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2542 results about "Offspring" patented technology
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In biology, offspring are the young born of living organisms, produced either by a single organism or, in the case of sexual reproduction, two organisms. Collective offspring may be known as a brood or progeny in a more general way. This can refer to a set of simultaneous offspring, such as the chicks hatched from one clutch of eggs, or to all the offspring, as with the honeybee.
CICM cells and non-human mammalian embryos prepared by nuclear transfer of a proliferating differentiated cell or its nucleus
InactiveUS6235970B1Simple procedureSimplifying and facilitating procedureNervous disorderMuscular disorderPresent methodNuclear transfer
An improved method of nuclear transfer involving the transplantation of donor differentiated cell nuclei into enucleated oocytes of the same species as the donor cell is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring, and for production of isogenic CICM cells, including human isogenic embryonic or stem cells. Production of genetically engineered or transgenic mammalian embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.
Owner:UNIVERSITY OF MASSACHUSETTS AMHERST
ADAM6 mice
ActiveUS8642835B2Reduces and eliminates ADAM activityImprove fertilityHydrolasesImmunoglobulins against growth factorsMatingNucleotide sequencing
Owner:REGENERON PHARM INC
Adam6 Mice
ActiveUS20120322108A1Reduce eliminateImprove fertilityHydrolasesImmunoglobulins against growth factorsMatingNucleotide sequencing
Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.
Owner:REGENERON PHARM INC
Cloning pigs using donor nuclei from non-quiescent differentiated cells
InactiveUS6235969B1Superior genotypes of pigsSpeed up genetic progressNervous disorderPeptide/protein ingredientsBiotechnologyPresent method
An improved method of nuclear transfer involving the transplantation of donor differentiated pig cell nuclei into enucleated pig oocytes is provided. The resultant nuclear transfer units are useful for multiplication of genotypes and transgenic genotypes by the production of fetuses and offspring. Production of genetically engineered or transgenic pig embryos, fetuses and offspring is facilitated by the present method since the differentiated cell source of the donor nuclei can be genetically modified and clonally propagated.
Owner:MASSACHUSETTS UNIV OF
Methods for diagnosing, preventing, and treating developmental disorders due to a combination of genetic and environmental factors
InactiveUS6912492B1Effective treatmentBiological modelsComputation using non-denominational number representationPervasive developmental disorderSchizophrenia
Owner:RUTGERS THE STATE UNIV
Gene regulation in transgenic animals using a transposon-based vector
InactiveUS7608451B2Improve efficiencyHigh copy numberEgg immunoglobulinsFood genetic modificationAnimal useTransgene
Owner:PROTEOVEC HLDG L L C
Method for sex determination of mammalian offspring
InactiveUS6489092B1Increase probabilityImprove integrityMicrobiological testing/measurementDead animal preservationSemen sampleMagnetic bead
A method for increasing the percentage of mammalian offspring of either sex which comprises contacting a semen sample with an antibody specific for the spermatozoa determinative of one sex and separating said spermatozoa from spermatozoa determinative of the other sex, said antibody being bound to a non-porous magnetic bead support having a diameter of 0.1 to 2 microns.
Owner:VICAM
Method for sex determination of mammalian offspring
InactiveUS6153373AIncrease probabilityImprove integrityImmunoglobulins against cell receptors/antigens/surface-determinantsArtificial cell constructsSemen sampleMagnetic bead
A method for increasing the percentage of mammalian offspring of either sex which comprises contacting a semen sample with an antibody specific for the spermatozoa determinative of one sex and separating said spermatozoa from spermatozoa determinative of the other sex, said antibody being bound to a non-porous magnetic bead support having a diameter of 0.1 to 2 microns.
