884 results about "Melatonin" patented technology

A dietary supplement of mitochondrial nutrients is designed for relieving stress, preventing and improving stress-related disorders, such as chronic fatigue syndrome, diabetes, age-associated cognitive dysfunction and diseases (Parkinson's and Alzheimer's disease). The supplement composition has the following nutrients: B vitamins (cyanocobalamin 2-1,000 ug, thiamin 1-1,000 mg, niacin 15-2,000 mg, pyridoxine 1-1,000 mg, Pantothenate 5-150 mg, folic acid 400-40,000 ug), alpha-tocopherol 10-800 mg, ascorbic acid 50-10,000 mg, calcium 20-2,000 mg, vitamin A 200-10,000 ug, alpha-lipoic acid 100-1,000 mg, N-acetyl cysteine 100-3,000 mg, L-carnosine 100-9,000 mg, tyrosine 100-9,000 mg, vanillin 10-100 mg, phosphatidylserine 10-800 mg, resveratrol 10-50 mg, dehydroepiandrosterone 1-50 mg, and melatonin 0.1-3 mg, all of which have been individually used experimentally or clinically for relieving stress, preventing and treating age- and stress-related disorders and diseases but no combination of these compounds has been used. Many embodiments also contain at least one adjunct ingredient such as coenzyme Q 10-200 mg, acetyl-L-carnitine 100-2,000 mg, choline 50-1,000 mg, and creatine 100-2,000 mg.

A stent is provided with a composition which includes melatonin and paclitaxel for use in treating smooth muscle cell proliferation, such as stenosis and preventing restenosis in vascular vessels.

The invention discloses an application of melatonin in reducing cadmium accumulation in plants. The application includes the following steps: (1) mixing melatonin and additives to form aqueous solution; (2) spraying the aqueous solution on plant leaf surfaces under cadmium stress or filling the aqueous solution in nutrient solution or soil where plants grow. The melatonin can quickly and efficiently reduce cadmium content in plant leaves, change distribution of cadmium ions in plant cells, and relieve damage of cadmium to cells; in addition, the melatonin is simple to prepare and convenient to use, does not cause product and environment pollution, does not generate phytotoxicity easily and has a wide application prospect.

A novel biphasic pharmaceutial or nutraceutical composition delivers both an immediate and a sustained dose of a pharmaceutical or nutraceutical agent in the same unit dose. An oral unit dose of melatonin includes melatonin in a sustained-release matrix contained in a solid phase, such as a tablet of capsule, and also includes melatonin in a film dispersed on the surface of the solid phase. Approximately 80 to 90 weight percent of the total amount of melatonin of each unit is contained in the sustained-release matrix and the remainder in the film. The novel composition permits a mammal, including a human being, to both rapidly fall asleep and remain asleep for a desired period of time by releasing an immediate-release dose and a sustained-release dose of melatonin.

Supplemental compositions, and methods for administering same to a user, are provided for promoting a restful night's sleep by speedily inducing a person to fall asleep and to maintain sleep, as well as alleviating minor aches and pains so as to further improve the quality of a person sleep. The supplemental composition may include at least an extract of Valerian Root, an extract of Willow Bark and Melatonin or a derivative thereof. The supplemental composition may be provided for consumption at least one time daily, e.g., prior to sleep.

The invention relates to the field of medical preparations, in particular to an enteric solid preparation containing lycopene, resveratrol or melatonin and a preparation method of the enteric solid preparation. The enteric solid preparation comprises one or more of lycopene, resveratrol and melatonin as an active ingredient, water-soluble and/or enteric carrier adjuvants or other pharmaceutic adjuvants. The water-soluble carrier adjuvants can be used as water-soluble solid dispersoid carriers; and the enteric carrier adjuvants are enteric polymers and can be used as enteric solid dispersoid carriers or enteric coating film materials. The lycopene, the resveratrol and the melatonin of the enteric solid preparation have favorable dissolubility in the intestinal tract, so that the medicament, namely, the enteric solid preparation, can be rapidly dissolved and released in the intestinal tract, and thus absorption and bioavailability of the lycopene, the resveratrol and the melatonin are increased. The enteric solid preparation containing the lycopene, the resveratrol and the melatonin can be suitable for application and industrial production of oral preparations, such as tablets, particles, pellets, capsules, enteric capsules, enteric coating tablets, enteric coating pellets, enteric coating particles and the like.

The invention relates to melatonin solution capable of improving the anti-stress capability of a plant. The melatonin solution contains a solvent, wherein the concentration of melatonin in the solvent is 75-100mmol/L; the anti-stress capability is salt-resistant, cold-resistant and iron deficiency-resistant capability; the working concentration of the melatonin solution is 75-100micromol/L after the melatonin solution is diluted by distilled water; preparation steps are as follows: adding melatonin in the solvent suitable for being used in agricultural production, stirring and dissolving to obtain a finished melatonin solution product. According to the melatonin solution disclosed by the invention, simple and practicable effects are achieved, the operation is simple, the stability is good, and salt-resistant, cold-resistant and iron deficiency-resistant capability of the plant can be improved.

Disclosed herein are substituted naphthalene-based melatonin (MT) receptor modulators and/or 5-HT receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.

The invention provides a culture liquid for promoting ectogenesis of embryo vitrified by an open pulled straw (OPS) method after thawing. Frozen 2-cell embryo after thawing is cultured in the culture liquid containing 10<-9> mol/L of melatonin (MT), so that the blastula development rate of the embryo is improved and the number of the cells in the embryo is increased, thereby improving the embryo quality, and providing a beneficial reference for further developing the study of OPS cryopreservation of livestock embryos.

An illumination system (1) includes a lighting device (3); a manipulation device (6) for a user to manipulate when the user intends to fall asleep; a control unit (2) for detecting a start time of measuring a sleep latency based on a manipulation time at which the manipulation device is manipulated, the sleep latency being a time period from a time at which the user intends to fall asleep to a time at which the user falls asleep; and a memory unit (14) for storing a reference time obtained based on the start time of measuring the sleep latency detected by the control unit. The control unit includes a lighting device control (15) subunit performing an illumination control to reduce the user's melatonin suppression from a preset timing before the reference time stored in the memory.

The invention discloses an external preparation for treating vitligo and a preparation and using method thereof. The external preparation comprises the following components in portion by weight: 10 to 30 portions of radix salviae miltiorrhizae, 10 to 30 portions of rhizoma drynariae, 10 to 30 portions of herba ecliptae, 10 to 30 portions of angelica, 10 to 30 portions of dodder, 10 to 30 portions of white fructus tribuli, 10 to 30 portions of purslane, 10 to 30 portions of dark plum, 10 to 30 portions of cnidium fruit, 10 to 30 portions of prepared fleece-flower root, 10 to 30 portions of safflower, 10 to 30 portions of black sesame, 10 to 30 portions of szechuan lovage rhizome, 10 to 30 portions of gromwell root, 10 to 30 portions of honeysuckle, 10 to 30 portions of malaytea scurfpea fruit, 2 to 8 portions of radix euphorbiae ebractealatae, 10 to 15 portions of toad shell and 2 to 8 portions of chilopod. The external preparation can invigorate blood circulation and eliminate freckles, inhibit epidermis sulphydryl and melatonin, and activate the activity of tyrosinase so as to recover or accelerate the generation and the transfer of melanin and recover the color element of pathological skin; and the preparation method is simple, and can obtain good economic benefit.