The invention provides an
oxiracetam agent and the preparation method, which relates to medical technical field and is used to induce the
drug to penetrate through blood-brain barrier and to improve treatment effects. The agent contains
oxiracetam nano-particle and excipientpharmaceutical
excipient. After improved, the
oxiracetam nano-particle and excipientpharmaceutical
excipient contains
drug core and a modified layer. The
drug core mainly comprises principal agent and carrier, wherein the carrier is
polymer material containing amino
polysaccharide with a content of 70 to 95 percent, and the principal agent is oxiracetam with a content of 5 to 30 percent. The invention adopts
polymer material containing amino
polysaccharide as carrier to carry the oxiracetam and endow the oxiracetam with good
brain targeting function. And the invention adopts surfactant to modify the nano surface of the carrier and lengthens the recycling time of the carrier nano-granule and the nano-particle in the recycling
system. Tests show that the blood-brain barrier
transmittance is 24h, which is 36.75 percent higher than ordinary oxiracetam agent and greatly enhances the dosage of oxiracetam passing through the blood-brain barrier.