3222results about How to "Prolong the action time" patented technology

The present invention relates to method of sustained-delivery of an active drug to a posterior part of an eye of a mammal to treat or prevent a disease or condition affecting said mammal, wherein said disease or condition can be treated or prevented by the action of said active drug upon said posterior part of the eye, comprising administering an effective amount of an ester prodrug of the active drug subconjunctivally or periocularly. Preferably, the active drug is more than about 10 times as active as the prodrug. Other aspects of this invention deal with the treatment of certain diseases by the periocular or subconjunctival delivery of an ester prodrug, and certain pharmaceutical products containing ester prodrugs for periocular or subconjunctival administration.

Disclosed is a novel use of an immunoglobulin Fe fragment, and more particularly, a pharmaceutical composition comprising an immunoglobulin Fe fragment as a carrier. The pharmaceutical composition comprising an immunoglobulin Fe fragment as a carrier remarkably extends the serum half-life of a drug while maintaining the in vivo activity of the drug at relatively high levels. Also, when the drug is a polypeptide drug, the pharmaceutical composition has less risk of inducing immune responses compared to a fusion protein of the immunoglobulin Fe fragment and a target protein, and is thus useful for developing long-acting formulations of various polypeptide drugs.

A pharmaceutical composition for the sustained release of an effective amount of a selective 5-hydroxytryptamine 3 (5-HT3) receptor antagonist for the prevention, reduction or alleviation of acute and delayed chemotherapy-induced nausea and vomiting (CINV) following a course of emetogenic chemotherapy, wherein the composition is administered by subcutaneous injection, the composition comprising a 5-HT3 receptor antagonist, a semi-solid delivery vehicle and a pharmaceutically acceptable liquid excipient; wherein the composition, when administered in a single dosage, provides a controlled release of the 5-HT3 receptor antagonist and prolonging the release of the 5-HT3 receptor antagonist that tracks the profile of the incidence of vomiting.

Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, X, Y, and n are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Compounds of formula (I), and salts, N-oxides, hydrates and solvates thereof are histone deacetylase inhibitors and are useful in the treatment of cell proliferative diseases, including cancers:wherein Q, V and W independently represent —N═ or —C═; B is a divalent radical selected from (B1), (B2), (B3), (B4), (B5) and (B6).wherein the bond marked * is linked to the ring containing Q, V and W through -[Linker1]- and the bond marked ** is linked to A through -[Linker2]-; A is an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system; -[Linker1]- and -[Linker2]- independently represent a bond, or a divalent linker radical; and R is (a) a radical of formula R1R2CHNH—Y-L1-X1—(CH2)z— or (b) a radical of formula R-L1-Y1—(CH2)z—,

The invention relates to a poly-gamma-glutamic acid synergistic fertilizer for strengthening fertilizer effect, which belongs to the fertilizer field. The invention comprises graininess fertilizer which comprises the poly-gamma-glutamic acid. The contents of the poly-gamma-glutamic acid and fertilizer in weight are as follows: 0.01 to 1 percent of the poly-gamma-glutamic acid and the remained content is fertilizer. The contents of poly-gamma-glutamic acid of the invention are strictly controlled and the poly-gamma-glutamic acid can be conveniently fertilized. The poly-gamma-glutamic acid is combined with to make full use of the feature as absorption promoter of fertilizer of the poly-gamma-glutamic acid, therefore, crops output is further raised. The fertilizer is released slowly and prolonged by around 4 times compared with the traditional fertilizer in soil. The invention promotes crop absorption and inhibits fertilizer ingredient decomposition and loss, therefore, fertilizer use is directly decreased by more than 20 percent. The pollution to environment is reduced without excessive or inappropriate fertilization.

The present invention relates to a novel compound (e.g., 24-ethyl-cholestane-3β,5α,6α-triol), its production, its use, and to methods of treating neoplasms and other tumors as well as other diseases including hypercholesterolemia, autoimmune diseases, viral diseases (e.g., hepatitis B, hepatitis C, or HIV), and diabetes.

Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a distintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water, an enteric coat on the sub-coat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose (hypromellose) and water.

The invention relates to an antibacterial finishing method for textile containing cellulose. The method uses natural polymer chitosan and sodium alginate as wall materials; traditional Chinese medicine extracts are used as a core material and are subjected to encapsulation by a micro capsule technology; then an afterfinishing method is employed to treat the microcapsule to the partially carboxymethylated textile containing cellulose, so as to endow the textile with antibacterial performance and good wash fastness through electrostatic attraction between the carboxyl on cellulose fiber and chitosan, as well as the crosslinking effect of the cross-linking agent. The raw materials employed by the invention are green, environment-friendly, safe and high-efficiency, and the obtained textile has good antibacterial effect on common staphylococcus aureus, Eschierichia coli and bacillus subtilis.

