539 results about "Cyanoacrylate" patented technology

The invention discloses a method of treating a patient for pleural effusion comprising percutaneously delivering an adhesive material to a pleural space of the patient. Suitable adhesive materials for performing any of the embodiments of the methods of the invention can be selected from the group consisting of hydrogels, collagen, poly(lactic acid), poly(glycolide), cyanoacrylates, glutaraldehyde, PEG, protein, and polysaccharide and derivatives thereof. The invention also discloses a pleural effusion treatment apparatus comprising an adhesive material adapted to adhere pleural membranes defining a pleural space and a pleural space access member adapted to deliver the adhesive material to the pleural space.

Blends made of bioabsorbable materials including glycolide, lactide, caprolactone, dioxanone, trimethylene carbonate, alkylene glycols, esteramides, etc., and polymers and copolymers thereof with cyanoacrylates are described. Processes for making the polymers and surgical articles made totally or in part from such polymers, including sutures, are also described.

Compositions for embolization are disclosed herein. The compositions disclosed can have a matrix-forming component, a solid-aggregate material, and a rheology modifying agent, wherein the matrix-forming component includes at least alkyl cyanoacrylate monomers, a stabilizer, and a plasticizer, and the solid-aggregate material includes at least a radiopacifier. The composition and a method of administering the composition are useful for treating vasculature abnormalities, particularly when the composition solidifies upon contact with an ionic environment, such as blood.

The present invention is directed toward cyanoacrylate-based tissue adhesive or sealant compositions comprising cyanoacrylate-capped heterochain polymers, such as those comprising one or more oxyalkylene, alkylene carbonate, and ester-units derived from cyclic lactones. Such compositions can be radiochemically sterilized and used in repairing internal organs or tissue blocking body conduits.

Disclosed are methods of spinal fixation involving application of a liquid medium which cures, hardens, polymerizes or otherwise serves to bind adjacent vertebrae together. The fixation which results from this binding may be temporary or essentially permanent in duration, and may be used to treat conditions or disease of the spine, such as inflammation, instability or fracture. In a preferred embodiment, the liquid medium comprises a low viscosity cyanoacrylate-based adhesive.

Disclosed are methods for sterilizing cyanoacrylate prepolymer compositions under E-beam irradiation conditions wherein the prepolymer remains in polymerizable form after sterilization.

The invention relates to a novel medical adhesive which can be subjected to crosslinking copolymerization and which has good biodegradability. A polymer substrate of the adhesive comprises both single alpha-cyanoacrylate and double alpha-diol cyanoacrylate monomer molecules. Olefinic bonds in single alpha-cyanoacrylate structure can be subjected to polymerization under a trace-amount anionic condition. The double alpha-diol cyanoacrylate in the polymer substrate can serve as a crosslinking agent, such that crosslinking copolymerization of the system can be carried out. Chain growth occurs with a three-dimensional multi-point polymerization manner. A gelling speed is fast, and linear polymerization degree of double-bond polymerization is low. A meshed main chain of the solid 3D-body high polymer obtained by polymerization has degradation sites. Degradation product path is clear, and the degradation product can be absorbed. The medical adhesive can be used in wound bonding, bleeding stopping at massive trauma, visceral and soft tissue wound closure, and the like. In addition, the medical adhesive has a potential purpose to be developed into a tissue engineering material.

A medical procedure kit incorporates one or more surgical tools necessary to perform at least part of a medical procedure, along with a container having a quantity of a medical adhesive. Medical adhesives are useful as an alternate or an adjunct to surgical sutures and / or staples in wound closure, as well as for covering and protecting surface wounds such as lacerations, abrasions, burns, stomatitis, sores, minor cuts and scrapes, and other wounds. As such, the inclusion of such an adhesive into a composite medical procedure kit can be of great assistance to a medical doctor or surgeon by providing in single kit form, tools necessary to complete many medical procedures, without having to use multiple procedure kits. The adhesive may be independently sterilized and wrapped from the other surgical tools of the resultant kit, and then associated into kit form, or assembled and sterilized together as a unitary kit. When the adhesive is incompatible with sterilizing procedures of the other components of the kit, the adhesive may be pre-sterilized and protected by a sterilization barrier that shields the adhesive from exposure to the sterilization process used to sterilize other tools of the procedure kit. The adhesive is preferably a 1,1 -disubstituted ethylene monomer, such as an alpha-cyanoacrylate.

