7681 results about "Low toxicity" patented technology

A medical device (10) includes a structure (12) adapted for introduction into a patient, the structure (12) being formed of a preferably non-porous base material (14) having a roughened or textured surface (16). The structure (12) is conveniently configured as a vascular stent with a base material (14) of stainless steel, nitinol or another suitable material. The medical device (10) also includes a layer (18) of a bioactive material posited directly upon the roughened or textured surface (16) of the base material (14) of the structure (12). The surface (16) of the base material (14) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface (16) is thought to have a mean surface roughness of about 10 μin. (about 250 nm) and a surface roughness range between about 1 μin. and about 100 μin. (about 25 nm and about 2.5 μm). The particularly preferred use of sodium bicarbonate as the abrasive to provide roughness or texture to the surface (16) of the base material (14) of the structure (12) is additionally advantageous in the low toxicity of the sodium bicarbonate to production workers, the ease of product and waste cleanup, and the biocompatibility of any residual sodium bicarbonate.

Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, at least one anti-inflammatory agent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.

Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.

The invention discloses an insecticide for agricultural pests. The insecticide contains 3-chloro-N<1>-(2-methyl-4-heptafluoroisopropyl phenyl)-N<2>-(1-methyl-1-cyanoethyl)phthalic diamide shown as a structural formula (I). The insecticide has ultrahigh insecticidal activity, high safety, reasonable toxicity, ecological toxicity and environmental compatibility, and belongs to a low-toxicity and environment-friendly pesticide.

The invention provides substituted diaryl compounds as shown in general formula (I) or their pharmaceutically acceptable salts, and also provides a preparation method; a class of novel broad-spectrum antiviral compounds and pharmaceutical salts targeting cytokines are screened and obtained through studies on structure-activity relationship and action mechanism of active compounds; the compounds not only have significant broad-spectrum antiviral activity, but also have the advantages of low toxicity and good pharmaceutical properties.

Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.

The present invention relates to the development of new porous particulate collagen sponges, combining the desirable features of low toxicity, resorbability, and satisfactory porosity, particularly when wetted in an aqueous medium. Accordingly, the present invention is directed to new porous, particulate, dehydrothermally cross-linked, wetted sponges, as well as a process for making them.

The present invention provides a medical device, preferably a contact lens, which a core material and an antimicrobial metal-containing LbL coating that is not covalently attached to the medical device and can impart to the medical device an increased hydrophilicity. The antimicrobial metal-containing coating on a contact lens of the invention has a high antimicrobial efficacy against microorganisms including Gram-positive and Gram-negative bacterial and a low toxicity, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material. Such lenses are useful as extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating thereon.

A method of treating a well consists of introducing into the wellbore a biodegradable fluid system containing a blend of lactic acid ester, such as ethyl lactate, and a fatty acid ester, such as methyl soyate. The fluid system may be further in the form of a microemulsion that is formed by combining a blend with one or more emulsifiers, an alcohol, and water. The fluid system may be used in displacement, well remediation and stimulation as well as additional, alternative applications such as the cleaning of surface and / or downhole equipment.

A method of treating a well consists of introducing into the wellbore a biodegradable fluid system containing a fatty acid ester, such as methyl soyate. The fluid system may further contain a lactic acid ester, such as ethyl lactate, and / or a nonionic surfactant. The fluid system may be used in displacement, well remediation and stimulation as well as additional, alternative applications such as the cleaning of surface and / or downhole equipment.

Hydroxypropyl-sulfobutyl-&bgr;-cyclodextrin, the preparation method, analytical method, and the pharmaceutical application thereof. The hydroxypropyl-sulfobutyl-&bgr;-cyclodextrin is a derivate of cyclodextrin which is substituted by hydroxypropyl group and sulfobutyl group: n-(2,3,6-O-2-hydroxypropyl)-m-(2,3,6-O-sulfobutyl)-&bgr;-cyclodextrin. The number of substituent groups per mole cyclodextrin is n hydroxypropyl groups and m sulfobutyl groups. “n” represents the average substituent degree of hydroxypropyl groups; “m” represents the average substituent degree of sulfobutyl groups; “n+m=z” is the gross average substituent degree, in which n is a random integer chosen from 1, 2, 3, 4, 5, 6, 7, 8, 9; m is a random integer chosen from 1, 2, 3, 4, 5, 6, 7, 8, 9; and the gross average substituent degree z is a random integer chosen from 2, 3, 4, 5, 6, 7, 8, 9, 10. The present invention shows low haemolysis and low toxicity.