The invention discloses an air purifying agent, which is composed of component A and component B. The component A is a liquid reactant prepared by percarbamide, diammonium phosphate, ammonium chloride, sodium lignosulfonate, tea polyphenol, water-soluble essence, and deionized water, while the component B is a solid reaction adsorbent prepared by a porous adsorbent, tourmaline, and a load reaction absorbent. Compared with similar products on the market, the air purifying agent of the invention has the advantages of rapid cleaning and lasting effectiveness. With the dual efficacy of sterilization and disinfection, and volatile pollution gas clearing, the air purifying agent has thorough effects and can generate objects with low toxicity or no toxicity. Characterized by easily available rawmaterials, simple preparation, low cost, and convenience for industrial production, the air purifying agent provided in the invention is proved by experiments to have a removal effect up to over 92% for high, medium and low concentration pollution.

The invention relates to a method for preparing a formaldehyde scavenging agent. The method comprises the following steps of: preparing raw materials such as natural mineral micro powder, water, a binder and amino acid in a mass ratio of 100:(50-1,000):(0.5-5):(1-20), wherein the particle size of the natural mineral micro powder is 0.3 to 5mm; mixing and stirring the natural mineral micro powder and the water at the temperature of between 15 and 30 DEG C for 1 to 3 hours to form suspension; adding the binder, and mixing and stirring at the temperature of between 15 and 30 DEG C for 0.5 to 2 hours to form suspension; adding the amino acid, and mixing and stirring at the temperature of between 15 and 30 DEG C for 0.5 to 1 hour to form suspension; feeding into a spray dryer, and preparing dry porous spherical particle fine powder at the temperature of between 80 and 250 DEG C; and putting the fine powder into a packaging bag, and sealing. The raw materials are cheap and readily available, efficiency is high, energy consumption is low, and the prepared formaldehyde scavenging agent is high in adsorption capacity and long in action time.

The invention discloses a differential metl-electrospinning jet head and belongs to the field of electrostatic spinning. The differential metl-electrospinning jet head mainly comprises a hopper, a charging barrel, a jet head body, an internal cone-shaped jet head, an airflow channel air inlet pipe, an airflow channel standpipe, an airflow channel insulating layer, a jet head inner body, a button, a jackscrew, a heating device, a temperature sensor, a screw rod, a coupler, a servomotor, a motor support, a grounding electrode, a receiving electrode plate and a high-voltage electrostatic generator. The differential metl-electrospinning jet head adopts a center-feeding and side-air-intake manner, ensures uniform melt circumferential distribution through the adjustment of the jackscrew, adopts the inner cone-shaped jet head, and can spin dozens of filaments through a single jet head, thereby achieving high spinning efficiency; and by the aid of hot air, the melt layer on the inner cone surface can be blown thinner, the filaments can be drawn, and a heat insulation role can be played on the environmental temperature to slow down cooling of the filaments and prolong the filament drawing time. Therefore, the spun filaments are thinner. The differential metl-electrospinning jet head has the advantages of simple structure, capability of spinning thin fibers and high spinning efficiency.

The invention discloses a controlled-release multilayer drug-loaded artificial bone and a preparation method thereof. The controlled-release multilayer drug-loaded artificial bone is a multilayer structure which is coated layer by layer and is composed of artificial bone carrier materials loaded with drugs or a multilayer structure which is coated layer by layer and is formed by alternately arranging the artificial bone carrier materials loaded with the drugs and artificial bone carrier materials loaded with no drugs; the outline of the controlled-release multilayer drug-loaded artificial bone can be cylindrical, cuboid, square or irregular; and the artificial bone carrier materials loaded with the drugs at different layers comprise the same or different drugs. The controlled-release multilayer drug-loaded artificial bone is prepared by adopting a three-dimensional stereoscopic printing rapid prototyping technology, and the drugs distributed at the different layers are released from outside to inside layer by layer, thereby being capable of realizing multidrug combined action, regulating the releasing sequence and time of the drugs and selecting appropriate drugs to load so as to achieve the individualized treatment goal. The invention can be applied to carrying out local chemotherapy and filling and repairing bone coloboma after eradication focuses of various infections, concretions, tumours and the like of the orthopedics department.

