62 results about "Keratoconus" patented technology

A method for stabilizing collagenous eye tissues by nitrite and nitroalcohol treatment. The topical stiffening agent contains sodium nitrite or a nitroalcohol in a buffered balanced salt solution and can be applied to the surface of the eye on a daily basis for a prolonged period. Application of the solution results in progressive stabilization of the corneal and scleral tissues through non-enzymatic cross-linking of collagen fibers. The compounds can penetrate into the corneal stroma without the need to remove the corneal epithelium. In addition, ultraviolet light is not needed to activate the cross-linking process. The resulting stabilization of corneal and scleral tissues can prevent future alterations in corneal curvature and has utility in diseases such as keratoconus, keratectasia, progressive myopia, and glaucoma.

The present invention is directed to a non-deforming contact lens for keratoconus patients comprising a central zone having a displaced central zone. In particular, the central zone is displaced from the geometric center of the lens. The shape of the central zone is egg or spoon-shaped and is rotationally asymmetrical with one semi-meridian that is shorter than a corresponding semi-meridian. An intermediate transition zone is formed integral with the periphery of the central zone, and a peripheral zone is formed integral with the periphery of the intermediate transition zone, forming a round contact lens.

A contact lens for cornea-correction crosslinking made of an ultraviolet transmitting material includes, on a cornea contact side, a pressing region projecting in a convex curved-surface shape at a position corresponding to the center of a corneal dome to be pressed and a relief region constituted by an annular concave portion in a circular arc shape, encircling the outer periphery of the pressing region. The contact lens corrects at least naked eye vision or keratoconus cornea by pressing both regions to the cornea and changing its shape. The contact lens includes a reservoir portion outside the pressing region in a lens thickness direction for a riboflavin solution, a communication hole communicating the reservoir portion inside with the pressing region, and an operation-side electrode having the same polarity as that of the riboflavin solution. The mounted contact lens allows riboflavin solution infiltration into corneal tissue by iontophoresis and ultra-violet ray irradiation.

The disclosure relates to a platform of using zebrafish in screening candidates for treating and / or preventing myopia and keratoconus disease. The disclosure is mainly based on that Lumican, one of several SLRPs, plays an important role in the regulation of fibrillogenesis or the genes affecting the size of eyeballs in zebrafish, in addition to playing an important role in clinical myopia. Therefore, the disclosure uses the established zebrafish model to further identify the drugs affecting the expression of lumican and collagen fibrillogenesis, and / or the regulation of eyeball size. These drugs are potential candidates for treating myopia and / or keratoconus disease.

An ocular system for detecting ocular abnormalities and conditions creates photorefractive digital images of a patient's retinal reflex. The system includes a computer control system, a two-dimensional array of infrared irradiation sources and a digital infrared image sensor. The amount of light provided by the array of irradiation sources is adjusted by the computer so that ocular signals from the image sensor are within a targeted range. Enhanced, adaptive, photorefraction is used to observe and measure the optical effects of Keratoconus. Multiple near-infrared (NIR) sources are preferably used with the photorefractive configuration to quantitatively characterize the aberrations of the eye. The infrared light is invisible to a patient and makes the procedure more comfortable than current ocular examinations.

Methods of stabilizing collagen fibrils in a cornea are disclosed. The stabilization may be effected by treating the cornea with a protein that crosslinks collagen fibrils, such as decorin. The stablization methods include treatment of corneas before, during, or after a surgical procedure, treatment of keratectasia, and treatment of keratoconus.

The present invention relates to novel pharmaceutical formulations. More specifically, the present invention relates to novel pharmaceutical formulations that are suitable for intraocular administration. The present invention also relates to the use of these formulations for the treatment of collagenic eye disorder such as, for example, the treatment of keratoconus.

A kit for determining a hypothetical cornea for use with post-LASIK and post myopia Ortho-K amendment. The kit has a reference table for determining conformation data by using at least one of following data: pre-treatment KM readings, post-treatment KM readings, power reduced from before- to after-treatment, and post-treatment cornea optical zone. The kit further comprises a plurality of conformed lenses based on the conformation data in predetermined increments from the reference table. The pre-treatment KM readings comprise pre-operative or pre-ortho-K readings. The post-treatment KM readings comprise post-operative or post ortho-K readings. The post-treatment cornea optical zone comprises post-operative or post-ortho-K cornea optical zone. Also, a method of determining a hypothetical cornea for use with post-LASIK and post myopia Ortho-K amendment is disclosed. The method has inputting pre-treatment KM readings, inputting post-treatment KM readings, inputting power reduced from before- to after treatment, inputting post-treatment cornea optical zone, calculating conformation data, which is adapted to be used to generate specification for conformed lenses. Another kit for determining a hypothetical cornea for use with Keratoconus and post-hyperopia Ortho-K amendment can be constructed using at least one of following data: pre-altered KM readings, post-altered KM readings, pre-altered refraction error, and post altered specifications. The kit further comprises a plurality of conformed lenses based on the conformation data in predetermined increments from the reference table. The pre-altered KM readings comprise pre-keratoconus or pre-hyperopia ortho-K readings. The pre-altered refraction errors comprise refraction errors from a set of normal corneas. The post-altered specifications comprise cone widths of Keratoconus or steepened cornea zone of hyperopic Ortho-K and also magnitude of off centering of the cone apex.