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829results about "Sulfonic acid esters preparation" patented technology

Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging

InactiveUS20060292073A1Maximum service lifeOrganic compound preparationSulfonic acid esters preparation1-amino-3-fluorocyclobutane-1-carboxylic acidCyclobutane
The radiolabeled non-natural amino acid 1-amino-3-cyclobutane-1-carboxylic acid (ACBC) and its analogs are candidate tumor imaging agents useful for positron emission tomography and single photon emission computed tomography due to their selective affinity for tumor cells. The present invention provides methods for stereo-selective synthesis of syn-ACBC analogs. The disclosed synthetic strategy is reliable and efficient and can be used to synthesize a gram quantity of various syn-isomers of the ACBC analogs, particularly, syn-[18F]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC) and syn-[123I]-1-amino-3-iodocyclobutane-1-carboxylic (IACBC) acid analogs.
Owner:EMORY UNIVERSITY

Mitoquinone Derivatives Used as Mitochondrially Targeted Antioxidants

This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxyphenyl alkyl triphenylphosphonium or methoxy dioxocyclohexadiene alkyl triphenylphosphonium derivatives. The compounds, compositions, dosage forms, uses and methods are useful in, for example, the treatment of diseases or conditions associated with oxidative stress.
Owner:ANTIPODEAN PHARMA

Suppression of carcinoma using high purity conjugated linoleic acid (CLA)

A method for the treatment of carcinoma in a human is disclosed, including administering to a human a therapeutically effective amount of 9-cis, 11-trans octadecadienoic acid formed by reacting an ester of ricinoleic acid with a tosyl chloride or a mesyl chloride to form a tosylate or mesylate of an ester of ricinoleic acid, and reacting the tosylate or mesylate of an ester of ricinoleic acid with diazabicyclo-undecene. The method includes administering to a human a purified conjugated linoleic acid (CLA) produced by a novel synthesis process for producing 9-cis, 11-trans octadecadienoic acid at room temperature in high yield including providing a tosylate or mesylate of a methyl ester of ricinoleic acid and providing a purified 9-cis, 11-trans octadecadienoic acid formed when the tosylate or mesylate reacts with diazabicyclo-undecene.
Owner:MATREYA

Gemini perfluoroalkylsulfonyloxybenzyl cationic surfactant as well as preparation and application thereof

The invention discloses a gemini perfluoroalkylsulfonyloxybenzyl cationic surfactant as well as preparation and application thereof. The structural general formula of the surfactant is as shown in a formula I, wherein Rf is perfluorobutylsulfonyl or perfluorohexylsulfonyl; n is 2, 3, 4 or 6; X is a counter anion. The perfluorobutylsulfonyl or the perfluorohexylsulfonyl is a fluorine-containing precursor material; the gemini perfluoroalkylsulfonyloxybenzyl cationic surfactant is obtained through the sulfonation of the fluorine-containing precursor material with p-hydroxybenzylalcohol, chlorination with a halogenating reagent and quaternization with tetramethyl alkyl diamine. The gemini cationic surfactant provided by the invention is free of a perfluorooctyl group with a lasting organic pollutant characteristic, high in surface activity and low in critical micelle concentration; an aqueous film-forming foam fire extinguishing agent obtained by compounding the gemini cationic surfactant with additives is quick in aqueous film-forming spreading speed and excellent in fire extinguishing performance.
Owner:HUAZHONG NORMAL UNIV +1

Bilastine preparation method

The invention discloses a Bilastine preparation method. The Bilastine preparation method includes that 2-nitroaniline which is low in price and easy to obtain is taken as a raw material which is subjected to reduction-n-cyclohexylmaleimide reaction, alkylation reaction, hydrolyzing and coupling prior to hydrolyzing to obtain Bilastine. With the method, shortcomings that harsh operation conditions, high toxicity, expensive raw materials and tedious operation in the prior art are overcome, reaction conditions in each step are moderate, and the synthetic method is simple in operation, easy to deal with, few in side products, high in yield and purity, low in production cost and suitable for industrial production.
Owner:SHANDONG LUOXIN PHARMA GRP HENGXIN PHARMA CO LTD

Compound for preparation of cariprazine and preparation method thereof

The invention relates to a compound for preparation of cariprazine and a preparation method thereof. The method can overcome the defects in the prior art, the used raw materials and reagents are low toxic, cheap and easily available, the reaction conditions are mild, fewer three wastes are generated, at the same time, the operation is simple and safe, and the yield is good, therefore the method is suitable for industrialized production.
Owner:NHWA PHARMA CORPORATION

Methods for producing cyclic benzamidine derivatives

In the present invention, the methods of producing a fluorinated cyclic benzamidine derivative (A), or a salt thereof, comprise the step of reacting a specific novel compound with ammonia or imide. The methods of this invention for producing a morpholine-substituted phenacyl derivative (B), or a salt thereof, comprise reaction of a specific novel compound with morpholine, reaction of the product with a halogenating reagent, and deketalization of the product. The methods of this invention for a producing cyclic benzamidine derivative (C), or a salt thereof, comprise the step of coupling compound (A), or a salt thereof, with compound (B), or a salt thereof, in the presence of an ether or a hydrocarbon. The methods of this invention for recrystallizing a cyclic benzamidine derivative (C), or a salt thereof, comprise the steps of dissolving compound (C), or the salt thereof, in a mixed solvent comprising an alcohol and water, or a mixed solvent comprising an ether and water, and after dissolution, adding additional water to precipitate crystals of compound (C), or the salt thereof.
Owner:EISIA R&D MANAGEMENT CO LTD
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