425 results about "Ethyl butyrate" patented technology

The invention discloses a novel carbonyl reductase, a gene, a mutant thereof, a recombinant expression vector containing the gene and the mutant, a recombinant expression transformant, a recombinase preparation method, and applications of the carbonyl reductase and recombinase to preparation of active chiral alcohols with a chiral carbonyl compound before asymmetrical reduction. The carbonyl reductase is derived from candida glabrata, is applied to preparation of a plurality of optically-active chiral alcohols such as (R)-chloromandelic acid methyl ester, (R)-2-hydroxy-4-phenyl ethyl butyrate, (R)-4-chlorin-3-phenyl ethyl butyrate and the like. Compared with other preparation methods, a product prepared through the method has high concentration, does not require additionally or slightly adding any expensive coenzyme, has high optical purity, and has the advantages of mild reaction conditions, easiness and convenience for operating, easiness for amplifying and the like, and has a good industrial application prospect in the production of clopidogrel, L-carnitine and perindopril antihypertensive medicinal intermediates.

There is provided in one embodiment of the invention an electrolyte for use in a lithium ion electrochemical cell. The electrolyte comprises a mixture of an ethylene carbonate (EC), an ethyl methyl carbonate (EMC), an ester cosolvent, and a lithium salt. The ester cosolvent comprises methyl propionate (MP), ethyl propionate (EP), methyl butyrate (MB), ethyl butyrate (EB), propyl butyrate (PB), or butyl butyrate (BB). The electrochemical cell operates in a temperature range of from about −60 degrees Celsius to about 60 degrees Celsius. In another embodiment there is provided a lithium ion electrochemical cell using the electrolyte of the invention.

The invention discloses an aqueous electrolyte solution of a secondary lithium ion battery with ferric phosphate considering as the positive material and with both the high temperature performance and the low temperature performance. The aqueous electrolyte solution comprises LiPF6 lithium salt, an organic solvent and a film-forming additive, and is characterized in that the electrolyte solution further comprises high temperature additive; the organic solvent is composed of one or a plurality of carbonic esters and one or more carboxylic esters with low melting point and high boiling point. The carboxylic esters with low melting point and high boiling point are selected from one or a combination of methyl butyrate, ethyl butyrate, propyl butyrate and butyl acetate. The high temperature additive is 1, 3- propane sultone and 1, 4- butane sultone. The electrolyte solution is used for maintaining both the circulation performance in a high temperature state and the low temperature laying performance of the secondary lithium ion battery with the ferric phosphate lithium as the positive material.

The invention provides a transparent hydrophobic and oleophobic functional coating material. The transparent hydrophobic and oleophobic functional coating material is prepared from fluorine-containing resin, silicon dioxide particles and a solvent, wherein the mass concentration of the fluorine-containing resin is 5 to 15%; the mass of the silicon dioxide particles accounts for 1 to 5% of the mass of the fluorine-containing resin; the fluorine-containing resin contains at least one of fluorine-containing acrylic resin, fluorocarbon resin, fluorine-containing acrylic modified polyurethane resin and fluorine-containing acrylic modified organic silicon resin; the fluorine content of the fluorine-containing resin is 10 to 50wt%, the particle size of the silicon dioxide particles is 10 to 40 nanometers, and a modifying solvent uses a fluoroalkyl silane coupling agent to modify; the solvent is prepared from ethyl acetate, butyl acetate, isoamyl acetate, ethyl butyrate, acetone, butanone, cyclohexanone, methylbenzene, xylene or nonafluorobutyl ether. The invention also provides a transparent hydrophobic and oleophobic functional coating layer which is made of the transparent hydrophobic and oleophobic functional material.

This invention pertains to a method for flavoring an ingestible composition with a flavoring agent in organoleptically purified form, unaccompanied by substances of natural origin present in mango. The flavoring agent may be used in a wide variety of ingestible vehicles such as chewing gum compositions, hard and soft confections, dairy products, beverage products including juice drinks and juice products, green vegetable and chicken products, and the like. The present invention also pertains to an ingestible composition comprising an ingestible vehicle and an organoleptically effective amount of the purified flavoring agent. The present invention also pertains to ethyl 4-(thioacetoxy)butyrate represented by the formula, CH3COS(CH2)3COOCH2CH3.

