936results about How to "Avoid inhibition" patented technology

The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 17 nucleobases which are complementary to human microRNAs. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC.

Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac / DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inhibitors, NSAIDs, taxanes and platinum containing compounds use broader language

Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac / DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of LAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inbhibitors, NSAIDs, taxanes and platinum containing compounds use broader language

A process for producing ethanol from a fibrous lignocellulosic raw material. After pre-treatment of the raw material, the fibrous fraction is first hydrolysed at high consistency and then the modified material is subjected simultaneously to continued hydrolysis with a cellulase and to ethanol fermentation in a fermentation mixture. Fermentation is continued to convert an essential portion of the available cellulose into ethanol, then a liquid fraction containing solubilized hemicelluloses is added to the fermentation mixture and fermentation continued. By means of the invention, high fermentation rates, high ethanol concentrations and low ethanol production costs can be attained.

The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 26 nucleobases which are complementary to human microRNAs selected from the group consisting of miR19b, miR21, miR122a, miR155 and miR375. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC.

This method for producing an aluminum composite including porous sintered aluminum, includes: mixing aluminum powder with a sintering aid powder containing either one or both of titanium and titanium hydride to obtain a raw aluminum mixed powder; adding and mixing a water-soluble resin binder, water, a plasticizer containing at least one selected from polyhydric alcohols, ethers, and esters, and a water-insoluble hydrocarbon-based organic solvent containing five to eight carbon atoms into the raw aluminum mixed powder to obtain a viscous composition; shape-forming the viscous composition on an aluminum foil or an aluminum plate and causing the viscous composition to foam to obtain a formed object prior to sintering; and heating the formed object prior to sintering in a non-oxidizing atmosphere to obtain an aluminum composite which includes porous sintered aluminum integrally joined onto the aluminum foil or the aluminum plate, wherein when a temperature at which the raw aluminum mixed powder starts to melt is expressed as Tm (° C.), then a temperature T (° C.) of the heating fulfills Tm-10 (° C.)≦T≦685 (° C.).

Compositions are provided that are targeted to tumors or tumor-associated neovasculature and enhance the function of tumor-infiltrating T cells. The compositions include fusion proteins that contain a T cell binding domain and a tumor / tumor-associated neovasculature targeting domain. The fusion proteins optionally contain a peptide / polypeptide linker domain and a domain that mediates dimerization or multimerization. The T cell binding domain can be a costimulatory molecule. Methods for using the fusion proteins to enhance an immune response are provided. Therapeutic uses for the disclosed compositions include the induction of tumor immunity.

Systems and methods are described for using methylnaltrexone to treat or prevent inhibition of gastrointestinal motility in equines. A method for preventing or treating opioid-induced and non-opioid-induced gastrointestinal dysfunction includes administering a quaternary derivative of noroxymorphone, preferably methylnaltrexone, to an equine before or after the onset of the gastrointestinal dysfunction.

The invention provides a method for producing biogas through high-solid two-phase three-stage anaerobic digestion by using perishable organic wastes, which comprises the following steps: the perishable organic wastes are hydrolyzed in a hydrolysis acidogenic reactor, and a mixture obtained after hydrolysis is acidified to generate a large number of organic acid products with low molecular weight; the bottom of the hydrolysis acidogenic reactor is communicated with the bottom of a methanogenic reactor through a circulation pump and a pipeline; the top of the methanogenic reactor is communicated with the top of the hydrolysis acidogenic reactor; and the acetic acid producing reaction is carried out in the methanogenic reactor and the methane producing reaction is continuously carried out. The invention can separate the hydrolysis acidogenic process from the acetic acid and methane producing process in the anaerobic digestion process so as to prevent organic acids generated by the perishable organic wastes from inhibiting methanogenesis. The device has simple processing procedure, low cost, easy maintenance and stable and reliable performance, is suitable for anaerobic digestion treatment of various perishable organic wastes, and has highly efficient and stable biogas production capacity of the perishable organic wastes through the anaerobic digestion.

