103 results about "Dimethylurea" patented technology

Highly concentrated, water-based dispersions of certain lipophilic and/or hydrophobic antimicrobially active materials are stabilized to a surprising degree by a surfactant combination including a nonionic acrylic graft copolymer surfactant and a alkoxylated polyarylphenol phosphate ester surfactant. The active materials may be present in dispersion concentrates of the present invention singly or in useful combinations. The active materials are selected from the group of fungicides and bactericides consisting of 1,2-benzisothiazol-3(2H)-one; 2-octyl-2H-isothiazol-3-one; 5-chloro-2-methyl-2H-isothiazol-3 -one; 2-methyl-2H-isothiazol-3-one; pyrithione zinc; 3-iodo-2-propynyl butylcarbamate; 2-methylthio-4-ethylamino-6-tert-butylamino-s-triazine; and 3-(4-isopropylphenyl)-1,1-dimethylurea, and mixtures thereof. The dispersion concentrates may be efficiently shipped and stored, and subsequently diluted with water to produce less concentrated dispersions when desired. Even at relatively high concentrations, the dispersion compositions of the present invention can be stored for months or years without significant loss of stability.

The invention discloses a 3-cyclohexyl-1,1-dimethylurea compound as well as a preparation method and application thereof. The 3-cyclohexyl-1,1-dimethylurea compound is used for preparing an antischizophrenic drug cariprazine. Compared with the prior art and report literatures, the preparation method of the 3-cyclohexyl-1,1-dimethylurea compound has the remarkable advantages of being free of removal of protecting groups such as Boc group, high in atom economy, low in cost and easy in getting of raw materials, mild in reaction condition, stable in yield, simple and convenient to operate, controllable in product quality, high in product purity, less in three waste pollution and easy to produce industrially. The structure formula of the 3-cyclohexyl-1,1-dimethylurea compound is as shown in (I) in the specification.

An epoxy resin composition comprising the following Component (A), Component (B), Component (C), and Component (D): Component (A): an organic phosphinic acid metal salt; Component (B): an epoxy resin; Component (C): dicyandiamide or a derivative thereof; and Component (D): a curing accelerator having a dimethylureido group. The epoxy resin composition described above, further comprising the Component (E) which is an imidazole-based curing accelerator having a curing initiation temperature of 100° C. or higher as measured by the following method. Measurement method of a curing initiation temperature: a sample resin composition is prepared by adding 10 parts by mass of an imidazole-based curing accelerator to 100 parts by mass of a bisphenol A type epoxy resin having an epoxy equivalent of 180 to 220, and mixing the components. For this sample resin composition, the calorific value is measured using a differential scanning calorimeter (DSC) at a rate of temperature increase of 10° C./min, and the temperature at the intersection point of the tangent line at the inflection point of the DSC curve thus obtained and the baseline is designated as the curing initiation temperature.

A blood cell analyzer diluent and a hemolytic agent, are characterized in that one litre diluent is provided with 12.0-4.0g of sodium chloride, 2.0-10.0g of sodium sulfate, 0.8-0.5g of 1,3,2-methylol urea, 0.2-0.5g of copper sulfite, 3.0-8.0g of EDTA-2Na, 0.2-0.7g of Piperacillin Sodium, a borate buffering liquid toning the ph value to 7.2-7.8, and the balance is water; one litre hemolytic agent is provided with 0.8-5.0g of potassium chloride, 0-60.0g of dodecyl trimethyl ammonium chloride, 14.0-0g of octadecyl trimethyl ammonium bromide, 6.0-10.0ml of isopropanol, carbonate or alcaine buffering liquid toning the ph value to 7.2-7.8, and the balance is water. The inventive reagent can form stable hemoglobin derivatives, and the absorption spectrum curves are similar when lambada is 540nm, lambada is 504nm, which can satisfy the clinical inspection requirement; the reagent does not contain cyanide, azide, and has non-toxicity, which can effective improve working atmosphere of operating staff, and can reduce harm of toxicant to personal health.

