75 results about "Buccal use" patented technology

Drug formulations for systemic drug delivery with improved stability and rapid onset of action are described herein. The formulations may be administered via buccal administration, sublingual administration, pulmonary delivery, nasal administration, subcutaneous administration, rectal administration, vaginal administration, or ocular administration. In the preferred embodiments, the formulations are administered sublingually or via subcutaneous injection. The formulations contain an active agent and one or more excipients, selected to increase the rate of dissolution. In the preferred embodiment, the drug is insulin, and the excipients include a metal chelator such as EDTA and an acid such as citric acid. Following administration, these formulations are rapidly absorbed by the oral mucosa when administered sublingually and are rapidly absorbed into the blood stream when administered by subcutaneous injection. In one embodiment, the composition is in the form of a dry powder. In another embodiment, the composition is in the form of a film, wafer, lozenge, capsule, or tablet. In a third embodiment, a dry powdered insulin is mixed with a diluent containing a pharmaceutically acceptable carrier, such as water or saline, a metal chelator such as EDTA and an acid such as citric acid. Devices for storing and mixing these formulations are also described.

Drug formulations for systemic drug delivery with improved stability and rapid onset of action are described herein. The formulations may be administered via buccal administration, sublingual administration, pulmonary delivery, nasal administration, subcutaneous administration, rectal administration, vaginal administration, or ocular administration. In the preferred embodiments, the formulations are administered sublingually or via subcutaneous injection. The formulations contain an active agent and one or more excipients, selected to increase the rate of dissolution. In the preferred embodiment, the drug is insulin, and the excipients include a metal chelator such as EDTA and an acid such as citric acid. Following administration, these formulations are rapidly absorbed by the oral mucosa when administered sublingually and are rapidly absorbed into the blood stream when administered by subcutaneous injection. In one embodiment, the composition is in the form of a dry powder. In another embodiment, the composition is in the form of a film, wafer, lozenge, capsule, or tablet. In a third embodiment, a dry powdered insulin is mixed with a diluent containing a pharmaceutically acceptable carrier, such as water or saline, a metal chelator such as EDTA and an acid such as citric acid. Devices for storing and mixing these formulations are also described.

The present invention provides a pharmaceutical composition for sublingual or buccal administration of actives with low to poor aqueous solubility, e.g. the indole hormone melatonin, which contains a solution of the active in a pharmaceutically acceptable solvent adsorbed or absorbed onto particles of a pharmaceutically acceptable carrier and methods of preparing and using the pharmaceutical composition.

A method and composition to help persons reduce or quit smoking is disclosed, employing raw tobacco leaves, or tobacco fluid extract, or food grade tobacco like flavor and aroma, and Antioxidants, with or without and SAMe and caffeine. All ingredients can be in a micro-powdered or liquid form, for buccal administration. The composition can be in a tablet or capsule that is intended to be slowly sucked and dissolved in the mouth, and that delivers the nicotine, caffeine or SAMe, proved to be effective in alleviating smoking withdrawal symptoms. The composition can also be embedded inside a soft squeezable plastic cigarette for simulated smoking, providing additional periodic doses of nicotine, caffeine and SAMe to satisfy cravings for cigarettes.

An oral administration device having a nipple member and a frangible seal is disclosed. And oral administration system having a nipple member and a syringe to fill the nipple member is disclosed. An oral administration device having a vacuum package surrounding the oral administration device is also disclosed.

Provided are compositions of cladribine and cyclodextrin which are especially suited for the oral and buccal administration of cladribine.

The present invention provides a pharmaceutical composition for sublingual or buccal administration of actives with low to poor aqueous solubility, e.g. the indole hormone melatonin, which contains a solution of the active in a pharmaceutically acceptable solvent adsorbed or absorbed onto particles of a pharmaceutically acceptable carrier and methods of preparing and using the pharmaceutical composition.

A levodropropizine novel preparation is provided in the present invention, a buccal tablet capable of buccal administration and releasing slowly in oral cavity composed of levodropropizine and corresponding supplementary. The present invention leads active component levodropropizine medicine to remain at focal part to act, in oral cavity local range medicine concentration is relative heightened, so working time is prolonged relatively.

