1021 results about "Nitro compound" patented technology

A method for preparing a functionalized polymer, the method comprising the steps of (i) polymerizing conjugated diene monomer by employing a lanthanide-based catalyst to form a reactive polymer, and (ii) reacting the reactive polymer with a nitro compound.

The invention relates to a catalyst for selective hydrogenation reaction of an aromatic nitrocompound and a preparation method of the catalyst. The catalyst consists of a catalyst carrier and active metal coated with carbon, wherein the catalyst carrier includes a carbon-base carrier, SiO2, TiO2 or Al2O3; the active metal is selected from Co, Fe, Ni or Cu and other poor and noble metals. The catalyst is prepared by adopting a Pechini type sol-gel process which comprises the steps of dispersing an active metal precursor to water containing a coordination compound, adding a polyhydric alcohol solution and a macromolecule auxiliary, then adding the carrier, stirring for dispersion, carrying out hydrothermal reaction, separating out solid on the lower layer, and calcining in the inert atmosphere to obtain the catalyst in which carbon coats the active metal. Compared with the prior art, the catalyst can realize the hydrogenation reaction of a substituted aromatic nitrocompound in the mild condition; substrate conversion rate and production selectivity are high; the catalyst has recyclable economy and good application prospect.

The invention relates to a manufacturing mode of environment-friendly and energy-saving M15_M85 methanol diesel oil. The methanol diesel oil is composed of diesel oil, methanol, and additives. The methanol diesel oil is prepared with operations under normal temperatures and normal pressures. The invention discloses a plurality of common additives used for preparing methanol diesel oil in modern times. If explosives and aviation fuels are appropriately utilized, methanol defalcated heat value can be well compensated. The theory is tentatively considered as a gaseous detonation theory. The additives can be selected from nitric acid esters, nitrates, nitro compounds, non-aromatic compounds, peroxides, and the like.

The invention provides a preparation method of a nitrogen doped carbon-encapsulated core-shell structure ferro-nickel nano-catalyst and the application of the nitrogen doped carbon-encapsulated core-shell structure ferro-nickel nano-catalyst in catalyzing an o-chloronitrobenzene hydrogenation reaction. According to the method, the novel nitrogen doped carbon-encapsulated core-shell structure ferro-nickel nano-catalyst is prepared by synthesizing a ferronickel layered doubled hydroxide precursor with small grain size and high surface energy through a nucleation crystallization isolation method, evenly mixing the ferronickel layered doubled hydroxide precursor with a melamine and dicyandiamide mixed carbon material precursor, and finally self-reducing at high temperature. The nitrogen doped carbon-encapsulated core-shell structure ferro-nickel nano-catalyst is efficiently applied to the reaction where halogenated aniline is generated through catalytic hydrogenation of a nitro-halogen compound, and the conversion rate of o-chloronitrobenzene and the selectivity of o-chloroaniline are respectively up to 95-100% and 98-100%. The structure of the novel nitrogen doped carbon-encapsulated core-shell structure ferro-nickel nano-catalyst is unique and novel, the process is green and energy-saving, the structure of the catalyst is stable, and the catalyst has a broad application prospect.

A method for stabilizing collagenous eye tissues by nitrite and nitroalcohol treatment. The topical stiffening agent contains sodium nitrite or a nitroalcohol in a buffered balanced salt solution and can be applied to the surface of the eye on a daily basis for a prolonged period. Application of the solution results in progressive stabilization of the corneal and scleral tissues through non-enzymatic cross-linking of collagen fibers. The compounds can penetrate into the corneal stroma without the need to remove the corneal epithelium. In addition, ultraviolet light is not needed to activate the cross-linking process. The resulting stabilization of corneal and scleral tissues can prevent future alterations in corneal curvature and has utility in diseases such as keratoconus, keratectasia, progressive myopia, and glaucoma.

A method for preparing a functionalized polymer, the method comprising the steps of (i) polymerizing conjugated diene monomer by employing a lanthanide-based catalyst to form a reactive polymer, and (ii) reacting the reactive polymer with a nitro compound.

The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and / or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

A C-nitroso compound having a molecular weight ranging from 225 to 1,000 (from 225 to 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less than about 25, is useful as an NO donor. When the compound is obtained from a carbon acid with a pKa less than about 10, it provides vascular relaxing effect when used at micromolar concentrations and this activity is potentiated by glutathione to be obtained at nanomolar concentrations. When the compound is obtained from a carbon acid with a pKa ranging from about 15 to about 20, vascular relaxing effect is obtained at nanomolar concentrations without glutathione. In another embodiment, a biocompatible polymer incorporates a C-nitroso moiety.