The invention relates to a power ultrasonic device for treating high-temperature metal melt under vacuum state and a method thereof, and belongs to the field of preparation of metal materials. The method has the technical characteristics that the power ultrasonic device is used for treating the high-temperature metal melt under the vacuum state. The power ultrasonic device is characterized in that tantalum with purity being 99.98% is taken as the material of a tool head, and stable and continuous ultrasonic waves can be conducted, and the power ultrasonic device can be prevented from being corroded by high-temperature metal liquid. During the casting process, a vacuum device is adopted for protecting an ultrasonic transducer, alloy to be treated and a temperature preservation device, on one hand, the tantalum tool head can be prevented from being oxidized to deteriorate, one the other hand, the degassing effect of the ultrasonic treatment on the metal melt can be improved by virtue of the vacuum condition. For the produced alloy material, the solidification tissue is fine and compact, the distribution is uniform, and the clarifying effect is good, so that the mechanical property is greatly improved. The invention provides a new technical means for application of ultrasonic treatment of high-temperature melt in industrial production.

The invention discloses a hydrogel paste and a preparation method thereof, wherein the hydrogel paste is composed of three layers: a backing layer, a hydrogel layer and a protecting film layer. The hydrogel layer is arranged between the backing layer and the protecting film layer; the hydrogel layer comprises the following components: 5-10% of macromolecule framework material, 0.5-2% of tackifier, 0.5-1% of filler, 0.03-1% of cross-linking agent, 0.03-1% of cross-linking regulator, 0.5-1% of acid-base regulator, 3-10% of humectant, 0.01-2% of preservative and the balance of distilled water; and the hydrogel layer also comprises 0.01-10% of active ingredient, such as whitening agent, antiphlogistic agent, essential oil, and the like. The hydrogel paste has an excellent slow-release property; the action time of the hydrogel paste is prolonged; a cross-linking effect of the cross-linking agent is fully utilized, so that the hydrogel paste is excellent in viscosity and cohesive strength; and the hydrogel paste is high in oxidation resistance, is safe and free from toxic side effect and is suitable for the treatment of dry, fragile and sensitive skins.

The invention provides a water soluble fertilizer containing high-concentration humic acid. The water soluble fertilizer comprises, by weight, 15-25 parts of a water soluble humic acid salt, 18-25 parts of urea, 9-15 parts of dipotassium hydrogen phosphate, 8-13 parts of potassium acetate, 0.5-2 parts of borax, 0.1-10 parts of polyglutamic acid, 1-5 parts of rhamnolipid, 5-10 parts of a hydroxymethyl cellulose aqueous solution and 30-40 parts of water. The water soluble fertilizer has humic acid content greater than or equal to 150g / L. The invention also provides a preparation method of the water soluble fertilizer containing high-concentration humic acid. The preparation method comprises the following steps of 1, carrying out heating stirring of the water soluble humic acid salt and water to obtain a humic acid salt solution, 2, adding dipotassium hydrogen phosphate, potassium acetate, borax, polyglutamic acid, rhamnolipid and urea into the humic acid salt solution, and carrying out heating stirring to obtain a mixed solution, and 3, carrying out emulsification of the hydroxymethyl cellulose aqueous solution and the mixed solution to obtain the water soluble fertilizer containing high-concentration humic acid. The water soluble fertilizer has obvious fertilizer efficiency, is environmentally friendly, stable and uniform and has a wide application range.

The present invention relates to compositions comprising at least one L-type calcium channel blocker, particularly the compound (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylate, in combination with at least one cholinesterase inhibitor, particularly donepezil, and uses thereof in methods of treatment.

The invention discloses a multi-phase fluid oil displacement and pulse unblocking integrated physical simulation experiment device and method. The device mainly comprises a multi-phase fluid generation and storage system, a multi-phase fluid spreading and impulse wave generation system, a reservoir core simulation system and a dynamic experiment data collection system. The multi-phase fluid spreading and impulse wave generation system comprises a multi-phase fluid injection pipeline, a pulse oscillation generation cavity casing, a collision body and a multi-phase fluid output and pulse wave spreading pipeline. The device mainly utilizes difference of gas and liquid elastic modulus to achieve conversion between pulse unblocking / oil displacement and gas (steam) injection functions to simplify the oil displacement / pulse simulation process in different oil reservoir exploitation processes. The experiment can relate to simulation of experiment processes of miscible-phase displacement and gas water alternative oil displacement, reservoir pulse unblocking, thick oil thermal exploitation storage layer steam injection, oil displacement-unblocking and the like. The device is reasonable in design, simple in operation process and capable of effectively simulating the multi-phase fluid oil displacement and pulse unblocking effects.

The present invention relates to a novel compound (e.g., 24-ethyl-cholestane-3β,5α,6α-triol), its production, its use, and to methods of treating neoplasms and other tumors as well as other diseases including hypercholesterolemia, autoimmune diseases, viral diseases (e.g., hepatitis B, hepatitis C, or HIV), and diabetes.