A self-film-forming composition in powder form, a reconstituted formula and a kit for oral use are provided, which allow an adequate colonization of the probiotic in the oral cavities together with asufficient residence time to allow beneficial effects against the pathogens related with oral conditions. Thus, the items provided are useful for the prevention and / or treatment of a condition relatedto alterations of the oral microbiota, and specifically for peri-implantitis. The self-film- forming composition in powder form comprises at least a gelifier agent and / or at least a bioadhesive agent, and at least one lactic acid bacteria strain.

The invention discloses a povidone-iodine spray, which is characterized in that it contains active agents povidone-iodine, potassium iodate and / or potassium iodide, glycerin and / or propylene glycol, flavoring agents and water. It not only has stable quality, Moreover, it is non-irritating to the skin and sticky touch, and is suitable for oral use to prevent and treat bacterial, fungal and viral infections.

A multi-modal absorption, medicine-delivery lozenge is provided. The lozenge includes a lozenge base for oral administration into a user's mouth, a medicinal active ingredient including an antihistamine convertible between ionized and non-ionized states, and a buffer present in an effective amount for establishing a pH in the individual's mouth which is characterized by a simultaneous presence of a first pharmacologically effective dose of the non-ionized form of the medicinal active ingredient for transmucosal absorption, and a second pharmacologically effective dose of the ionized form of the medicinal active ingredient for gastro-intestinal absorption.

A kit for treating psychosis by administering a pharmaceutically acceptable liquid composition of Asenapine to oral mucosa includes a formulation having Asenapine, or a pharmaceutically acceptable salt or hydrate thereof, ethanol, and water and a multidose pump filled with the formulation. The Asenapine compositions are stable for an extended period of time at normal storage conditions.

The present invention is a delivery system for sublingual and / or buccal delivery comprising at least one functional oil (i.e. acting as an oil delivery base); at least one surfactant; and at least onepharmaceutically active agent. The invention also includes a method for treating diabetes, for regulating blood glucose levels and / or for treating hyperglycaemia by sublingual or buccal administration of the delivery system where the pharmaceutical agent is insulin and / or an insulin analogue or mimetic, and / or a glucagon-like peptide-1 agonist.

The present invention provides a kit comprising, in separate compartments of a container, the following components (a) and (b): (a) a combination of apomorphine or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable excipient or carrier; and (b) a solution which comprises a diluent and a pH modifying agent; the components being presented such that they can be combined at the point of use into a formulation which is adjusted to a pH ranging from mildly acidic to alkaline and which is suitable for buccal administration. The formulation is useful in treating Parkinson's disease and in promoting sexual function.

The invention discloses an oral administration device. After improvement of the oral administration device, a suction nozzle is movably buckled through an upper screw cap, the upper screw cap and a lower screw cap are tightly screwed through an upper thread, an inner-outer cup and the lower screw cap are tightly screwed through a lower thread, and a connecting disc and a waterproof pad are arranged in the lower screw cap; the suction nozzle is provided with a suction nozzle wall and an upper guide tube wall, a warm water outflow hole is formed in an end part of the suction nozzle wall, an upper guide tube cavity is formed in the upper guide tube wall, and a liquid medicine outflow hole is formed in an end part of the upper guide tube cavity; a lower guide tube wall is arranged at the upperend of the lower screw cap, a liquid medicine inflow hole and a lower guide tube cavity are correspondingly formed in the lower part of the lower guide tube wall, and a warm water outflow hole is formed in the upper end of the lower screw cap; the inner-outer cup is provided with a liquid medicine cup wall, a liquid medicine cup is formed in the liquid medicine cup wall, and a piston head and a push rod are connected to form a medicine boost mechanism which is wholly located in the liquid medicine cup correspondingly. After improvement, the oral administration device is suitable for childrenof different ages, stimulation of bitterness of medicines can be reduced greatly, a child can suck actively, and medicine feeding becomes simpler and easier; less medicine remains in a guide tube of the administration device, an assembly process is simple, and the administration device is convenient to clean.