The present invention is directed to methods and compositions for use to control parasitic mites of honey bees, particularly Varroa mites. In one aspect, the invention is directed to control of parasitic mites of honey bees wherein the active ingredient is a miticidally effective amount of a selected ketone or 1-heptanol, ethyl butyrate, benzaldehyde, heptaldehyde, or d-limonene. In a second aspect, the invention is directed to control of parasitic mites of honey bees wherein the active ingredient is an effective attractant amount of 2-heptanone. The attracted mites are then trapped or otherwise removed from the locus of the bees. The present invention is also directed to methods and compositions which include 2-heptanone to control hive invading pests of honey bees.

The invention relates to a method for preparing a pitavastatin calcium raw material by asymmetric hydrogenation in the technical field of medicinal chemistry. The method comprises the following steps: performing catalytic hydrogenation on 4-benzyloxy-ethyl-acetoacetate I by using a chiral catalyst to prepare (S)-4-benzyloxy-3-hydroxy-ethyl-butyrate, and then obtaining the pitavastatin calcium through a series of reactions such as Claisen condensation, reduction, hydroxyl protection, removal of benzyl, oxidation and the like. In the invention, the highly-efficient chirality added value is realized by the use of catalytic amount of the chiral catalyst (wherein the ratio of substrate to the catalyst can reach 3, 000 to 1), and by performing the asymmetric hydrogenation and the reduction on non-chiral ketones to generate chiral alcohols compounds directly (wherein the enantioselectivity can be up to 94.3 percent).

The invention relates to a lithium iron phosphate battery with lithium ion battery electrolyte suitable for ultralow-temperature charging and discharging. The lithium ion battery electrolyte comprises lithium salt, a multi-element organic solvent and additives, wherein the additives comprise a low-melting-point additive, a film forming additive and a high-temperature additive; the multi-element organic solvent contains at least three of ethylene carbonate, diethyl carbonate, dimethyl carbonate, methyl ethyl carbonate, propylene carbonate and butylene carbonate; the low-melting-point additive contains at least one of 4-methyl-1,3-dioxolane, methyl acetate, methyl propionate, methyl butyrate, ethyl butyrate, propyl butyrate and butyl acetate; the high-temperature additive is at least one of methyl ester, di-n-propyl carbonate and 1,3-propane sultone. The lithium iron phosphate battery with the electrolyte can charge and discharge at an ultralow temperature and in a high-temperature environment, and is stable in performance and long in recycling life.

The invention discloses a method for synthesizing highly-pure bendamustine hydrochloride, which comprises the following steps: taking [1-methy-2(4'-ethyl butyrate)-5-amino]-1H-benzimidazole as a raw material; and orderly reacting the [1-methy-2(4'-ethyl butyrate)-5-amino]-1H-benzimidazole with ethylene oxide and phosphorus oxychloride through the four steps of substitution, hydrolysis, salification and refinement so as to produce the bendamustine hydrochloride. The method in the invention is mild in condition, simple in operation, short in synthesis period and suitable for scaled-up industrial production; and the purity of the synthesized bendamustine hydrochloride is over 99.5 percent, while monomeric impurity is below 0.1 percent, which meet the quality standards of raw material medicament.