Owner:VICAM
Cloning using donor nuclei from a non-quiesecent somatic cells
InactiveUS6215041B1Superior genotypes of cowsSpeed up genetic progressNew breed animal cellsPeptide/protein ingredientsEmbryoSomatic cell
Owner:MASSACHUSETTS UNIV OF A PUBLIC INSTION OF HIGHER EDUCATION OF THE COMMONWEALTH OF MASSACHUSETTS AS REPRESENTED BY ITS AMHERST CAMPUS
Adam6 mice
ActiveUS20130254911A1Reduces and eliminates ADAM activityImprove fertilityHydrolasesImmunoglobulins against growth factorsNucleotide sequencingMale mice
Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.
Owner:REGENERON PHARM INC
Method for molecular genealogical research
A genealogical research and record keeping system and method for identifying commonalities in haplotypes and other genetic characteristics of two or more individual members of a biological sample. Chromosomal fragments identical by descent identify family ties between siblings, parents and children and ancestors and progeny across many generations. It is particularly useful in corroborating and improving the accuracy of genealogical data, and identifying previously unknown genetic relationships.
Owner:ANCESTRY COM DNA
No maintenance lethal mosquito breeding trap
Owner:BETTE JAMES ROBERT
Processes for clonal growth of hepatic progenitor cells
A method of propagating mammalian endodermally derived progenitors such as hepatic progenitors, their progeny, or mixtures thereof is developed which includes culturing mammalian progenitors, their progeny, or mixtures thereof on a layer of embryonic mammalian feeder cells in a culture medium. The culture medium can be supplemented with one or more hormones and other growth agents. These hormones and other growth agents can include insulin, dexamethasone, transferrin, nicotinamide, serum albumin, beta-mercaptoethanol, free fatty acid, glutamine, CUSO4, and H2SeO3. The culture medium can also include antibiotics. Importantly, the culture medium does not include serum. The invention includes means of inducing the differentiation of the progenitors to their adult fates such as the differentiation of hepatic progenitor cells to hepatocytes or biliary cells by adding, or excluding epidermal growth factor, respectively. The method of producing mammalian progenitors is useful in that the progenitors can be used subsequently in one or more of the following processes: identification of growth and differentiation factors, toxicological studies, drug development, antimicrobial studies, or the preparation of an extracorporeal organ such as a bioartificial liver.
Owner:THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
Class I and Class II MHC Profiling for Social and Sexual Matching of Human Partners
An improved process of matching people with one another, for social and / or sexual purposes, based on the profiles of the participants' Class I and Class II MHC genes. The quality of this human matching is inversely proportional to the number of common alleles of said genetic profiles of the individuals. Higher quality matches of this type result in greater sexual attraction, more attractive physical odor, and offspring with more robust immune systems among matched participants.
Owner:HOLZLE ERIC
Recombinant vector and non-GMO gene editing plant screening method
ActiveCN106222193AInexpensive screening methodSimple screening methodVector-based foreign material introductionAngiosperms/flowering plantsResistant genesHerbicide screen
The invention discloses a recombinant vector and a non-GMO gene editing plant screening method. An initial carrier in the recombinant vector is a CRISPR / Cas9 carrier which contains sgRNA gene, Cas9 gene and screening label gene and is used for plant gene editing, the recombinant vector carries a BelRNAi expression element, and a hairpin RNA interference fragment interfering with bentazone resistance gene is generated through transcription of the BelRNAi expression element. By introducing the BelRNAi expression element to the initial carrier and conducting bentazone herbicide screening on future generation plants, offspring with target gene mutated are reserved, and it is also ensured that the mutated offspring do not contain transgenic fragments; screening method is cheaper, simpler and more effective.