Liquid hemostatic coating materials comprise a cyanoacrylate monomer and a solvent system comprising a volatile, non-reactive liquid that is non-stinging and non-irritating to a user. The material forms a coating or bandage in the form of a film that when applied and adhered to a surface or to the skin of a user inhibits the application surface from adhering to another surface.

Applicators for storing, sterilizing, and dispensing adhesives are provided. The applicators comprise a porous tip, a body, and a container containing a polymerizable cyanoacrylate monomer adhesive. The applicators are sterilized by radiation, and following sterilization, the adhesive remains substantially unpolymerized for about twenty four months.

Disclosed are kits of parts comprising a first container comprising a cyanoacrylate composition and a second container comprising a compatible antimicrobial agent and, in particular, a compatible iodine containing antimicrobial agent. Mixture of these compositions provide for in situ formation of an antimicrobial polymeric cyanoacrylate film on mammalian skin.

The invention discloses a 3D printing composition, its preparation and application methods and a product thereof. According to the material, cyanoacrylate and a powder material are used as main bodies; a solvent is added to adjust fluidity of the material; and simultaneously, certain amounts of a plasticizer, a thickener, a flexibilizer, a stabilizer, a cross-linking agent, a pigment, a degassing agent and the like are contained to raise stability of the material and mechanical property of a printing product. As the material is a liquid and solidification process of the material is controlled by controlling conditions such as environment humidity, temperature and the like during printing, an ink-jet printing head which has been developed comparatively mature at present can be used for printing. The composition provided by the invention has characteristics of high printing precision, fast forming speed and low cost. Meanwhile, a printing product has high mechanical strength. The composition is a novel green 3D printing material.

Processes for modifying the viscosity of medically useful cyanoacrylate compositions are described. The processes are carried out by providing to a fluid composition comprising a polymerizable monomer a controlled dose of high-energy radiation sufficient to effect a viscosity increase to a precise predetermined value. Compositions produced via these process are also disclosed.

The invention discloses a sulfydryl / cyano acrylic ester UV curable adhesive composition, which comprises: 5 to 60 percent of sulfydryl compound which is selected from a sulfydryl alkyl acid ester and alkyl hydrosulfide; 5 to 60 percent of alpha-cyanoacrylate of a formula below; 0 to 60 percent of a prepolymer selected from polyester acrylate prepolymers, epoxy acrylate prepolymers and urethane acrylate prepolymers; 0 to 50 percent of active monomer which is selected from acrylic esters having a mono-functional group, double functional groups and multiple functional groups, allyl compounds and ethenyl compounds; 1 to 10 percent of photoinitiator; and 0 to 10 percent of assistant. The UV curable adhesive composition has a quick curing capability, high adhesive strength and low internal stress; and the obtained cured layer is flexible and can be widely to bond metal, metal oxides, plastics, rubber, glass, polyester and other substrate materials.

Disclosed are methods and compositions for closing and sealing a wound, laceration, incision, or other percutaneous opening using an adhesive. In one preferred embodiment, the sides of the percutaneous opening are brought together in apposition and the adhesive is applied topically over the apposed opening and the skin adjacent thereto. Adhesives used in the methods of the preferred embodiments exhibit sufficient viscosity to substantially prevent flow of the adhesive into the percutaneous opening. Adhesives may also be used in surgical applications, as a covering for a trauma to the outer surface of the skin, or as a secondary means of closure in combination with other means of closure, including staples and sutures. In a preferred embodiment, the adhesive is a adhesive comprising cyanoacrylate monomer, cyanoacrylate polymer, and a plasticizer.

Disclosed are methods for sterilizing cyanoacrylate prepolymer compositions under visible light irradiation conditions wherein the prepolymer remains in polymerizable form after sterilization.

A monomeric adhesive composition includes a polymerizable monomer, such as a 1,1-disubstituted monomer such as a cyanoacrylate, and an antimicrobial agent, wherein the antimicrobial agent is a phenolic active compound. Examples of suitable phenolic active compounds include halogenated phenol compounds such as chlorinated phenol compounds (such as triclosan) and brominated phenol compounds.

An adhesive applicator for applying medical adhesives, particularly cyanoacrylates, to incisions such as those made during minimally invasive surgery. The applicator employs a pipette tip or similar narrow flow restrictor tip to close the incision and a body of foam to seal the incision. Methods of using the applicator are also disclosed.

