3412 results about "Acetamide" patented technology

Tissue adhesives formed by reacting poly(hydroxylic) compounds derivatized with acetoacetate groups and / or polyamino compounds derivatized with acetoacetamide groups with an amino-functional crosslinking compound are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; and anti-adhesive applications are described.

The present invention provides a preparation method of (S)-4-hydroxyl-2-oxo-1-pyrrolidine acetamide. The preparation method comprises: (S)-4-halogen-3-hydroxyl butyric ester as a raw material reacts under the conditions with polar solvent and alkalinity to prepare the crude product of (S)-4-hydroxyl-2-oxo-1-pyrrolidine acetamide; and the crude product is purified. The preparation method is characterized in that inorganic alkali is added for a plurality of times in the reaction process under the condition with alkalinity so as to control the pH value in the reaction to be less than or equal to 8.5. A large quantity of repeated tests are completed to determine that the optimum pH value of the reaction under the condition with alkalinity is less than or equal to 8.5, and the alkali is added in batches to strictly control the pH value of the whole reaction process, so that the alkali conditions required in the reaction can be satisfied and the reaction can be performed completely, and the target product (S)-oxiracetam is prevented from being damaged in the alkaline solution, thereby improving the yield rate of the target product (S)-oxiracetam and reducing the cost.

Methods of reducing injury to crop foliage and achieving weed control using encapsulated acetamide herbicides are described. Herbicidal microcapsules comprising herbicide core material and a shell wall encapsulating the core material are also described. The microcapsules provide reduced crop injury through controlled herbicide release.

The present invention relates to a process for the preparation of chiral 4-hydroxy-2-oxo-1-pyrrolidine acetamide. The process comprises adding sodium cyanide together with citric acid to a solution of chiral epichlorohydrin to obtain chiral 3-chloro-2-hydroxypropionitrile by ring opening reaction of the chiral epichlorohydrin, reacting the obtained product with an alcohol containing hydrochloride gas to obtain chiral 4-chloro-3-hydroxybutyric acid ester, and reacting the obtained product in a presence of a base with glycinamide or with glycine ester accompanied by ammonolysis with ammonia to produce the targeted chiral 4-hydroxy-2-oxo-1-pyrrolidine acetamide. The process according to the present invention provides optically pure 4-hydroxy-2-oxo-1-pyrrolidine acetamide in high yield and in high purity, which is suitable for industrial mass-production.

The present invention relates to compositions of and methods for producing timed or retarded release formulations that contain glucosamine sulfate, beta-(1,4)-2-amino-2-deoxy-D-glucose, and chondroitin, (C14H19NO14SNa2)n; N-acetylchondrosanine (2-acetamide-2-deoxi-D-galactopiranose) and D-gluoronic acid copolymer and / or their dietary and nutraceutically acceptable salts of the same and / or hydrates of the active substance that provide a timed release formulation of the active substance.

Pharmaceutical compositions comprising modafinil in the form of particles of defined size. The particle size of modafinil can have a significant effect on the potency and safety profile of the drug.

The invention discloses 2-pyridine-oxyl(sulfide)benzoyloxy acetamide compound with general formula(I); wherein X is H or S; R1 is H, halogen, or 4,6-dimethoxy pyrimidine-2- radicel; R2 is H or alkyl from C1-C6; R3 is alkyl from C1-C6, phenyl, substituted phenyl, alkyl from C1-C3, or pyrimidyl substituted with alkoxy from C1-C3; R4 is H or alkyl from C1-C6. When both R3 and R4 are alkyls, nitrogen atoms of R3 and R4, which can be connected at the same time, develop into a five-membered ring or a hexatomic ring whose 1-2 carbon atoms can be substituted by oxygen atom and nitrogen atom. The compound (I)is of activity in weeding and is safe to crops like soybean, cotton, earthnut, cole, corn, etc.