The invention discloses a supercritical multisource multielement thermal fluid injection-production system and injection-production method. The system comprises a supercritical multisource multielement thermal fluid generating system and an oil tube. The oil tube is arranged in an exploiting shaft; the supercritical multisource multielement thermal fluid generating system comprises a supercritical gasification reactor and a supercritical mixed combustion reactor; in the presence of supercritical water, a gasification reaction is performed on fuel slurry in the supercritical gasification reactor, and the gasification product of the reaction and oxygen-containing gas dissolved in the supercritical water combust in the supercritical mixed combustion reactor to form a supercritical multisource multielement thermal fluid containing supercritical water and carbon dioxide; the supercritical mixed combustion reactor is connected to the oil tube. The supercritical multisource multielement thermal fluid injection-production system provided by the invention has the effects that thermal efficiency is high, the viscosity of thickened oil is reduced, the flowability of the thickened oil is improved and the recovery efficiency is increased.

The invention discloses a preparation method of modified micron zero-valent iron and an application method of the modified micron zero-valent iron in remediation of heavy metal contaminated soil. The preparation method of the modified micron zero-valent iron comprises the steps of cleaning of iron raw materials, preparation of micro iron, ultrafine grinding and modifying treatment. A modifying agent composed of water, xanthan gum, sulfide, a stabilizing agent, zeolite and blast furnace slag is adopted in the step of modifying treatment. The preparation method of the modified micron zero-valent iron has the beneficial effects that the production process of the modified micron zero-valent iron is simple, and the effect similar or superior to micron zero-valent iron is achieved while the cost is reduced; and in addition, the reaction activity is controlled, the oxidation rate is decreased, excellent stability is obtained, and the acting time of the micron zero-valent iron is longer. By the adoption of the application method of the modified micron zero-valent iron, the remediation cost of heavy metal contaminated underground water is further reduced. According to the preparation method of the modified micron zero-valent iron and the application method of the modified micron zero-valent iron in remediation of heavy metal contaminated soil, organic fertilizer is added in the soil treatment process so that the fertility of soil can be improved, the structure of soil can be improved through humic acid produced by the organic fertilizer, heavy metal elements, such as lead, chromium and arsenic, in underground water can be removed, and the concentration of pollutants such as nitrate and perchlorate can be reduced.

The invention relates to the technical field of compound fertilizer, in particular to garden waste biomass charcoal-based compound fertilizer and a preparation method thereof. The preparation method includes steps that cracking garden waste under a high temperature to obtain garden waste biomass charcoal and combustible gas; mixing raw material of the compound fertilizer with 8-12% of garden waste biomass charcoal according to the total raw material weight of the compound fertilizer, melting, granulating and gathering granules; cooling the gathered granules under negative pressure, and sieving; enveloping the sieved granules, packaging and delivering to obtain the garden waste biomass charcoal-based compound fertilizer. The garden waste biomass charcoal-based compound fertilizer is rich in nutrient substance, coordinating and durable in nutrient element release, high in fertilizer nutrient use efficiency, capable of effectively improving and fertilizing the soil, improving the fertilizer utilization rate, increasing the organic substance content of the soil, lowering the volume weight of the soil, improving the moisture and fertility preserving ability of the soil and accelerating the crop growth, and also capable of obviously improving the crop output and improving the crop quality.

The present invention relates to biocompatible polymeric beads and to biocompatible delivery systems comprising same for controlled or sustained release of bioactive molecules. In particular, the invention relates to polymeric beads having a two-phase core and shell structure and to polymeric delivery systems comprising same that provide sustained release of the bioactive compound.

The invention discloses a method for improving the bench blasting quality of a deep-hole of super-hard rocks. The method includes the following steps that blast holes are formed in a step of a blast area, hole mesh parameters are determined, and perpendicular drilling is conducted; explosive loading structures are determined, and the explosive loading structures for segmented explosive loading and mixed explosive loading are adopted in the blast holes at the same time; explosives are determined, wherein the explosives are selected according to according to matching coefficients of explosive wave impedance and rock wave impedance; blasting parameters are determined and include the length W of a resistance line of a base plate, the hole pitch a, the row distance b, the super depth h and the blast hole filling length l; and blasting is conducted, wherein the explosives are loaded, the blast holes are filled with stemming on the tops of the blast holes, reverse blasting is conducted from the bottoms of the blast holes, and blasting is conducted in an inter-hole elementary error sequence. According to the method for improving the bench blasting quality of the deep-hole of super-hard rocks, due to the fact that the hole mesh parameters, the explosive loading structures, the explosives, the blasting parameters, the blasting position and the blasting sequence are reasonably selected, multi-way comprehensive functions are achieved, the performance of the explosives is fully achieved, the sufficient reaction of the explosives is ensured, the utilization rate of the blast holes is increased, and the boulder frequency and bedrocks of rock blasting are reduced.