The invention discloses a marine modified silicone-acrylic resin antifouling antibacterial coating. Raw materials of the coating comprise modified silicone-acrylic resin, chlorosulfonated polyethylene, teflon, a vinylidene fluoride-hexafluoropropene copolymer, nano-silver, carbon nanotube, carbon fiber, nano-sized iron oxide, nano-zinc oxide, kaolin, lanthana, 3-(3,4-dichlorophenyl)-1,1-dimethylurea, PTPB, 4,5-dichloro-2-n-octyl-3-isothiazolinone, trimethyl silicone oil, a coalescing agent, a dispersant, an antifoaming agent, a corrosion inhibitor, a leveling agent and a thickening agent. The marine modified silicone-acrylic resin antifouling antibacterial coating has high hardness and good antifouling property and antibacterial property, and has an effect of inhibiting adhesion of multiple marine organisms when in use.

The invention provides a preparation method for an artificial antigen of theophylline. The preparation method comprises the following steps of: (a) preparing and detecting a hapten: reacting 5,6-diamido-1,3-dimethylurea pyrimidine (1) with glutaric anhydride to obtain the hapten containing carboxyl; (b) preparing and detecting the artificial antigen: combining the hapten with bovine serum albumin (BSA) by utilizing a carbodiimide method, so as to prepare the artificial antigen of the theophylline, namely theophylline-bovine serum albumin. According to the preparation method, the prepared artificial antigen of the theophylline can be subjected to animal immunization to obtain corresponding theophylline antibodies and can be used for researching various theophylline immunoassay methods, and a relatively convenient, fast and accurate way is provided for the detection of the theophylline.

The invention discloses a preparation method of 6-amino-1,3-dimethyluracil. According to the preparation method, cyanoacetic acid and 1,3-dimethylurea undergo condensation under the action of acetic anhydride so as to obtain 2-cyano-N-methyl-N-[(methylamino)carbonyl]acetamide; and then 2-cyano-N-methyl-N-[(methylamino)carbonyl]acetamide undergoes a cyclization reaction under an alkaline conditionso as to obtain 6-amino-1,3-dimethyluracil. The 6-amino-1,3-dimethyluracil has a good system stabilizing effect when used as a main component of a PVC stabilizer along with zinc stearate, and has a better synergistic effect than a commonly-used counterpart in the industry at present. The 6-amino-1,3-dimethyluracil can absorb HCl and also can replace unstable chlorine atoms. On the other hand, the6-amino-1,3-dimethyluracil also can react with ZnCl2 to generate a metal complex and inactivate ZnCl2. Thus, long-term stability of a PVC sample is greatly enhanced.

The invention provides a preparation method of 6-chloro-1,3-dimethyluracil, which comprises the following steps: carry out reflux reaction on 1,3-dimethylbarbituric acid and a chlorinating agent in a water-insoluble organic solvent to obtain a reaction mixture; and adding water to quench the reaction to obtain the 6-chloro-1,3-dimethyluracil, wherein the chlorinating agent comprises phosphorus oxychloride. The preparation method provided by the invention reduces the consumption of phosphorus oxychloride, and does not need to perform vacuum distillation on the phosphorus oxychloride. Furthermore, additives can be added in the reaction process to enhance the yield of the 6-chloro-1,3-dimethyluracil. The invention also provides a method for synthesizing 1,3-dimethylbarbituric acid, which is implemented by reacting 1,3-dimethylurea, dimethyl malonate and a condensing agent in an organic solvent. The method avoids using abundant malonic acid and acetic anhydride.

The invention belongs to the technical field of organic synthesis, and provides a novel method for synthesizing cariprazine. The novel method comprises the following steps: firstly, carrying out condensation reaction on trans-2-(4-(3,3-dimethyl ureido) cyclohexyl) acetic acid and 1-(2,3-dichlorophenyl) piperazine to obtain 3-(trans-4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-2-oxo-ethyl}-cyclohexyl)-1,1-dimethylurea; and secondly, reducing 3-(trans-4-{2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-2-oxo-ethyl}-cyclohexyl)-1,1-dimethylurea by using borane to obtain the cariprazine. The method hasthe advantages that process steps are greatly shortened, the purity of a final product is ensured and the total yield is obviously increased.