The invention discloses a method for synthesizing halogen aromatic amines by halogen aromatic nitro compounds through liquid phase hydrogenation, which is characterized in that: the reaction for synthesizing the halogen aromatic amines by the halogen aromatic nitro compounds through liquid phase hydrogenation is carried out in the presence of a Pd / C catalyst under the condition of no solvent; and the method for preparing the Pd / C catalyst comprises the following steps of: performing impregnation pretreatment on active carbon by using aqueous solution of potassium halide, and filtering and washing until the filter liquor does not contain halide ions; preparing the pretreated active carbon into slurry by using de-ionized water, adding aqueous solution of HaPdCl4 dropwise for impregnation treatment, adjusting the pH value to alkali, and filtering and washing until the filter liquor is neutral; and preparing the obtained filter cakes into slurry by using de-ionized water, reducing in aqueous solution of reducing agent by a wet method, and filtering and washing until the filter liquor is neutral to obtain the Pd / C catalyst. The catalyst is adopted to prepare the halogen aromatic amines under the condition of no solvent, the selectivity is over 99.9 percent, the product quality meets the medical requirements, the production process is simplified, the production cost and energy consumption are reduced, the production efficiency is improved, and adverse factors such as solvent and product steam severely harming human bodies and polluting environment are improved.

The present invention discloses a water-based cutting fluid for vermicular cast iron processing, and a dilution solution thereof. The water based cutting fluid comprises 3-10% of an anti-rust additive, 4-10% of fatty acid amide, 2-3% of organic amine, 3-10% of long-chain fatty acid, 2-5% of fatty alcohol polyoxyethylene ether, 5-8% of petroleum sodium sulfonate, 1-5% of a coupling agent, 10-15% of an extreme pressure additive, 15-20% of a synthetic ester, 1-2% of a sterilization agent, 0.5-1.0% of an anti-forming agent, and 32-45% of water, wherein the anti-rust additive is a boric acid anti-rust additive and dicarboxylic acid, and the coupling agent is a fatty alcohol and / or aliphatic ether. The water-based cutting fluid of the present invention has characteristics of good lubrication performance, good cooling performance, good anti-rust property, no chlorine, diamine, nitrite and other nitro compounds, no environmental pollution, no irritating odor, easy cutting, easy powder settlement, and effective cutter service life prolonging.

The invention discloses a composition containing HFC-161 and a stabilizer, wherein the stabilizer is selected from one or more of epoxy compound, nitro-compound, hindered amines, hindered phenols, secondary arylamines, beta-diketones, phosphite esters, salicylic acid esters, cinnamic acid esters, hydroxybenzophenones, hydroxybenzoic acids, hydroxylphenyl benzotriazoles, hydroxylphenyl triazines, oxanilides, formamidines, polyhydric alcohols, ortho-formates, organosulfur compounds, olefins, ethanol amines and fatty amines. The composition provided by the invention is capable of keeping a stable state in a long time under the coexistence of air or oxygen, and capable of being used as a heat transfer composition in the form of a liquid or a gas, a refrigerant, an aerosol propellant and the like.

A supported non-noble metal catalyst used for preparation of an azo compound from an aromatic nitro compound by hydrogenation coupling is disclosed, an active component of the supported non-noble metal catalyst is any one or more than two of Co, Mn, Fe, Ni and Cu, a carrier is a nitrogen-doped carbon-inorganic oxide composite, the content of the active component in the catalyst is 0.1-15wt%, and an inorganic oxide is any one of alumina, aluminum hydroxide, magnesium oxide, magnesium hydroxide, silica, SBA-15, magnesium aluminum hydrotalcite, titanium oxide and cerium oxide. A preparation process is as follows: the active component and a nitrogen-containing complex are together impregnated on the inorganic oxide, and then calcined at certain temperature. The catalyst has excellent catalytic performance in the preparation of the azo compound from a nitro compound by selective hydrogenation coupling one-step method. The catalyst is simple in preparation, and has high catalytic activity and stability.

