591results about How to "Good tissue compatibility" patented technology

A seal that contacts a portion of a patient to provide a comfortable interface between an external device, such as a respiratory mask, and the patient. The seal includes an elastic casing filled with a soft gel substance having a cone penetration of from about 5 to 200 penetrations.

The invention discloses a Zn-Mg zinc alloy and a preparation method and application thereof. The zinc alloy contains Zn and Mg; and the weight percentage of Mg in the zinc alloy is 0-20%, 0 not included. The zinc alloy further contains microelements which are at least one of strontium, calcium, silicon, phosphorus, lithium, silver, tin and rare earth elements; and in the zinc alloy, the mass percentage of the microelements is 0-3%, 0 not included. The mechanical performance of the Zn-Mg zinc alloy accords with the strength and toughness requirements of a medical implant material; the Zn-Mg zinc alloy is non-toxic, has excellent histocompatibility and blood compatibility, and can be degraded in vivo; and metal ions obtained from dissolving can be absorbed and used by living bodies to promote bone growth, or can be removed from the bodies through metabolism.

This invention discloses a compound antibacterial silk nanometer fibrous material, accounting for weight its component proportion are: Sericin protein 58-90%; chitosan or chitin 0-40%, antibacterial agent 0-5%, electric conduction 1-4%,crossing linking 1-4%. Its process is: dissolve the pure sericin protein, antibiotics separately in polar solvent, join electric conduction medicinal preparation and crosslinking agent, using the static electricity spinning technique, making the average aperture for 0.5-5.0 micron, factor of porosity 60-90%, the mean diameter is 40-100nm and the material is nanometer textile fiber adhesive-bonded membrane. This invention has good organization compatibility with human body, Antibiotics and sericin insoluble is in homogeneous solvent, massive holes among the nanometer textile fiber adhesive-bonded membrane, which has outstanding aqueous percolation permeability, antibacterial agent distributes evenly in the nanometer textile fiber, and the medicine release effect is perfect, so it can be a kind of ideal resist bacteria injured medical material.

A high strength abrasion resistant surgical suture material with improved tie down characteristics and tissue compliance with braided yarns formed of ether-ketone variant. The suture features a multifilament jacket formed of braided yarns of ether-ketone variant, optionally braided with yarns of polyester, silk, nylon, ultrahigh molecular weight polyethylene or aramid fibers. The braided jacket surrounds a core formed of twisted yarns of ether-ketone variant or ultrahigh molecular weight polyethylene. The suture has exceptional strength, is ideally suited for most orthopedic procedures, and can be attached to a suture anchor or a curved needle.

The invention relates to a medical hydrogel dressings and a preparation method thereof. The hydrogel dressings is prepared by taking 10-30% by mass of starch and 2-15% by mass of water-soluble polymer as raw materials, utilizing a guanidinesalt polycondensate as an anti-bacterial agent, adding a cross-linking agent, and reacting at the temperature of 40-80 DEG C. The operation steps are as follows: adding the starch and the water-soluble polymer in a solvent to prepare into a solution, regulating the pH value of the solution by a NaOH solution, heating for gelatinization, cooling, adding the anti-bacterial agent and the cross-linking agent, stirring to form a mixed solution, pouring the mixed solution into a die, and reacting at the temperature of 40-80 DEG C to obtain the anti-bacterial hydrogel. Compared with the prior art, the hydrogel dressings in the invention has the advantages of good swelling property, high transparency, moderate mechanic strength, excellent bacteria invasion resistance, wide raw material sources, cheap raw materials, good tissue compatibility and favorable medical application prospect, and can effectively prevent wound infection.

The invention provides a cross-linked hyaluronic acid gel and a preparation method thereof. A preparation contains cross-linked hyaluronic acid and uncrosslinked hyaluronic acid, and the cross-linked hyaluronic acid is prepared by reacting a cross-linking agent and hyaluronic acid molecules to form the cross-linked hyaluronic acid gel in the alkaline environment, and then removing the cross-linking agent. The cross-linked hyaluronic acid gel has excellent biocompatibility and long half-life, and is suitable for tissue filling, bone joint lubricating or medicament slow-releasing preparation, and the like.