The invention relates to an alcoholic drink storage utensil and a preparation method thereof. The alcoholic drink storage utensil is a ceramic product having an alcoholic drink alcoholization function and is composed of purple sand, an alcoholic drink purifying solvent, an energy activator and an environment-imitating solvent, wherein the purple sand accounts for 70-80% of the raw materials, the alcoholic drink purifying solvent accounts for 5-20% of the raw materials s, the energy activator accounts for 5-20% of the raw materials s, and the environment-imitating solvent accounts for 2-6% of the raw materials. The alcoholic drink purifying solvent contains major elements of potassium, sodium, calcium, magnesium and phosphorus and further contains zinc, iron, selenium, copper, strontium, iodine, fluorine and metasilicic acid; the energy activator can be tourmalinite or negative ion powder or a mixture of the tourmalinite and the negative ion powder; the environment-imitating solvent is diatomite. The function of the ceramic products is that parameters such as acetaldehyde, methanol, n-propanol, sec-butyl alcohol, isobutanol, n-butanol and isoamyl alcohol, and the like can be reduced to a different degree; parameters such as ethyl acetate, ethyl butyrate, ethyl lactate and ethyl caproate, and the like can be raised to different degrees. According to the invention, the alcoholic drink has good shade, virgin whiteness, no thickness, no pungent smell and no other off-flavors.

The invention relates to a preparation method of essence for an electronic cigarette with strawberry flavor. The preparation method comprises the following steps: a first step of preparing materials according to a certain mass percent; a second step of stirring and mixing prepared ethyl butyrate, styralyl acetate, benzyl alcohol, phenethyl alcohol, ethyl benzoate, strawberry acid, alpha-ionone, beta-ionone, beta-dihydrogen damascenone, waxberry aldehyde and gamma-octyl lactone in sealed space; a third step of adding the prepared ethyl maltol, vanillin, methyl cinnamate and raspberry ketone in the uniformly stirred and mixed liquor in sequence, and stirring until dissolving completely; and a fourth step of placing the completely dissolved liquor under the room temperature for ageing for 30 hours-60 hours. According to the preparation method disclosed by the invention, the whole process is simple and controllable, the prepared electronic cigarette has special thick fresh strawberry flavor which is strong and mellow, and lasting, so that breath of a user is fresh.

The invention discloses a food attractant of Bactrocera minax. The food attractant comprises the following components in percent by weight: 2%-10% of brown sugar, 1%-10% of acetic acid, 0.5%-10% of alcohol, 2%-6% of honey, 0.2%-1% of ethyl acetate or ethyl butyrate, 0.03%-0.05% of preservative, 0.01%-0.2% of insecticide and 100% of water; or 3%-20% of protein substance is used for replacing the honey and the ethyl acetate or ethyl butyrate. The food attractant disclosed by the invention can be widely used for emergence-period monitoring and trapping control of the Bactrocera minax, is fast in effect, good in control effect, low in cost, convenient to use and good in lasting property, and can reduce the maggoty fruit rate obviously without causing pesticide residue of fruits.

The invention relates to a biological preparation method of (S)-4-chloro-3-hydroxybutyrate ethyl, which uses 4-chloro-3-carbonyl ethyl butyrate as a substrate and enables the substrate to be subjected to asymmetric reduction reaction in the presence of a biological catalyst, a cofactor and a hydrogen donor to produce the (S)-4-chloro-3-hydroxybutyrate ethyl, wherein the biological catalyst is recombinant ketone reductase and the hydrogen donor is isopropyl alcohol; the asymmetric reduction reaction is carried out in a hybrid system of aqueous buffer solution and toluene with pH of 7.0-9.0, and the volume ratio of the aqueous buffer solution to the toluene is 4-20:1. The method provided by the invention solves the problems of requirement of additional coenzyme system, too much added organic solvent, low efficiency of catalyst and high cost in the traditional biological preparation method. The method provided by the invention has the advantages of mild reaction condition, high reaction efficiency and simple operation, and the concentration of the substrate can be increased to 40%, thus improving the preparation efficiency of (S)-4-chloro-3-hydroxybutyrate ethyl and reducing the reaction cost greatly.

