10797results about How to "Little side effects" patented technology

The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., DHA.

The present invention relates to traditional Chinese medicine for treating coronary heart disease and stenocardia is made from (by wt.%) salvia root 50-97%, notoginseng 2-48% and borneol 0.2-3%, in which the salvia root and notoginseng and hot extracted with water, then filtering, concentrating, alcohol precipitating, standing still, recovering ethyl alcohol, concentrating, into extractum, further blended with borneol and adjuvant polyglycol-6000 to form into product.

The invention relates to a Chinese herbal medicine paste for relieving pain, comprising a plurality of medicine materials of angelica, cassia twig, rhizoma chuanxiong, olibanum, myrrh, sylvestris, pubescent angelica, milettia reticulate, pheretima, siegesbeckiae, balsamine, japan yam rhizome, futokadsura stem, orientavine, a millet liquor flavored with the root bark, nuxvomica, Chinese polyphaga, homalomena rhizome, Chinese clematis radix clematidis with fixed weight proportions. The preparation method comprises the following steps: immerse the Chinese herbal medicine materials with fixed weight proportions into sesame oil; 1 kilogram medicine consumes 0.5kg sesame oil; after sever days of immersion, heat mixture for boiling and deslag the mixture; place the residual material on cloth to form a plaster. When in use, slightly heat the plaster and adhere the plaster to the affected part; and each plaster can be used for four days. The Chinese herbal medicine paste has the advantages of effective pain relief and elimination, simple application, rapid and persistent therapeutic effect and low side effect.

A compound having an ability to bind to an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6), for example, the compound represented by formula (I) of the present invention, a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and / or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like. wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.

The invention relates to a Chinese medicinal preparation for treating cancer, and the Chinese medicinal preparation is prepared from 110 raw material drugs, such as yew, barbed skullcap herb, hairyvein agrimony and laggera pterodonta. The preparation can be oral solution, granules, powder, capsules, electuary and tablets. 110 Chinese medicaments are adopted, and monarch, minister, assistant and guide drugs are reasonably compatible and are comprehensively taken to play the effect of treating both principal and secondary aspect of cancers. The raw material drugs adopted in the Chinese medicinal preparation are common Chinese medicaments, and are low in manufacture cost and small in side effect. The medicament has the advantages of capabilities of effectively strengthening the body immunity and attacking pathogen without hurting a body along with quick response, high curative rate, high heal rate, low relapse rate, treatment of both principal and secondary aspect of cancers, safety and reliability, and can be used for treating various types of cancers, especially lung cancer, gastric cancer, liver cancer, esophagus cancer, pancreatic cancer, cervical cancer and breast cancer.

The invention relates to a wound treating agent for humans and / or animals which contains a zeolite-iodine inclusion compound, to the use of such wound treating agent for the preparation of wound-stilling materials, especially compresses, plasters and / or dressing material, and to such wound-stilling materials.

The invention discloses a traditional Chinese medicine preparation for treating cancer, which is prepared by 103 types of bulk drugs such as solidago decurrens, Chinese sage herb, hypericum japonicumand the like. A preparation method of the traditional Chinese medicine preparation comprises the following steps: preparing the bulk drugs into water extract by a conventional method; using the prepared water extract for preparing oral solution by a traditional method; drying the obtained water extraction, then conducting grinding and sieving; taking the throughs for extracting powder, and using the extracted powder for preparing tablets, granules, electuaries or capsules by a traditional method. The preparation method also can be as follows: sieving out the dust of the bulk drugs, conductinggrinding and sieving, taking the throughs, conducting disinfection and sterilization to obtain raw powder, and using the raw powder for preparing tablets, granules, electuaries or capsules by a traditional method. With drugs mixed rationally, the traditional Chinese medicine preparation addresses both the symptoms and root causes of cancer. The bulk drugs are frequently-used common Chinese drugs,have low preparation cost and small side effect, and can effectively enhance own immunity, attack pathogen while do not damage body. The traditional Chinese medicine preparation can cure various typesof cancer, particularly lung cancer, stomach cancer, liver cancer, esophageal cancer, pancreatic cancer, cervical cancer and breast cancer.

