The invention discloses a 3D printing composition, its preparation and application methods and a product thereof. According to the material, cyanoacrylate and a powder material are used as main bodies; a solvent is added to adjust fluidity of the material; and simultaneously, certain amounts of a plasticizer, a thickener, a flexibilizer, a stabilizer, a cross-linking agent, a pigment, a degassing agent and the like are contained to raise stability of the material and mechanical property of a printing product. As the material is a liquid and solidification process of the material is controlled by controlling conditions such as environment humidity, temperature and the like during printing, an ink-jet printing head which has been developed comparatively mature at present can be used for printing. The composition provided by the invention has characteristics of high printing precision, fast forming speed and low cost. Meanwhile, a printing product has high mechanical strength. The composition is a novel green 3D printing material.