The invention discloses a heterogeneous catalyst for selective hydrogenation reaction of an aryl nitro-compound. The heterogeneous catalyst consists of 10-90 weight percent of base metal particles and 10-90 weight percent of nitrogen-doped carbon nano tubes, wherein the nitrogen content in the nitrogen-doped carbon nano tubes is 0.01-20.0 weight percent. The preparation method comprises the following steps: by taking a carbohydrate as a raw material, uniformly mixing the carbohydrate with an artificial template agent in the presence of base metal salts, preserving the temperature of 400-650 DEG C for 0.5-2 hours in an inert atmosphere, raising the temperature to 700-1200 DEG C, and calcining for 0.5-2 hours, thereby obtaining the heterogeneous catalyst. The heterogeneous catalyst containing base metals is generated in situ through a specific method, is stable to air and water heat, is applied to the selective hydrogenation reaction of the aryl nitro-compound and has excellent catalytic activity and selectivity.

The present invention relates to a composition comprising: (i) an anti-microbial agent comprising a polymeric biguanide, alone or in combination with at least one other microbiologically active component selected from the group consisting of quaternary ammonium compounds, monoquaternary heterocyclic amine salts, urea derivatives, amino compounds, imidazole derivatives, nitrile compounds, tin compounds or complexes, isothiazolin-3-ones, thiazole derivatives, nitro compounds, iodine compounds, aldehyde release agents, thiones, triazine derivatives, oxazolidine and derivatives thereof, furan and derivatives thereof, carboxylic acids and the salts and esters thereof, phenol and derivatives thereof, sulphone derivatives, imides, thioamides, 2-mercapto-pyridine-N-oxide, azole fungicides, strobilurins, amides, carbamates, pyridine derivatives, compounds with active halogen groups, and organometallic compounds; and (ii) an amphoteric co-polymer of the Formula (1): wherein:[A] is of Formula (9), [B] is of Formula (10), [C] is of Formula (12), [D] is of Formula (13), and X is of Formula (11), wherein [A], [B], [C] and [D] may occur in any order; T is an optionally substituted substituent; L, G and Z each independently is an optionally substituted linking group; R1, R2 and R3 are each independently H, optionally substituted C1-20-alkyl or optionally substituted C3-20-cycloalkyl; R4 and R5 are each independently H or C1-4-alkyl; q is 15 to 1000; p is 3 to 50; J is an optionally substituted hydrocarbyl group; F is an acidic substituent; E is a basic substituent; m is 0 to 350; n is 1 to 75; v is 0 to 100; y is 1 to 100; b is 0, 1 or 2; s is 0 or 1; w is 1 to 4; and provided that at least one of R4 and R5 is H.

The invention discloses a loading type Pd base metal nanometer cluster catalyst, a preparing method and applications thereof. The catalyst comprises Pd metal nanometer particles of 1-25nm, or bimetal or polymetal nanometer particles containing Pd, and ferric oxide nanometer particles, wherein the ferric oxide nanometer particle is used as the carrier, has the primary particle size of 5-200nm, and has the general formula of FeyOx; the bimetal or polymetal nanometer particles are selected from one or a plurality of Pt, Rh, Ru, Os, Ir and Re; when the metal nanometer particles are Pd nanometer particles, x / y is greater than 1, but is smaller than 4 / 3, or is greater than 4 / 3, but is smaller than 3 / 2; and when the metal nanometer particles are bimetal or polymetal nanometer particles containing Pd, x / y is greater than 1, but is smaller than or equal to 3 / 2. The catalyst has excellent activity, selectivity and stability on the selective hydrogenating synthesis chlorinated arylamine of the chlorinated aromatic compounds, solves the problems of hydrogenolysis and dechlorination of products in the process of the Pd catalyst catalyzing the chlorinated aromatic compounds to hydrogenate to prepare the chlorinated arylamine, and has important industrial application values.

A catalyst carrying ionic liquid and metallic nanoparticles for preparing high-quality arylamine by hydrocatalyzing aromatic nitro compound is prepared through preparing immobilized ionic liquid by bonding the ionic liquid onto carrier, binding it with the active component containing transition metal or precursor, and reductive exchange. Its advantages are low reaction temp, long service life and no waste generation.

The invention discloses a method for rapidly pickling fish by mixed fermentation of microorganisms. According to the method, fresh fish or frozen fish is rapidly prepared into the pickled fish by the procedures of pre-treating fish bodies, pickling by a low-temperature wet pickling method, rinsing, inoculating a mixed microorganism fermenting agent, carrying out gradient low-temperature drying and the like, so that the time for pickling and processing the fishes can be shortened and the flavor of fish pickled products can be improved; nitrite and nitro compounds are prevented from being generated in a process of pickling the fish products, and the edible safety of the fish pickled products is guaranteed; the pickled fish processed by the method is good in flavor, is short in pickling time, low in salt content and free of the nitro compounds; the operation method is simple, the production cost is low, the energy consumption is low, the environmental pollution is small and the product quality is stable; and the economic benefits of manufacturing enterprises can be improved.