The invention discloses a UBF reactor used for coupled denitriding via anaerobic ammonia oxidation-sulfur-based autotrophic denitrification, and a system and a denitriding method thereof, and belongs to the technical field of waste water processing. The denitriding method is suitable to be used for processing high mmonia nitrogen low C / N waste water, partial nitrification is used for providing all reaction substrates of anaerobic ammonia oxidation, marcasite is used for providing electron donors of sulfur-based autotrophic denitrification; porous limestone is taken as a supporting framework of a limestone filling layer; and nitrite nitrogen generated via nitrosation, and nitrate nitrogen generated via nitrification and anaerobic ammonia oxidation are taken as electron acceptors. The denitriding method is high in ammonium-nitrogen removal rate; operation stability is high; compared with conventional nitration-denitrification denitriding method, the denitriding method possesses following advantages: no extra organic matter is added as the electron donor, marcasite is ued for providing the electron donors of sulfur-based autotrophic denitrification bacteria, cost is low, controllability is high, effluent is stable, sludge yield is low, and energy consumption is low.

The invention discloses a breeding sewage treatment method which comprises the following steps of: firstly deslagging sewage, then hydrolyzing, acidifying and regulating, then treating the sewage through a UASB (Upflow Anaerobic Sludge Blanket) reactor, and then carrying out corresponding biochemical treatment through a first-stage A / O treatment system, an intermediate sedimentation tank and a second-stage A / O treatment system sequentially; then sequentially carrying out dephosphorization treatment and flocculation treatment on the sewage subjected to the biochemical treatment to remove sediments, wherein supernatant liquid flows into a final sedimentation tank for further sedimentation, and then the supernatant liquid flows into a pH regulating tank so that the pH value of the supernatant liquid is regulated to be 6-9; then carrying out sterilizing treatment so as to achieve emission on standard. The breeding sewage treatment method disclosed by the invention realizes high-efficiency low-consumption synchronous treatment on carbon, nitrogen and phosphorous to remove total nitrogen, ammonia nitrogen and total phosphorus, thereby ensuring the water quality, improving the production efficiency and greatly reducing the production cost; the breeding sewage treatment method disclosed by the invention has the advantages of simple process, stability in system, small occupied area, low operating cost and the like.

The invention relates to an environment-friendly composite microbial preparation, preparation thereof, and application thereof to aquaculture. An environment-friendly composite microbial water purifying agent comprises the following components in percentage by weight: 20 to 40 percent of bacillus subtilis, 10 to 20 percent of bacillus licheniformis, 10 to 15 percent of bacillus megaterium, 10 to 15 percent of brevibacillus laterosporus, 5 to 10 percent of bacillus pumilus, 5 to 20 percent of bacillus coagulans and 2 percent of biological activating agent. The high-concentration composite microbial preparation is prepared by screening eight strains of probiotics by simulating the physiological functions of normal microbial flora in an aquaculture environment and through scientific compatibility, so that division and cooperation amount the bacterial strains can be realized, a biological enhancement technology can be combined with an indigenous flora activating technology, complex problems in a culture water body can be solved completely, the using amount is small, the cost is low, and the competitive advantage is remarkable.

The present invention discloses a continuous flow shortcut nitrification-anaerobic ammonium oxidation biological denitrification method based on granular sludge, and an apparatus. The method comprises: 1) carrying out sludge inoculation culture, and carrying out an active sludge adaptation period; 2) starting a shortcut nitrification-anaerobic ammonium oxidation reaction; 3) performing an anaerobic ammonium oxidation granular sludge formation and growth period; and 4) performing a stable operation period of a granular sludge continuous flow system. The apparatus comprises a water inlet tank, a bioreactor, a sedimentation tank and a hydraulic screen filter, wherein the water inlet tank, the bioreactor, the sedimentation tank and the hydraulic screen filter are sequentially communicated, the influent of the water inlet tank is communicated with high ammonia nitrogen wastewater, the effluent is communicated with the bioreactor, the concentrated sludge on the bottom of the sedimentation tank is communicated with the bioreactor through a sludge reflux pump, a fixation filler, a stirrer, a filtration screen and an aeration head communicated with an air compressor are arranged inside an anoxic reactor, the sedimentation tank is provided with a clear overflow port communicated with the hydraulic screen filter through a pipeline, the effluent of the hydraulic screen filter is the final effluent, and the retained granular sludge refluxes to the bioreactor.