The invention provides an irradiation cross-linking oil resistance type soft low smoke zero halogen flame-retardant cable material which comprises the following components in parts by weight: 60-90 parts of ethylene-vinylacetate copolymer, ethylene-propylene-diene rubber and ethylene-octylene copolymer, 0-20 parts of nitrile rubber, 10-30 parts of interface compatilizer, 80-130 parts of flame retardant, 2-15 parts of flame-retardant synergist, 0.5-1.0 part of antioxidant, 1-2 parts of cross-linking sensitizing agent and 0.5-1.0 part of lubricant. The preparation method of the cable material in the invention mainly comprises the steps of silane surface modification treatment of the flame retardant, mixing and extruding of a double screw mixer-extruder unit or an internal mixer unit, brace water cooling or water ring particle cutting and the like. The cable material provided by the invention has the advantages of superior flame resistance (single cable can vertically burn), good mechanical properties, especially high softness, oil resistance, high-temperature resistance (the cable material can be used in a range of minus 40 DEG C-125 DEG C), low smoke, low toxicity and excellent processability.

The present invention discloses two crystal models and the preparation method of the anti-hyperuricemia drug 2-(3-ayano-4-isobuoxy phenyl)-4-methyl-5- thiazole acid. The preparation method of the crystal models commonly uses the low-toxicity ethanol, ethyl acetate or acetone as the solvent; the safety is relatively high. In addition, the hygroscopicity of the two crystal models is low in the high-humidity environment and the two crystal models are suitable for the steady pharmaceutical preparation.

The invention is directed to novel prodrug compounds, compositions comprising the prodrug compounds, methods of making the prodrug compounds and methods of using the prodrug compounds. The prodrug compounds comprise a biologically active entity linked to a masking moiety via a linking moiety. The prodrug compounds are selectively activated at or near target cells and display lower toxicity and possibly a longer in vivo or serum half-life than the corresponding naked biologically active entity.

A method of treating a well consists of introducing into the wellbore a biodegradable fluid system containing a blend of lactic acid ester, such as ethyl lactate, and a fatty acid ester, such as methyl soyate. The fluid system may be further in the form of a microemulsion that is formed by combining a blend with one or more emulsifiers, an alcohol, and water. The fluid system may be used in displacement, well remediation and stimulation as well as additional, alternative applications such as the cleaning of surface and / or downhole equipment.

The invention discloses a biomedical TiZrNbTa high-entropy alloy and a preparation method thereof. The high-entropy alloy has a chemical formula of (TiaZrb)x(NbcTad)yMz; the atomic percents of all components are as follows: a not more than 35 at% and not less than 0, b not more than 35 at% and not less than 0, c not more than 35 at% and not less than 0, d not more than 35 at% and not less than 0, a+b=x, c+d=y, x not more than 70 at% and not less than 5, y not more than 70 at% and not less than 5, M is any one or more in V, Mo, Sn, W, Mn, Al, Fe, Co, Ni, Cu, Cr and Zn, z not more than 35 at% and not less than 0, and x+y+z=100. The alloy is higher in strength, excellent in plasticity and low in Young modulus; the components of the alloy is free of poison on human bodies, or are low-toxicity elements to satisfy the biomedical demands; and the high-entropy alloy is broad in application prospect in the aspect of biomedical materials.

The invention discloses a general A-type foam extinguishing agent easy to degrade. The general A-type foam extinguishing agent easy to degrade comprises the following components in parts by weight: 8%-25% of main foaming agents, 5%-20% of auxiliary foaming agents, 20%-40% of cosolvents, 0.1%-5% of foam stabilizers and the balance of water, and also comprises a proper amount of wetting penetrating agents, corrosion inhibitors and preservatives. The foam extinguishing agent has the characteristics of excellent fire extinguishing, heat-insulation protection performance and low toxicity, and can be used for rapidly fighting commonly-seen solid fire and liquid fire.

The invention belongs to the technical field of pesticide formulation and in particular relates to a composite bactericidal composite and applications thereof in aspect of preventing and curing the fungicidal and bacteria diseases of grains, fruits and vegetables. The composite bactericidal composite comprises effective ingredient A and B, wherein the effective ingredient A is prochloraz or othermetal salt composite, and the effective ingredient B comprises at least one of penconazole, imazalil sulfate, ethirimol, bupirimate, SYP-Z048, thifluzamide, mandipropamid, ethaboxam, polyoxin, polyoxin B, benziothiazolinone, famoxadone, dithianon and zinc thiazole. The composite has high efficiency, low toxicity, low residue, good environment compatibility and low cost.