The invention discloses a g-C3N4 nanosheet / CdS composite visible-light-driven photocatalyst and a preparing method and application thereof and belongs to the technical field of material preparation and photocatalysis. The catalyst is directly obtained with the solvothermal method by taking two-dimensional ultra-thin g-C3N4 nanosheets as the matrix, cadmium acetate dihydrate and thioacetamide as raw materials, and ethyl alcohol as the solvent. Compared with general block g-C3N4 / CdS, the two-dimensional ultra-thin g-C3N4 nanosheet / CdS composite photocatalyst prepared with the method has the advantages that the two substances are in tighter contact, the specific surface area is larger, photon-generated electron-hole can be better separated, and photocatalytic efficiency is higher. Under the shining of sunlight, the composite photocatalyst enables catalytic degradation of organic pollutants such as methyl orange in water to be achieved well. The preparing method is easy, raw materials are easy to obtain, visible light catalysis efficiency is high, and the application prospect is wide in the photocatalysis field.

The invention discloses a synthesis process of acesulfame potassium, which uses acetylacetamide as raw material and inert organic solvent as solvent. Under the low temperature of -50-15 DEG C, catalyst and cyclizing reagent are added for ring closure reaction, after the reaction, the temperature is controlled in the range of -15-60 DEG C, and water is added for hydrolysis; after the hydrolysis, the reaction liquid stands to laminate, the water layer is extracted by the inert organic solvent to remove the aqueous phase and combine the organic phase, then water is added in the organic phase to wash and remove the aqueous phase, base is added in the organic phase for neutralizing and resting to laminate, the organic phase is recycled and the aqueous phase is decompressed and concentrated to obtain the crude acesulfame potassium, and finally the pure acesulfame potassium is obtained through decoloration by activated carbon and purification by recrystallization. The synthesis process of the acesulfame potassium uses the acetylacetamide as the raw material and has the characteristics of simple process, short procedure, low cost and good product quality.

The invention belongs to the field of medicinal chemical engineering, and relates to application of 2-arylimidazo[1,2-alpha]pyridine-3-acetamide derivatives to prepare medicines for controlling PTSD (posttraumatic stress disorder). Specifically, the invention relates to application of a compound shown as a formula I and pharmaceutically salts thereof to prepare medicines for controlling and / or treating and / or auxiliarily treating PTSD, wherein the compound and the pharmaceutically salts thereof are used as TSPO (translocator protein) ligands. The TSPO ligands such as the compounds shown as the formula I and the pharmaceutically salts are capable of effectively preventing and / or treating and / or auxiliarily treating PTSD, and can be used to prevent medicines for controlling and / or treating and / or auxiliarily treating PTSD.

The invention discloses polyvinylidene fluoride / graphene composite and a preparation method thereof. The preparation method includes: reducing oxidation graphene by reductant, mixing the reduced graphene and polyvinylidene fluoride with N, N-dimethylacetamide solvent to be solution, drying and hot-pressing the solution to obtain the polyvinylidene fluoride / graphene composite. The prepared polyvinylidene fluoride / graphene composite has the following advantages that 1) dielectric constant of the polyvinylidene fluoride / graphene composite is high and can reach 7940 on the condition of 100Hz frequency and the weight percentage of the graphene is 0.02; and 2) flexibility is fine. Meanwhile, the preparation method has the advantages of simple operation and high stripping and dispersing degree of graphene and the like.

There is provided a series of novel α-(N-sulfonamido)acetamide compounds of the Formula (I)wherein R, R1, R2 and R3 are defined herein, which are inhibitors of β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by anti-amyloid activity.

The manufacture method of a kind of zirconia fibre cotton relates to the field of resistance of fire fibre material. We compose van-style acetamide acetone zirconium polymer according to chloridze zirconia, acetamide acetone and three-ethylamine. We use methanol as the dilute impregnant, we mix round them to let hloridize zirconia, acetamide acetone and three-ethylamine react at 40-20 deg.C, and we can receive poly-acetamide acetone zirconium van-substance. Four-hydrogen furan filtrate and remove the outgrowth hydrochloric three-ethylamine. The offspring dissolve in the filature liquid made of methanol. After centrifugal swing, we can receive van-substance fibre. After we do special hear treatment, the zirconia fibre cotton we receive has the characteristic of good filature ability, high content of zirconium, equality andclarity and jarles capability. It can be used as industrial stove, roomage fusion stove, atomic energy reactor and the high temperature heat insulation material used in aviation and military. The material of the invention cost low, the method is easy, the impregnant can be recycled, the preparation of fibre cost low.