The invention discloses a system and method for treating municipal sewage through short-cut denitrification-anaerobic ammonia oxidation after short-cut nitrification-anaerobic ammonia oxidation and belongs to the field of sewage biological treatment. The system comprises a raw water tank, an organic matter removal and dephosphorization SBR reactor, a short-cut nitrification SBR reactor, an anaerobic ammonia oxidation granular sludge UASB reactor, a second regulating water tank and a short-cut denitrification-anaerobic ammonia oxidation UASB reactor. All functional floras are subjected to advantageous culture in different reactors according to respective growth characteristics, so that a sludge age contradiction between denitrification and dephosphorization is solved, and stability of the treatment system is enhanced; real-time control is applied to the short-cut nitrification SBR reactor to solve the problem that short-cut nitrification with a low ammonia and nitrogen level is hard to maintain stably; water discharged from the short-cut nitrification reactor and water discharged from the organic matter removal reactor are mixed to solve the problem that continuous flow half short-cut nitrification is hard to maintain; short-cut denitrification-anaerobic ammonia oxidation is used for further treatment of water discharged from the anaerobic ammonia oxidation reactor to solve the problem that nitrate nitrogen is generated during anaerobic ammonia oxidation.

The invention provides a technology and a method for treating urban sewage by three-section short-cut nitrification / anaerobic ammonia oxidation, and belongs to the technical field of biological treatment of sewage. A raw water tank, an organic substance removal sequencing batch reactor (SBR), a first regulating water tank, a short-cut nitrification SBR (provided with an on-line monitoring and feedback control system), a second regulating water tank and an autotrophic nitrogen removal up-flow anaerobic sludge bed / blanket (UASB) reactor are sequentially connected in series in the technology; and the sludge is separated according to the sludge age, so that the contradiction between denitrification and phosphorus removal sludge age is solved. By applying the real-time control technology of the short-cut nitrification SBR to the autotrophic nitrogen removal technology, the problems that the half short-cut of low ammonia nitrogen short-cut nitrification in continuous flow is difficult to maintain, the concentration ratio of ammonia nitrogen to nitrous in the effluent is difficult to control and the like are solved. By successfully applying the anaerobic ammonia oxidation technology todeep denitrification treatment of the domestic sewage, urban sewage treatment with high efficiency and low energy consumption is realized.

The invention provides a method for treating nitrobenzene and aniline waste water. The invention treats waste water mainly through immobilized microorganisms - an anaerobic biofilter (I-AF) and immobilized microorganisms - a biological aerated filter (I-BAF); wherein: the waste water is homogenized through a regulating tank and then enters a sedimentation tank to remove suspended substances (SS) in the waste water by putting into polymeric iron or polymeric aluminum for coagulation reaction; and the yielding water reach the up-to-standard discharge after entering a three-grade I-AF reactor and a four-grade I-BAF reactor for the further treatment. For detailed method and steps, please see the description. The method has advantages that the biological treatment improves the toxin immunity of microorganisms by adopting the immobilized microorganism technique, thereby realizing the high efficient biologic removal to poisonous harmful substances such as high concentration nitrobenzene and aniline, reducing the treatment costs and realizing the up-to-standard discharge of waste water. The purposes of the invention are applied to the treatment of wastewater containing nitrobenzene and aniline, as well as the treatment to high concentration organic waste water and the like.

The present invention relates to a hydrogenation method for producing clean diesel oil, after the raw material oil is mixed with circulating hydrogen, the mixture enters into a second hydrogenating reactor area, under the action of hydrogenation refining catalyst, the reaction is performed, after the reaction effusion is cooled, separated and fractionated, naphtha distillate, light diesel oil distillate and heavy diesel oil distillate are got, after a part or whole heavy diesel oil distillate is mixed with new hydrogen, the mixture enters into a first hydrogenating reactor area, and contacts with the hydrogenating reforming catalyst to perform reaction, the reactant enters into the second hydrogenating reactor area directly without separation, the left heavy diesel oil distillate and the light diesel oil distillate are mixed to get the diesel oil product. The adoption method of the present invention can treat high sulpher, high nitrogen and high drying point diesel oil distillate, under the relaxer operation condition, 2 type and 3 type of standard clean diesel oil which meet the requirement of the World Fuel Oil Code can be got. The present invention has simple flow and low operation pressure, the investment for equipments and the operation cost are all comparatively lower.