The invention discloses a production system and a production method for preparing 6-amino-1, 3-dimethyluracil. According to the method, a methyl cyanoacetyl urea solution and caustic soda liquid are used as raw materials, the methyl cyanoacetyl urea solution and the caustic soda liquid are input into an impinging stream reactor at a certain speed and are in rapid contact and fully mixed in the reactor, then the mixture enters a reaction kettle, the temperature of the reaction kettle is controlled to be 50-150 DEG C, the reaction kettle is provided with an online pH meter, the pH value is controlled according to the end point, and caustic soda liquid is supplemented; the method comprises the following steps: reacting a dimethyl cyano acetylurea solution with liquid caustic soda in a reaction kettle to generate 6-amino-1, 3-dimethyluracil slurry, and carrying out centrifugal separation to obtain the product 6-amino-1, 3-dimethyluracil. In the reaction process, the 6-amino-1, 3-dimethyluracil is prepared through impinging stream atomization reaction, and the particle size distribution can be controlled. According to the invention, the caustic soda liquid and the dimethyl cyanoacetylurea solution are continuously fed, and the two solutions are rapidly and uniformly mixed in the impinging stream mixer, so that the reaction efficiency is improved, and good economic efficiency can be obtained.

The invention discloses a method to prepare 1, 3-dimethyl barbituric acid through the reaction of malonic ester and 1, 3-dimethylurea. The method adopts sodium alcoholate as catalyst and lower aliphatic alcohol or the mixture of the lower aliphatic alcohol and phene, toluene or dimethyl benzene as solvent, wherein, the catalyst and the solvent are blended in a reactor to a raised temperature of 60-120 DEG C and done with reflux reaction for 9-10 hours; after the completion of the reaction, the reacted product is cooled to precipitate solid which is then filtered and then dissolved in water; then the pH of the solution is adjusted to 1-2 by adding hydrochloric acid and cooled to precipitate crystal, which is filtered again and crystallized again to obtain the 1, 3-dimethyl barbituric acid. The invention has low-cost raw materials, simple operation and high product yield.

The invention discloses a synthetic method of high-purity high-yield theophylline. The synthetic method comprises the following steps: preparing 6-amino-5-bromo-1,3-dimethyl uracil by adopting sodium acetate trihydrate, 6-amino-1,3-dimethyl uracil, anhydrous acetic acid and liquid bromine; preparing 6-amino-5-benzylamino-1,3-dimethyl uracil by adopting 6-amino-5-bromo-1,3-dimethyl uracil and benzylamine; preparing 1,3-dimethyl-7-benzyl xanthene by adopting 6-amino-5-benzylamino-1,3-dimethyl uracil, p-toluene sulfonic acid, triethyl orthoformate and DMF (dimethyl formamide); and preparing theophylline from 1,3-dimethyl-7-benzyl xanthene, a palladium carbon catalyst and methanol in a hydrogen high-pressure environment. According to the synthetic method disclosed by the invention, the reaction starting material is simple and easy to obtain, the used reagents are safe and environment-friendly, the production cost is greatly reduced, and the preparation process is simple and easy to operate; and compared with the prior art, the reaction environment related to each step is small in pollution, and the yield and purity of obtained theophylline are greatly improved.