The invention relates to a guided tissue regeneration membrane, which comprises a compact coating and a loose coating, wherein the compact coating is composed of collagen-I or collagen-I composite hyaluronic acid; and the loose coating is composed of collagen-I or collagen-I composite calcium salt. A preparation method of the guided tissue regeneration membrane comprises the following steps of: preparing a collagen solution or a collagen and hyaluronic acid mixed solution by the use of acetic acid; injecting the solution into a self-made die, and drying it in the air to prepare the compact coating; injecting the collagen solution or a mixed liquor of the collagen solution and calcium salt onto the compact coating, and uniformly spreading; precooling the die at ultralow temperature, followed by freeze-drying to prepare the guided membrane with the compact coating and loose coating structure; carrying out vacuum high-temperature crosslinking and chemical crosslinking; and finally cleaning. The regeneration membrane has good histocompatibility and mechanical strength, low antigenicity and strong guided tissue regeneration capability. Its degradation rate in vivo is 3-8 months. The method is easy to operate, is suitable for automatic and continuous large-scale production, and solves the problems of large size of collagen membrane and material uniformity during industrial production.

The invention discloses an artificial hip joint consisting of multilayer shell core composite structural components. The artificial hip joint comprises an artificial acetabulum and an artificial thigh bone. The artificial hip joint is characterized in that: the artificial acetabulum has a multilayer shell core composite structure and consists of a ceramic acetabulum lining, a transition layer, a porous metal, a porous alloy or a porous toughened ceramic acetabulum shell; the artificial thigh bone has a multilayer shell core composite structure and consists of a ceramic spherical shell layer, a transition layer and a toughened ceramic inner core. The ceramic acetabulum lining and the spherical shell layer of the artificial thigh bone have high hardness, corrosion resistance and abrasion resistance; the artificial acetabulum shell layer and the inner core of the thigh bone have high toughness and impact resistance; and the transition layers are made of gradient composite materials between the materials for the shell layer and the inner core layer, and have the functions of increasing the bonding strength between the shell layer and the inner core layer, reducing the interface stressbetween the shell layer and the inner core layer and the like. The artificial hip joint has the characteristics of long service life, high reliability, high performance and the like.

The invention relates to a piezoelectric active bone repair composite material and a preparation method thereof, aiming at solving the problems that the existing material does not have biocompatibility and is poor in piezoelectric property. The piezoelectric active bone repair composite material comprises ceramic particle filler with a core-shell structure, and polymer matrix, wherein the ceramic particle filler with the core-shell structure is evenly dispersed in the polymer matrix; the core body of the ceramic particle filler with the core-shell structure is formed by ceramic particles, and the surfaces of the ceramic particles are covered by organic matter coating layers. The invention also provides the preparation method of the piezoelectric active bone repair composite material. The preparation method can be widely applied to the field of preparation of the bone repair composite material.

The invention discloses a polysaccharide / autosolidification calcium phosphate composite bone cement composition, which comprises the following components in percentage by weight: 10 to 95 weight percent of autosolidification calcium phosphate bone cement and 5 to 90 weight percent of polysaccharide. The bone cement composition can obtain bone cement with high strength, good toughness, strong plasticity, quick solidification, and good biocompatibility and degradability, thereby overcoming the defects of inadequate toughness and slow degradation in human bodies existing in the prior calcium phosphate bone cement materials and the defects existing in a plurality of enhancement methods in the prior art, and better meeting the requirement of operation use.

