material medical preparation; the identification is thin-layer chromatography identification performed on radix rubiae contrast drug, swertiamarin, pseudo-ginseng contrast medicinal materials, pseudo-ginseng saponin, ginsenoside, radix angelicae contrast medicinal materials, imperatorin, isoimperatorin, radix cyathulae contrast medicinal materials and cyasterone in the radix rubiae-angelica Chinese material medical preparation. The method is an analysis method for controlling medicine quality through controlling the activity component of the radix rubiae-angelica Chinese material medical preparation; the radix rubiae-angelica quality standard is improved and perfected; on the basis of departmental standard, the medicine quality control is improved, the quality stability and safety are guaranteed, the product technical level is improved; the quality standard of the radix rubiae-angelica Chinese material medical preparation is comprehensively promoted by means of a modern analysis method, thus the production technique of the radix rubiae-angelica is more strict and reasonable.

The invention relates to a method for extracting, separating and purifying imperatorin and cnidium lactone from fructus cnidii. The method takes the medicinal material fructus cnidii as a material, and comprises the following steps: (1) extraction; (2) high performance liquid chromatography separation and analysis; (3) semipreparative high performance liquid chromatography separation and purification; (4) purity detection and structural identification of the compounds. The separation and purification are carried out by using a semipreparative high performance liquid chromatography, wherein a mobile phase is of methanol-water, two components with high purity are obtained, and the two components respectively are the imperatorin and cnidium lactone through identification. The technological process is green and environment-friendly, serious harm to the environment does not exist, and the comprehensive cost is low.

The present invention relates to a method of isolating imperatorin, a potent inducible nitric oxide synthase inhibitor and anti-inflammatory candidate, from citrus citrus.

The invention relates to a micro-emulsion pharmaceutical composite gel ointment which is free of oil bleeding on surface. Computability of volatile components and water-soluble bases in the gel ointment is improved. As proved by transdermal absorption tests, transdermal absorption of imperatorin in the pharmaceutical composition gel ointment in the micro-emulsion form is improved, and is close to the transdermal absorption degree of ferulic fluid, and synchronously transdermal absorption of different components different in property can be improved by the micro-emulsion form. Besides, as proved by tests of preliminary stability of the micro-emulsion pharmaceutical composition gel ointment in three forms, the micro-emulsion form is favorable for enhancing stability of volatile components in the formula.

The invention belongs to the chemical and pharmaceutical field, and relates to a method for separating and purifying cnidium lactone and imperatorin from a fructus cnidii extract. The method comprises the steps: crushing a fructus cnidii medicinal material, adding anhydrous ethanol, carrying out cold immersion extraction, filtering the extraction liquid, concentrating under reduced pressure to obtain an extractum, dispersing the extractum in water, and extracting with petroleum ether; merging petroleum ether layers, and carrying out reduced pressure distillation to obtain a fructus cnidii extractum; and dissolving the fructus cnidii extractum in methanol, filtering, and carrying out supercritical fluid chromatography separation, wherein a chromatographic column is a C18 chromatographic column, a mobile phase is a supercritical fluid, and an improving agent is methanol. In the purification process, the supercritical carbon dioxide is used, organic solvents harmful to the environment are not used, the production process is green and environmentally friendly, and the obtained products have no harmful substance residues.

This invention relates to a method for extracting the effective components from Cnidium monnier. The method comprises: (1) pulverizing Cnidium monnier fruits, and sieving with a 20 mesh sieve; (2) extracting in a supercritical extraction apparatus to obtain Cnidium monnier extract; (3) dissolving Cnidium monnier extract with the same amount of ether under ultrasonication, filtering, adding the same amount of petroleum ether to the filtrate, standing at a low temperature, and filtering to obtain crystalline substances and the filtrate; (4) recrystallizing the crystalline substances with ethanol to obtain imperatorin; and (5) volatilizing ether from the filtrate, standing at a low temperature, and filtering to obtain crystals; (6) recrystallizing with ethanol to obtain osthole. The purity of the obtained compounds can be determined by thin-layer chromatography, high performance liquid chromatography and melting point detection method. The method has such advantages as high product purity, high yield, good repeatability, simple process, low toxicity.