Owner:ZHEJIANG UNIV +1
Jacketed vessel for holding semen for sex biasing mammals through artificial insemination and systems and methods for enhancing the probability of sex biasing using the same
InactiveUS20060147894A1Increase the number ofIncrease success rateDead animal preservationGerm cellsSemen sampleMammal
A jacketed container for holding a semen sample from a mammalian donor at a predetermined temperature for a predetermined period of time prior to incubation to enhance the probability of obtaining offspring of a selected sex through artificial insemination is disclosed. In one embodiment, the semen sample is collected and insulated by a high-heat capacity material that has been preconditioned to a temperature between about 30° C. to about 40° C. before the semen is cooled to a temperature of about 12° C. In a second embodiment, the semen sample is collected and insulated by a high-heat capacity material that has been preconditioned to a temperature between about 4° C. to about 20° C. before the semen is cooled to a temperature of about 12° C.
Owner:VICAM
No maintenance lethal mosquito breeding trap
A device into which gravid (pregnant) female mosquitos are attracted to deposit their eggs and where both the adult and her offspring are then eliminated. The trap is set in the out-of-doors at the onset of the mosquito breeding season and is replenished by rain water and, by its unique construction, a larvicide within is protected from flushing and photo degradation thereby making it maintenance free throughout the mosquito breeding season. The low cost trap is constructed from biodegradable paperboard and at the end of the mosquito breeding season, decomposes, thereby foreclosing the possibility that the trap will become a breeding incubator.
Owner:BETTE JAMES ROBERT
Self-adaptive genetic particle swarm hybrid algorithm optimization method
InactiveCN108846472AImprove global search performanceImprove convergence accuracyArtificial lifeGenetic algorithmsGenes mutationMutation probability
Owner:BEIHANG UNIV
Lactobacillus separation strains with anti-inflammatory activity and application thereof
The invention discloses two lactobacillus separation strains with anti-inflammatory activity and beneficial properties, which are Lactobacillus sakei GMNL-76 and Lactobacillus reuteri GMNL-89. The two lactobacillus separation strains are respectively preserved in the Bioresouce Collection and Research Center (BCRC) of the Food Industry Research and Development Institute (FIRDI) by preservation numbers of BCRC 910355 and BCRC 910340 and preserved in the China Center for Type Culture Collection (CCTCC) by the preservation numbers of CCTCC M 207153 and CCTCC M 207154. The two lactobacillus separation strains and subculture offspring thereof can be used for preparing various food products and pharmaceutical composition for curing and / or mitigating diseases (such as rheumatoid arthritis) relevant to inflammation.
Owner:GENMONT BIOTECH
Method for selectively breeding improved variety of China turtle
InactiveCN101120662AQuality improvementAnimal reproductionClimate change adaptationEcological environmentGermplasm
The present invention relates to a turtle artificial cultivating method, in particular to a method selecting and breeding the good Chinese turtle strain, which resolves the technical problems of the prior art that the turtle is not selected for breeding in different growth periods, the selection of the turtle is not enough to mix the defective turtle in different periods and the quality-degraded turtle, thereby leading to the degradation of the quality of the offspring of the cultivated parent turtle; the quality is reduced, the growth is slowed down and the disease-resistant ability is weakened. The present invention firstly selects the ecological environment and then selects the parent turtle, the fertilized egg, the juvenile turtle, the adult turtle and the reserve parent turtle in turn; wherein, the selection rate of the parent turtle is from eighty percentages to eighty five percentages; the selection rate of the juvenile turtle is from twenty five percentages to thirty five percentages; the selection rate of the adult turtle is from forty five percentages to fifty five percentages and the selection rate of the reserve parent turtle is from sixty five percentages to seventy five percentages.
Owner:杭州萧山天福生物科技有限公司
Double resistance CRISPR/Cas9 carrier and application
The invention relates to a double resistance CRISPR / Cas9 carrier and application. The invention provides the double resistance carrier having both hygromycin B resistance and Basta resistance at the same time; the double resistance carrier is obtained by inserting sequences and fragments derived from multiple different carriers into a sequence of a carrier pFGC5941 by enzyme-cutting and linking up, and constructing. Hygromycin B is used for screening in a conversion process, and Basta is used for screening offspring transgenic plants not containing an external source T-DNA sequence in offspring plants. Two resistances, i.e., the hygromycin B and the Basta are used to respectively serve as screening marks of the transgenic plants for the first time, a feasible manner is provided for screening transgenic offspring not containing the external source T-DNA sequence, determining the existence of external source T-DNA by a complex molecular biology detection experiment is avoided, and the offspring transgenic plants not containing the external source T-DNA sequence can be obtained by directly screening the Basta resistance and performing phenotype combination.