The invention provides a collagen matrix freezing gel used for biomedical materials and a preparation method thereof. The collagen matrix freezing gel is the collagen extracted from skins or tendons of healthy domestic animals using the enzyme method with the molecular weight of 280 to 320kDa and a well maintained triple helical structure; the collagen reacts for 1 to 7 days in the condition of low temperature of 0 to minus 50 DEG C in a die after through cross linked and modified reaction with hydroformylation polysaccharide, then extrudes the die and is defrosted, thus forming the collagen matrix freezing gel. The preparation of the collagen matrix freezing gel of the invention in particular relates to the extraction of the collagen, the preparation of the hydroformylation polysaccharide and the synthesis of hydroformylation polysaccharide-collagen matrix freezing gel. The hydroformylation polysaccharide-collagen matrix freezing gel prepared by the invention improves the mechanical property, thermal stability and anti-enzyme degradation, etc., of pure collagen gels, and the freezing gel has the advantages of porosity, plasticity, hydrophilic property and non-toxicity, and can be used as biomedical materials such as bio-scaffold, cell cultivation, drug controlled release and biological dressings.

The invention discloses a bacterial cellulose / collagen-chitosan composite material and a preparation method thereof. The method comprises the following steps of: 1) preparing bacterial cellulose and purifying the prepared bacterial cellulose; 2) fully immersing collagen into a bacterial cellulose network by a negative-pressure osmose process or a positive-pressure method, and crosslinking collagen in the bacterial cellulose / collagen composite material by using a cross-linking agent to obtain a bacterial cellulose / collagen interpenetration network composite material; and 3) removing the unreacted cross-linking agent from the composite material, and soaking in an antibacterial agent solution of chitosan or the derivative of chitosan to prepare the composite material with an antibacterial effect. The bacterial cellulose / collagen composite material is prepared by the negative-pressure method or the positive-pressure method, so that the defect of insufficient immersing amount of collagen in other preparation methods is overcome, and the problems of poor effect, long production cycle and high cost are solved; and the prepared composite material is excellent in mechanical property, high in water permeability, high in air permeability, high in biocompatibility, high in biological activity and high in antibacterial property.

The invention discloses a chitosan / polylysine in-situ gel and a preparation method thereof. The gel is an in-situ gel prepared from 1-5.5 percent by weight of sulfhydrylization chitosan and 0.1- 3.2 percent by weight of maleimide polylysine. The preparation method comprises the following steps of synthetizing the polylysine containing maleimide double bonds, and preparing a maleimide polylysine solution by taking a PBS (phosphate buffer solution) as a solvent; preparing a sulfhydrylization chitosan solution by taking the PBS as a solvent; and uniformly mixing the two solutions under the condition of physiological pH value to obtain the in-situ gel. The invention has the advantages that the preparation process is simple, and the prepared in-situ gel simulates the components, the structure and the functional characteristics of polysaccharide / polypeptide of a natural extracellular substrate, helps to increase histocompatibility of a material, promotes cell adhesion growth and has wide application prospects in the fields of tissue engineering and drug release.

The present invention discloses one kind of cell culturing rack material and its preparation process. The cell culturing rack material is prepared with silk as main material, and through degumming, dissolving, purifying and drying to form fimbrin; dissolving together with collagen or gelatin in the same kind of solvent; high voltage electrostatic spinning to obtain 3D netted nanometer fiber non-woven felt of fimbrin base material, collagen, gelatin, etc. and final organic alcohol treatment. The cell culturing rack material has average fiber diameter smaller than 100 nm, average pore size of 1.0-5.0 microns and porosity of 70-90%. Test shows that the nanometer fiber material has no toxicity, no irritation, no sensibilization, excellent tissue compatibility and perforated pore structure, and may be used as cell culturing rack material for repairing human body tissue.

The invention discloses a polylactic acid-based composite material surgical medical film and a preparation method thereof. By adopting electrostatic spinning equipment and exploring proper technological parameters, different types of polylactic acid-based composite material macromolecular fiber thin films are finally formed and are applied to the field of biomedicine. In addition, by regulating and controlling composition of a macromolecular composite material system and thickness of an electro-spinning thin film, the surgical medical film which has good flexibility, high tensile strength, controllable degradation rate as well as excellent waterproof, antibacterial and air permeable performances is obtained finally. The surgical medical film is applicable to the field of various biomedicines such as healing film, wound surface dressing and anti-adhesion medicine; the medical film not only can be better adhered to tissues and avoid biotoxicity, but also can effectively promote transmission functions of blood, nutrients and growth factors in a human body due to the nature of semipermeable membrane. The process of the invention is simple and environment-friendly; the preparation method is easy to operate, low in cost, applicable to large-scale production and good in controllability, and is expected to be widely applied to various medical fields.