A method of preparation of a cross-linked hydrogel by graft copolymerisation, said method comprises the steps of preparing an aqueous solution comprising one or more hydrophilic polymers, a cross-linking agent and a photoinitiator comprising a water-soluble peroxydisulphate, subjecting said solution to irradiation and obtaining the cross-linked hydrogel, wherein the hydrophilic polymers are saturated and the cross-linking agent acts as a co-catalyst of cross-linking. The hydrogel is fast to produce and has low toxicity. The hydrogel may be suitable for use in medical devices such as dressings and the like.

The invention discloses a beneficiation method for recovering zinc, lead and silver from a zinc leaching residue. The method basically comprises the following steps of: recovering water-soluble zinc by a washing, zinc leaching and precipitating method to obtain a zinc concentrate; and recovering lead and silver to obtain a lead-silver concentrate by a disperse, size mixing, surface modifying and floating method. When the zinc content in the precipitate obtained by the washing, zinc leaching and precipitating method is lower, selective floating and enriching are carried out on the precipitate to obtain the zinc concentrate; and selective size mixing and floating are carried out on the leaching residue to recover indissoluble zinc in the leaching residue and then the indissoluble zinc is sent to a lead and silver recovery system. The method has the advantages that the process is simple, and required equipment investment is less; the production cost is low to ensure that an economical treatment method is found for the zinc leaching residue with a low zinc content; roasting with coal is not needed, thus the smoke pollution problem is avoided; return water can be recycled; and floatingtailings are subjected to low-toxicity treatment, and dry stockpiling can be used for replacing full size tailings library stockpiling, therefore, potential safety hazards of the full size tailings library are eliminated.

A primer composition with reduced toxicity suited for reduced-energy ammunition comprises bismuth (III) oxide as the principal oxidizer and contains a portion of propellant composition mixed therein. This composition may also be used in a cartridge which is otherwise substantially free of any other propellant compound and preferably produces a residue which is substantially free of toxic substances.

The present invention mainly relates to formation of zebrafish with hepcidin gene knocked out, by the use of CRISPR / Cas9 technology, a unique PAM region is designed, so that the hepcidin gene in the zebrafish is knocked out, and other genes are not accidentally injured. The first case of hepcidin knockout transgenic animal model zebrafish has great significance, the hepcidin is a major factor in the regulation of iron, once the hepcidin is knocked out, an animal model can be successfully molded into an iron overload animal model, the human factor intervention can be excluded, the hepcidin has great significance to iron expression researches, meanwhile compared with the traditional gene knockout technology, the CRISPR / Cas9 technology has low toxicity, high accuracy, high efficiency, short success cycle and other characteristics, and the hepcidin gene can be faster knocked out.

A compound having immunosuppressive activity with low toxicity or a pharmacological salt thereof. The compound has a general formula (I) shown below or a pharmacologically acceptable salt thereof, or a pharmacologically acceptable prodrug thereof

The invention discloses a halogen-free flame retardant thermoplastic polyolefin cable material. The cable material consists of the following components in parts by weight: 0-40 parts of polyethylene resin, 20-80 parts of ethylene copolymer, 20-40 parts of compound flame retardant, 5-20 parts of compatilizer, 4-50 parts of flame retardant synergist, 1-4 parts of coupling agent, 0.5-4 parts of antioxidant and 1-10 parts of processing aid. According to the halogen-free flame retardant thermoplastic polyolefin cable material disclosed by the invention, the flame retardant is formed by compounding a borate flame retardant and a phosphorus nitrogen flame retardant; by adding a small amount of compound flame retardant, the cable material obtains a good flame retardant effect and an excellent smoke suppression effect; and the cable material has low smoke density and low toxicity index.