Owner:INST OF CROP SCI CHINESE ACAD OF AGRI SCI
Method of imparting disease resistance to plants by reducing polyphenol oxidase activities
InactiveUS7122719B2Reduce expressionReduced visual symptomBiocideOxidoreductasesSolanum tuberosumTransgene
The present invention relates to a method for enhancing a plant's resistance to diseases and / or bruising by transforming the plant with sense and antisense polyphenol oxidase encoding sequences from potato. The invention also relates to transgenic plants and progeny thereof with reduced polyphenol oxidase activity.
Owner:MONSANTO TECH LLC
Animal sex control method based on Rbmy gene editing and application
ActiveCN105861554AIncrease productivityNucleic acid vectorFermentationControl animalPlant Germ Cells
The invention discloses an animal sex control method based on Rbmy gene editing and application. The method controls animal sex by using CRISPR / Cas9 system to specifically cut Rbmy gene on Y chromosome. Rbmy gene encodes a germ cell specific nucleoprotein, this protein is an important factor related to spermatogenesis, and by cutting Rbmy gene, it is possible to deactivate Rbmy gene, thus Y sperm or fertilized ovum with Y sperm is deactivated and cannot develop into a normal embryo, birth ratio of female animals is finally increased and sex control is achieved. Therefore, sex ratio of animal offspring can be controlled through the method so that the ratio of female animals with better economic value is increased and production efficiency and economic effect are greatly improved.
Owner:SOUTH CHINA AGRI UNIV
Reduction of fitness evaluations using clustering techniques and neural network ensembles
InactiveUS20050209982A1Increase the number ofReduce in quantityDigital computer detailsDigital dataNerve networkFitness function
One embodiment of the invention proposes an evolutionary optimization method. In a first step, an initial population of individuals is set up and an original fitness function is applied. Then the offspring individuals having a high evaluated quality value as parents are selected. In a third step, the parents are reproduced to create a plurality of offspring individuals. The quality of the offspring individuals is evaluated by means of a fitness function, wherein selectively the original or an approximate fitness function is used. Finally, the method goes back to the selection step until a termination condition is met. According to an embodiment, the step of evaluating the quality of the offspring individuals consists in grouping all λ offspring individuals in clusters, selecting for each cluster one or a plurality of offspring individuals, resulting in altogether ξ selected offspring individuals, evaluating the ξ selected offspring individuals by means of the original fitness function, and evaluating the remaining λ-ξ offspring individuals by means of the approximate fitness function.
Owner:HONDA RES INST EUROPE
Homologous recombination in multipotent adult progenitor cells
InactiveUS20060228798A1Increase and decrease its productionImprove the usefulnessVertebrate cellsArtificial cell constructsProgenitorMammal
The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and / or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided.
Owner:ABT HOLDING COMPANY +1
Grouper large scale total-artificial breeding method
ActiveCN103493759ANot easy to breedImprove sound insulationClimate change adaptationPisciculture and aquariaFisheryCaptive bred
The invention discloses a grouper large scale total-artificial breeding method. The method comprises the steps of parent cultivation, artificial reproduction, offspring seed production, leaving pond of offspring seeds, and temporary rearing in a net cage. The grouper large scale total-artificial breeding method is suitable for seedling cultivation of orange-spotted groupers, or saddletail groupers, or giant groupers, or Hong Kong grouper, or East Star Groupers. The grouper large scale total-artificial breeding method solves the problem that the death rate of groupers in a current seedling cultivation technology is high, and broad prospect of scale development of grouper cultivation is achieved.
