842results about How to "Improve proliferative ability" patented technology

The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.

The invention discloses a pyrimido or pyridopyridone compound shown in the formula I and its preparation method and use and belongs to the technical field of drug preparation. The pyrimido or pyridopyridone compound can efficiently and selectively inhibit cyclin-depedent kinase (Cdks) CDK4 and CDK6 activity and prevent tumor cell division through inhibiting CDK4 / CDK6. The pyrimido or pyridopyridone compound can be used for treating various diseases caused through imbalance of cell cycle control based on CDK4 and CDK6 and is especially suitable for cancer treatment.

The invention discloses an anti-aging cosmetic skin care product, which contains 0.001-3wt% of plant stem cell actives and 0.01-3wt% of Dragosine carnosine. The plant stem cell actives are PhytocelltecTM MalusDomestica apple stem cells, PhytocelltecTMSolarVitis grape stem cells, PhytocelltecTMAlpRose rose leaf stem cells, PhytocelltecTMArgan At least one of nut stem cells and RegenistemRiceAp red rice stem cells, and its preparation method: adding plant stem cell active substances and Dragosine carnosine to beauty and skin care products. The product of the present invention contains plant stem cell active substance and Dragosine carnosine at the same time. Under the synergistic effect of these two components, the product can obviously improve skin quality, improve skin elasticity, and improve skin proliferation ability, and the effect is obviously higher than adding plant stem cell active substance alone or Dragosine Carnosine.

The invention discloses a method for preparing butyric acid bacteria powder by microencapsulated propagation culture and application, which belong to the technical field of microbial agents. In the invention, an initial strain is clostridium butyricunm JSIM-MCB20040312 with the preservation number of CGMCC (China General Microbiological Culture Collection) No.1647; the butyric acid bacteria powder is prepared by the steps of activation of butyric acid bacteria seeds, microencapsulated embedding of the butyric acid bacteria seeds, viable counting and preparation of butyric acid bacteria powder, wherein the concentration of the obtained bacteria powder is not less than 1.0*1011 / g. The viable organism propagation capacity of the butyric acid bacteria subjected to microencapsulated embedding is enhanced; a strict anaerobic environment created by liquid sealing of nitrogen gas or carbon diode and other inert gases or paraffin is avoided; a high-concentration bacteroid can be obtained without introducing air into a general fermentation tank for culturing; the production cost is low and the requirement for fed microbial additives on viable count can be met; the butyric acid bacteria powder also has the characteristics of heat resistance, acid resistance and favorable entericsolubility and is suitably used as animal intestine probiotics; and intestinal diseases of livestock and poultry farming animals such as chicken, pigs and the like are effectively prevented and the growth of the bred animals is promoted.

The invention discloses a serum-free medium of a stem cell, which comprises a basal medium and an additive, wherein the basal medium is DMEM / F12 (Dulbecco Modified Eagle Medium / F12); the additive comprises 2-15%(v / v) of serum replacement, 20-100ug / ml vitamin C, 0.5-10ng / ml stem cell growth factor, 5-20ng / ml human platelet-derived growth factor and 1-5mmol / ml L-glutamine. The serum-free medium of the stem cell for cell culture has the advantages of short cell cycle, strong multiplication capacity, good cell uniformity and high purity, effectively inhibits differentiation of the stem cell and adherence growth of an endothelial cell, ensures purity and dryness of the stem cell and is free from ingredients of animal origin such as fetal calf serum, and the stem cell obtained by the medium is suitable for clinical application.

The invention discloses a BC (Bacterial Cellulose) / PVA (Polyvinyl Alcohol) composite material, as well as preparation method and application thereof. The preparation method comprises the following steps of: (1) preparing a medical BC wet film block; (2) preparing a polymer solution preparation, namely, under the conditions of high temperature of 95-130 DEG C and high pressure of 0.05-0.15 MPa, preparing a 20-40wt% PVA water solution, namely the polymer solution; (3) soaking the BC wet film block in the polymer solution; and (4) carrying out freeze thawing crosslinking to form the composite material. According to the PVA / BC composite series material prepared by the preparation method, when the PVA concentration reaches 20%, the modulus of compression reaches more than 30 MPa, especially, when the PVA concentration reaches 28%, the modulus of compression reaches more than 50 MPa, the composite material can be used for preparing a replacement for meniscus or cartilage tissue, or preparing replication products of meniscus or cartilage tissue, and the composite material can meet the mechanical strength requirement of bearing tissues, such as the foot cartilage and the meniscus.