The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturase family members. The invention also provides recombinant expression vectors containing desaturase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g., DHA.

The invention relates to a Chinese medicinal composition for treating rheumatism. Diagnosis and treatment based on an overall analysis of the illness and the patient's condition is performed on the basis of the basic theory of traditional Chinese medical science, so the Chinese medicinal composition is particularly suitable for treating diseases such as rheumatic pyretic arthralgia, wind-cold damp arthralgia, blockage of phlegm and blood stasis and the like. In addition, the Chinese medicinal composition is also used for treating amenorrhea and fetal abortion (terminal pregnancy). The invention also relates to various pharmaceutically-acceptable formulations of the Chinese medicinal composition and particularly a minium black plaster, a preparation and a preparation method of the Chinese medicinal composition. The Chinese medicinal composition has the characteristics that: the diagnosis and treatment based on an overall analysis of the illness and the patient's condition is performed, the pertinence is high, the convenience is provided for patients who suffer from the rheumatism and the curative effect is definite; and thus, the Chinese medicinal composition is a comprehensive Chinese traditional treatment formula.

It is intended to provide compositions and foods for use in the treatment, prophylaxis, or amelioration of diseases or symptoms which can be treated, prevented or ameliorated by activating PPAR, in particular, insulin resistant diabetes and hyperlipidemia. Namely, medicinal compositions usable in treating, preventing or improving diseases or symptoms which can be treated, prevented or ameliorated by activation PPAR which contain humulones, isohumulones or lupulones or pharmaceutically acceptable salts or solvates thereof.

The invention belongs to the technical field of medicaments, and in particular relates to a hetero-aromatic ring shown by a general formula (I) as well as a derivative type tyrosine kinase inhibitor, a pharmaceutically acceptable salt or a stereoisomer thereof, wherein X, Z, W, R1, R2, R3, L1, L2, a, b, c, d, e, p, q, A and B are as defined in the specification. The invention also relates to preparation methods of these compounds, a pharmaceutical preparation containing these compounds, and important functions of these compounds in preparation of medicaments for treating B cell related leukemia (such as B cell chronic lymphocytic carcinoma and non-hodgkin lymphoma) and autoimmune diseases (such as rheumatoid arthritis, systemic lupus erythematosus and the like).

This invention discloses a compound antibacterial silk nanometer fibrous material, accounting for weight its component proportion are: Sericin protein 58-90%; chitosan or chitin 0-40%, antibacterial agent 0-5%, electric conduction 1-4%,crossing linking 1-4%. Its process is: dissolve the pure sericin protein, antibiotics separately in polar solvent, join electric conduction medicinal preparation and crosslinking agent, using the static electricity spinning technique, making the average aperture for 0.5-5.0 micron, factor of porosity 60-90%, the mean diameter is 40-100nm and the material is nanometer textile fiber adhesive-bonded membrane. This invention has good organization compatibility with human body, Antibiotics and sericin insoluble is in homogeneous solvent, massive holes among the nanometer textile fiber adhesive-bonded membrane, which has outstanding aqueous percolation permeability, antibacterial agent distributes evenly in the nanometer textile fiber, and the medicine release effect is perfect, so it can be a kind of ideal resist bacteria injured medical material.

The invention relates to injection amphiphilic-microsphere-containing hyaluronic acid mixed gel and a preparation method thereof. The microsphere material relates to amphiphilic materials of PLLA-PEG, PLGA, PLGA-PEG and the like. The molecular weight of PLLA or PLGA is 10,000-500,000, the molecular weight of PEG is 1,000-10,000, and in PLGA, LA / GA=90 / 10-10 / 90. The average grain diameter of the microsphere is 1-200 [mu[m, and the mass percent of the microsphere in the gel is 1-50%; the gel is made from hyaluronic acid, divinyl sulphone crosslinked hyaluronic acid, or glycidyl ether crosslinked hyaluronic acid, the molecular weight of the hyaluronic acid is 100,000-3,000,000, and the mass percent of the hyaluronic acid is 1-50%. The gel can be also made from animal-derived collagen, chitosan, amino acid cellulose and sodium alginate. The microsphere mixed gel is prepared in a sodium chloride solution or a phosphate buffered solution with the osmotic pressure of 250-350 mOsm / L and pH of 6.5-7.5. According to the invention, the amphiphilic microsphere is directly mixed with hyaluronic acid gel, can be uniformly distributed in the gel easily, and is unlikely to aggregate into blocks in the water environment of a human body after being injected.