Owner:NINGDE NANHAI AQUATIC PRODS TECH
Method for artificially breeding sepia lycidas gray
ActiveCN102939924AImprove hatchabilityImprove survival rateClimate change adaptationPisciculture and aquariaOpossumAnimal science
The invention discloses a method for artificially breeding sepia lycidas gray, and the method is characterized by comprising the following steps of (1) parent breeding: selecting a harmless parent with complete body into a temporary culture cement tank to be temporarily cultivated, feeding the parent with chilled fishes twice a day, wherein the feeding quantity is 2 to 5 percent of the weight of the sepia lycidas gray; (2) artificial breeding: placing an egg attaching device inside the temporary culture cement tank, mating the male and the female parents to lay eggs, and then transferring the eggs into a hatching tank to be hatched; and (3) offspring breeding: transferring the hatched seedlings into a seedling tank, feeding fairy shrimp nauplius or copepoda in the early stage, feeding copepoda, opossum shrimp or larval prawn in the middle stage, and feeding fresh live fishes and small shrimps in the late stage, completing the breeding of the seedling when the length of the seedling is more than 2cm, the trunk length is more than 1.2cm, the trunk width is more than 0.9cm and the weight is more than 0.3g, and taking out the seedlings with water. The method has the advantages of high survival rate, easiness in cultivation, large cultivation specification, strong disease resistance and fast growth.
Owner:NINGBO UNIV
Staged desalinization culturing method for penaeus vannamei boone
InactiveCN102165925AOvercoming the Difficulty of Osmotic Pressure Change DeathImprove survival rateClimate change adaptationPisciculture and aquariaDesalinationWater quality
The invention discloses a staged desalinization culturing method for penaeus vannamei boone. The method comprises the steps such as selection of penaeus vannamei boone offspring seeds, a staged offspring seed desalting process, treatment on quality of offspring seed desalination water, treatment on quality of water in a culturing process, routine culture and management and the like. By utilizing the staged desalinization culturing method for penaeus vannamei boone provided by the invention, the problem that penaeus vannamei boone dies due to osmotic pressure change caused by salinity change is overcome, and the desalinization culturing of the penaeus vannamei boone is achieved, thus the method provided by the invention has important practical application value.
Owner:高雷
Reduction of fitness evaluations using clustering techniques and neural network ensembles
InactiveUS7363281B2Reduce in quantityWeight optimizationDigital computer detailsDigital dataNerve networkComputer science
The invention relates to an evolutionary optimization method. First, an initial population of individuals is set up and an original fitness function is applied. Then the offspring individuals having a high evaluated quality value as parents are selected. In a third step, the parents are reproduced to create a plurality of offspring individuals. The quality of the offspring individuals is evaluated selectively using an original fitness function or an approximate fitness function. Finally, the method returns to the selection step until a termination condition is met. The step of evaluating the quality of the offspring individuals includes grouping all offspring individuals in clusters, selecting for each cluster one or a plurality of offspring individuals, resulting in altogether selected offspring individuals, evaluating the selected offspring individuals by the original fitness function, and evaluating the remaining offspring individuals by means of the approximate fitness function.
Owner:HONDA RES INST EUROPE
Production method for summer offspring of Songjiang blue pickerel
InactiveCN1915007AArtificial reproductionRealize large-scale farmingClimate change adaptationPisciculture and aquariaBroodstockJuvenile fish
A method for culturing the minnow of roughskin sculpin includes such steps as capturing the parent fish in near sea in early spring, temporarily culturing in indoor pool, using flowing water to stimulate the parents for estrus, natural mating, ovipositing, collecting fertilized ova, natural incubating in natural seawater in pool, regulating illuminance for correcting the strong phototaxis, applying nutritive forage, improving water quality, and post culturing.
Owner:HEBEI AGRICULTURAL UNIV.
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