The invention discloses an angelica dahurica decoction piece quality prediction method based on hyperspectral imaging depth analysis. The method comprises the following steps of: step 1, obtaining anangelica dahurica powder sample; step 2, acquiring data information of the angelica dahurica powder sample; step 3, preprocessing hyperspectral data; 4, selecting a characteristic wave band, removing an abnormal sample, and preparing a modeling data set; 5, dividing the data set and establishing a DBN prediction model; and step 6, performing model performance evaluation. According to the method, modeling is carried out on the basis of a deep belief network with a wavelength feature selection method for diversified hyperspectral images, and the most efficient prediction model is found, so that the imperatorin content in various anangelica dahurica decoction pieces can be rapidly and accurately quantified, efficient quality prediction of traditional Chinese medicine preparations is realized, and product grading and production decision making are assisted.

The invention relates to the field of medicinal fertilizers, in particular to an organic corn medicinal fertilizer and a preparation method thereof. The organic corn medicinal fertilizer comprises the following raw materials in part by weight: 10 to 19 parts of imperatorin, 10 to 20 parts of tender catchweed bedstraw herb, 1 to 5 parts of Chinese pulsatilla root, 20 to 30 parts of corn straw and 30 to 60 parts of farm fertilizer. The preparation method comprises the following steps of: cutting the corn straw, the imperatorin and the tender catchweed bedstraw herb off; washing the Chinese pulsatilla root, cutting the Chinese pulsatilla root off, boiling the cut Chinese pulsatilla root in water, and separating and collecting Chinese pulsatilla root decoction and Chinese pulsatilla root residues; composting, wherein a composting surface is formed at each height of 10 to 15 centimeters; spraying the Chinese pulsatilla root decoction on each composting surface until finishing composting; and covering composts by using a plastic film and sealing until the composts are decomposed thoroughly. By the organic corn medicinal fertilizer, the aims of 'changing wastes into wealth' and 'integrating medicines and fertilizers' are fulfilled, and the organic corn medicinal fertilizer has the effects of soil repair, low carbon and safety and can supply nutrient elements to corn comprehensively.

The invention provides a method for separating and purifying isoimperatorin and imperatorin from angelica dahurica. The method comprises the following steps: crude angelica dahurica medicine is ground, petroleum ether is added, the mixture is subjected to backheating and refluxing, and an extracting solution is filtered and subjected to pressure reduction concentration to obtain an angelica dahurica extract; the angelica dahurica extract is dissolved with methanol, the mixture is filtered, a filtering product is subjected to supercritical fluid chromatographic separation, a chromatographic column adopts the C18 chromatographic column, a mobile phase adopts a supercritical fluid, and an improving agent adopts the methanol. An organic solvent harmful to the environment is not used, the production process is environment-friendly, and a product is free of residual hazardous substances; carbon dioxide is easy to recycle, and the energy consumption and the production cost are low.

The invention discloses imperatorin sustained release tablets and a preparation method thereof. The imperatorin sustained release tablets comprise the following components in percentage by mass: 10.0 to 20.0 percent of imperatorin, 10.0 to 20.0 percent of sustained release medium and the balance of auxiliary material. The sustained release medium is one or more of hydroxypropyl methyl cellulose, polyvinylpyrrolidone, carbomer, sodium carboxymethylcellulose, methylcellulose and ethylcellulose. The imperatorin sustained release tablets provided by the invention can be used for treating hypertension disease. The imperatorin and the sustained release medium are proportioned, therefore the imperatorin can be released in the sustained release medium slowly and stably so as to fulfill the aim of controlling the release rate of the imperatorin.

The invention discloses an HPLC measurement method for content of multi-index components in rhizoma corydalis pain relieving drop pills. A high performance liquid chromatography (HPLC) method is adopted; a mixed contrast solution is used as a contrast, and tetrahydropalmatine is used as a reference; meanwhile, 7 main components, including protopine, palmatine, dehydro-corydaline, tetrahydropalmatine, corydaline, imperatorin and isoimperatorin, in the rhizoma corydalis pain relieving drop pills are measured simultaneously. According to the method, QAMS is realized; measurement of multiple components is realized by adopting relative correction factors among the components; the quality of the multiple components of a traditional Chinese medicine is controlled, thus realizing evaluation on quality of multiple indexes of the rhizoma corydalis pain relieving drop pills. The method is easy and convenient to operate, and quick; the detection cost and time are greatly reduced; the working efficiency and the practicability of the method are improved; the quality of traditional Chinese medicinal products can be controlled more effectively, comprehensively and accurately; stability and uniformity of the product quality are guaranteed, so that the aim of safe and effective taking of the product is fulfilled.

