The invention relates to the technical field of medical plastic surgery. According to the advantages that human hair has high resistance to physical and chemical factors, stable properties, acid and alkali resistance, is not easy to be absorbed and degraded by tissues, is easy to obtain, can be repeatedly obtained, and is easy to process, it overcomes the existing There are deficiencies of soft tissue filler materials. Using the middle section of solid autologous human hair as raw material, after cleaning, bleaching, grinding, freeze-drying, packaging, and cobalt 60 irradiation treatment, the bleached human hair is made into powder homogenate and liquid human hair keratin particles of different thicknesses , to provide a human hair keratin soft tissue filling material that is derived from autologous body, is easy to obtain, is safe and non-toxic, has good tissue compatibility, is easy to be tolerated by the human body, and can stimulate collagen proliferation and is suitable for injection. Realize the long-term repair of skin and soft tissue, and meet the needs of soft tissue filling materials in the field of plastic surgery.