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Controlled-release multilayer drug-loaded artificial bone and preparation method thereof

A technology of artificial bone and drug loading, which is applied in the fields of medical science, bone implants, and medical devices, and can solve the problems of no relevant reports on 3D printing technology

Inactive Publication Date: 2010-10-20
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, 3D printing technology is mainly used in the preparation of tissue engineering scaffolds, the preparation of organ models, and the preoperative guidance of simulation operations and oral drug delivery. Wu et al. [10] In 1996, the introduction of three-dimensional printing technology was the first to conduct preliminary exploratory research on the preparation of drug delivery devices. Katstra et al. [11] Using 3D printing technology, using lactose as a carrier and sodium fluorescein as a model drug, a controlled-release drug delivery system for oral administration has been prepared. However, there is no relevant report on 3D printing technology in terms of drug-loaded artificial bones.

Method used

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  • Controlled-release multilayer drug-loaded artificial bone and preparation method thereof
  • Controlled-release multilayer drug-loaded artificial bone and preparation method thereof
  • Controlled-release multilayer drug-loaded artificial bone and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0047] Preparation of isoniazid-rifampicin controlled-release drug-loaded artificial bone

[0048] 1) Select L-polylactic acid (molecular weight: 100k / GPC) as the carrier material, pulverize it with a pulverizer, screen the powder with a particle size of about 150 μm, and mix it with excipients polyvinylpyrrolidone K30 and hydroxypropyl methylcellulose E50 by 96 : 2: 2 (mass ratio) fully mix and set aside;

[0049] 2) Two anti-tuberculosis drugs with different mechanisms of action, isoniazid and rifampicin, are selected for use (in terms of design, these two drugs are placed on the second and fourth layers and the first and third layers respectively, and the design is a two-drug sequential release, also known as double-drug double-peak release, hierarchical structure see figure 2 ;)

[0050] 3) Take 80ml of acetone, 8ml of ethanol, 12ml of distilled water and 0.5ml of glycerin and mix them in the container, then add 1g of polyvinylpyrrolidone, 1.5g of sodium lauryl sulfate ...

Embodiment 2

[0062] Preparation of levofloxacin single-drug controlled-release drug-loaded artificial bone

[0063] Select L-polylactic acid (molecular weight: 100k / GPC) as the carrier material, pulverize it with a pulverizer, screen the powder with a particle size of about 150 μm, and mix it with excipients polyvinylpyrrolidone K30 and hydroxypropylmethylcellulose E50 at a ratio of 96:2 : 2 (mass ratio) fully mix and set aside. Levofloxacin was selected as a representative drug, placed on the second and fourth layers respectively, and designed as a single-drug pulse release. Take 80ml of acetone, 8ml of ethanol, 12ml of distilled water and 0.5ml of glycerin and mix them in the container, then add 1g of polyvinylpyrrolidone, 1.5g of sodium lauryl sulfate and 0.2g of sodium chloride to fully dissolve, and prepare a bonding liquid. 20ml was injected into print head 1 (i.e. blank ink cartridge) for later use, and another 20ml of the above-mentioned adhesive liquid was added, and 3g of levofl...

Embodiment 3

[0066] Preparation of levofloxacin-tobramycin controlled-release drug-loaded artificial bone

[0067] Select L-polylactic acid (molecular weight: 100k / GPC) as the carrier material, pulverize it with a pulverizer, screen the powder with a particle size of about 150 μm, and mix it with excipients polyvinylpyrrolidone K30 and hydroxypropylmethylcellulose E50 at a ratio of 96:2 : 2 (mass ratio) fully mix and set aside. Two antibiotics with different mechanisms of action, levofloxacin and tobramycin, were selected as representative drugs, placed in layers 2 and 4 and layers 1 and 3 respectively, and designed as a double-drug sequential release (also known as double-drug double-peak release) . Take 80ml of acetone, 8ml of ethanol, 12ml of distilled water and 0.5ml of glycerin and mix them in the container, then add 1g of polyvinylpyrrolidone, 1.5g of sodium lauryl sulfate and 0.2g of sodium chloride to fully dissolve, and prepare a bonding liquid. Add 3g of tobramycin to 20ml to p...

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Abstract

The invention discloses a controlled-release multilayer drug-loaded artificial bone and a preparation method thereof. The controlled-release multilayer drug-loaded artificial bone is a multilayer structure which is coated layer by layer and is composed of artificial bone carrier materials loaded with drugs or a multilayer structure which is coated layer by layer and is formed by alternately arranging the artificial bone carrier materials loaded with the drugs and artificial bone carrier materials loaded with no drugs; the outline of the controlled-release multilayer drug-loaded artificial bone can be cylindrical, cuboid, square or irregular; and the artificial bone carrier materials loaded with the drugs at different layers comprise the same or different drugs. The controlled-release multilayer drug-loaded artificial bone is prepared by adopting a three-dimensional stereoscopic printing rapid prototyping technology, and the drugs distributed at the different layers are released from outside to inside layer by layer, thereby being capable of realizing multidrug combined action, regulating the releasing sequence and time of the drugs and selecting appropriate drugs to load so as to achieve the individualized treatment goal. The invention can be applied to carrying out local chemotherapy and filling and repairing bone coloboma after eradication focuses of various infections, concretions, tumours and the like of the orthopedics department.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a drug-loaded artificial bone for surgery and a preparation method thereof. Background technique [0002] Soft tissue injury and wound contamination in open fractures are prone to soft tissue infection or osteomyelitis, often leading to delayed union or even nonunion of fractures. Therefore, soft tissue infection and posttraumatic osteomyelitis in open fractures have always been important clinical problems. The routine treatment methods are: strict debridement, proper fixation, early closure of the wound as much as possible, and full-body application of sufficient, broad-spectrum, and potent antibiotics to prevent infection. However, long-term systemic application of antibiotics may bring about a series of side effects such as: liver and kidney damage, etc., and there are disadvantages that the drug is difficult to enter the lesion area lacking blood supply, the local drug concen...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61M31/00A61L27/46A61L27/18A61L27/12
Inventor 郑启新伍卫刚郭晓东吴永超潘海涛
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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