The invention provides a preparation method and detection method for oxides of ticagrelor, i.e., (1S,2S,3R,5S)-3-[7-{[(1R,2S)-2-(3.4-difluorophenyl)cyclopropyl]amino}-5-(propylthionyl)-3H-[1,2,3]triazolo-[4,5-d]pyrimidine-3-yl]-5-(2-hydroxyethoxyl)cyclopentane-1,2-diol and (1S,2S,3R,5S)-3-[7-{[(1R,2S)-2-(3.4-difluorophenyl)cyclopropyl]amino}-5-(propylthioacyl)-3H-[1,2,3]triazolo-[4,5-d]pyrimidine-3-yl]-5-(2-hydroxyethoxyl)cyclopentane-1,2-diol, and application of the oxides in the quality control research of ticagrelor.