1628results about How to "Increase lethality" patented technology

A buttstock for a firearm having a buffer recoil mechanism is collapsible and adjustable. The buttstock includes a lower receiver extension having a bore therein that fits over the buffer recoil mechanism, the lower receiver extension being fixed to the buffer recoil mechanism; a buttstock body having a bore therein for receiving the lower receiver extension; a locking lever disposed along the bottom edge of the buttstock body; a locking pin disposed in the buttstock body and in the locking lever; and a compression spring disposed around the locking pin for biasing the locking pin towards the lower receiver extension.

An apparatus for sterilizing or disinfecting fluids, which comprises a fluid conduit, an ultraviolet light source, which is at least partially within the fluid conduit, and an air drive unit coupled to the fluid conduit. The ultraviolet light source generates an ultraviolet light, which kills microorganisms in the fluid, thus sterilizing or disinfecting the fluid. The air dive unit creates air bubbles in the fluid, such as for fish tanks, fish hatchery ponds, or the like. In accordance with one embodiment of the present invention, the ultraviolet light source comprises an ultraviolet light bulb being surrounded by a protective sleeve. The protective sleeve preferably comprises a UV transmissive material, which may comprise a fluoropolymer material, such as PTFE, FEP, PFA, AF and Tefzel ETFE.

A system and method can provide a command and control paradigm for integrating robotic assets into human teams. By integrating sensor to detect human interaction, movement, physiology, and location, a net-centric system can permit command of a robotic platform without an OCU. By eliminating the OCU and maintaining the advantages of a robotic platform, a robot can be used in the place of a human without fatigue, being immune to physiological effects, capable of non-humanoid tactics, a longer potential of hours per day on-station, capable of rapid and structured information transfer, has a personality-free response, can operate in contaminated areas, and is line-replaceable with identical responses. A system for controlling a robotic platform can comprise at least one perceiver for collecting information from a human or the environment; a reasoner for processing the information from the at least one perceiver and providing a directive; and at least one behavior for executing the directive of the reasoner.

This invention discloses a compound antibacterial silk nanometer fibrous material, accounting for weight its component proportion are: Sericin protein 58-90%; chitosan or chitin 0-40%, antibacterial agent 0-5%, electric conduction 1-4%,crossing linking 1-4%. Its process is: dissolve the pure sericin protein, antibiotics separately in polar solvent, join electric conduction medicinal preparation and crosslinking agent, using the static electricity spinning technique, making the average aperture for 0.5-5.0 micron, factor of porosity 60-90%, the mean diameter is 40-100nm and the material is nanometer textile fiber adhesive-bonded membrane. This invention has good organization compatibility with human body, Antibiotics and sericin insoluble is in homogeneous solvent, massive holes among the nanometer textile fiber adhesive-bonded membrane, which has outstanding aqueous percolation permeability, antibacterial agent distributes evenly in the nanometer textile fiber, and the medicine release effect is perfect, so it can be a kind of ideal resist bacteria injured medical material.

The invention relates to a method used for in vitro proliferation of NK cells, and more specifically relates to a method used for realizing large-scaled proliferation of NK cells via autologous peripheral blood mononuclear cell in vitro cultivating. According to the method, proliferation and activation of NK cells are realized via different cytokine combination. The method comprises following steps: autologous peripheral blood mononuclear cells are inoculated in CD3 antibody and CD16 antibody pre-coated culture bottles, and are subjected to stimulation for 16 to 24h; and a serum-free medium containing IL-2 and IL-18 is added. According to the method, CD3 antibody and CD16 antibody are immobilized via coating, direct stimulating activation of NK cells is performed, so that toxicity of NK cells is increased greatly, activation and proliferation of NK cells are realized using two cytokines IL-2 and IL-18, proliferation multiple and cytotoxicity of NK cells are ensured, and culturing cost of NK cells is reduced greatly.

The invention relates to a preparation method and application of an autologous CAR (chimeric antigen receptor)-T cell. An established CD28-CD137-CD19-CD3 full-length gene is guided into a T-cell of a patient by a CRISPR / Cas9 technology to prepare the CAR-T cell, and the CAR-T cell is subjected to expansion in vitro and then returns in the body of the patient to perform anti-tumor treatment. Compared with the traditional tumor treatment method, the method has the advantages that the method is cell targeted therapy and small in side effect; the gene modified T cell can stably express an antigen binding domain on the surface and identify a target antigen, and does not have MHC limit; and the tumor treatment effect is improved.

The invention discloses a biopesticide bactericide prepared from Chinese herbs and the use of the biopesticide bactericide. The bactericide is prepared from the following components in percentage by weight: 45%-55% of garlic extract, 15%-25% of heartleaf houttuynia herb extract, 10%-20% of purslane extract, 8%-15% of extract of folium artemisiae argyi, gingko and sweet wormwood, and 3%-5% of sulfur powder. The biopesticide bactericide prepared from Chinese herbs has a strong killing effect on pathogenic bacteria of pythium rot, damping off, rice blast and the like of crops such as rice, wheat and vegetables; the bactericide is capable of achieving the purpose of preventing and treating fungus and bacterial disease, and also capable of promoting the expression of a defensive enzyme system in the bodies of plants, improving the disease resistance of the plants and promoting the increase of production of crops; meanwhile, the prevention and treatment effect of the bactericide on soil-borne diseases propagated via soil is above 90%.