The present invention relates to a novel technology of continuous nitration and denitration, extraction, hydrogenation and reduction of H acid, and belongs to the technical field of H acid production. In the novel technology, H acid is prepared with liquid naphthalene through sulfonation, continuous nitration and denitration, extraction, hydrogenation and reduction, concentration, alkali fusion and separation of the H acid. The present invention not only solves the problems in the traditional technological process that the steps are more, the process is complex, the labor intensity of workers is high, the yield rate of the H acid is low and the pollution of wastewater is serious, but also eliminates the factors that the slightly inaccurate control over the reaction temperature and time of nitration and denitration can easily cause explosive polynitro compounds and thus hidden danger of security. The present invention has the advantages that the process is shortened, the byproducts are fewer, and the labor intensity is reduced. The continuous nitration and denitration has the advantages that the occupied area is small, the production capacity is high, the energy consumption is low, the yield rate is improved by 8 percent compared with the traditional process, about 1 ton of sulphuric acid is saves in production of one ton of the product, and the wastewater discharge is reduced. No iron ions are contained in the materials, the product quality of the H acid is improved, and the workshop production environment is obviously better.

The present invention relates to a method of preparing a molecularly imprinted polymer (MIP), which are used for the recognition of target molecules comprising: co-polymerising at least one functional monomer and at least one cross-linking monomer in the presence of at least one template, wherein oxyanions are used as template and the steric and / or electronic structure of the template is at least partly analogous to the target molecule. The target molecules may be nitro-containing compounds, such as nitroaromatic compounds, or lactones. MIPs selective for explosive nitro-aromatic substances may be produced without handling these hazardous compounds. The invention further relates to a method of determining if a sample contains nitro-containing compounds, such as nitroaromatic compounds, or lactones, MIPs selective for nitro-containing compounds and / or lactones, especially nitro-aromatic compounds and a kit, comprising a molecularly imprinted polymer selective for nitro-aromatic compounds and / or lactones. The invention also relates to use of isosteric and / or isoelectronic oxyanions for the production of MIPs for recognition of nitro-containing compounds, especially nitroaromatic compounds, and lactones.

The invention provides a preparing method of crizotinib. The preparing comprises the following steps of: 1) preparing (S)-construction phenethyl alcohol by taking acetophenone the structural formula of which is shown in a formula (1) as a raw material; 2) preparing a nitrocompound; 3) preparing an aromatic amine compound; 4) preparing a bromo-compound; 5) preparing an N-Boc compound; and 6) preparing the crizotinib. Compared with the prior art, the preparing method of the crizotinib has the advantages that 1, the conventional biological enzymatic method and chemical resolution method are replaced by an organic micromolecule catalysis method, thus the whole line is short in reaction cycle, high in yield, simple in operation, wide in raw material source and low in price; and 2) the preparing method of the crizotinib is high in total yield, the obtained product has high optical purity, the required reaction condition and reaction process are easy to control, and a new choice is provided for preparation and production of the medicament crizotinib.

The invention provides an amino metal organic framework material containing an active metal component. The amino metal organic framework material is used as a carrier; and the active metal component is dispersed in the carrier, wherein the weight of the active metal component is 0.05-15% of that of the amino MOFs material. According to the invention, a mixed solution is formed from the carrier and an active metal precursor containing a carbanyl group; amino in the MOFs material is reacted with the carbanyl group in the active metal precursor, so that the active metal precursor is connected to the MOFs material; then, the material is prepared through a reduction method; uniform dispersion of the active metal component in the MOFs material is realized; when the material is used as the catalyst, the catalytic effect is obvious because of high dispersion of the active component, for example, the amino metal organic framework material is used in a process for preparing aromatic amine by hydrogenation reduction of an aromatic nitro compound, etc.

The invention provides an etching liquid composition for nickel or nickel alloy so as to enable the solving of the problems existing in the prior art that etching rate of nickel is low or corrosion to copper is great, and operating liquid has poor stability. The etching liquid composition comprises nitric acid or sulfuric acid, hydrogen peroxide, ammonium salts, aromatic amine, nitro compounds and deionized water. The etching liquid composition provided in the invention has a uniform and stable etching rate, no residues and no corrosion to other metals except nickel, especially no corrosion to copper.