The invention discloses a method for preparing (R)-2-hydroxy-4-phenyl ethyl butyrate by catalyzing recombinant carbonyl reductase, which belongs to the technical field of biological engineering. The method comprises the following steps of: cloning gene segments of carbonyl reductase (IolS) and glucose dehydrogenase (GDH) from bacillus subtilis CGMCC NO.1.1508, expressing an IolS gene and a GDH gene in series by adopting a dual-starter method to construct a recombinant plasmid pET24a-G-T7-I, and introducing the plasmid into escherichia coli BL21(DE3); and under the condition of not adding or adding a small amount of NADP+cofactors, performing biotransformation by taking a cell-free extract of the escherichia coli recombinant plasmid as a catalyst, 2-oxo-4-phenyl ethyl butyrate as a substrate and glucose as a substrate to obtain (R)-2-hydroxy-4-phenyl ethyl butyrate, wherein the enantiomeric excess value of the product is higher than 99.5 percent. In the method, IolS and GDH are co-expressed, so that efficient regeneration of an intra-cellular cofactor NADP(H) is realized, production cost is lowered, and a good industrial application prospect is achieved.

The invention provides daily-used apple essence and a preparation method thereof. The daily-used apple essence consists of components including, by weight, from 0.8 to 1.2% of 2-methyl ethyl butyrate, from 0.8 to 1.2% of acetate isoprene diene ester, from 0.8 to 1.2% of allyl cyclohexanepropionate, from 1.3 to 1.8% of isocyclocitral, from 1.5 to 2.5% of triplal, from 1.5 to 2.5% of pentadecanolide, from 2.0 to 3.0% of hexyl acetate, from 2.5 to 3.5% of jasmine pyran, from 3.5 to 4.5% of allyl heptylate, from 3.5 to 4.5% of peach ketone, from 5.5 to 6.5% of fructone, from 7.5 to 8.5% of peach aldehyde, from 8.0 to 12.0% of dihydromyrcenol, from 10.0 to 14.0% of dihydromyrcenol, from 14.0 to 18.0% of dimethyl benzyl carbinyl butyrate and from 24.0 to 28.0% of high cis butyl cyclohexyl acetate. The preparation method includes (1) preparing materials; (2) stirring the materials; (3) allowing the materials to stand and filtering the materials; (4) detecting obtained products; (5) and filling the products. The apple essence is fresh and fragrant, and is high in natural feeling and rich in fragrance, base fragrance is lasting, and the apple essence can be applied to various daily-used products needing apple tone.

The invention provides a base which can be combined with multiple fruit essences and enable the fruit essences to generate sweetness and aroma. The base contains 2-10% of isoamyl isovalerate, 10-20% of isoamyl acetate, 15-20% of ethyl acetate, 10-20% of butyl acetate, 1-2% of sweet orange oil, 0.8-1.5% of lemon oil, 10-20% of isoamyl butyrate and 20-30% of ethyl butyrate. The base can be used in food, tobaccos and daily necessities, such as toothpaste, shampoo, toilet soap and the like.

An object is to provide a water absorbent resin composition containing a water absorbent resin as a main component, with excellent deodorant property and antimicrobial property without impairing appearance and absorption characteristics of the water absorbent resin. The water absorbent resin composition according to the first aspect includes a water absorbent resin containing a polyacrylic acid (salt)-based water absorbent resin as a main component, and an extract of bamboo and an extract of tea. The water absorbent resin composition according to the second aspect includes a water absorbent resin containing a polyacrylic acid (salt)-based water absorbent resin as a main component, and at least two kinds of compounds selected from a group consisting of hexanoic acid (salt), ethyl butyrate, and 3-methyl-2-cyclopenten-1-one. In addition, the method for producing the water absorbent resin composition according to the third aspect includes the step of adding an alcoholic solution of an extract of bamboo, before or after polymerization of an unsaturated monomer containing an acrylic acid (salt) as a main component.

