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Chemical medical adhesive composition and preparation method thereof

A technology of adhesives and compositions, applied in surgical adhesives, applications, medical science and other directions, can solve the problems of insufficient bonding strength and difficulty in defects, etc.

Inactive Publication Date: 2015-10-07
SHAANXI BOYU REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In view of the deficiencies in the prior art, the purpose of the present invention is to overcome the disadvantages caused by quality control during the preparation of existing medical adhesives; and the shortcomings of limited in vitro use and (or) insufficient bonding strength, etc., to provide a convenient preparation , moderate curing speed, high bonding strength, biodegradable chemical medical adhesive composition and its preparation method, the composition comprising:

Method used

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  • Chemical medical adhesive composition and preparation method thereof
  • Chemical medical adhesive composition and preparation method thereof
  • Chemical medical adhesive composition and preparation method thereof

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Embodiment

[0026] The following examples will further illustrate the present invention, but are not intended to limit the scope of the present invention. Any modifications and changes made by those skilled in the art without departing from the spirit of the present invention are within the scope of the present invention.

[0027] Prepare composition (1) according to the chemical medical adhesive preparation method of the present invention, concrete steps are as follows: in dry box (water content≤1ppm, oxygen content≤1ppm, inert gas), with α-cyanoacrylic Butyl is 100 parts by weight. First, 20 parts of n-butyl α-cyanoacrylate, 2.5 parts of tackifier poly-a-n-butyl cyanoacrylate, and 1.5 parts of plasticizer tri-n-butyl citrate are added. Soak in 0.5M dilute sulfuric acid and wash, then stir and mix for 45 minutes in the glass container after high temperature sterilization at 40°C and 120r / min, then add 0.01 part of p-methoxyphenol and 0.05 part of p-toluenesulfonic acid as stabilizers, Pe...

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Abstract

The invention relates to a chemical medical adhesive composition and a preparation method thereof. The composition is composed of cyanoacrylate, plasticizer, tackifier, stabilizer and other aids. The chemical medical adhesive composition can be quickly polymerized under the initiation of negative ions and produce the adhesive capacity, has high adhesive strength, releases low heat during adhering and has good environment-friendly performance, and adhesive membranes can be degraded and completely excreted out of the body. Therefore, the biodegradable medical adhesive can be used for various wound adhesion, large-area wound hemostasis, closure of internal organ and soft tissue wounds, and is convenient to use.

Description

technical field [0001] The invention relates to the field of medical polymer materials, in particular to a biodegradable chemical medical adhesive composition and a preparation method thereof. Background technique [0002] Medical adhesive is a branch of medical polymer. It takes biological tissue as the bonding object. Most of the tissues and organs of the human body can be replaced by adhesive technology during the treatment process, without anesthesia; wound healing After that, it will fall off automatically. The medical adhesive itself is sterile and has antibacterial effect, so infection rarely occurs. Because of its remarkable curative effect on certain diseases, its unique characteristics and convenient operation, it is welcomed by clinicians. [0003] At present, medical adhesives play a very important role in clinical practice. They have been widely used in human tissues as adhesives, hemostatic agents, sealants, and embolic agents. A large number of basic experime...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61L24/06
Inventor 仇智丽
Owner SHAANXI BOYU REGENERATIVE MEDICINE CO LTD
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