The invention provides an activated carbon loaded compound metal catalyst, a preparation method and application thereof. The catalyst is prepared from a carrier, an active ingredient and an auxiliary, wherein the carrier is activated carbon, the active ingredient is at least one of platinum, palladium and rhodium, and the auxiliary is at least one of iron, zinc, cobalt and copper. The catalyst can be applied to a reaction for synthesizing a corresponding amine compound by catalytic hydrogenation, and has high catalytic activity and high hydrogenation speed, the reduction process is effectively promoted by the using method, and a nitro group influenced by power supply group can be quickly reduced into amino by 100 percent. The catalyst is mild in conditions, good in stability and more in using times in the circular using process.

The invention discloses amorphous alloy catalyst with controllable grain size being smaller than 50 nm and uniform grain size distribution, and adds a new variety for the prior amorphous alloy catalyst field. The activity ratio surface area of the amorphous alloy catalyst is 10 to 50 m<2> / g, the particle diameter can be controlled in the range of 2 to 50 nm, and the grain size distribution is uniform. The invention realizes the amorphous alloy catalyst with the grain size being smaller than 50 nm and achieves the controllable grain size and the uniform grain size distribution through the preparation method for controlling the reduction reaction rate by oil in water microemulsion. The amorphous alloy catalyst of the invention can be taken as hydrogenation catalyst containing unsaturated functional group compounds such as alkene, alkyne, arene, nitrile, nitro compound, carbonyl compound, etc., not only the catalytic performance is superior to the catalytic performance of the ordinary amorphous alloy catalyst, but also the catalytic performance can be controlled; the life of the catalyst is longer than the life of the ordinary amorphous alloy catalyst, and the catalyst can be recovered and reused time after time.

The invention discloses preparation of a high-activity graphene-load platinum catalyst and application of the catalyst to a hydrogenation reaction of an aromatic nitro-compound, in particular to a high-activity catalyst used in a hydrogenation reaction of an aromatic nitro-compound and a preparation method thereof. A carrier of the catalyst is graphene; and an active ingredient is metal platinum.Specific to the current situation of small application range of graphene and large difficulty in large-scale preparation and application, ethylene glycol is taken as a reducing agent in the method, and Pt nanoparticles are successfully and uniformly loaded on a graphene oxide nano-sheet and are applied to the hydrogenation reaction of the aromatic nitro-compound, so that the high-activity graphene-load platinum catalyst represents catalytic activity which is remarkably superior to that of a Pt catalyst loaded with a normal carbon carrier.

The invention discloses a catalyst as well as a preparation method and application of the catalyst. The catalyst is composed of a carrier and a composite carbon-metal quantum dot supported on the carrier; the particle size of the catalyst ranges from 100nm to 1000nm; the carrier is a mesoporous carbon microsphere; the composite carbon-metal quantum dot is not larger than 15nm and contains 10-90% of metal; the metal in the composite carbon-metal quantum dot is one or a combination of several of platinum, palladium, iridium, ruthenium and rhodium; the loads of platinum, palladium, iridium, ruthenium and rhodium are respectively 0-10.0%, 0-10.0%, 0-10.0%, 0-10.0% and 0-5.0% based on the mass of the carrier, and the loads of palladium, platinum and rhodium are not equal to zero; and the total load of the metal is 1.0-11.5%. The invention provides the application of the catalyst to reaction for synthesizing a chlorinated aromatic amine compound shown as a formula (II) by carrying out selective catalytic hydrogenation on a chlorinated aromatic nitrocompound shown as a formula (I), and the catalyst has the characteristics of high hydrogenation reaction rate, high conversion rate, high catalytic activity and high stability.

The invention discloses a catalyst for loading silver on SiO2, a preparation method and application in a selective catalytic hydrogenation of chloro-aromatic compounds, nitryl-aromatic ene, nitryl-aromatic aldehydes, nitryl-aromatic ketone, and nitryl-aromatic polyamide. The synthetic method is that tetraethoxysilane and aminopropyl-triethoxysilane are added by weight proportion of 1: 0.1-1: 25 into an ammonia solution containing definite AgNO3, then the solution is stirred to form gelatinate under room temperature and dried under 100-200 DEG C for about 4-12 hours, thus obtaining the catalyst. The synthetic catalyst of the invention solves two problems of current catalytic hydrogenation of aromatic nitro-compounds: (1) a secondary reaction of dechlorination is generated during the hydrogenation of chloronitrobenzenes of aromatic nitro-compounds; (2) the selectivity of reaction is poor when alkene, aldehydes, ketone, nitrile and amide groups coexist.