The invention relates to a preparation method of an oral biofilm. The preparation method comprises the following steps: adding type I collagen protein into an acetic acid solution to prepare a collagen-acetic acid swelling solution; adding chondroitin sulfate and stirring to prepare a collagen-chondroitin sulfate serous fluid; carrying out vacuum freeze-drying; pressing to prepare a collagen composite film; spraying the collagen-chondroitin sulfate serous fluid between two layers of the collagen composite film, and carrying out vacuum freeze-drying; carrying out high temperature vacuum crosslinking; and sterilizing after crosslinking to obtain a collagen-chondroitin sulfate composite oral biofilm. The invention has the following beneficial effects: the oral biofilm prepared by the above method has good histocompatibility, suitable controllable degradability and absorbability, low antigenicity and good plasticity and mechanical property; the oral biofilm is used in oral operation; and the three-dimensional porous structure of the oral film provides a tissue engineering scaffold for repairing of wounded tissues, is beneficial to invasion of cells and differential growth and can induce reparative regeneration of defective tissues, and specific thickness of the biofilm can effectively prevent ingrowth of soft tissue.

The invention provides a medical cross-linking sodium hyaluronate gel derivative product and a preparation method thereof. The preparation contains cross-linking hyaluronic acid and non-crosslinked hyaluronic acid; the cross-linking hyaluronic acid reacts with hyaluronic acid molecules by using a cross-linking agent under the alkaline environment and forms cross-linking hyaluronic acid gel, and then the cross-linking agent is removed to prepare the medical cross-linking sodium hyaluronate gel derivative product. The product has good biocompatibility and longer half-life period and is suitable for tissue filling, bone articular lubrication or medicine sustained-release preparation and the like.

The present invention relates to preparation process of biodegradable nanometer silica / polylactic acid composite material, and belongs to the field of nanometer composite material preparing technology. The preparation process includes the following steps: 1. dispersing nanometer silica particle in solvent, and adding lactic acid to produce dehydrating polycondensation and obtain polylactic acid with nanometer silica particle grafted to the surface; and 2. dispersing modified nanometer silica particle in solvent, adding the high molecular weight polylactic acid in the weight ratio between nanometer silica and polylactic acid being 3-30 %; stirring, ultrasonically dispersing, molding and volatilizing solvent to obtain nanometer composite material film; and drying at 40deg.c for 48 hr to obtain final product.

The invention relates to a method for preparing a nanofiber bracket material using levorotatory polylactic acid as matrix. The method comprises the following steps: dissolving the levorotatory polylactic acid as the matrix in a solution of dichloromethane and dimethyl formamide, and stirring and centrifuging the mixture to obtain an electrostatic spinning solution; placing a polylactic acid solution into a 5 milliliter glass syringe, and applying high voltage on the glass syringe; advancing the levorotatory polylactic acid solution in the glass syringe; preparing the mixed solution into a nanofiber material film through a electrostatic spinning technology; and modifying the nanofiber material film to obtain the nanofiber bracket material of which the fiber diameter is between 50 and 500 nanometers and the fiber porosity is more than 90 percent. The method solves the defects that a PLLA porous bracket still has too long degradation time, and degradation products can cause tissue inflammations easily and the like. The method has the advantages of flexible texture, better water permeability and air permeability, excellent tissue compatibility, controllable biodegradability, and no antigenicity.