The invention relates to the technical field of pest prevention and control, particularly relates to a medicine for preventing and controlling water lettuce, and also relates to a preparation method and an application method thereof. An efficient environment-friendly water lettuce prevention and control medicine consists of the following components in percentage by weight: 30-40% of N-(3,4-dichlorophenyl)-N',N'-dimethylurea, 25-35% of N-(phosphonomethyl) glycine, 20-30% of aluminum potassium sulfate dodecahydrate, 0.2-5% of nonionic surfactant and 0.2-5% of vegetable oil. Through the invention, an effect of upper control and lower curing can be realized; 24 days later, the leaves and root tips of the water lettuce thoroughly die and are dissolved, the death rate reaches 100%, and regeneration is avoided; and moreover, the medicine is nontoxic and harmless and environment-free, and prevents influence on the organisms of water bodies (aquatic fish and poultry) as well as secondary pollution.

Method of single step electrochemical generation of chlorinated urea, chlorinated dimethylurea and other chlorourea derivatives is disclosed. The chlorinated species are generated in situ and upon demand and can be used for microbial control in industrial water treatment.

The present invention relates to trans-N-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-N′,N′-dimethylurea (cariprazine), its salts, close analogs, derivatives, pharmaceutical compositions, metabolites and combinations for use in the treatment of symptoms of autism spectrum disorder in general, and preferably the object of the present invention is to treat one or more symptoms of autism.

Furthermore, it was also found that cariprazine, its salts, close analogs, derivatives, pharmaceutical compositions, metabolites and combinations are suitable for treatment of conditions such as Asperger's syndrome, atypical autism (otherwise known as pervasive developmental disorder not otherwise specified; PDD-NOS), Rett syndrome, childhood disintegrative disorder, attention deficit hyperactivity disorder (ADHD) and sensory integration dysfunction.

The invention discloses an antifouling water-based latex coating, which is prepared from acrylic ester copolymer emulsion, an extender pigment, a pigment dispersing agent, an antifouling agent, and an mildew preventive and a preservative through taking water as a dispersing medium, wherein the extender pigment is titanium dioxide, the pigment dispersing agent is sodium dodecyl benzene sulfonate, the antifouling agent is 3-(3,4-dichlorophenyl)-1,1-dimethylurea, the mildew preventive is 8-hydroxyquinolinato copper, and the preservative is ethyl p-hydroxybenzoate. The antifouling water-based latex coating is prepared from the acrylic ester copolymer emulsion, the extender pigment, the pigment dispersing agent, the antifouling agent and the mildew preventive, thus having the characteristics of being low in cost, stable in quality, good in antifouling property, mildew-proof, good in corrosion resistance, and long in storage time.

The invention relates to synthesis of N-methylmethyl carbamate, which comprises the following steps: adding dimethyl carbonate and 1,3-dimethylurea in a mol ratio of (15-1):1 and a catalyst into a stainless steel reaction kettle, wherein the catalyst accounts for 1-12 mol% of the raw material 1,3-dimethylurea; and reacting in the closed reaction kettle at 80-200 DEG C under the reaction pressure of 0.1-5.0 MPa for 0.5-10 hours to obtain the N-methylmethyl carbamate. The method has the advantages of mild reaction conditions and simple process, and is easy to operate; and the generated MMC is high in yield and easy to separate.

The invention discloses an environment-friendly phase-change heat storage energy-saving brick and a preparation method thereof, which relate to the technical field of energy-saving bricks. The energy-saving brick is prepared from the following materials: waste polished tile residue powder, modified porous basalt, Xinjiang Qieganbulake vermiculite tailings, attapulgite clay, expanded perlite, silicon nitride fiber, calcium chloride, trimethylolpropane, cationic polyacrylamide, phenyl salicylate, sodium tripolyphosphate, 1,3-dimethylurea, a calcium sulphoaluminate expanding agent, a foaming agent, a foam stabilizer and a coupling agent. According to the preparation, the environment-friendly phase-change heat storage energy-saving brick is prepared by material mixing, shaping and curing. Theenergy-saving brick disclosed by the invention is easy and convenient to prepare, the cost is low, the energy-saving brick has excellent mechanical property, flame-retardant and thermal insulation properties, corrosion and weathering resistance, waterproof and anti-freezing properties and the like, application fields are wide, and the energy-saving brick is safe and reliable.