105 results about "Ylide" patented technology

A process for the preparation of alkyl esters of N-protected oxo-azacycloalkylcarboxylic acids of Formula III: comprises contacting a ketosulfoxonium ylide of Formula II: with an iridium catalyst to obtain Compound III, wherein PG1 is an amine protective group; k is 0, 1, or 2; and RU, R1, R2, and R3 are defined herein. An embodiment of the process further com rises contacting a compound of Formula I: with a sulfoxonium halide of formula (RU)3S(O)Z, wherein Z is halide, in the presence of a strong base to obtain Compound II. Additional embodiments add a series of process steps leading to the synthesis of 7-oxo-1,6-diazabicyclo[3.2.1]octanes suitable for use as β-lactamase inhibitors.

The invention discloses a preparation method of (E)-3-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino) pyrimidine-5-yl] acrolein which can be used as a rosuvastatin intermediate. The preparation method comprises the following steps: reacting 4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino) pyrimidine-5-yl-formaldehyde with a sulfur ylide reagent under an alkaline condition to generate an epoxide shown in the formula III; then, reducing in the presence of a metal catalyst to generate a compound shown in the formula II; and finally reacting the compound shown in the formula II to generate the target product. The preparation method is simple in process and low in cost; no expensive catalyst is used; the generation of byproducts is reduced effectively so that the post-treatment becomes simple and easy to operate; in addition, the reaction yield is improved greatly; and therefore, the preparation method is quite suitable for large-scale industrial production.

The invention relates to a phosphonium salt compound containing precursor of biphosphorus ylide cyclopentadienyl cyclocarbene as well as a preparation method and application thereof, which belong to the field of organic synthesis. The adopted technical scheme is as follows: the general formula of the phosphonium salt compound containing precursor of biphosphorus ylide cyclopentadienyl cyclocarbene: FORMULA, wherein R is alkyl or aryl, X is selected from F-, Cl-, Br-, I-, PF6-, BF4-, SbF6-, ClO4- or N3-. The preparation method of the phosphonium salt compound comprises the following steps of: adding 1, 1'-ferrocene bimercury compound, tertiary phosphine PR3 and palladium chloride to an organic solvent, refluxing under protection of N2, filtering, evaporating to dryness and recrystallizing to obtain the phosphonium salt compound. In addition, in the invention, the phosphonium salt compound is used as a catalyst ligand so that the phosphonium salt compound and the metal salt act togetherto catalyze and synthesize alpha-aryl derivatives of carbonyl compound by one step. The application test indicates that compared with traditional N-heterocyclocarbene ligand, the phosphonium salt compound has excellent catalytic activity.

The invention relates to an emulsion polymerizing preparation method of polyethylene / silicon dioxide core-shell structure composite material in the technical field of composite materials. The method is that: bis-(1, 5-cyclooctadiene) nickel and ethyl 4,4,4-trifluoro-2-(triphenylphosphine ylide)-acetoacetic ester is dissolved in toluol or benzene, and then is stirred, thus obtaining ethylene polymerization catalyst. A supported catalyst is obtained by mixing the ethylene polymerization catalyst and middle-hole silicon dioxide nano granules functionalized by ethylene; by dispersing the supported catalyst in water, adding a surface active agent and carrying out an ultrasonic treatment, stable emulsion is obtained; at last, polyethylene / silicon dioxide emulsion is obtained by inputting the ethylene, increasing the temperature and polymerizing. After drying the emulsion, the annealing is carried out above the fusion temperature of the polyethylene, thus obtaining the polyethylene / silicon dioxide core-shell structure composite material. The composite material not only can be independently used as material, but also can be used as additives of other polymer nano-composite materials.

A synthesis method of sulfo-group-containing sulfur ylide comprises the following steps: reacting synthesized sulfonate represented by formula (IV) with a methylation reagent at 220-260 DEG C for 1-6h to obtain sulfur ylide represented by formula (III) when the reaction is finished; and carrying out an epoxidation reaction on the sulfur ylide of formula (III) and carbonyl compounds represented byformula (II) in a solvent at a reaction temperature of 40-60 DEG C for 1-7 h under the action of an alkaline substance, carrying out post-treatment on the reacted solution to obtain an oxirane derivative represented by formula (I), and simultaneously treating and recovering the generated protosolid sulfonate. The invention also discloses an application of the sulfo-group-containing sulfur ylide.The product is small in irritation and easy to be dissolved in water; and when the product is applied to the epoxidation reaction, the raw material alkyl sulfonate can be recycled, so that the industrial cost is reduced, and the production efficiency is improved.

Viscosifying polymers are effectively degraded during a well treatment operation with an ylide breaker or a vitamin B cofactor. The vitamin B cofactor is an ylide, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B9 or vitamin B12 or mixtures thereof. Such breakers are effective at room and elevated temperatures and high pH environments.

The invention belongs to the technical field of medicine synthesis, and especially discloses a method for preparing 7-amino-3-vinyl cephalosporanic acid. The preparation method takes GCLE as an initial raw material, the GCLE and sodium iodide and triphenylphosphine are reacted in a mixing system of an organic solvent and water to generate phosphine salt, a certain amount of alkali lye is added in an organic phase for reacting to generate the corresponding phosphorus ylide, excess free alkali in an organic phase is removed through washing, formaldehyde and ylide are added for a wittig reaction, the organic phase is concentrated to a certain weight, phenol is added for removing carboxyl protection, amino protection is removed, crystallization is carried out to obtain 7-AVCA. The synthesis method does not require a mixing organic solvent, can realize recovery of sodium iodide and formaldehyde, has the advantages of high product yield, good quality, no three wastes generation, and environmental protection, and is suitable for large scale industrial production.

Produced or flowback water from an underground reservoir having been treated with a fluid containing a viscosifying polymer and a vitamin B1 and / or ylide breaker may be recycled by deactivating the vitamin B1 and / or ylide breaker with a sulfur or phosphorus containing nucleophilic agent.

The invention relates to a method for preparing the compound of Alpha, Beta-di-hydroxyl carboxylic ester. Ionic liquid [bmim] PF6 and water are used to form two phase reaction media; phenyl diazotate or EDA reacts with water to form hydroxyl oxy ylide under the catalysis of a catalyst rhodium acetate and then aldehyde which withdraws electrons is applied to catching the active intermediate, thereby constructing the compounds of the target product of formula (I) and (II), namely, the compound of the Alpha, Beta-di-hydroxyl carboxylic ester. The method of the invention adopts raw materials which are cheap and easy to get and a 'one-pot' method to construct two chiral carbons at the same time, has short preparation line, simple operation, mild reaction conditions, a catalyst which can be recycled and reused for a plurality of times, low synthesis cost, no pollution to environment and comparatively good economic and social benefits and is conducive to industrial production. Ar1 in the formula is phenyl or phenyl with a substituent group and Ar2 is substituted phenyl with an electron withdrawing group.