The invention discloses a dual-polarization Doppler weather radar ground clutter inhibition method based on fuzzy logic, and the method comprises the steps: processing volume scanning data of a dual-polarization Doppler weather radar into 360 radial lines, wherein the interval between each two adjacent radial lines is one degree, and the data of each radial line comprises seven echo characteristic physical quantities: intensity, a mean Doppler speed, a spectrum width, a difference reflectivity factor, a difference propagation phase shift, and a correlation coefficient; setting the seven physical quantities which respectively comprise the intensity, the mean Doppler speed, the spectrum width, the difference reflectivity factor, the difference propagation phase shift, and the correlation coefficient; enabling seven fuzzy results to be assigned with corresponding weight values, carrying out accumulating and obtaining a ground clutter criterion of one echo point; Determining that the intensity echo of the point is the ground clutter when the ground clutter criterion of one echo point is greater than a threshold value; inhibiting the ground clutter of the dual-polarization Doppler weather radar through the ground clutter criterion of each echo point, and compensating a hole of a current layer after clutter inhibiting through employing the echo intensity value of a corresponding point in an upper layer in the volume scanning data.

A process for producing ethanol from a fibrous lignocellulosic raw material. After pre-treatment of the raw material, the fibrous fraction is first hydrolysed at high consistency and then the modified material is subjected simultaneously to continued hydrolysis with a cellulase and to ethanol fermentation in a fermentation mixture. Fermentation is continued to convert an essential portion of the available cellulose into ethanol, then a liquid fraction containing solubilized hemicelluloses is added to the fermentation mixture and fermentation continued. By means of the invention, high fermentation rates, high ethanol concentrations and low ethanol production costs can be attained.

The invention discloses a polymorphic microorganism aggregate autotrophic nitrogen removal integrated device which is provided with a reaction tank, wherein the reaction tank is internally filled with microorganism aggregates and is provided with a water decanting device with a vertical push rod, fixed packing, an aerator, an online pH value detector, an online dissolved oxygen detector, an online ammonia nitrogen detector and an online nitrate nitrogen detector; the reaction tank is connected with a water inlet pipeline, a water outlet pipeline, a sludge outlet pipeline, an air pipeline, an overflow pipeline, a water inlet pump, a blast blower and an electrically operated valve; the reaction tank is also provided with an online gas flowmeter and a PLC (Programmable Logic Controller); the online gas flowmeter, the online pH value detector, the online dissolved oxygen detector, the online ammonia nitrogen detector and the online nitrate nitrogen detector are all connected with the PLC through signals. An operation method comprises the steps: (1) inoculating sludge; (2) carrying out habituated culture; (3) starting partial nitrification reaction; (4) inoculating anaerobic ammonium oxidization granular sludge; (5) proliferating the anaerobic ammonium oxidization granular sludge; (6) culturing an anaerobic ammonium oxidization bacterium biological film; (7) stably operating the autotrophic nitrogen removal integrated device. The polymorphic microorganism aggregate autotrophic nitrogen removal integrated device is suitable for denitrification treatment of medium and high concentration ammonia nitrogen sewage, simple in structure, high in degree of automation, good in denitrification effect and low in operation cost.

An object of the present invention is to provide a method of efficiently leaching copper from a copper sulfide ore containing chalcopyrite or enargite as a main constituent under versatile conditions for actual operation.A method of leaching copper from a copper sulfide ore, characterized by comprising using, as a leaching solution, a sulfuric acid solution containing iodide ions and ferric (III) ions in an excessive amount relative to the iodide ions and leaching copper from a copper sulfide ore; or a method of leaching copper from a copper sulfide ore, characterized by comprising leaching copper from a copper sulfide ore with the use of a leaching solution further containing water-soluble ligands such as chloride ions that can stabilize ferric (III) ions in addition to the above components, is provided.