The invention relates to a preparation method and application of an autologous CAR (chimeric antigen receptor)-T cell. An established CD28-CD137-CD19-CD3 full-length gene is guided into a T-cell of a patient by a CRISPR / Cas9 technology to prepare the CAR-T cell, and the CAR-T cell is subjected to expansion in vitro and then returns in the body of the patient to perform anti-tumor treatment. Compared with the traditional tumor treatment method, the method has the advantages that the method is cell targeted therapy and small in side effect; the gene modified T cell can stably express an antigen binding domain on the surface and identify a target antigen, and does not have MHC limit; and the tumor treatment effect is improved.

The invention relates to the field of medicaments, in particular to an integrin blocking agent HM-3 which has the function of inhibiting tumor angiogenesis, integrin affinity and a bonding capacity and application thereof. The blocking agent is a polypeptide modified with polyethylene glycol, and the modified integrin blocking agent polypeptide can be applied to treatment of solid tumors. During application of the integrin blocking agent to preparation of a tumor treatment medicament, the sequence and structure of the integrin blocking agent is mPEG-SC20k-Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-Gly-Gly-Arg-Gly-Asp. The integrin blocking agent polypeptide designed in the invention is scientific, reasonable, practical and effective, can be used for preparing a treatment medicament for treating human solid tumors, and has remarkable social value and market value; and the treatment spectrum of the integrin blocking agent is expanded greatly, and novel thought and prospect are provided for future development of medicaments.

The invention discloses a baokangling multi-element probiotics oral liquid for treating a digestive system disease and a preparation method of the oral liquid, wherein the oral liquid is comprised of Radix Codonopsis, Atractylodes Rhizoma, Astragalus mongholicus, Rhizoma Dioscoreae, Crataegus pinnatifida, Fructus Hordei Germinatus, Radix Glycyrrhizae, Poria cocos, Ganoderma lucidum, pericarpium citri reticulatae, Fructus citrus sarcodactylis, Fructus Amomi, Cortex Magnoliae Officinalis, Lignum Aquilariae Resinatrm, Cyperus rotundus, Fructus Lycii, Angelica sinensis, Radix Salviae Miltiorrhizae, bletilla striata, unshelled Ascidia, Radix Bupleuri, Radix Paeoniae alba, Corydalis yanhusuo, Radix Glehniae, Polygonatum odoratum, Fructus Schizandrae, Rhizoma Coptidis, peeled Semen Raphani, Semen Lablab Album, Panax notoginseng powder, Fructus Aurantii Immaturus, Radix Aucklandiae, Coix seed, endothelium corneum gigeriae galli, Fructus Corni, lotus seeds and Lindera aggregate. The above traditional Chinese medicinal materials are decocted according to a certain weight ratio and subjected to probiotics fermentation so as to obtain the multi-element probiotics oral liquid. The oral liquid has unique treating effect proven by clinical application. The traditional Chinese medicines are decomposed from macromolecules to micromolecules through biotransformation, so that the effects of absorbing quickly and taking effect instantly are obtained; furthermore, the secondary components and invalid components of the traditional Chinese medicines are converted into the essential nutrient substances incapable of synthetizing by themselves in the human body, so that the curative effect is improved. The application range of the oral liquid is broadened and the quality guarantee period is prolonged.

A SLA-A component contained in red sage root and its composition for treating cardiovascular and cerebrovascular diseases are prepared through extracting in water or alcohol, concentrating, depositing in alcohol, eluting, recovering eluting solution, drying, chromatography by silica gel column, eluting with organic solvent and recovering solvent. Its advantages are sure curative effect and low by-effect.

