The invention provides systems and methods for detection, grading, scoring and tele-screening of cancerous lesions. A complete scheme for automated quantitative analysis and assessment of human and animal tissue images of several types of cancers is presented. Various aspects of the invention are directed to the detection, grading, prediction and staging of
prostate cancer on serial sections / slides of
prostate core images, or
biopsy images. Accordingly, the invention includes a variety of sub-systems, which could be used separately or in conjunction to automatically grade cancerous regions. Each
system utilizes a different approach with a different
feature set. For instance, in the quantitative analysis, textural-based and morphology-based features may be extracted at image- and (or) object-levels from regions of interest. Additionally, the invention provides sub-systems and methods for accurate detection and mapping of
disease in whole slide digitized images by extracting new features through integration of one or more of the above-mentioned classification systems. The invention also addresses the modeling,
qualitative analysis and assessment of 3-D
histopathology images which assist pathologists in
visualization, evaluation and diagnosis of diseased tissue. Moreover, the invention includes systems and methods for the development of a tele-screening
system in which the proposed computer-
aided diagnosis (CAD) systems. In some embodiments, novel methods for
image analysis (including
edge detection,
color mapping characterization and others) are provided for use prior to
feature extraction in the proposed CAD systems.