The invention provides a method for preparing high-purity bendamustine hydrochloride. The method comprises the following steps of: (1) completely dissolving oily or colloidal 4-{5-[bis-(2-ethoxyl)amino]-1-methyl-2 benzimidazole}ethyl butyrate in 0.1 to 0.5g / ml solution of C1 to C4 alkyl acetate, wherein the dissolution temperature is 0 to 40 DEG C; (2) adding C5 to C8 hydrocarbons into the solution obtained in the step (1) dropwise, stirring the mixed solution at the temperature of between 10 DEG C below zero and 40 DEG C for crystallization, filtering the mixed solution to obtain solids of 4-{5-[bis-(2-ethoxyl)amino]-1-methyl-2 benzimidazole}ethyl butyrate; (3) performing chlorination on the solids of 4-{5-[bis-(2-ethoxyl)amino]-1-methyl-2 benzimidazole}ethyl butyrate obtained in the step 2 and thionyl chloride, performing hydrolysis by using concentrated hydrochloric acid to obtain salts, and purifying the salts to obtain the crude products of bendamustine hydrochloride; and (4) refining the crude products of bendamustine hydrochloride obtained in the step 3 by using water to obtain the finished products of bendamustine hydrochloride. The purity of the products prepared by the method of the invention is over 99.5 percent, and the content of single impurity is below 0.1 percent; and the method has the advantages of high yield, high product stability and suitability for industrialized production.

The invention relates to a production method of a sesame-flavor white spirit by fragrance-flavor technique, belonging to the technical field of brewage. According to the production method, sorghum, corn, rice, wheat and glutinous rice used as raw materials are subjected to secondary grain soaking, 50 DEG C low-temperature grain soaking, yeast mud sump fermentation for 60-120 days, and yeast powder fermentation characteristic technique for sesame-flavor white spirit. Thus, the sesame-flavor white spirit prepared by the fragrance-flavor technique is high in alcoholic strength but can not make people drunk; the invention greatly lowers the contents of pesticide residues, tannin and other harmful substances as well as ethyl butyrate and part of higher alcohols in the raw materials; and meanwhile, the invention increases the particular flavor characteristic substance 3-methylthio-propanol of the sesame-flavor white spirit to 1 mg / L above.

The present invention is directed to methods and compositions for use to control parasitic mites of honey bees, particularly Varroa mites. In one aspect, the invention is directed to control of parasitic mites of honey bees wherein the active ingredient is a miticidally effective amount of a selected ketone or 1-heptanol, ethyl butyrate, benzaldehyde, heptaldehyde, or d-limonene. In a second aspect, the invention is directed to control of parasitic mites of honey bees wherein the active ingredient is an effective attractant amount of 2-heptanone. The attracted mites are then trapped or otherwise removed from the locus of the bees. The present invention is also directed to methods and compositions which include 2-heptanone to control hive invading pests of honey bees.

The invention discloses a superlow-temperature lithium ion battery electrolyte. The electrolyte is prepared from the following raw materials of organic solvents, lithium salt and a film forming additive, wherein the organic solvents comprise carbon disulfide, ethyl butyrate, diglyme and N,N-dimethylformamide; the lithium salt is lithium tetrafluoroborate; the film forming additive consists of vinylene carbonate and any one of ethylene sulfate, lithium difluorophosphate and imidodisulfuryl fluoride. Compared with t traditional carbonate solvents, the electrolyte has the advantages that the melting point of the used organic solvent is very low, and the higher ion conductivity is still maintained at superlow temperature of -40 DEG C; the additive forms a film at the surface of a cathode, andcan form a stable SEI (solid electrolyte interface) film with low impedance, so as to quickly intercalate and de-intercalate the lithium ions at low temperature. The invention also discloses the lithium ion battery using the electrolyte. The lithium ion battery can reach excellent low-temperature discharge and cycle properties under the superlow-temperature environment.

The invention discloses a maple flavor formula, which is mainly composed of ethyl maltol, methyl cyclopentenolone, ethyl butyrate, furanone, vanillin, a caramel reactant, maltol, 2,3,5-trimethyl pyrazine, isoamyl alcohol and guaiacol. The maple flavor prepared by the formula has obvious advantages that caramel reactant obtained from natural reaction is used as the key material, and a matching formula is employed for preparation of the maple flavor. As a food additive used in food, the maple flavor can endow a product with a maple aroma and taste with natural sense; at the same time, the added natural caramel reactant reduces stiff chemical smell of a single aroma material for the product and increases maple taste, so that the quality and quantity of aroma are higher than those of the similar domestic essence; and the heat resistance and stability of the product are also higher than those of the similar domestic product.

