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Preparing process and medical application of SLA-A contained in red sage root and its composition

A technology of SLA-A and composition, applied in the field of medicine, can solve the problems of inconvenience of taking, low content of active ingredients, poor stability, etc., and achieve the effect of strong treatment and prevention of cardiovascular and cerebrovascular diseases, less side effects, and clear curative effect.

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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] As a drug for treating cardiovascular diseases, the traditional Chinese medicine Salvia miltiorrhiza has a wide range of clinical applications, has a broad basis for clinical medication, and has significant curative effects. However, this traditional Chinese medicine has disadvantages such as inconvenience in taking, low content of active ingredients, and poor stability.
It has been reported at home and abroad that the preparation of "Danshen" is widely used in the prevention and treatment of cardiovascular diseases, but there are no reports in the literature on the effective parts of the preparation of "Danshen" and its sustained-release preparations, medical uses and preparation methods.

Method used

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  • Preparing process and medical application of SLA-A contained in red sage root and its composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Preparation of effective part of Danshen (SLA-A)

[0013] Take Danshen medicinal material and crush it into coarse powder, add 10 times the weight of medicinal material in water, heat and extract twice at 80°C for 1.5 hours each time, filter, combine the secondary extracts, and quickly cool to room temperature. According to the ratio of the amount of the upper column sample (equivalent to medicinal materials) to the amount of wet resin (1:8 / W:V), polyamide adsorption column chromatography is performed, and 10 column bed volumes are eluted with water, followed by 10 elutions with 60% ethanol. Column bed volume, 60% ethanol eluted part, the solvent was recovered under reduced pressure, the resultant was put on a silica gel column, eluted with chloroform-ethanol gradient, the SLA-A fraction was collected, and the solvent was recovered. The yield is not less than 0.04%, (the salvianolic acid A content is greater than or equal to 90%).

Embodiment 2

[0015] Preparation of Danshen Sustained-release Coated Pellets

[0016] Preparation process (see attached photo)

[0017] Among them: pill heart prescription:

[0018] Effective part of Danshen 20mg

[0019] Vc 1mg

[0020] Sodium chloride 8mg

[0021] Sodium carboxymethyl starch 25mg

[0022] Lactose 42mg

[0023] Coating solution prescription 1 (dosage per 100ml):

[0024] Ethylcellulose 3g

[0025] PEG400 2g

[0026] Diethyl phthalate 0.6g

[0027] Ethanol to 100ml

[0028] Coating solution prescription 2 (dosage per 100ml):

[0029] Ethylcellulose 3g

[0030] PEG400 1.3g

[0031] Diethyl phthalate 0.6g

[0032] Ethanol to 100ml

[0033] Coating solution prescription 3 (dosage per 100ml):

[0034] Ethylcellulose 3g

[0035] PEG4000.3g

[0036] Diethyl phthalate 0.6g

[0037] Ethanol to 100ml

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Abstract

A SLA-A component contained in red sage root and its composition for treating cardiovascular and cerebrovascular diseases are prepared through extracting in water or alcohol, concentrating, depositing in alcohol, eluting, recovering eluting solution, drying, chromatography by silica gel column, eluting with organic solvent and recovering solvent. Its advantages are sure curative effect and low by-effect.

Description

Technical field: [0001] The present invention relates to the technical field of medicine, specifically, it relates to the preparation method and medical use of the traditional Chinese medicine Salvia miltiorrhiza SLA-A and its composition, which can be expected to have medical use as an anti-cardiovascular and cerebrovascular disease drug. Background technique: [0002] The traditional Chinese medicine Salvia miltiorrhiza has a wide range of clinical applications as a drug for treating cardiovascular diseases, has a broad clinical drug basis, and has significant curative effects. However, this traditional Chinese medicine has disadvantages such as inconvenience in taking, low content of active ingredients, and poor stability. It has been reported at home and abroad that the preparation of "Danshen" is widely used in the prevention and treatment of cardiovascular diseases, but the effective parts of the preparation of "Danshen" and its slow-release preparations, medical uses a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/216A61P9/10
Inventor 王金辉潘文军李铣
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