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A pressure sensor for an extracorporeal circulating circuit includes a liquid chamber, a pressure measuring means, and a liquid flow path. The liquid chamber includes a reference surface not deformed by a pressure in the extracorporeal circulating circuit, a deforming surface disposed separated from the reference surface and deformed at least partially by a pressure in the extracorporeal circulating circuit, a first connection surface that joins the deforming surface with the reference surface to form a closed liquid-tight space inside them and is not deformed by a pressure in the extracorporeal circulating circuit, a liquid inflowing port provided in the side surface of the first connection surface, and a liquid outflowing port disposed away by ½ to less than one round from the inflowing port in the flowing direction of liquid introduced along the inner periphery of the side surface of the first connection surface. The pressure measuring means measures the deformation amount of the deforming surface, and is disposed outside the liquid chamber; and the liquid flow path is liquid-tightly connected with the liquid inflowing port so that liquid to be introduced into the liquid chamber flows in along the inner periphery of the side surface of the first connection surface.

Disclosed is a cell which can express a non-natural oligomeric protein, which has, introduced therein, a gene encoding an exogenous polypeptide corresponding to at least one endogenous polypeptide constituting a natural oligomeric protein, and in which the expression of the endogenous polypeptide is inhibited.

The present invention relates to certain new pyridin analogues of Formula (I)to processes for preparing such compounds, to their utility as P2Y12 inhibitors and as anti-trombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.

The present invention is directed to the administration of aerosolized particles to specific area of the lungs, and in particular to the targeted delivery of aerosolized pharmaceutical formulations to a specific area of the lungs. More specifically, the present invention relates to devices and methods for depositing aerosolized particles to a specific area of the lungs by regulating aerosolizing parameters of the device. The present invention also relates to devices, systems and methods for disease management, where the aerosolizing parameters are adjusted based on monitoring at least one health parameter.