In one embodiment, the invention relates to processes for producing acesulfame potassium. In one embodiment, the process comprises the step of reacting a first reaction mixture to form an amidosulfamic acid salt such as a trialkyl ammonium amidosulfamic acid salt. The first reaction mixture comprises sulfamic acid, an amine, and smaller amounts, if any, acetic acid, e.g., less than 1 wt % (10000 wppm). In terms of ranges, the first reaction mixture may comprise from 1 wppm to 1 wt % acetic acid. The process further comprises the step of reacting the amidosulfamic acid salt with diketene to form an acetoacetamide salt. In preferred embodiments, the amidosulfamic acid salt formation reaction is conducted at pH levels from 5.5 to 7.0. The process further comprises the step of deriving the acesulfame-K from the acetoacetamide salt.

The invention discloses a new synthesizing technique of chiral drug (S)-alpha-ethyl-2-oxo-1-pyrrolidine acetamide ( left Piracetam) intermediate (S)-(+)-2-aminobutanamide hydrochlorate, which comprises the following steps: adopting 2-brobutyrate as initial raw material; aminating; esterifying; ammonolyzing; detaching; looping; obtaining the object compound; making mixed rotary free alkaline (+-)-2-aminobutanamide; adopting half-quantum resolution method to connect chemical detaching salt to evolve salt; removing the detaching agent through alkalization; obtaining the (S)-(+)-2-aminobutanamide hydrochlorate with optical activity; using the mother liquor to make the product. The invention improves the receiving rate and saves the cost of raw material with simply technical operation and low cost, which resolves the resolved mother liquor after racemic action again to reduce the pollution of environment, therefore fitting for industrialized manufacturing.

The invention relates to a blocking remover of a gas well shaft. The blocking remover comprises, by weight, 5-25% of an alcohol ether compound, 0.5-10% of a dispersant, 1-10% of a cleaning agent, and 0.5-5% of chelating agent, with the balance being a nitrogen-containing polar solvent, wherein the nitrogen-containing polar solvent is one selected from N,N dimethyl formamide, N,N dimethyl acetamide, and N-methyl pyrrolidone, the alcohol ether compound is one selected from glycol-ether, glycol-propyl ether, glycol-butyl ether, and diglycol-ether, the disperant whose micelle particle size is from 20nm to 100nm is a middle-phase microemulsion-type dispersant mixed by kerosene, water, a surfactant and a cosurfactant, the cleaning agent is one selected from allene diamine, acetonitrile and pentylamine, and the chelating agent is one selected from sodium citrate and EDTA. The blocking remover has the advantages that corrosivity is weak, that the speed of dissolving blockage is fast, that the product performance is stable in high temperatures, and that the blocking remover can reduce damages caused by water locking and fouling in areas close to gas wells, and can recover the permeability of storing layers.

The present invention provides a method of treatment, prevention and / or delay of progression of neuropathic pain by a specific dosing regime of acetam derivatives.

The process of synthesizing composite polyimide / nanometer barium titanate film with high dielectric constant includes the following steps: adding maleic anhydride and diamine in the same molar amount into N-methyl-2-pyrrolidone or N, N-dimethyl acetamide as solvent to compound solution with solid content of 10-20 %, adding nanometer modifying barium titanate particle in the amount less than 40 % of the composite film weight into the solution and ultrasonically dispersing, stirring continuously at room temperature for 18-24 hr to obtain polyamic acid, pouring the polyamic acid on glass plate mold, and vacuum heating to eliminate solvent and iminate to obtain the composite polyimide / nanometer barium titanate film. Thus prepared film has excellent heat stability, high oxidative degradation resistance, high dielectric constant and low dielectric loss, and may be used for wound film capacitor, printed circuit board, semiconductor device, etc.