The invention relates to a preparation method of an organic exhaust gas micro-emulsion absorption liquid, and a method for applying the micro-emulsion absorption liquid for cleaning industrial organic exhaust gas comprising benzene, toluene, xylene, and the like. The invention belongs to the technical field of atmosphere pollution control. The absorption liquid is prepared from the components of, by mass, 80-90% of water, 0.5-3% of a surfactant, 7-19.5% of a coupling agent, and 0.02-0.06% of an auxiliary agent. The surfactant is sufficiently mixed with water, such that a surfactant solution is obtained; the auxiliary agent is dissolved in water, such that an auxiliary agent solution is obtained; the two solutions are combined and uniformly mixed; and the coupling agent is added, and the obtained solution is stirred, such that the organic exhaust gas micro-emulsion absorption liquid is obtained. The organic exhaust gas micro-emulsion absorption liquid is suitable to be used for controlling exhaust gas containing benzene-series volatiles, and has the advantages of convenient raw material source, low cost, mild and stable property, low toxicity, environment-friendliness, no absorption tower corrosion or blocking phenomena, no severe influence to human health, high removal rate to organic exhaust gas, no need of pretreatment upon exhaust gas, and low investment and running cost. Saturated absorption liquid and absorbed organics can be recycled, such that waste can be turned useful.

Methods of manufacturing a rechargeable power cell are described. Methods include providing a slurry or paste of negative electrode materials having low toxicity and including dispersants to prevent the agglomeration of particles that may adversely affect the performance of power cells. The methods utilize semi-permeable sheets to separate the electrodes and minimize formation of dendrites; and further provide electrode specific electrolyte to achieve efficient electrochemistry and to further discourage dendritic growth in the cell. The negative electrode materials may be comprised of zinc and zinc compounds. Zinc and zinc compounds are notably less toxic than the cadmium used in NiCad batteries. The described methods may utilize some production techniques employed in existing NiCad production lines. Thus, the methods described will find particular use in an already well-defined and mature manufacturing base.

The invention relates to an agricultural chemical missible oil preparation with biological diesel oil dissolvent, the ingredient comprises agricultural chemical original raw pesticide, dissolvent, and emulsifying agent, wherein the dissolvent is biological diesel oil or is mixed dissolvent which is mixed by biological diesel oil and conventional agricultural chemical in any proportion. The invention uses biological diesel oil as dissolvent to replace or partially replace conventional dissolvent in the prior art, which has the advantages of high efficiency, safety, environmental protection, and low toxicity, and can reduce the cost of agricultural chemical.

The invention discloses a soft low-smoke halogen-free flame-retardant polyolefin cable material and a preparation method thereof. The cable material comprises the following components (based on by mass part ratio): 80-90 parts of copolymer of ethylene-vinylacetate, 10-20 parts of linear low-density polyethylene, 65-130 parts of an inorganic fire retardant through surface treatment, 10-30 parts of high-effective flame retardant synergist, 10-20 parts of high molecular compatilizer, 0.9-1.5 parts of antioxidant and 1-2 parts of processing aid. The preparation method comprises the steps of resin blending extrusion; surface treatment of the inorganic fire retardant; batching, mixing, extrusion, granulation and the like. Compared with the prior art, the invention has the characteristics of predominant flame retardation (an oxygen index up to 36), excellent toughness, excellent bending resistance, low density (density is only 1.28g / cm<3>), low smoke, low corrosion, low toxicity, environmental protection, good processability, bright surface of extrudates and the like.

The present invention provides improved solvent systems for the preparation of liquid formulations of urease or nitrification inhibitors, specifically NBPT, comprising alkylene glycol alkyl ethers. The solvent systems provided good solubility of the urease inhibitor as well as at least one of improved stability, lower flammability, lower toxicity, improved cold temperature storage, improved handling, improved adsorption onto and / or solubility with solid media such as UFP or urea. Methods of making and using the compositions are also provided.

The invention belongs to the technical field of medicines, and discloses a delivery system based on protein-phospholipid. The system comprises a protein-phospholipid dispersion with the weight ratio of between 1:100 and 100:1, wherein the grain size of the protein-phospholipid is between 5 and 1,000nm, and the surface of the phospholipid or the surface and the inside of the phospholipid are coated / covered by a protein layer. The preparation method comprises: preparing a phospholipid containing phase, preparing a protein containing water phase, performing the homogenization treatment on the phospholipid containing phase and the protein containing water phase at a temperature of between 0 and 40 DEG C and under a pressure of between 400 and 40,000psi, and obtaining a dispersion system with the average grain size of less than 1,000nm. The delivery system has the advantages of realizing the delivery in various ways such as injection, oral taking, cavities and canals, skin and the like, and lowering side effects of medicines. The delivery system solves the problems of drug-loading rate and stability of protein nano-grain and liposome, and adopts low-toxicity organic solvent, even no organic solvent; and the preparation method is easy for industrialized application, and can prepare a liquid type protein-phospholipid containing delivery system.