The invention discloses self-compacting lightweight aggregate machine-made sand concrete. The sand concrete comprises the following raw materials in parts by weight: 260-330 parts of concrete, 140-160 parts of fly ash, 30-40 parts of mineral powder, 20-40 parts of silica fume, 420-500 parts of machine-made sand, 100-110 parts of light sand, 360-400 parts of lightweight aggregate, 150-160 parts of water, 6.8-8.3 parts of a water reducer, 0.45-2.8 parts of a slump preserving agent and 0.18-0.22 part of an air entraining agent, wherein the slump preserving agent is obtained by compounding isopentenol polyoxyethylene ether (TPEG), acrylic acid and a compound molecular weight regulator, the air entraining agent is a rosin soap type air entraining agent obtained by compounding rosin, caustic soda, triethanolamine and sodium lauryl sulfate. The machine-made sand is used to replace natural sand, and the concrete prepared by a secondary mixing method solves the problems of easy flotation of lightweight aggregate concrete aggregate, shortage of natural sand supply, and high water demand rate, easy separation and poor pumpability of lightweight aggregate machine-made sand concrete.