The present invention belongs to the field of food preserving technology, and is especially method of prolonging preservation period one steamed bread. Compound preserving modifier comprising starch hydrolase 1-7 wt%, hemicellulase 3-7 wt%, lipase 3-7 wt%, emulsifier 40-70 wt%, hydrophilic colloid 15-40 wt%, and coagulation inhibitor 2-6 wt%, is mixed into dough; the dough is pressed and formed into steamed bread blank; and the steamed bread blank is leavened with low temperature supersaturated steam to produce the steamed bread. The steamed bread has improved internal structure, softened core, high antiageing performance and high water content. Its internal cellular gluten structure can limit water escape and delay ageing. At the same time, composite biological mildew inhibitor is sprayed to the surface of steamed bread to inhibit flora growth effectively.

The invention aims at providing a pantoprazole sodium freeze-dried powder injection and comprises pantoprazole sodium and mannitol with the weight ratio of 1: 2 to 5. The invention is simple in formula and little in side effect; products prepared by the method are plump in appearance, good in complex solubility and excellent in quality with the adoption of an advanced freezing and drying process.

The invention relates to a Chinese herbal medicine lactagogue feed for a sow. The Chinese herbal medicine lactagogue feed comprises the following components: wheat, corn, bean pulp, tofu skin, calcium hydrophosphate, rice bran oil, mountain flour, salt, lysine, antioxidant, potassium chloride, magnesium sulfate, vitamin premix, microelement premix and traditional Chinese medicine additive, wherein the traditional Chinese medicine additive comprises the following bulk drugs: cowherb seed, ligusticum wallichii, hawthorn, herba epimedii, pericarpium citri reticulatae, radix ophiopogonis, astragalus mongholicus, dandelion, angelica sinensis, bighead atractylodes rhizome, akebiaquinata, madder, honeysuckle, elecampane, medicated leaven and medlar. By adopting a new formula and the traditional Chinese medicine additive, the nutritional requirement of milking sows is met, the palatability is good, the immunity, milk yield and milk quality of the sows are improved, the productivity of piglets is improved, and the hurt on the sows and the piglets by chemical medicine is avoided. The Chinese herbal medicine lactagogue feed has the advantages of little toxic and side effect, no drug tolerance, no residue and the like, and the side effect on the food safety is reduced.

Methods and kits for treating or preventing psoriasis or a symptom associated with psoriasis in a subject are described. The methods involve topical applications to the subject a therapeutically effective amount of an α2 adrenergic receptor agonist, such as brimonidine.

The present invention provides diaryl ether derivatives that exhibit significant immunosuppressive effects with less side effects.The diaryl derivatives of the present invention are represented by the following general formula (1): one example is 2-amino-2-[4-(3-benzyloxyphenoxy)-2-chlorophenyl]propyl-1,3-propanediol.

The invention discloses a controlled-release multilayer drug-loaded artificial bone and a preparation method thereof. The controlled-release multilayer drug-loaded artificial bone is a multilayer structure which is coated layer by layer and is composed of artificial bone carrier materials loaded with drugs or a multilayer structure which is coated layer by layer and is formed by alternately arranging the artificial bone carrier materials loaded with the drugs and artificial bone carrier materials loaded with no drugs; the outline of the controlled-release multilayer drug-loaded artificial bone can be cylindrical, cuboid, square or irregular; and the artificial bone carrier materials loaded with the drugs at different layers comprise the same or different drugs. The controlled-release multilayer drug-loaded artificial bone is prepared by adopting a three-dimensional stereoscopic printing rapid prototyping technology, and the drugs distributed at the different layers are released from outside to inside layer by layer, thereby being capable of realizing multidrug combined action, regulating the releasing sequence and time of the drugs and selecting appropriate drugs to load so as to achieve the individualized treatment goal. The invention can be applied to carrying out local chemotherapy and filling and repairing bone coloboma after eradication focuses of various infections, concretions, tumours and the like of the orthopedics department.

