41 results about "Phenetidine" patented technology

The present invention provides, according to an aspect thereof, a novel process for the preparation of dronedarone [1] and pharmaceutically acceptable salts thereof. According to a preferred embodiment, the process comprises N-acetylating of p-anisidine or p-phenetidine with acetic anhydride, reacting of the obtained N-(4-alkoxyphenyl)acetamide with 2-bromohexanoyl chloride or bromide in the presence of aluminum chloride or bromide to obtain N-[3-(2-bromohexanoyl)-4-hydroxyphenyl]acetamide [6a], converting the compound [6a] into 2-butyl-5-benzofuranamine hydrochloride [12a] and subsequently converting [12a] into [1] or pharmaceutically acceptable salts thereof. In accordance with another aspect of this invention, there are provided novel intermediates, inter alia the novel compounds [6a] and [12a]. The novel intermediates of the present invention are stable, solid compounds, obtainable in high yields, which can be easily purified by crystallization and stored for long periods of time.

The invention discloses a preparation and crystallization method of phenacetin, and belongs to the field of chemical industry. According to the preparation and crystallization method, p-phenetidine is reacted with an acid in water so as to obtain a p-phenetidine salt; the p-phenetidine salt is reacted with an anhydride in a buffer solution system; after reaction, a mixed solution of water and an organic solvent is added into an obtained reaction solution, and phenacetin crystals are obtained via stirring. Product yield is high; two-step reaction total yield is higher than 92%; the obtained products are crystalline solids; stability is high; purity is high, and is higher than 99%; reaction time is short; reaction conditions are mild; product separation operation is simple; direct filtering separation can be carried out after reaction; and batch production period is shortened greatly.

The invention discloses a synthesis method of m-phenetidine by a one-pot reaction. The method comprises the following steps: m-aminophenol, alkali and a solvent are thrown into a reaction vessel, and then only an alkylating agent or a catalyst and an alkylating agent are added at the same time, after materials are added, the reaction vessel is enclosed, and stirring is carried out for 0.5-1 hour at room temperature; the temperature is raised to 40-80 DEG C, a reaction is carried out for 1-8 hours, after the reaction, obtained reaction solution is cooled to room temperature and filtered, and filtrate is obtained; reduced pressure distillation for the filtrate is carried out, and m-phenetidine is obtained. The synthesis method of m-phenetidine has the characteristics of low reaction temperature, high safety performance, convenient operation, high purity and high yield of the product, etc.

The invention relates to a preparation process of o-aminophenetole, which is characterized in that nitrobenzene, sulfuric acid and ethanol mixture are used as raw materials to prepare the o-aminophenetole, and the process is used for preparing the o-aminophenetole and ammonium sulfate through the steps of catalytic hydrogenation reduction, solid-liquid separation, water addition for dissolution, solid-liquid separation, acid-base neutralization, oil-water separation and the like. According to the method, nitrobenzene is adopted to replace o-nitrochlorobenzene, high temperature and high pressure are not needed, three wastes are not discharged, the method is a safe, environment-friendly and efficient o-aminophenetole synthesis process, and the purity of the obtained product reaches 99.90% or above and completely reaches the drug standard.

The invention discloses a recycling method for pyridoxal manganese-containing wastewater and belongs to the technical field of wastewater treatment. The method includes the steps that manganese-containing pyridoxal filtrate with manganese dioxide filtered out after filtering and a sodium carbonate solution or a sodium bicarbonate solution are subjected to a first-time reaction, then filtering is performed, and a pyridoxal solution and manganese carbonate solids are obtained; filtering is performed after the pyridoxal solution and p-phenetidine are subjected to a second-time reaction, and Schiff base solids and filtrate are obtained; and finally, the filtrate is filtered, and NaCL solids and recycled water are obtained. By utilizing the method, the concentration of Mn2+ in the pyridoxal manganese-containing wastewater can be effectively lowered to 0.5 mg / L, the manganese removing rate is increased to 95%, and the Schiff base yield is increased to 90%; and besides, the purity of manganese carbonate recycled through the method reaches up to 90%, and quality is good.

The invention provides a synthesis process of 5'-pyridoxal phosphate. The process comprises the following steps: first adding p-aminophenethyl ether into the pyridoxal solution to react to generate pyridoxal Schiff base; then adding pyridoxal Add the Schiff base into the ionic liquid, stir until fully dissolved, and obtain an ion mixed solution; then add polyphosphoric acid to the ion mixed solution in which the pyridoxal Schiff base has been dissolved, stir and react, and perform cooling treatment after the reaction, and the ion Solids are precipitated in the mixed solution; the solid particles precipitated in the ion mixed solution are filtered, the solid obtained by filtration is 5'-pyridoxal phosphate Schiff base, and the obtained liquid is a phosphorus-containing ionic liquid; finally the obtained 5'- The pyridoxal phosphate Schiff base is hydrolyzed and purified to obtain the final product 5'-pyridoxal phosphate. The process is simple to operate, economical and efficient, and has high yield.

The invention relates to a process for preparing phenetidine and aniline by taking a mixture of nitrophenetol and nitrochlorobenzene as a raw material. The process comprises the following steps that: (1) a step of the catalytic hydrogenation reaction and the catalytic dechlorination reaction, during which, ethanol is taken as a solvent, the mixture of the nitrophenetol and the nitrochlorobenzene is taken as the raw material, catalyst is added, hydrogen is aerated; (2) a step of the solid-liquid separation, during which, solid and liquid in the material obtained from the step (1) after the catalytic hydrogenation reaction and the catalytic dechlorination reaction are separated, a liquid phase comprises phenetidine, aniline, ethanol, hydrochloride and water and is utilized in the next step;(3) a step of the liquid-liquid separation, during which, the oil phase-water phase liquid-liquid separation is performed in the material obtained in the step (2), the phenetidine and aniline in the oil phase is utilized in the next step; (4) a step of distillation separation, during which, the distillation separation is performed in the oil phase to produce the products of para aminophenyl ethylether, o-phenetidineand aniline. The process for preparing the aminoanisole and the aniline has the advantages that: (1) the cost is low, the preliminary treatment step is saved, and the process is simple; (2) the process is clean, the energy consumption is low, and the 'three wastes' are little; (3) the purity of the product is high.