A polycarbonate composition is disclosed comprising a polycarbonate resin, a 3-hydroxychromone dye, and an ultraviolet absorber selected from the group consisting of cyanoacrylates, malonates, and oxanilides. The combination of the 3-hydroxychromone dye and ultraviolet absorber results in a composition with good color retention and strong initial fluorescent emission intensity.

Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.

An adhesive composition is provided particularly excellent in thermal shock resistance for adhesive strength as well as high shear adhesive strength, peel adhesive strength and impact adhesive strength. The adhesive composition of the present invention contains (a) a 2-cyanoacrylate such as 2-ethoxyethyl 2-cyanoacrylate and (b) a polyfunctional cyanoacrylate having two or more 2-cyanoacryloyl groups, the number average molecular weight of the polyfunctional cyanoacrylate (b) is in the range from 1,000 to 50,000, and preferably from 2,000 to 30,000, and the content of the polyfunctional cyanoacrylate (b) is in the range from 1 to 400 parts by weight, and preferably from 1 to 200 parts by weight based on 100 parts by weight of the 2-cyanoacrylate (a).

The invention relates to a chemical medical adhesive composition and a preparation method thereof. The composition is composed of cyanoacrylate, plasticizer, tackifier, stabilizer and other aids. The chemical medical adhesive composition can be quickly polymerized under the initiation of negative ions and produce the adhesive capacity, has high adhesive strength, releases low heat during adhering and has good environment-friendly performance, and adhesive membranes can be degraded and completely excreted out of the body. Therefore, the biodegradable medical adhesive can be used for various wound adhesion, large-area wound hemostasis, closure of internal organ and soft tissue wounds, and is convenient to use.

A latent fingerprint developing compound is formed by mixing cyanoacrylate, a solvent, and a fluorogenic reagent to provide a homogenous blend. The mixture is then solidified with the mixture having the characteristic of being capable of sublimating at a given temperature and in its sublimated state reacting with one or more of the constituent components of the residue of a latent fingerprint to form a discernable fluorescent image of the print. A latent fingerprint may be developed by exposing a substrate containing the latent print to the sublimated fumes of the compound.

An adhesive applicator, for applying medical adhesives, and particularly cyanoacrylates, including a body (20) comprising an internal reservoir (22) and an opening between the internal reservoir (22) and the exterior of the body (20); a sponge (26) disposed over the opening; a slotted tip nozzle (30) disposed over the sponge (26); and a small orifice tip nozzle (40) disposed over the slotted tip nozzle.(30)

The invention belongs to the technical field of functional macromolecule and experimental mechanics, and provides a gripping device for testing pull-power property of low intensity hydrogel. The device includes a dumbbell shaped mould, a gripping device A applied to a reciprocally moving testing machine and accessories thereof, or includes a dumbbell shaped mould, a gripping device B applied to a reciprocally moving testing machine and accessories thereof; different gripping devices correspond to different accessories. The reciprocally moving testing machine applies static, dynamic load to hydrogel samples, and finishes curve measurement for power and displacement. The present invention has the effects and benefits that the pull provided by the gripping device when pulling to the gripping head of hydrogel samples, replaces in the original method the adhesive force of using glue, whose main component is cyanoacrylate, to stick the hydrogel sample on the gripping device. The present invention enhances the measurement accuracy for the pull-power property of low intensity hydrogel. The device has strong controllability, operates conveniently and fast, and is simple for production and promotion.

A fast-bonding and long-lasting adhesive composition with a high viscosity for attaching eyelash / hair extension systems to human eyelash / hair, comprising: a cyanoacrylate monomer having a straight alkyl chain length of from 4 to 16 carbon atoms; an organic polymer thickening agent; an inorganic thickening agent; and a bonding accelerator, wherein the inorganic thickening agent does not separate from the composition.

An applicator has a reservoir adapted to contain a fluid and a pad in fluid communication with the reservoir. A tab serves to seal the fluid reservoir at a breakable connection, with breaking of the breakable connection allowing passage of fluid from the reservoir into the pad. The tab may be removable, or it may be embedded in the tab. Fluids with which use of the applicator is contemplated include sterilizable fluids for therapeutic applications to tissue, including topical liquids such as tissue adhesives for surgical applications, coatings and sealants. One candidate fluid is a cyanoacrylate prepolymer.