An agent for preventing scale formation and a method for preventing scale formation include a polymer which has at least 50% of N-vinyl formamide units or N-vinyl acetamide units and a phosphorus compound added to water in a cooling water system, a boiler water system, or the like. The scale preventing agent and scale preventing method of the present invention are effective in preventing the adherence of various types of scales which are generated in cooling water systems, boiler water systems, and the like. In particular, the present invention is effective in preventing the adherence of silica and calcium scale.

The present invention provides, according to an aspect thereof, a novel process for the preparation of dronedarone [1] and pharmaceutically acceptable salts thereof. According to a preferred embodiment, the process comprises N-acetylating of p-anisidine or p-phenetidine with acetic anhydride, reacting of the obtained N-(4-alkoxyphenyl)acetamide with 2-bromohexanoyl chloride or bromide in the presence of aluminum chloride or bromide to obtain N-[3-(2-bromohexanoyl)-4-hydroxyphenyl]acetamide [6a], converting the compound [6a] into 2-butyl-5-benzofuranamine hydrochloride [12a] and subsequently converting [12a] into [1] or pharmaceutically acceptable salts thereof. In accordance with another aspect of this invention, there are provided novel intermediates, inter alia the novel compounds [6a] and [12a]. The novel intermediates of the present invention are stable, solid compounds, obtainable in high yields, which can be easily purified by crystallization and stored for long periods of time.

The present invention relates to 2-[3-(2,2-Difluoro-benzo[1,3]dioxol-5-ylamino)-5-(2,6-dimethyl-pyridin-4-yl)-[1,2,4]triazol-1-yl]-N-ethyl-acetamide and analogues or pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy.The invention particularly relates to a potent positive allosteric modulator of nicotinic acetylcholine receptors which have the capability of increasing the efficacy of nicotinic receptor agonists.

Glycoproteins comprising a glycan of the formula (102) are disclosed; wherein b is 0 or 1; the GlcNAc residue optionally fucosylated; and Su(A)x is a sugar derivative comprising x functional groups A, wherein x is 1, 2, 3 or 4 and A is independently selected from the group consisting of an azido group, a keto group, an alkynyl group, a thiol group, a halogen, a sulfonyloxy group, a halogenated acetamido group, a mercaptoacetamido group and a sulfonylated hydroxyacetamido group.Protein-conjugates having glycoproteins according to the invention conjugated to a molecule of interest (e.g., an active substance) are also disclosed. Examples include modified antibodies, antibody-conjugates, and antibody-drug conjugates (ADCs). Processes for the preparation of the modified glycoproteins according to the invention and methods for the preparation of a protein-conjugate according to the invention are mentioned.

The present invention relates to an aligning agent for liquid crystal containing at least a polymer and solvent selected from polyamic acid and polyimide gained by dewatering closed-loop, the solvent contains: (A) a first solvent containing compound with formula (I); (B) a second solvent selected from at least one of N-methyl-2-pyrrolidone, gamma-butyrolactone, 1,3-dimethyl-2-imidazolone, N, N-dimethylformamide and N, N- dimethylacetylamide; and (C) a third solvent selected from at least one of butyl cellosolve, diacetone alcohol, carbonic sub-propyl ester, diethylene glycol diethyl aether and ethyl-3- oxethyl propionic ether. (In formula (I) the R respectively represents alkyl with 3 to 10 carbon atoms).