It is intended to provide water-soluble derivative of camptothecins which are excellent in therapeutic effect and suitable for chemotherapy for cancer. Namely, a water-soluble high-molecular weight derivative of camptothencins being excellent in sustained-release which is obtained by ester-bonding a carboxylic acid group of a polyethylene glycol-polycarboxylic acid polymer to a phenolic hydroxyl group of phenolic camptothencins.

The invention discloses a groove carrying-type coating decomposable drug eluting stent, which comprises a stent main body and a drug coating, wherein the outer surface of the stent main body is provided with a drug-borne groove, the drug coating is coated in the drug-borne groove, and the drug coating comprises a biological decomposable polymer and an active drug. The drug eluting stent not only solves the combination problem between the coating and the stent, and improves the validity and the safety of the drug stent in the operation and application process, but also solves the restenosis and the late thrombosis inside the stent.

The invention discloses a topical skin composition, the preparation method and application in the treatment of psoriasis, herpes zoster and neuro dermatitis, which comprises (a) an acceptable carrier in pharmacy, and (b) effective dose of water extract of raw herbal materials or extract of waterborne organic solution; wherein, the raw herbal materials comprises goldenrod, clove, radixstemonae, seed of cowherb, pseudolari cortex, pubescent holly, glycyrrhiza, dictamnus dasycarpus, angelica sinensis, safflower, gleditsia sinensis lam, uncaria, cynachum paniculatum and Chinese yam.

The invention discloses multifunctional nano compound treating fluid for protecting paper cultural relics. The multifunctional nano compound treating fluid takes deionized water as a solvent, and comprises nano magnesium hydroxide, nano titanium dioxide and hydroxyethyl cellulose, wherein nano magnesium hydroxide accounts for 0.2-1.0% of the weight of deionized water, nano titanium dioxide accounts for 0.1-0.8% of the weight of deionized water, and hydroxyethyl cellulose accounts for 0.2-0.8% of the weight of deionized water. The invention also discloses a preparation method of the multifunctional nano compound treating fluid. The multifunctional nano compound treating fluid can be used for large-area treatment of the paper cultural relics, and can be used for providing protection for deacidification, solidification, light-resistant degradation and mould proofing of the paper cultural relics during a large-area treatment of the paper cultural relics. The pH value of the paper cultural relics treated by the multifunctional nano compound treating fluid can reach an alkalescence degree, and the paper cultural relics have a certain alkali residue, can resist external acid, can be greatly improved in tensile strength, and have a certain antibacterial property.

A lithium ion battery electrolyte having good cyclic effects is disclosed. The electrolyte includes an organic solvent, a lithium salt and an additive. The additive includes a mono-isocyanate-group alkoxy silane compound and a film forming compound. The invention also discloses a lithium ion battery having good cyclic effects. The isocyanate-group alkoxy silane compound in the electrolyte is cheap, can be easily synthesized, and can be adopted as an effective water removing agent and be synergistic with the film forming compound at the same time. A stable SEI film can be formed on the surface of an electrode material, structure stability of cathode and anode materials in a charge-discharge cyclic process is increased, and electrolyte decomposition on electrode surfaces is avoided, and therefore the cyclic performance of the lithium ion battery under room-temperature and high-temperature conditions can be effectively improved.

The invention discloses a long-acting recombinant human follicle-stimulating hormone-Fc fusion protein (hFSH-Fc) and a preparation method thereof. The recombinant hFSH-Fc is a dimerization fusion protein. An amino acid sequence of the hFSH-Fc comprises an hFSHbeta subunit, CTP (carboxy-terminal peptide), an hFSHalpha subunit, a flexible peptide linker and a human IgG (immunoglobulin G)2 Fc variant from the N terminal to the C terminal in sequence. The hFSH-Fc has longer half-life in vivo and smaller side effects than existing hFSH. The invention also relates to an application of a recombinant hFSH-Fc composition to preparation of drugs for treating and / or preventing infertility.