The invention discloses a preparation method of mango-flavored essence for electronic cigarettes. The preparation method comprises the following preparation steps: step 1, preparing raw materials according to certain mass percent; step 2, stirring and mixing prepared cis-3-hexen-1-ol, cis-3-hexenyl acetate, ethyl acetate, ethyl butyrate, allyl hexanoate, butyric acid, glyceryl triacetate, propylene glycol, phenethyl alcohol, ethyl thioacetate, para-mentha-8-thiolone and delta-decalactone / ethanol in a sealed space; step 3, sequentially adding prepared ethyl maltol, maltol, cedar leaf oil, sweet orange oil terpeneless, linalool and mango ketone into the stirred mixed solution; stirring until all the raw materials are completely dissolved; step 4, putting a mixed solution at room temperature and ageing for 30h to 60h. According to the preparation method of mango-flavored essence for the electronic cigarettes, disclosed by the invention, the mango-flavored essence has a special rich and fresh mango flavor and the flavor is rich, mellow and lasting; the mango-flavored essence has no nicotine, has the mango flavor which is favored by the majority of female consumers and has the effect of refreshing breath of a user.

The invention relates to a ketoreductase mutant deriving from wild type ketoreductase of lactobacillus kefir. The ketoreductase mutant is capable of converting ethyl-4-chloroacetoacetate to generate (S)-4-chloro-3-hydroxy ethyl butyrate and has one or multiple of mutations in A94S, F147V, L199P and A202V. The ketoreductase mutant provided by the invention has obvious high specific enzyme activity which is improved by 2-20 times in comparison with the wild type ketoreductase; the enzyme can be used for biologically catalyzing to convert the ethyl-4-chloroacetoacetate to generate (S)-4-chloro-3-hydroxy ethyl butyrate; the reaction condition is mild, and the requirement on equipment is low, the production process is free from high temperature or cooling, and the energy consumption is low; since the enzyme catalysis is efficient and unique in selectivity, the method can be used for producing statins key intermediate (S)-4-chloro-3-hydroxy ethyl butyrate without producing byproduct, and the purification is convenient; in addition, the vast majority solvent in the reaction is water, the three-waste emission is low, and the ketoreductase mutant is environmental friendly.

The invention provides a recombinant escherichia coli for preparing (S)-4-chlorine-3-hydroxyl ethyl butyrate by adopting asymmetric transformation and an application of the recombinant escherichia coli. The recombinant escherichia coli simultaneously comprises a carbonyl reductase gene and a glucose dehydrogenase gene; the sequences of the carbonyl reductase gene and the glucose dehydrogenase gene are respectively shown in SEQ ID NO.1 and SEQ ID NO.3. The recombinant escherichia coli provided by the invention can be applied to high-activity and high-selectivity catalysis of COBE to generate (S)-CHBE; the enzyme activity can be up to 33.1U / mg, and reaches the highest level reported in the literature; substrate and product inhibition are removed in situ by virtue of macroreticular resin, so that the accumulation of the final product (S)-CHBE can reach 3,000mM; the transformation rate of the final substrate can be up to 100%; the optical purity e.e% of the product cam reach 99.4%; and compared with the prior art, the optical purity is significantly improved.

The invention relates to an essence with red bean fragrance. The essence with red bean fragrance is composed of: isoamyl acetate with a mass percentage concentration of 1%, ethyl butyrate with a mass percentage concentration of 1%, beta-damascone, beta-ionone with a mass percentage concentration of 1%, 2-methylpyrazine with a mass percentage concentration of 1%, 2, 5-dimethylpyrazine, 2-acetylpyrazine with a mass percentage concentration of 1%, melonal, 4-ketoisophorone, ethyl maltol, thiol, menthyl acetate, menthol with a mass percentage concentration of 1%, vanillin, ethyl vanillin with a mass percentage concentration of 1%, vanillin propylene glycol acetal, 2-methoxy-3-isobutyl pyrazine with a mass percentage concentration of 1%, and a solvent. The raw materials are added into a container in order according to the formula and are stirred evenly to obtain the essence with red bean fragrance. The essence provided by the invention has outstanding characteristic fragrance of red beans, has strong natural feel and harmonious, soft and delicate fragrance, and can be used for perfuming of drinks, pastries and other food.