The invention relates to a novel ZnIn2S4 / NH2-MIL-125(Ti) composite visible-light catalyst and belongs to the technical field of photocatalysis. The novel ZnIn2S4 / NH2-MIL-125(Ti) composite visible-light catalyst is characterized in that ZnIn2S4 is nanosheet-shaped and is uniformly distributed on the surface of lumpy NH2-MIL-125(Ti), and the mass percent of the NH2-MIL-125(Ti) is 20.0% to 6.0%. A preparation method comprises the steps: (1) dissolving a certain amount of tetrabutyl titanate and 2-amino terephthalic acid in a mixture solution of N,N-dimethylformamide and methanol, and carrying out a crystallizing reaction for 48 hours in an autoclave at the temperature of 150 DEG C, so as to obtain the NH2-MIL-125(Ti); (2) dispersing the synthesized NH2-MIL-125(Ti) into a certain volume of ethanol in an ultrasonic dispersion manner, then, sequentially adding a certain amount of propanetriol, indium chloride, zinc chloride and thioacetamide into the dispersion while carrying out stirring, carrying out a crystallizing reaction for 10 hours in an autoclave at the temperature of 180 DEG C to 200 DEG C so as to obtain a solid product, and subjecting the obtained solid product to filtrating, washing and drying, thereby obtaining the ZnIn2S4 / NH2-MIL-125(Ti) composite visible-light catalyst. The preparation method of the composite visible-light catalyst is environmentally-friendly and is simple in process. The prepared composite catalyst has very high visible-light catalytic activity and has a potential application value in photocatalytic hydrogen production using solar energy.

Biaryl acetamide compounds and compositions and their methods of use are provided for modulating the activity of class III receptor tyrosine kinases and for the treatment, prevention or amelioration of one or more symptoms of disease of disorder mediated by class III receptor tyrosine kinases.

The invention relates to a self-lubricating wear-resistant coating swash plate, which consists of a metallic matrix and a self-lubricating wear-resistant coating, wherein annular planes on two sides of the metallic matrix are coated with the self-lubricating wear-resistant coating, and the components of the self-lubricating wear-resistant coating comprise a main material of high molecular materials, fluoroplastics, solid lubricants and inorganic matters. A process for producing the self-lubricating wear-resistant coating swash plate comprises that: the self-lubricating wear-resistant coating is coated on the swash plate after being prepared into a liquid coating, and a method for preparing the liquid coating comprises the steps of using a solvent of N-methyl pyrrolidone or dimethyl acetamide to dissolve the main material of the high molecular materials first, and then adding the fluoroplastics, the solid lubricants and the inorganic matters into the mixture to perform sufficient stirring and dispersion so as to prepare the liquid coating with certain solid content. The swash plate has the advantages of good self-lubricating and wear-resistant performance, simple production process and low production cost, and does not contain metallic lead which is harmful to human bodies and the environment.

The invention discloses a chemical separating method for an aluminum foil in a waste lithium ion battery positive plate. The method comprises the following steps of: (1) adding the waste lithium ion battery positive plate into a surfactant solution, performing ultrasonic oscillation treatment to loosen surface components of the positive plate, washing, drying, filtering and recovering the positive plate; (2) putting the positive plate treated in the step (1) into a mixed solution of N, N-dimethylacetamide and N-methylpyrrolidone, heating, taking the positive plate out, and washing with water; (3) putting positive plate treated in the step (2) into water, performing ultrasonic oscillation till the aluminum foil as well as active substances of an anode, a conducting agent and a bonding agent; and (4) filtering a solution obtained in step (3), washing to obtain a mixture containing the active substances, the conducting agent, the bonding agent and the aluminum foil, and screening to obtain a dissociative aluminum foil sheet. In the method, the aluminum foil sheet can be recovered directly; and compared with the conventional method for extracting an aluminum foil after dissolving with alkali, the chemical separating method has the advantages: the process is simplified, and cost is lowered.

The invention relates to a synthetic method for linezolid, which dissolves a 3-fluoro-4- morpholinyl laniline and an N-2(R)-epoxy acetamide in an organic solvent to react for 10 to 30 hours in a temperature of 20 to 100 DEG C, and acquires an N-{2(R)-2-[(3-fluoro-4 morpholine-4-base phenyl) amino]-2-hydroxy ethyl}; then an acquired compound and a carbonylation agent are dissolved in a halohydrocarbon organic solvent and reacted for 0.5 to 5 hours in a temperature of 0-50 DEG C under the catalysis of a base catalyst, thereby acquiring the linezolid. The method of the invention uses an ordinary reagent and normal plant conditions in industry, the reaction condition is mild and the steps are simple.