The invention discloses a Zn-Li series zinc alloy as well as a preparation method and application thereof. The Zn-Li series zinc alloy comprises Zn and Li; and based on weight percent, the mass percent content of the Li in the zinc alloy accounts for 0 to 30%, but not including 0. The preparation method of the Zn-Li series zinc alloy comprises the following steps: (1) mixing the Zn and the Li to obtain a mixture; (2) treating the mixture according to the following step a) or step b) and then cooling the mixture to obtain the zinc alloy: a) under the protection of a CO2 and SF6 atmosphere, carrying out smelting or sintering on the mixture; and b) under the protection of a vacuum atmosphere, dissolving hydrogen gas into the mixture and carrying out the smelting. The zinc alloy prepared by the preparation method disclosed by the invention has an excellent mechanical property and can provide a long-term effective supporting force in vivo; and the zinc alloy has excellent cellular compatibility, blood compatibility and tissue and organ compatibility and can be used for preparing biomedical implant materials.

The present invention discloses the preparation process of microcapsule with included anticancer medicine. The process adopts colloid particle containing polyelectrolyte as template, assembles polyelectrolytes with dislike charges via layer-by-layer self-assembling to the surface of colloid particle, and dissolves or decomposes the colloid particle to obtain hollow polymer microcapsule containing polyelectrolyte. The microcapsule has wall micro structure and thickness capable of being regulated precisely in nanometer size, and the contained polyelectrolyte can interact with the medicine so as to include the medicine into the microcapsule. The included medicine has controllable release speed. Introducing polyelectrolyte with grafted polyglycol to the surface of the microcapsule can raise the biocompatibility of the microcapsule. The process of the present invention is simple, feasible and repeatable, and suitable for inclusion and controllable release of various kinds of water soluble anticancer medicine.

The invention relates to a preparation method of an anti-adhesion absorbable hernia patch. The preparation method adopts a two-step spinning method and includes first degrading a polycaprolactone (PCL) fiber layer with long period as a support base layer in electrospinning mode, then degrading a poly lactic-co-glycolic acid (PLGA) fibrous membrane as a function layer in electrospinning mode and reasonably selecting a solvent in the PLGA electrospinning process to obtain a double-layer fibrous membrane material with a double-layer fibrous membrane firmly. The fibrous membrane material prepared by the method combines excellent dynamic performance of PCL and histocompatibility of PLGA and can be widely used in the hernia repair technology.

The invention relates to a multi-aperture nerve repairing tube and a preparation method and application thereof. The multi-aperture nerve repairing tube is a cylinder with a length-diameter ratio of 0.1-1, and multiple microtube channels are axially distributed in parallel inside; and the ratio of the diameter of each microtube channel to the diameter of the cylinder is 0.04-0.2. The multi-aperture nerve repairing tube provided by the invention has good histocompatibility, proper and controllable degradation absorbability, low antigenicity and good plasticity and mechanical properties. The multi-aperture nerve repairing tube provided by the invention can effectively promote the repair of the injured spinal nerve, and also can be used as a cell transplantation carrier to carry different nerve growth factors and stem cells for repairing the spinal nerve injury. The multi-aperture nerve repairing tube provided by the invention is favorable for the intrusion, differentiation and growth of the nerve cell; and the tubular biomaterial is connected with the far and near broken ends of the nerve, and can induce the axon of the regenerated nerve to grow from the near end to the far end along the tube cavity and stimulate the growth of the neuron of the organism. The multi-aperture nerve repairing tube can be used for promoting the repair of spinal nerves.

The invention discloses a tissue engineering scaffold material for repairing cartilage defects and a preparation method thereof. The tissue engineering scaffold material is prepared by the following steps of: cleaning the spongy bone at the shoulder blade of a fresh pig; cutting the spongy bone into small blocks with diameter of between 5 and 10mm and thickness of between 3 and 5mm; degreasing, decalcifying and deproteinizing; immersing with alcohol for 30 minutes; and air-drying, wherein the decalcifying time is 6 hours. The prepared demineralized spongy bone matrix (DSBM) has the characteristics of relatively simple and convenient preparation method, and capacity of being obtained on a large scale, can be stored for a long time at a low temperature and is economic and cheap. The material can be prepared into different shapes and sizes according to the shapes of the defects to be repaired, so the material is convenient to apply. The DSBM remains a natural netlike gap structural system of the pig spongy bone, has high cellular compatibility, biocompatibility and degradability and is a very good cartilage tissue engineering scaffold material.

