1456 results about "Polylysine" patented technology

The invention provides compositions for the treatment of disorders characterized by dryness including dry eye and dry mouth. The compositions commonly comprise a conjugate of hyaluronic acid and polylysine. These conjugates are attached to affected body tissues or surfaces using transglutaminase, and preferably endogenous transglutaminase.

A mixed micellar aerosol pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal lauryl sulphate, at least three micelle forming compounds, a phenol and a propellant. The micelle forming compounds are selected from the group consisting of lecithin, hyaluronic acid, pharmaceutically acceptable salts of hyaluronic acid, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linoleic acid, linolenic acid, monoolein, monooleates, monolaurates, borage oil, evening of primrose oil, menthol, trihydroxy oxo cholanyl glycine and pharmaceutically acceptable salts thereof, glycerin, polyglycerin, lysine, polylysine, triolein, polyoxyethylene ethers and analogues thereof, polidocanol alkyl ethers and analogues thereof. The amount of each micelle forming compound is present in a concentration of from 1 to 20 wt./wt. % of the total formulation, and the total concentration of micelle forming compounds are less than 50 wt./wt. % of the formulation. The propellant, e.g. a fluorocarbon propellant, provides enhanced absorption of the pharmaceutical agent.

The invention discloses a biological compatibility surface coater and self-assembling coating method of planted medical apparatus, which is characterized by the following: the coater is prepared by self-assembling coating method layer by layer, which accelerates esoderma and resists thrombus constituted by two or more macromolecular materials with certain positive and negative load; the positive load material is chitose, chitin, polylysine and so on; the negative load material is disebrin, hyaluronic acid, alginic acid, polyamino acid and so on; the crosslinker and biological active factor or drug can be added to accelerate the growth of the cell; the coater satisfies the request of biologically medical transplantation.

The invention discloses a method for immobilizing VEGF-carried heparin/polylysine nanoparticles on a Ti surface, which comprises the following steps: by utilizing the characteristic that Hep and PLL can produce static interactions to form nanoparticles, mixing VEGF-carried Hep and PLL to form VEGF-carried nanoparticles; preparing a DM coating on the Ti material surface; and by utilizing the characteristic that the DM and primary amino group can generate Michael addition and Schiff base reaction, immobilizing the amino-containing nanoparticles onto the sample surface in a covalent mode, thereby constructing the biologically modified surface with anticoagulation and endothelium promotion functions. By constructing a nanoparticle modifying layer with anticoagulation and endothelium promotion characteristics on the Ti surface, the invention obviously improves the blood compatibility and endothelium injury restorability of the material.

The present invention relates to novel compositions comprising microspheres and/or nanospheres containing condensed polyanionic bioactive agents, such as DNA. The polyanionic bioactive agent in the microspheres and/or nanospheres is preferably condensed using a polycationic condensing agent, such as poly-L-lysine. The present invention further relates to methods for producing the microspheres and/or nanospheres containing condensed polyanionic bioactive agents.

The invention provides a sustained-release composite microbial fertilizer and a preparation method thereof. The fertilizer comprises a fertilizer core and an envelope wrapping the fertilizer core, wherein the fertilizer core contains polyacrylamide, epsilon-polylysine, ascorbic acid, EDTA (ethylene diamine tetraacetic acid), a composite microbial agent and the balance being organic filler. The fertilizer is stable and efficient, and can be easily absorbed and utilized by crops, and damage and pollution to soil can be effectively avoided.

The invention relates to drug-loading nano-micelles, and a preparation method and an application thereof. According to the to drug-loading nano-micelles, a polyethylene glycol derivative-polylysine-polyleucine amphiphilic triblock copolymer is adopted as a carrier, and self-assembly is carried out in a water solution, such that nano-micelles with a three-layer structure transferring gene and medicine are formed. With the hydrophobic effect between polyleucine, the copolymer forms a core of the micelles in water, such that a hydrophobic medicine docetaxel is entrapped. With polylysine, the nano-micelles are positively charged, such that negatively charged anti-apoptotic protein small interfering RNA can be bonded. Polyethylene glycol is used for protecting the stability of the nano-micelles loading the medicines and gene, and a cycle time of the nano-micelles in vivo is prolonged. The nano-micelles are used for loading both an anti-apoptotic protein small interfering RNA gene medicine and a docetaxel medicine, such that the gene treatment medicine and the chemotherapeutic medicine cooperates in treating cancer, and a synergetic effect of the two medicines can be developed. Therefore, a direction is provided for better treatment of breast cancer.

The invention discloses a chitosan/polylysine in-situ gel and a preparation method thereof. The gel is an in-situ gel prepared from 1-5.5 percent by weight of sulfhydrylization chitosan and 0.1- 3.2 percent by weight of maleimide polylysine. The preparation method comprises the following steps of synthetizing the polylysine containing maleimide double bonds, and preparing a maleimide polylysine solution by taking a PBS (phosphate buffer solution) as a solvent; preparing a sulfhydrylization chitosan solution by taking the PBS as a solvent; and uniformly mixing the two solutions under the condition of physiological pH value to obtain the in-situ gel. The invention has the advantages that the preparation process is simple, and the prepared in-situ gel simulates the components, the structure and the functional characteristics of polysaccharide/polypeptide of a natural extracellular substrate, helps to increase histocompatibility of a material, promotes cell adhesion growth and has wide application prospects in the fields of tissue engineering and drug release.

The invention discloses a novel high-strength hydrogel which is prepared by the following steps: synthesizing a first network hydrogel from a polyelectrolyte (such as hyaluronate, polyglutamic acid, chondroitin sulfate or polylysine); and after soaking the hydrogel in a double-bond functional polyethyleneglycol water solution for some time, taking out, and crosslinking to obtain the high-strength double-network hydrogel. The synthesized high-strength hydrogel has favorable biocompatibility, can be used as a tissue engineering/repair scaffold material or the like, and has wide applicability in the field of biomedical materials.

The invention relates to the technical field of litchi preservation, and particularly discloses a room-temperature litchi storage preservative, and a preparation method and an application of the preservative. The preservative mainly comprises carboxymethyl-chitosan, nisin, natamycin, tea polyphenol, epsilon-polylysine, citric acid and phytic acid; litchi fruit is soaked in a preservation solution, and then aired, so that the litchi fruit can be stored at a room temperature; the quality and low level browning of the litchi fruit can be kept for a long time at the room temperature. Litchi treated by the preservative has the characteristics that the preservative is good in preservation effect, safe, environment-friendly, simple to operate and convenient to use; the preservative is extensive in source, low in cost, edible, and easy to degrade; no pesticide residue risk exists; short-term preservation during room-temperature storage and room-temperature logistics can be achieved; the preservative is a novel preservation material with a great development potential.