An alcohol free or low alcohol fermented malt based beverage is disclosed. The malt based beverage has an alcohol content of not more than 1.0 vol. % preferably not more than 0.7 vol. % having an aroma profile close to the one of alcoholic lager beers. The beverage has 7.00-30.00 ppm ethyl acetate and 0.01-0.20 ppm ethyl butyrate. The beverage preferably has the esters 0.05-2.00 ppm isoamyl acetate; 0.01-0.10 ppm ethyl butyrate; and 0.01-0.05 ppm ethyl hexanoate. The beverage preferably has the higher alcohol 5.00-30.00 ppm (iso-)amyl alcohol. The (iso)amyl alcohol is defined as the sum of 3-methyl butanol and 2-methyl butanol.

The invention discloses a condensed milk essence containing natural cream enzymatic hydrolysate. The condensed milk essence is characterized by mainly comprising alcohol, delta-decalactone, delta-dodecalactone, 4-methyl-5-beta-hydroxyethyl thiazole (sulfurol), furanone, vanillin, dodecanoic acid, tetradecanoic acid, hexadecanoic acid, ethyl butyrate, ethyl acetate and cream enzymatic hydrolysate. By using the natural cream enzymatic hydrolysate as a main component, the condensed milk essence has fuller mouthfeel and softer, more realistic and more natural fragrance and flavor in comparison with other condensed milk essences. The stability and fragrance quality of the condensed milk essence is superior to that of domestic similar essence products. As a food additive, the prepared condensed milk essence is used for enhancing flavor of final products such as foods and beverages, endows the products with natural tastes, and can obviously improve and increase inherent quality of flavored products.

The invention relates to an (S)-chloride-3-ethyl 3-hydroxybutyrate biological preparation method, which includes: utilizing 4-chloride-3-carbonyl ethyl butyrate as substrate so that the substrate can be asymmetrically reduce to generation (S)-4-chloride-3-ethyl 3-hydroxybutyrate under the existence of biocatalyst and hydrogen donor, wherein the biocatalyst is ketoreductase KRED102, the hydrogen donor is isopropanol, the asymmetric reduction is carried in water-phase buffer solution with pH (potential of hydrogen) value of 5.0-9.0, and polyethylene glycol 400 as dispersant and divalent metal ions as enzymatic activity intensifier are added into the reaction system. By adding auxiliaries low in cost and wide in sources, the (S)-chloride-3-ethyl 3-hydroxybutyrate biological preparation method overcomes the defects of low substrate concentration and long enzyme reaction time and the like during conventional enzyme catalyzing production effectively, is simple in operation and particularly applicable to popularization and application in the pharmaceutical industry.

The invention discloses a high-abrasion-resistance anti-aging tire rubber material. The high-abrasion-resistance anti-aging tire rubber material is prepared from the following raw materials in parts by weight: 45-55 parts of epichlorohydrin rubber, 35-40 parts of ethylene propylene diene monomer, 20-25 parts of butadiene styrene rubber, 10-15 parts of chloroprene rubber, 1.5-2 parts of zircoaluminate coupling agent TL-5, 3-3.5 parts of 1,1,3,3-tetramethylperoxyphenoxybutyl acetate, 1.3-1.6 parts of 3,3-bis(tertiary pentylperoxy)ethyl butyrate, 2-4 parts of potassium carboxylacrylate, 4-7 parts of divinyl benzene, 10-12 parts of magnesium oxide, 25-30 parts of channel black, 20-30 parts of superfine hollow microspheres, 10-15 parts of lignin fiber, 25-30 parts of nano sepiolite powder, 20-25 parts of nano boron nitride, 30-40 parts of zinc borate, 2-3 parts of calcium stearate, 4-6 parts of barium stearate, 5-8 parts of phenyl petroleum sulfonate, 1-3 parts of antiager TMDQ and 2-4 parts of antiager NBC.