The invention relates to the technical field of medical apparatuses and instruments, in particular to a meshy degradable blood vessel stent and a preparation method thereof. The meshy degradable blood vessel stent is woven by degradable polymer filaments and has a certain shape; the filament is composed of degradable polymer and a certain content of auxiliary agent; a degradable polymer solution containing a drug and / or an X-ray developer forms a film on the surface of the meshy stent; and the degradable blood vessel stent has an automatically swelling function, has enough intensity to resist the resilience force of the arterial wall, and can automatically degrade after finishing a certain time of mechanical support on the organ tube wall; and the degraded product has no toxic and side effect on the tissue, thus a secondary operation for taking out the conduit is unnecessary, and the treatment and diagnosis on the vascular diseases are enhanced through coating the drug or the X-ray developer.

The invention relates to a kind of hydrophobia vaccine for human, which in detail relates to a freeze-drying hydrophobia vaccine for human and its preparation method. It is contained in physiological soluble buffer solution with pH being 7-8, the sodium chloride weight proportion is 0.4-1.0%, one or several from mycose, sucrose, gelatin, maltose and dextran is used as stabilizing agent, the concentration is 0.5-5%; the weight proportion of shaping agent for freeze-drying agent is 1-5%, and the purified hydrophobia viral antigen concentration is 4-20 IU per ml.

The invention belongs to the technical field of medical biological materials, and particularly relates to a preparation method of a biomedical amino acid-polyether-polyester triblock copolymer. The method comprises the following steps of: initiating lactone ring opening polymerization under a vacuum condition to prepare a polyether-polyester copolymer, and adding a polymer, amino acid, a catalyst and a solvent into a reaction kettle; and reacting to obtain an amino acid-polyether-polyester triblock copolymer, and removing water and the solvent left in a polymerization system to obtain the amino acid-polyether-polyester triblock copolymer. The method is easy to operate and is practicable; reaction conditions are easy to control; and the obtained copolymer has a stable structure, and can be used for entrapping slightly-soluble medicaments to meet the requirements of clinical treatment.

The invention discloses multifunctional medical biological bone cement. The multifunctional medical biological bone cement is prepared from the following raw materials in percentage by mass: 5%-15% of polyacrylic acid microspheres, 20% of bioactive glass, 64.9%-74.9% of calcium phosphate bone cement and 0.1% of nanometer alendronate sodium microspheres, wherein the sum of the mass percentages of the raw materials is 100%. The multifunctional medical biological bone cement has the function of water absorption self-expansion; the using amount of the bone cement can be reduced, and further the leakage of the bone cement is reduced; the multifunctional medical biological bone cement has relatively good tissue compatibility, can be used for inducing the formation of new bones and enhancing the strength of vertebral bodies, is degradable in vivo without in vivo foreign matter residues; and meanwhile, the controlled-release alendronate sodium has the effects of resisting osteoporosis, reducing the absorption of bones and furthering enhancing the vertebral bodies. Therefore, the multifunctional medical biological bone cement has the advantages of little consumption, promotion of bone formation and bone absorption resistance when applied to vertebroplasty.

The invention relates to a bionic nerve graft used for peripheral nervous recovery and a preparation method and application thereof. The bionic nerve graft comprises a chitosan film conduit and a fibrous protein hydrogel beam positioned in the chitosan film conduit, wherein the fibrous protein hydrogel beam is prepared from fibrous protein through an electrospinning technique. The bionic nerve graft prepared by the preparation method is formed by the filling of the chitosan film conduit and the fibrous protein hydrogel beam of a multi-stage orientation structure, wherein a nerve regrowth space is effectively supported by a chitosan film, the orientational regeneration of a nerve axon is effectively guided by the fibrous protein hydrogel beam of multi-stage orientation, the cell affinity and the mechanical property of whole materials are good, and in addition, degrading speed and the repairing speed of peripheral nervous tissues are matched.