The invention discloses a combined collector for floatation of a porphyry copper-molybdenum mine and a floatation method thereof. The combined collector is characterized by at least comprising phthalate and carboalkoxy (aryloxy)-thiourea. The combined collector is used in a process of the floatation of the porphyry copper-molybdenum mine and the method comprises the following steps of: performing the floatation on molybdenum, copper and the like in which the molybdenum is as a majority; floating molybdenite and part of copper sulfide minerals with high floatability so as to obtain a molybdenum and copper mixed concentrate with high a molybdenum recovery rate; and enhancing the recovery of the copper sulfide minerals with poor floatability. Due to the adoption of the combined collector and the method, the problem of strong inhibiting effect on the molybdenite caused by a high-alkali environment of lime in a conventional mixed floatation process of the porphyry copper-molybdenum mine is solved effectively; and the method has the characteristics of simple and reasonable flow, high molybdenum recovery rate and the like.

Smac mimetics that inhibit IAPs.

The present invention provides anti-PCI antibodies having Protein C inhibitor (PCI)-neutralizing activity, and the uses thereof. Through the generation and screening of anti-PCI antibodies, the inventors successfully isolated anti-PCI antibodies which inhibit PCI's inhibitory effect on the production and activity of activated Protein C (aPC). The antibodies of the present invention suppress PCI's inhibitory effect on aPC production and / or the aPC inactivation by PCI, and thus can be used to maintain aPC activity and sustain the effects of aPC physiological activities, such as suppression of the activation of blood coagulation system and anti-inflammatory functions. The present invention also provides uses of the antibodies of the present invention in treating diseases such as thrombosis and sepsis using aPC. In treatments by aPC administration, the therapeutic effect of aPC can be sustained by administering an antibody of the present invention. The antibodies of the present invention can be used in the treatment and prevention of diseases such as thrombosis and sepsis.

The invention discloses a color image enhancement method based on improved multi-scale Retinex. Firstly an unprocessed color image is read, a conventional multi-scale Retinex algorithm is improved, and the average brightness component of a current pixel is calculated by adopting bilateral filtering so that brightness component estimation based on the bilateral filtering method is obtained; secondly local contrast enhancement is performed according to the size relation of brightness of each pixel point and domain average brightness thereof; and finally the brightness image after enhancement is compared with the brightness component of the original image, RGB information of the recovered and enhanced image is linearly adjusted, and color image enhancement is obtained finally. The color image enhancement method has advantages of image detail recovery, elimination of the "halo" phenomenon, meeting the human eye visual effect and short operation time.

Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5'-untranslated sequences, 3'-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are disclosed.

The invention provides an oil type release agent die casting containing 70 to 98 parts by weight of a solvent having a specified flash point, 1 to 10 parts by weight of mineral oils and / or synthetic oils having a high viscosity, 15 parts by weight or less of a silicone oil, and 1 to 5 parts by weight of additives having a lubricating function, wherein the flash point of the agent is in the range of 70 to 170° C., and dynamic viscosity of the agent is 2 to 30 mm2 / s or higher at 40° C., and a method for setting a mixing ratio of the solvent, a casting method, and a spraying unit for the case of using the release agent.

The invention provides a method for treating livestock and poultry breeding waste water. The method mainly comprises the following steps of solid-liquid separation treatment, efficient nitrogen-phosphorus biochemical circulation treatment, modified oxidation ditch treatment, sludge reflux treatment, filtration and sterilization treatment and the like. The invention aims to provide the method for treating the livestock and poultry breeding waste water, which is high in capability of removing ammonia nitrogen, total nitrogen and total phosphorus and low in investment cost and running cost, and is easier to manage. The waste water treated by adopting the method provided by the invention can meet the requirement of the national Discharge standard of water pollutants for livestock and poultry breeding GB18596-2001; not only can the up-to-standard discharge requirement in the waste water treatment of the livestock and poultry breeding industry be effectively met, but also the difficult problem of removing the ammonia nitrogen while an organic matter is degraded is also solved; and the method is suitable for the waste water treatment of breeding farms on different breeding scales, similarly, is also suitable for the treatment of municipal domestic waste water and waste water with a high COD (chemical oxygen demand) or high ammonia nitrogen characteristic, and is wide in application prospect.