The invention provides a method used for detecting the content of coumarin components in an angelica dahurica medicinal material on the basis of UPLC and the quantitative analysis of multiple components by a single marker. According to the method, four components in the coumarin components in the angelica dahurica medicinal material can be detected at the same time on the basis of the quantitativeanalysis of multiple components by the single marker. Compared with a common HPLC detection method, the method has the advantages of better stability, higher accuracy, shorter detection time, higherefficiency and lower detection cost. According to the method adopted, the content of isoimperatorin, oxypeucedanin and oxypeucedanin hydrate is calculated through a relative correction factor f and chromatographic peak positioning under the condition of lack of isoimperatorin, oxypeucedanin and oxypeucedanin hydrate reference substances; and therefore, the measurement of the content of the coumarin components of the isoimperatorin, oxypeucedanin and oxypeucedanin hydrate in the angelica dahurica can be realized, and a new method is provided for the quality control of the angelica dahurica.

The invention provides the application of imperatorin in preparing antineoplastic drugs with multi-drug resistance (MDR), wherein the imperatorin is extracted from angelica roots. The oncolytic effect of the imperatorin on tumor cells with MDR is obviously better than that of normal clinical medicines such as adriamycin, cis-platinum and the like, and the mechanism of killing high-expression P-glycoprotein tumor cells by the imperatorin is not affected by the high-expression P-glycoprotein tumor cells, the imperatorin induces the apoptosis of tumor cells with MDR and then ensure the tumor cells with MDR to be consistent with parental drug sensitive cells. Because currently, the medicines which can reverse the MDR of tumor cells clinically are lacking, the imperatorin has a good application prospect in preparing antineoplastic drugs with MDR.

The invention relates to a construction method of an HPLC fingerprint of Qian Bai Bi Yan Pian. The method comprises the steps of: carrying out preparation of a mixed reference substance solution, wherein hyperoside, p-hydroxycinnamic acid, notopterol, chrysophanol, isoimperatorin, chlorogenic acid, imperatorin, amentoflavone, physcion, emodin, osthole, caffeic acid and kaempferol reference substances are added into a solvent to obtain the mixed reference substance solution; carrying out preparation of a test substance solution, wherein a sample of Qian Bai Bi Yan Pian is added into methanol with a volume fraction of 25%-100% for extraction, and subsequent filtrate is obtained after filtration of extract to obtain the test substance solution; and respectively injecting the mixed reference substance solution and the test substance solution into a high performance liquid chromatography, and carrying out measurement and determination to obtain the fingerprint. The constructed fingerprint can comprehensively reflect quality information of Qian Bai Bi Yan Pian, has the advantages of fastness, stability, high precision, high reproducibility and the like, and can be used for quality control of Qian Bai Bi Yan Pian.

The invention provides an angelica dahurica coumarin extract, wherein the total content of coumarin is not lower than 44.672mg / g, and the content of imperatorin is not lower than 68.623mg / g. The invention further provides an extraction method and a quality control method of the extract. The angelica dahurica coumarin extract has high extraction purity, high content of coumatin, stable quality andfunction of 5-hydroxytryptamine regulation, is capable of treating diseases caused by 5-hydroxytryptamine besides migraine, has distinguished efficacy and strong pertinency of indications, and provides a new choice for clinical treatment.

The invention relates to the field of medicine and pharmacology, in particular to medical application of an imperatorin against enteritis. The imperatorin disclosed by the invention is used as a PXR (Pregnane X Receptor) receptor stimulant for preventing and treating inflammation, diarrhea and the like caused by ulcerative colitis, chronic colitis and crohn disease.

The invention relates to a treating agent for removing drug residues in wastewater of an amoxicillin production workshop. The treating agent is compounded from components as follows: 2, 6-dimethyl-2,6-octadiene-8-ol, actein, methyl 2-aminobenzoate, ferrous gluconate, psoralen, 4-methyl-1-(1-methyl ethyl)-3-cyclohexene-1-ol, 2,4-dimethylthiazole, salicin, schisandrin, polyoxyethylene lauryl ether, cyclopentadecanolide, imperatorin, polyacrylamide, acetyl-11-carbonyl-beta-boswellic acid and isolicoflavone. The treating agent has high complexing capability with a target substance, and the removal rate can reach 99.9%.