Disclosed is an air purification filter with novel active media that attracts, migrates, binds, and destroys pathogens, including sub-micron pathogens, that are suspended in the air passing through the filter. These properties are incorporated in the micro-fibers comprising the active filter media by several novel methods. One embodiment uses polymers or solgel bound monomers of quaternary ammonium compounds as a biocide with both chemotactic and pathogen membrane lysing properties. Another embodiment uses biocide chemicals blended into the melt before filter fibers are extruded and electret dipole charged. The attracting-binding properties of the embodiments may be enhanced by including electropositive Boehmite nano-fiber strands in the active media, by coating a reversible voltage charged electro-conductive polymer, by the use of supplemental fusing and lysing chemicals, and by optional ion field charging of incoming pathogens.

A method for enhancing anticancer capability of CIK cells is provided. The method includes knockout of a PD-1 gene of the CIK cells based on a CRISPR / Cas9 technique. The invention also provides enhanced type CIK cells obtained by the method. Experiments prove that the knockout of the PD-1 gene from the CIK cells can effectively enhance anti-hepatoma capability of the CIK cells, thus providing novel effector cells for tumor cellular immunotherapy.

The invention discloses a homogeneous material-containing corundum-mullite high-strength abrasion-resisting plastic, belonging to the field of high-temperature abrasion-resisting fireproofing material, comprising high-aluminum homogeneous material, alumina fine powder, silica fine powder, clay, phosphoric acid, aluminum dihydrogen phosphate solution, pure calcium aluminate cement and the like as raw materials, wherein the homogeneous material is as follows: the content of Al2O3 is 70-90% and the volume density is 2.9-3.5g.cm<-3>. Synthetic homogeneous material with low water-absorption, low porosity and high homogeneity is used for substituting the traditional natural raw material of sintered alumina clinker with high-absorption, high porosity and low homogeneity or composite raw material system of corundum and mullite to produce homogeneous corundum-mullite high-strength abrasion-resisting plastic. Distinguished from the castable, the plastic can be directly utilized in the construction method of smearing and ramming without supporting a module. The material of the invention is good in workability, high in strength, good in abrasive resistance and optimal in on-site usage effect, which is in favour of prolonging service life of furnace lining and improving utilization efficiency of the high-temperature furnace.

The invention discloses a method for amplification and activation of NK cells by K562 cells. The method comprises that through synergism of K562 cells transfected by transmembrane interleukin 21, CD14, CD19, CD86 and CD137, and low-concentration interleukin 2, NK cells are subjected to directed amplification and activation. Compared with the existing similar compounds, the compound provided by the invention has a stronger lymphocyte amplification and activation capability and higher efficiency. The method has wide prospects in immunological therapy.

An improved light gas gun launches a projectile in a light gas atmosphere as it travels through a frictionless barrel to achieve high muzzle velocities, decreased acoustic signatures, and increased ranges. The light gas atmosphere is introduced by a purge valve prior to firing or by a muzzle valve that holds a positive light gas pressure on the barrel and breech. The muzzle valve also routes the majority of propellant gases through a suppression canister, reducing the light gas gun's acoustic signature. The frictionless barrel uses light gas propellant routed through gas bearings to keep the projectile centered in the barrel and preclude the projectile from contacting the barrel walls, eliminating barrel wear. The system includes a projectile assembly that stores light gas from the firing and injects it into the boundary layer, reducing drag, increasing range and lethality, and decreasing acoustic signature of the projectile down range.

A weapon system comprises a first, second and third sensor and a range detecting means. The weapon system further comprises a weapons platform removably mounted to a moveable vehicle. The weapons platform includes a gun. The first sensor is mechanically attached to the gun for sensing an image. The second sensor senses a position of the gun, including at least an elevation and azimuth. The third sensor detects a rate and altitude of the moveable vehicle. The range detecting means detects a range of the gun to the target. The weapon system also comprises an image processor for processing the image from the first sensor, a display for displaying the processed image and a controller. The controller calculates an expected impact point for a round of fire based upon the sensed and detected data, and superimposes the expected impact point on the processed image on the display.

A system and method can provide a command and control paradigm for integrating robotic assets into human teams. By integrating sensor to detect human interaction, movement, physiology, and location, a net-centric system can permit command of a robotic platform without an OCU. By eliminating the OCU and maintaining the advantages of a robotic platform, a robot can be used in the place of a human without fatigue, being immune to physiological effects, capable of non-humanoid tactics, a longer potential of hours per day on-station, capable of rapid and structured information transfer, has a personality-free response, can operate in contaminated areas, and is line-replaceable with identical responses. A system for controlling a robotic platform can comprise at least one perceiver for collecting information from a human or the environment; a reasoner for processing the information from the at least one perceiver and providing a directive; and at least one behavior for executing the directive of the reasoner.

The invention discloses an in-vitro large-scale amplification method of natural killer cells. The method comprises the following steps: collecting and separating peripheral blood mononuclear cells; sorting natural killer cells; culturing the natural killer cells; and collecting the natural killer cells. The method utilizing immunomagnetic beads to sort the natural killer cells has the advantages of simplicity in establishing and operation, and high comprehensive efficiency; and the effect of the method adopting in-vitro amplification of the immunomagnetic bead shorted NK cells is 2-3 times the effect of present amplification methods, so the method disclosed in the invention has great application values in the field of in-vitro large-scale amplification.