A kind of synthetic technique of 5'-pyridoxal phosphate

Abstract

The invention provides a synthesis process of 5'-pyridoxal phosphate. The process comprises the following steps: first adding p-aminophenethyl ether into the pyridoxal solution to react to generate pyridoxal Schiff base; then adding pyridoxal Add the Schiff base into the ionic liquid, stir until fully dissolved, and obtain an ion mixed solution; then add polyphosphoric acid to the ion mixed solution in which the pyridoxal Schiff base has been dissolved, stir and react, and perform cooling treatment after the reaction, and the ion Solids are precipitated in the mixed solution; the solid particles precipitated in the ion mixed solution are filtered, the solid obtained by filtration is 5'-pyridoxal phosphate Schiff base, and the obtained liquid is a phosphorus-containing ionic liquid; finally the obtained 5'- The pyridoxal phosphate Schiff base is hydrolyzed and purified to obtain the final product 5'-pyridoxal phosphate. The process is simple to operate, economical and efficient, and has high yield.

Description

technical field [0001] The invention relates to the technical field of organic synthesis, in particular to a synthesis process of 5'-pyridoxal phosphate. Background technique [0002] Ionic liquids, also known as room temperature ionic liquids, room temperature molten salts, organic ionic liquids, etc., refer to salts that are liquid only at room temperature or low temperature. The characteristic of ionic liquid is that it has no significant vapor pressure. On the one hand, it will not become a vapor and disperse into the atmosphere. It is a green solvent. On the other hand, it can have a wide range of liquid states. In addition, the positive and negative ions in ionic liquids can be composed of organic ions and inorganic ions, so they have good solubility for many substances, and most of them are aprotic, which can reduce the phenomenon of solvation and solvation. Good electrical conductivity, thermal and chemical stability. There are many types of ionic liquids, and ther...

AI Technical Summary

Problems solved by technology

Pyridoxal 5'-phosphate is mainly used as a coenzyme to participate in the amino acid reaction enzyme in the human body. Once the amino acid is missing, the activity of the enzyme will be inhibited and the entire amino acid reaction will stop, which will seriously endanger the health of the human body.

However, most of the existing methods for synthesizing pyridoxal phosphate are cumbersome and the overall yield is not ideal.

At present, there are few manufacturers of pyridoxal 5'-phosphate in the market. Most of these manufacturers' synthesis processes are old and the yield is low, especially the low yield of phosphorylation reaction, which will lead to 5'-pyridoxal phosphate The selling price of pyridoxal is relatively high, so there is a large room for profit improvement in the production of pyridoxal 5'-phosphate

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